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Volumn 40, Issue 4, 2017, Pages 237-253

Obesity-Induced Neuroinflammation: Beyond the Hypothalamus

Author keywords

bioactive lipid; blood brain barrier; high fat diet; lipopolysaccharide; memory; PUFA

Indexed keywords

AMYGDALA; BRAIN CORTEX; BRAIN STEM; COGNITIVE DEFECT; DEPRESSION; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; ANIMAL; BRAIN; IMMUNOLOGY; INFLAMMATION; METABOLISM;

EID: 85015331450     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2017.02.005     Document Type: Review
Times cited : (396)

References (111)
  • 1
    • 84962949589 scopus 로고    scopus 로고
    • Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants
    • 1 Di Cesare, M., et al. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet 387 (2016), 1377–1396.
    • (2016) Lancet , vol.387 , pp. 1377-1396
    • Di Cesare, M.1
  • 3
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: when the immune system subjugates the brain
    • 3 Dantzer, R., et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 9 (2008), 46–56.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 46-56
    • Dantzer, R.1
  • 4
    • 84949908018 scopus 로고    scopus 로고
    • The neuropathology and cerebrovascular mechanisms of dementia
    • 4 Raz, L., et al. The neuropathology and cerebrovascular mechanisms of dementia. J. Cereb. Blood Flow Metab. 36 (2016), 172–186.
    • (2016) J. Cereb. Blood Flow Metab. , vol.36 , pp. 172-186
    • Raz, L.1
  • 5
    • 64449085655 scopus 로고    scopus 로고
    • Obesity and vulnerability of the CNS
    • 5 Bruce-Keller, A.J., Obesity and vulnerability of the CNS. Biochim. Biophys. Acta 1792 (2009), 395–400.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 395-400
    • Bruce-Keller, A.J.1
  • 6
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • 6 Lumeng, C.N., Saltiel, A.R., Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121 (2011), 2111–2117.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 7
    • 84891719310 scopus 로고    scopus 로고
    • Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?
    • 7 Thaler, J.P., et al. Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?. Diabetes 62 (2013), 2629–2634.
    • (2013) Diabetes , vol.62 , pp. 2629-2634
    • Thaler, J.P.1
  • 8
    • 84924295797 scopus 로고    scopus 로고
    • Hypothalamic microinflammation: a common basis of metabolic syndrome and aging
    • 8 Tang, Y., et al. Hypothalamic microinflammation: a common basis of metabolic syndrome and aging. Trends Neurosci. 38 (2015), 36–44.
    • (2015) Trends Neurosci. , vol.38 , pp. 36-44
    • Tang, Y.1
  • 9
    • 84929952571 scopus 로고    scopus 로고
    • Hypothalamic innate immune reaction in obesity
    • 9 Kalin, S., et al. Hypothalamic innate immune reaction in obesity. Nat. Rev. Endocrinol. 11 (2015), 339–351.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 339-351
    • Kalin, S.1
  • 10
    • 80053897594 scopus 로고    scopus 로고
    • Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IkappaB kinase beta/nuclear factor-kappaB-mediated inflammatory pathways in mice
    • 10 Lu, J., et al. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IkappaB kinase beta/nuclear factor-kappaB-mediated inflammatory pathways in mice. Brