메뉴 건너뛰기




Volumn 26, Issue 3, 2012, Pages 629-648

The Antifolates

Author keywords

Antifolates; Folate receptor mediated endocytosis; Folate receptors; Methotrexate; Pemetrexed; Pralatrexate; Proton coupled folate transporter (PCFT); Reduced folate carrier (RFC)

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; AMINOPTERIN; CYCLOPHOSPHAMIDE; DIHYDROFOLATE REDUCTASE INHIBITOR; DIHYDROFOLIC ACID; FLUOROURACIL; FOLATE RECEPTOR 1; FOLATE RECEPTOR 2; FOLATE TRANSPORTER; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; ONYX 0801; PEMETREXED; PRALATREXATE; RALTITREXED; TETRAHYDROFOLIC ACID; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84859955788     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2012.02.002     Document Type: Review
Times cited : (213)

References (105)
  • 1
    • 0014806608 scopus 로고
    • Kinetics of normal and leukemic leukocyte populations and relevance to chemotherapy
    • Skipper H.E., Perry S. Kinetics of normal and leukemic leukocyte populations and relevance to chemotherapy. Cancer Res 1970, 30:1883-1897.
    • (1970) Cancer Res , vol.30 , pp. 1883-1897
    • Skipper, H.E.1    Perry, S.2
  • 2
    • 84959819736 scopus 로고
    • A quantitative comparison of the antileukemic effectiveness of two folic acid antagonists in mice
    • Goldin A., Venditti J.M., Humphreys S.R., et al. A quantitative comparison of the antileukemic effectiveness of two folic acid antagonists in mice. J Natl Cancer Inst 1955, 15:1657-1664.
    • (1955) J Natl Cancer Inst , vol.15 , pp. 1657-1664
    • Goldin, A.1    Venditti, J.M.2    Humphreys, S.R.3
  • 3
    • 78651010566 scopus 로고
    • Temporary remission in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl glutamic acid (aminopterin)
    • Farber S., Diamond L.K., Mercer R.D., et al. Temporary remission in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl glutamic acid (aminopterin). N Engl J Med 1948, 238:787-793.
    • (1948) N Engl J Med , vol.238 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2    Mercer, R.D.3
  • 4
    • 79952738916 scopus 로고    scopus 로고
    • The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs
    • Goldman I.D., Chattopadhyay S., Zhao R., et al. The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs. Curr Opin Investig Drugs 2010, 11:1409-1423.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1409-1423
    • Goldman, I.D.1    Chattopadhyay, S.2    Zhao, R.3
  • 5
    • 33847364471 scopus 로고    scopus 로고
    • Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications
    • Chattopadhyay S., Moran R.G., Goldman I.D. Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. Mol Cancer Ther 2007, 6:404-417.
    • (2007) Mol Cancer Ther , vol.6 , pp. 404-417
    • Chattopadhyay, S.1    Moran, R.G.2    Goldman, I.D.3
  • 6
    • 59849093173 scopus 로고    scopus 로고
    • Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues
    • Zhao R., Matherly L.H., Goldman I.D. Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med 2009, 11:e4.
    • (2009) Expert Rev Mol Med , vol.11
    • Zhao, R.1    Matherly, L.H.2    Goldman, I.D.3
  • 7
    • 51849146937 scopus 로고    scopus 로고
    • Structure and function of the reduced folate carrier A paradigm of a major facilitator superfamily mammalian nutrient transporter
    • Matherly L.H., Hou Z. Structure and function of the reduced folate carrier A paradigm of a major facilitator superfamily mammalian nutrient transporter. Vitam Horm 2008, 79C:145-184.
    • (2008) Vitam Horm , vol.79 C , pp. 145-184
    • Matherly, L.H.1    Hou, Z.2
  • 8
    • 51849142643 scopus 로고    scopus 로고
    • Exploitation of the folate receptor in the management of cancer and inflammatory disease
    • Leamon C.P., Jackman A.L. Exploitation of the folate receptor in the management of cancer and inflammatory disease. Vitam Horm 2008, 79:203-233.
    • (2008) Vitam Horm , vol.79 , pp. 203-233
    • Leamon, C.P.1    Jackman, A.L.2
  • 9
    • 77957921048 scopus 로고    scopus 로고
    • Folate-targeted therapies for cancer
    • Xia W., Low P.S. Folate-targeted therapies for cancer. J Med Chem 2010, 53:6811-6824.
    • (2010) J Med Chem , vol.53 , pp. 6811-6824
    • Xia, W.1    Low, P.S.2
  • 10
    • 79960481261 scopus 로고    scopus 로고
    • Mechanisms of membrane transport of folates into cells and across epithelia
    • Zhao R., Diop-Bove N., Visentin M., et al. Mechanisms of membrane transport of folates into cells and across epithelia. Annu Rev Nutr 2011, 31:177-201.
    • (2011) Annu Rev Nutr , vol.31 , pp. 177-201
    • Zhao, R.1    Diop-Bove, N.2    Visentin, M.3
  • 11
    • 33947424386 scopus 로고    scopus 로고
    • Human reduced folate carrier: translation of basic biology to cancer etiology and therapy
    • Matherly L.H., Hou Z., Deng Y. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy. Cancer Metastasis Rev 2007, 26:111-128.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 111-128
    • Matherly, L.H.1    Hou, Z.2    Deng, Y.3
  • 12
    • 33751244559 scopus 로고    scopus 로고
    • Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
    • Qiu A., Jansen M., Sakaris A., et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006, 127:917-928.
    • (2006) Cell , vol.127 , pp. 917-928
    • Qiu, A.1    Jansen, M.2    Sakaris, A.3
  • 13
    • 0002058353 scopus 로고
    • Historical perspective on key advances in the biochemistry and physiology of folates
    • Wiley-Liss, New York, M.F. Picciano, E.L. Stokstad (Eds.)
    • Stokstad E.L. Historical perspective on key advances in the biochemistry and physiology of folates. Folic acid metabolism in health and disease 1990, 1-21. Wiley-Liss, New York. M.F. Picciano, E.L. Stokstad (Eds.).
    • (1990) Folic acid metabolism in health and disease , pp. 1-21
    • Stokstad, E.L.1
  • 14
    • 0019943145 scopus 로고
    • Accumulation of 5-methyltetrahydrofolate in cobalamin-deficient L1210 mouse leukemia cells
    • Fujii K., Nagasaki T., Huennekens F.M. Accumulation of 5-methyltetrahydrofolate in cobalamin-deficient L1210 mouse leukemia cells. J Biol Chem 1982, 257:2144-2146.
    • (1982) J Biol Chem , vol.257 , pp. 2144-2146
    • Fujii, K.1    Nagasaki, T.2    Huennekens, F.M.3
  • 15
    • 79959420922 scopus 로고    scopus 로고
    • Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes
    • Schramm V.L. Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes. Annu Rev Biochem 2011, 80:703-732.
    • (2011) Annu Rev Biochem , vol.80 , pp. 703-732
    • Schramm, V.L.1
  • 16
    • 0344393780 scopus 로고    scopus 로고
    • Resistance to antifolates
    • Zhao R., Goldman I.D. Resistance to antifolates. Oncogene 2003, 22:7431-7457.
    • (2003) Oncogene , vol.22 , pp. 7431-7457
    • Zhao, R.1    Goldman, I.D.2
  • 17
    • 0027485543 scopus 로고
    • Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism
    • Lowe K.E., Osborne C.B., Lin B.F., et al. Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism. J Biol Chem 1993, 268:21665-21673.
    • (1993) J Biol Chem , vol.268 , pp. 21665-21673
    • Lowe, K.E.1    Osborne, C.B.2    Lin, B.F.3
  • 18
    • 0024808080 scopus 로고
    • Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism
    • Shane B. Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. Vitam Horm 1989, 45:263-335.
    • (1989) Vitam Horm , vol.45 , pp. 263-335
    • Shane, B.1
  • 19
    • 0025251752 scopus 로고
    • Reversal of methotrexate cytotoxicity to human bone marrow cells and leukemic K562 cells by leucovorin: methotrexate polyglutamates formation as a possible important factor
    • Koizumi S., Ueno Y., Ohno I., et al. Reversal of methotrexate cytotoxicity to human bone marrow cells and leukemic K562 cells by leucovorin: methotrexate polyglutamates formation as a possible important factor. Jpn J Cancer Res 1990, 81:1162-1167.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 1162-1167
    • Koizumi, S.1    Ueno, Y.2    Ohno, I.3
  • 20
    • 0019800796 scopus 로고
    • Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo
    • Poser R.G., Sirotnak F.M., Chello P.L. Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo. Cancer Res 1981, 41:4441-4446.
    • (1981) Cancer Res , vol.41 , pp. 4441-4446
    • Poser, R.G.1    Sirotnak, F.M.2    Chello, P.L.3
  • 21
    • 0020686617 scopus 로고
    • Analysis of the role of membrane transport and polyglutamylation of methotrexate in gut and Ehrlich tumor in vivo as factors in drug sensitivity and selectivity
    • Fry D.W., Anderson L.A., Borst M., et al. Analysis of the role of membrane transport and polyglutamylation of methotrexate in gut and Ehrlich tumor in vivo as factors in drug sensitivity and selectivity. Cancer Res 1983, 43:1087-1092.
    • (1983) Cancer Res , vol.43 , pp. 1087-1092
    • Fry, D.W.1    Anderson, L.A.2    Borst, M.3
  • 22
    • 0021167732 scopus 로고
    • Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro
    • Fabre I., Fabre G., Goldman I.D. Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro. Cancer Res 1984, 44:3190-3195.
    • (1984) Cancer Res , vol.44 , pp. 3190-3195
    • Fabre, I.1    Fabre, G.2    Goldman, I.D.3
  • 23
    • 34548026299 scopus 로고    scopus 로고
    • The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption
    • Zhao R., Min S.H., Qiu A., et al. The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption. Blood 2007, 110:1147-1152.
    • (2007) Blood , vol.110 , pp. 1147-1152
    • Zhao, R.1    Min, S.H.2    Qiu, A.3
  • 24
    • 84875168040 scopus 로고
    • Hereditary folate malabsorption [internet]
    • University of Washington, Seattle, Seattle (WA), R.A. Pagon, T.D. Bird, C.R. Dolan (Eds.)
    • Diop-Bove N., Kronn D., Goldman I.D. Hereditary folate malabsorption [internet]. GeneReviews 1993-2008, University of Washington, Seattle, Seattle (WA). R.A. Pagon, T.D. Bird, C.R. Dolan (Eds.).
    • (1993) GeneReviews
    • Diop-Bove, N.1    Kronn, D.2    Goldman, I.D.3
  • 25
    • 0842304934 scopus 로고    scopus 로고
    • A prominent low-pH methotrexate transport activity in human solid tumor cells: contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier
    • Zhao R., Gao F., Hanscom M., et al. A prominent low-pH methotrexate transport activity in human solid tumor cells: contribution to the preservation of methotrexate pharmacological activity in HeLa cells lacking the reduced folate carrier. Clin Cancer Res 2004, 10:718-727.
    • (2004) Clin Cancer Res , vol.10 , pp. 718-727
    • Zhao, R.1    Gao, F.2    Hanscom, M.3
  • 26
    • 81555195479 scopus 로고    scopus 로고
    • Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter
    • Desmoulin S.K., Wang L., Hales E., et al. Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter. Mol Pharmacol 2011, 80:1096-1107.
    • (2011) Mol Pharmacol , vol.80 , pp. 1096-1107
    • Desmoulin, S.K.1    Wang, L.2    Hales, E.3
  • 27
    • 50549085728 scopus 로고    scopus 로고
    • The proton-coupled folate transporter (PCFT): impact on pemetrexed transport and on antifolate activities as compared to the reduced folate carrier
    • Zhao R., Qiu A., Tsai E., et al. The proton-coupled folate transporter (PCFT): impact on pemetrexed transport and on antifolate activities as compared to the reduced folate carrier. Mol Pharmacol 2008, 74:854-862.
    • (2008) Mol Pharmacol , vol.74 , pp. 854-862
    • Zhao, R.1    Qiu, A.2    Tsai, E.3
  • 28
    • 2342461116 scopus 로고    scopus 로고
    • Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier; association with the presence of a secondary transport pathway
    • Zhao R., Hanscom M., Chattopadhyay S., et al. Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier; association with the presence of a secondary transport pathway. Cancer Res 2004, 64:3313-3319.
    • (2004) Cancer Res , vol.64 , pp. 3313-3319
    • Zhao, R.1    Hanscom, M.2    Chattopadhyay, S.3
  • 29
    • 0141815941 scopus 로고    scopus 로고
    • Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter
    • Volk E.L., Schneider E. Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res 2003, 63:5538-5543.
    • (2003) Cancer Res , vol.63 , pp. 5538-5543
    • Volk, E.L.1    Schneider, E.2
  • 30
    • 0345724724 scopus 로고    scopus 로고
    • The MRP family of drug efflux pumps
    • Kruh G.D., Belinsky M.G. The MRP family of drug efflux pumps. Oncogene 2003, 22:7537-7552.
    • (2003) Oncogene , vol.22 , pp. 7537-7552
    • Kruh, G.D.1    Belinsky, M.G.2
  • 31
    • 33750975065 scopus 로고    scopus 로고
    • The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
    • Assaraf Y.G. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updat 2006, 9:227-246.
    • (2006) Drug Resist Updat , vol.9 , pp. 227-246
    • Assaraf, Y.G.1
  • 32
    • 0007834184 scopus 로고
    • Reversal of aminopterin and amethopterin toxicity by citrovorum factor
    • Schoenbach E.B., Greenspan E.M., Colsky J. Reversal of aminopterin and amethopterin toxicity by citrovorum factor. J Am Med Assoc 1950, 144:1558-1560.
    • (1950) J Am Med Assoc , vol.144 , pp. 1558-1560
    • Schoenbach, E.B.1    Greenspan, E.M.2    Colsky, J.3
  • 33
    • 0014172857 scopus 로고
    • Methotrexate infusions and intensive supportive care in the management of children with acute lymphocytic leukemia: follow-up report
    • Djerassi I. Methotrexate infusions and intensive supportive care in the management of children with acute lymphocytic leukemia: follow-up report. Cancer Res 1967, 27:2561-2564.
    • (1967) Cancer Res , vol.27 , pp. 2561-2564
    • Djerassi, I.1
  • 34
    • 0014608878 scopus 로고
    • Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates
    • Hryniuk W.M., Bertino J.R. Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates. J Clin Invest 1969, 48:2140-2155.
    • (1969) J Clin Invest , vol.48 , pp. 2140-2155
    • Hryniuk, W.M.1    Bertino, J.R.2
  • 35
    • 0016261388 scopus 로고
    • Clinical trials and pharmacokinetics of intermittent high-dose methotrexate-" leucovorin rescue" for children with malignant tumors
    • Pratt C.B., Roberts D., Shanks E.C., et al. Clinical trials and pharmacokinetics of intermittent high-dose methotrexate-" leucovorin rescue" for children with malignant tumors. Cancer Res 1974, 34:3326-3331.
    • (1974) Cancer Res , vol.34 , pp. 3326-3331
    • Pratt, C.B.1    Roberts, D.2    Shanks, E.C.3
  • 36
    • 0022262215 scopus 로고
    • Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates
    • Allegra C.J., Chabner B.A., Drake J.C., et al. Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J Biol Chem 1985, 260:9720-9726.
    • (1985) J Biol Chem , vol.260 , pp. 9720-9726
    • Allegra, C.J.1    Chabner, B.A.2    Drake, J.C.3
  • 37
    • 0010105962 scopus 로고
    • Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates
    • Allegra C.J., Drake J.C., Jolivet J., et al. Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proc Natl Acad Sci U S A 1985, 82:4881-4885.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 4881-4885
    • Allegra, C.J.1    Drake, J.C.2    Jolivet, J.3
  • 38
    • 0022970777 scopus 로고
    • The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis
    • Allegra C.J., Fine R.L., Drake J.C., et al. The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis. J Biol Chem 1986, 261:6478-6485.
    • (1986) J Biol Chem , vol.261 , pp. 6478-6485
    • Allegra, C.J.1    Fine, R.L.2    Drake, J.C.3
  • 39
    • 0022637441 scopus 로고
    • Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide
    • Baggott J.E., Vaughn W.H., Hudson B.B. Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide. Biochem J 1986, 236:193-200.
    • (1986) Biochem J , vol.236 , pp. 193-200
    • Baggott, J.E.1    Vaughn, W.H.2    Hudson, B.B.3
  • 40
    • 0023130109 scopus 로고
    • The effects of 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells
    • Matherly L.H., Barlowe C.K., Phillips V.M., et al. The effects of 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. J Biol Chem 1987, 262:710-717.
    • (1987) J Biol Chem , vol.262 , pp. 710-717
    • Matherly, L.H.1    Barlowe, C.K.2    Phillips, V.M.3
  • 41
    • 0022642429 scopus 로고
    • Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells
    • Matherly L.H., Barlowe C.K., Goldman I.D. Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells. Cancer Res 1986, 46:588-593.
    • (1986) Cancer Res , vol.46 , pp. 588-593
    • Matherly, L.H.1    Barlowe, C.K.2    Goldman, I.D.3
  • 42
    • 0029788523 scopus 로고    scopus 로고
    • Concepts in use of high-dose methotrexate therapy
    • Treon S.P., Chabner B.A. Concepts in use of high-dose methotrexate therapy. Clin Chem 1996, 42:1322-1329.
    • (1996) Clin Chem , vol.42 , pp. 1322-1329
    • Treon, S.P.1    Chabner, B.A.2
  • 43
    • 33745647522 scopus 로고    scopus 로고
    • Understanding and managing methotrexate nephrotoxicity
    • Widemann B.C., Adamson P.C. Understanding and managing methotrexate nephrotoxicity. Oncologist 2006, 11:694-703.
    • (2006) Oncologist , vol.11 , pp. 694-703
    • Widemann, B.C.1    Adamson, P.C.2
  • 44
    • 76749095066 scopus 로고    scopus 로고
    • Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children's Oncology Group report
    • Gaynon P.S., Angiolillo A.L., Carroll W.L., et al. Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children's Oncology Group report. Leukemia 2010, 24:285-297.
    • (2010) Leukemia , vol.24 , pp. 285-297
    • Gaynon, P.S.1    Angiolillo, A.L.2    Carroll, W.L.3
  • 45
    • 77954155076 scopus 로고    scopus 로고
    • Leptomeningeal metastasis
    • Chamberlain M.C. Leptomeningeal metastasis. Semin Neurol 2010, 30:236-244.
    • (2010) Semin Neurol , vol.30 , pp. 236-244
    • Chamberlain, M.C.1
  • 46
    • 77953669077 scopus 로고    scopus 로고
    • Osteosarcoma: review of the past, impact on the future. The American experience
    • Jaffe N. Osteosarcoma: review of the past, impact on the future. The American experience. Cancer Treat Res 2009, 152:239-262.
    • (2009) Cancer Treat Res , vol.152 , pp. 239-262
    • Jaffe, N.1
  • 47
    • 55349149663 scopus 로고    scopus 로고
    • Practical issues in the management of low-risk gestational trophoblast tumors
    • Savage P., Seckl M., Short D. Practical issues in the management of low-risk gestational trophoblast tumors. J Reprod Med 2008, 53:774-780.
    • (2008) J Reprod Med , vol.53 , pp. 774-780
    • Savage, P.1    Seckl, M.2    Short, D.3
  • 48
    • 77954576948 scopus 로고    scopus 로고
    • Classical cyclophosphamide, methotrexate, and fluorouracil chemotherapy is more effective in triple-negative, node-negative breast cancer: results from two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer
    • Colleoni M., Cole B.F., Viale G., et al. Classical cyclophosphamide, methotrexate, and fluorouracil chemotherapy is more effective in triple-negative, node-negative breast cancer: results from two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer. J Clin Oncol 2010, 28:2966-2973.
    • (2010) J Clin Oncol , vol.28 , pp. 2966-2973
    • Colleoni, M.1    Cole, B.F.2    Viale, G.3
  • 49
    • 38049103907 scopus 로고    scopus 로고
    • HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials
    • Gennari A., Sormani M.P., Pronzato P., et al. HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials. J Natl Cancer Inst 2008, 100:14-20.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 14-20
    • Gennari, A.1    Sormani, M.P.2    Pronzato, P.3
  • 50
    • 67549107120 scopus 로고    scopus 로고
    • Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research
    • Salliot C., van der H.D. Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research. Ann Rheum Dis 2009, 68:1100-1104.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1100-1104
    • Salliot, C.1    van der, H.D.2
  • 51
    • 36348969477 scopus 로고    scopus 로고
    • Current pharmacologic treatment paradigms for inflammatory bowel disease and the potential role of granulocyte/monocyte apheresis
    • Schwartz D., Ferguson J.R. Current pharmacologic treatment paradigms for inflammatory bowel disease and the potential role of granulocyte/monocyte apheresis. Curr Med Res Opin 2007, 23:2715-2728.
    • (2007) Curr Med Res Opin , vol.23 , pp. 2715-2728
    • Schwartz, D.1    Ferguson, J.R.2
  • 52
    • 67349285418 scopus 로고    scopus 로고
    • Advances in the pathogenesis and treatment of IBD
    • Braus N.A., Elliott D.E. Advances in the pathogenesis and treatment of IBD. Clin Immunol 2009, 132:1-9.
    • (2009) Clin Immunol , vol.132 , pp. 1-9
    • Braus, N.A.1    Elliott, D.E.2
  • 53
    • 64749083236 scopus 로고    scopus 로고
    • Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference
    • Kalb R.E., Strober B., Weinstein G., et al. Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. J Am Acad Dermatol 2009, 60:824-837.
    • (2009) J Am Acad Dermatol , vol.60 , pp. 824-837
    • Kalb, R.E.1    Strober, B.2    Weinstein, G.3
  • 54
    • 78049530106 scopus 로고    scopus 로고
    • ANCA-associated vasculitides-advances in pathogenesis and treatment
    • Chen M., Kallenberg C.G. ANCA-associated vasculitides-advances in pathogenesis and treatment. Nat Rev Rheumatol 2010, 6:653-664.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 653-664
    • Chen, M.1    Kallenberg, C.G.2
  • 55
    • 70350168925 scopus 로고    scopus 로고
    • Necrotizing vasculitis-a 2009 update
    • Sharaf P.H., Yazici Y. Necrotizing vasculitis-a 2009 update. Bull NYU Hosp Jt Dis 2009, 67:303-305.
    • (2009) Bull NYU Hosp Jt Dis , vol.67 , pp. 303-305
    • Sharaf, P.H.1    Yazici, Y.2
  • 56
    • 79960462879 scopus 로고    scopus 로고
    • Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group
    • Matloub Y., Bostrom B.C., Hunger S.P., et al. Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood 2011, 118:243-251.
    • (2011) Blood , vol.118 , pp. 243-251
    • Matloub, Y.1    Bostrom, B.C.2    Hunger, S.P.3
  • 57
    • 77957331593 scopus 로고    scopus 로고
    • Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma
    • Abramson J.S., Hellmann M., Barnes J.A., et al. Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma. Cancer 2010, 116:4283-4290.
    • (2010) Cancer , vol.116 , pp. 4283-4290
    • Abramson, J.S.1    Hellmann, M.2    Barnes, J.A.3
  • 58
    • 79961016780 scopus 로고    scopus 로고
    • Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404)
    • Asselin B.L., Devidas M., Wang C., et al. Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404). Blood 2011, 118:874-883.
    • (2011) Blood , vol.118 , pp. 874-883
    • Asselin, B.L.1    Devidas, M.2    Wang, C.3
  • 59
    • 0027304579 scopus 로고
    • Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin
    • DeGraw J.I., Colwell W.T., Piper J.R., et al. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin. J Med Chem 1993, 36:2228-2231.
    • (1993) J Med Chem , vol.36 , pp. 2228-2231
    • DeGraw, J.I.1    Colwell, W.T.2    Piper, J.R.3
  • 60
    • 0033818197 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate
    • Krug L.M., Ng K.K., Kris M.G., et al. Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate. Clin Cancer Res 2000, 6:3493-3498.
    • (2000) Clin Cancer Res , vol.6 , pp. 3493-3498
    • Krug, L.M.1    Ng, K.K.2    Kris, M.G.3
  • 61
    • 0037409795 scopus 로고    scopus 로고
    • Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression
    • Wang E.S., O'Connor O., She Y., et al. Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression. Leuk Lymphoma 2003, 44:1027-1035.
    • (2003) Leuk Lymphoma , vol.44 , pp. 1027-1035
    • Wang, E.S.1    O'Connor, O.2    She, Y.3
  • 62
    • 70349310325 scopus 로고    scopus 로고
    • Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies
    • O'Connor O.A., Horwitz S., Hamlin P., et al. Phase II-I-II study of two different doses and schedules of pralatrexate, a high-affinity substrate for the reduced folate carrier, in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies. J Clin Oncol 2009, 27:4357-4364.
    • (2009) J Clin Oncol , vol.27 , pp. 4357-4364
    • O'Connor, O.A.1    Horwitz, S.2    Hamlin, P.3
  • 63
    • 34848829782 scopus 로고    scopus 로고
    • Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma
    • O'Connor O.A., Hamlin P.A., Portlock C., et al. Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma. Br J Haematol 2007, 139:425-428.
    • (2007) Br J Haematol , vol.139 , pp. 425-428
    • O'Connor, O.A.1    Hamlin, P.A.2    Portlock, C.3
  • 64
    • 0029157160 scopus 로고
    • Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs
    • Habeck L.L., Mendelsohn L.G., Shih C., et al. Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. Mol Pharmacol 1995, 48:326-333.
    • (1995) Mol Pharmacol , vol.48 , pp. 326-333
    • Habeck, L.L.1    Mendelsohn, L.G.2    Shih, C.3
  • 65
    • 0025997350 scopus 로고
    • ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study
    • Jackman A.L., Taylor G.A., Gibson W., et al. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Res 1991, 51:5579-5586.
    • (1991) Cancer Res , vol.51 , pp. 5579-5586
    • Jackman, A.L.1    Taylor, G.A.2    Gibson, W.3
  • 66
    • 0031671255 scopus 로고    scopus 로고
    • Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group
    • Cocconi G., Cunningham D., Van Cutsem E., et al. Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group. J Clin Oncol 1998, 16:2943-2952.
    • (1998) J Clin Oncol , vol.16 , pp. 2943-2952
    • Cocconi, G.1    Cunningham, D.2    Van Cutsem, E.3
  • 67
    • 53349162393 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1)
    • Popov I., Carrato A., Sobrero A., et al. Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1). Eur J Cancer 2008, 44:2204-2211.
    • (2008) Eur J Cancer , vol.44 , pp. 2204-2211
    • Popov, I.1    Carrato, A.2    Sobrero, A.3
  • 68
    • 0035986787 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil
    • Kempin S., Gutierrez J., Wilson E., et al. Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil. Cancer Invest 2002, 20:992-995.
    • (2002) Cancer Invest , vol.20 , pp. 992-995
    • Kempin, S.1    Gutierrez, J.2    Wilson, E.3
  • 69
    • 0030891198 scopus 로고    scopus 로고
    • LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Shih C., Chen V.J., Gossett L.S., et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997, 57:1116-1123.
    • (1997) Cancer Res , vol.57 , pp. 1116-1123
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3
  • 70
    • 0026494947 scopus 로고
    • A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
    • Taylor E.C., Kuhnt D., Shih C., et al. A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. J Med Chem 1992, 35:4450-4454.
    • (1992) J Med Chem , vol.35 , pp. 4450-4454
    • Taylor, E.C.1    Kuhnt, D.2    Shih, C.3
  • 71
    • 4644224936 scopus 로고    scopus 로고
    • Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier
    • Wang Y., Zhao R., Goldman I.D. Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clin Cancer Res 2004, 10:6256-6264.
    • (2004) Clin Cancer Res , vol.10 , pp. 6256-6264
    • Wang, Y.1    Zhao, R.2    Goldman, I.D.3
  • 72
    • 33644975527 scopus 로고    scopus 로고
    • The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line
    • Chattopadhyay S., Zhao R., Krupenko S.A., et al. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther 2006, 5:438-449.
    • (2006) Mol Cancer Ther , vol.5 , pp. 438-449
    • Chattopadhyay, S.1    Zhao, R.2    Krupenko, S.A.3
  • 73
    • 67650456927 scopus 로고    scopus 로고
    • Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition
    • Racanelli A.C., Rothbart S.B., Heyer C.L., et al. Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. Cancer Res 2009, 69:5467-5474.
    • (2009) Cancer Res , vol.69 , pp. 5467-5474
    • Racanelli, A.C.1    Rothbart, S.B.2    Heyer, C.L.3
  • 74
    • 78650362440 scopus 로고    scopus 로고
    • Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas
    • Rothbart S.B., Racanelli A.C., Moran R.G. Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. Cancer Res 2010, 70:10299-10309.
    • (2010) Cancer Res , vol.70 , pp. 10299-10309
    • Rothbart, S.B.1    Racanelli, A.C.2    Moran, R.G.3
  • 75
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang N.J., Rusthoven J.J., Symanowski J., et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003, 21:2636-2644.
    • (2003) J Clin Oncol , vol.21 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3
  • 76
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N., Shepherd F.A., Fossella F.V., et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004, 22:1589-1597.
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 77
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti G.V., Parikh P., Von Pawel J., et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008, 26:3543-3551.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3
  • 78
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
    • Ciuleanu T., Brodowicz T., Zielinski C., et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 2009, 374:1432-1440.
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3
  • 79
    • 0037039451 scopus 로고    scopus 로고
    • Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors
    • Andreassi J.L., Moran R.G. Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors. Biochemistry 2002, 41:226-235.
    • (2002) Biochemistry , vol.41 , pp. 226-235
    • Andreassi, J.L.1    Moran, R.G.2
  • 80
    • 0035313188 scopus 로고    scopus 로고
    • Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells
    • Zhao R., Gao F., Goldman I.D. Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochem Pharmacol 2001, 61:857-865.
    • (2001) Biochem Pharmacol , vol.61 , pp. 857-865
    • Zhao, R.1    Gao, F.2    Goldman, I.D.3
  • 81
    • 34548207202 scopus 로고    scopus 로고
    • Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability
    • Chattopadhyay S., Tamari R., Min S.H., et al. Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability. Oncologist 2007, 12:808-815.
    • (2007) Oncologist , vol.12 , pp. 808-815
    • Chattopadhyay, S.1    Tamari, R.2    Min, S.H.3
  • 82
    • 0036562507 scopus 로고    scopus 로고
    • Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy
    • Niyikiza C., Baker S.D., Seitz D.E., et al. Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer Ther 2002, 1:545-552.
    • (2002) Mol Cancer Ther , vol.1 , pp. 545-552
    • Niyikiza, C.1    Baker, S.D.2    Seitz, D.E.3
  • 83
    • 0037842139 scopus 로고    scopus 로고
    • Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma
    • Scagliotti G.V., Shin D.M., Kindler H.L., et al. Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. J Clin Oncol 2003, 21:1556-1561.
    • (2003) J Clin Oncol , vol.21 , pp. 1556-1561
    • Scagliotti, G.V.1    Shin, D.M.2    Kindler, H.L.3
  • 84
    • 33947375647 scopus 로고    scopus 로고
    • Molecular basis of antifolate resistance
    • Assaraf Y.G. Molecular basis of antifolate resistance. Cancer Metastasis Rev 2007, 26:153-181.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 153-181
    • Assaraf, Y.G.1
  • 85
    • 79960835886 scopus 로고    scopus 로고
    • Establishment of pemetrexed-resistant non-small cell lung cancer cell lines
    • Zhang D., Ochi N., Takigawa N., et al. Establishment of pemetrexed-resistant non-small cell lung cancer cell lines. Cancer Lett 2011, 309:228-235.
    • (2011) Cancer Lett , vol.309 , pp. 228-235
    • Zhang, D.1    Ochi, N.2    Takigawa, N.3
  • 86
    • 34547669346 scopus 로고    scopus 로고
    • In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression
    • Hanauske A.R., Eismann U., Oberschmidt O., et al. In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression. Invest New Drugs 2007, 25:417-423.
    • (2007) Invest New Drugs , vol.25 , pp. 417-423
    • Hanauske, A.R.1    Eismann, U.2    Oberschmidt, O.3
  • 87
    • 18244378306 scopus 로고    scopus 로고
    • Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis
    • Mauritz R., Peters G.J., Priest D.G., et al. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochem Pharmacol 2002, 63:105-115.
    • (2002) Biochem Pharmacol , vol.63 , pp. 105-115
    • Mauritz, R.1    Peters, G.J.2    Priest, D.G.3
  • 88
    • 12944312685 scopus 로고    scopus 로고
    • Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis
    • Zhao R., Zhang S., Hanscom M., et al. Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Clin Cancer Res 2005, 11:1294-1301.
    • (2005) Clin Cancer Res , vol.11 , pp. 1294-1301
    • Zhao, R.1    Zhang, S.2    Hanscom, M.3
  • 89
    • 1942535095 scopus 로고    scopus 로고
    • A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro
    • Kamen B.A., Smith A.K. A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro. Adv Drug Deliv Rev 2004, 56:1085-1097.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1085-1097
    • Kamen, B.A.1    Smith, A.K.2
  • 90
    • 33947362046 scopus 로고    scopus 로고
    • The folate receptor: what does it promise in tissue-targeted therapeutics?
    • Salazar M.D., Ratnam M. The folate receptor: what does it promise in tissue-targeted therapeutics?. Cancer Metastasis Rev 2007, 26:141-152.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 141-152
    • Salazar, M.D.1    Ratnam, M.2
  • 91
    • 14644392093 scopus 로고    scopus 로고
    • Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    • Parker N., Turk M.J., Westrick E., et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005, 338:284-293.
    • (2005) Anal Biochem , vol.338 , pp. 284-293
    • Parker, N.1    Turk, M.J.2    Westrick, E.3
  • 92
    • 73649093148 scopus 로고    scopus 로고
    • Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages
    • Puig-Kroger A., Sierra-Filardi E., Dominguez-Soto A., et al. Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Cancer Res 2009, 69:9395-9403.
    • (2009) Cancer Res , vol.69 , pp. 9395-9403
    • Puig-Kroger, A.1    Sierra-Filardi, E.2    Dominguez-Soto, A.3
  • 93
    • 34249321972 scopus 로고    scopus 로고
    • Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate
    • Reddy J.A., Dorton R., Westrick E., et al. Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate. Cancer Res 2007, 67:4434-4442.
    • (2007) Cancer Res , vol.67 , pp. 4434-4442
    • Reddy, J.A.1    Dorton, R.2    Westrick, E.3
  • 94
    • 35548957255 scopus 로고    scopus 로고
    • Preclinical antitumor activity of a novel folate-targeted dual drug conjugate
    • Leamon C.P., Reddy J.A., Vlahov I.R., et al. Preclinical antitumor activity of a novel folate-targeted dual drug conjugate. Mol Pharm 2007, 4:659-667.
    • (2007) Mol Pharm , vol.4 , pp. 659-667
    • Leamon, C.P.1    Reddy, J.A.2    Vlahov, I.R.3
  • 95
    • 71449112911 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and exposure-toxicity relationship of a folate-vinca alkaloid conjugate EC145 in cancer patients
    • Li J., Sausville E.A., Klein P.J., et al. Clinical pharmacokinetics and exposure-toxicity relationship of a folate-vinca alkaloid conjugate EC145 in cancer patients. J Clin Pharmacol 2009, 49:1467-1476.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1467-1476
    • Li, J.1    Sausville, E.A.2    Klein, P.J.3
  • 96
    • 79952746215 scopus 로고    scopus 로고
    • EC-145, a folate-targeted vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers
    • Dosio F., Milla P., Cattel L. EC-145, a folate-targeted vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers. Curr Opin Investig Drugs 2010, 11:1424-1433.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1424-1433
    • Dosio, F.1    Milla, P.2    Cattel, L.3
  • 97
    • 44849127008 scopus 로고    scopus 로고
    • Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors
    • Fisher R.E., Siegel B.A., Edell S.L., et al. Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors. J Nucl Med 2008, 49:899-906.
    • (2008) J Nucl Med , vol.49 , pp. 899-906
    • Fisher, R.E.1    Siegel, B.A.2    Edell, S.L.3
  • 98
    • 2642514921 scopus 로고    scopus 로고
    • Preclinical evaluation of (99m)Tc-EC20 for imaging folate receptor-positive tumors
    • Reddy J.A., Xu L.C., Parker N., et al. Preclinical evaluation of (99m)Tc-EC20 for imaging folate receptor-positive tumors. J Nucl Med 2004, 45:857-866.
    • (2004) J Nucl Med , vol.45 , pp. 857-866
    • Reddy, J.A.1    Xu, L.C.2    Parker, N.3
  • 99
    • 80053989452 scopus 로고    scopus 로고
    • Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results
    • van Dam G.M., Themelis G., Crane L.M., et al. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results. Nat Med 2011, 17:1315-1319.
    • (2011) Nat Med , vol.17 , pp. 1315-1319
    • van Dam, G.M.1    Themelis, G.2    Crane, L.M.3
  • 100
    • 29244449017 scopus 로고    scopus 로고
    • BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors
    • Gibbs D.D., Theti D.S., Wood N., et al. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors. Cancer Res 2005, 65:11721-11728.
    • (2005) Cancer Res , vol.65 , pp. 11721-11728
    • Gibbs, D.D.1    Theti, D.S.2    Wood, N.3
  • 101
    • 77957224999 scopus 로고    scopus 로고
    • Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors
    • Desmoulin S.K., Wang Y., Wu J., et al. Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. Mol Pharmacol 2010, 78:577-587.
    • (2010) Mol Pharmacol , vol.78 , pp. 577-587
    • Desmoulin, S.K.1    Wang, Y.2    Wu, J.3
  • 102
    • 80054932788 scopus 로고    scopus 로고
    • Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits beta-glycinamide ribonucleotide formyltransferase
    • Wang L., Desmoulin S.K., Cherian C., et al. Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits beta-glycinamide ribonucleotide formyltransferase. J Med Chem 2011, 54:7150-7164.
    • (2011) J Med Chem , vol.54 , pp. 7150-7164
    • Wang, L.1    Desmoulin, S.K.2    Cherian, C.3
  • 103
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: high- resolution measurements reveal a lack of correlation
    • Helmlinger G., Yuan F., Dellian M., et al. Interstitial pH and pO2 gradients in solid tumors in vivo: high- resolution measurements reveal a lack of correlation. Nat Med 1997, 3:177-182.
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3
  • 104
    • 0027966042 scopus 로고
    • Metabolic consequences of a reversed pH gradient in rat tumors
    • Stubbs M., Rodrigues L., Howe F.A., et al. Metabolic consequences of a reversed pH gradient in rat tumors. Cancer Res 1994, 54:4011-4016.
    • (1994) Cancer Res , vol.54 , pp. 4011-4016
    • Stubbs, M.1    Rodrigues, L.2    Howe, F.A.3
  • 105
    • 0032927078 scopus 로고    scopus 로고
    • Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy
    • Raghunand N., Altbach M.I., van Sluis R., et al. Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy. Biochem Pharmacol 1999, 57:309-312.
    • (1999) Biochem Pharmacol , vol.57 , pp. 309-312
    • Raghunand, N.1    Altbach, M.I.2    van Sluis, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.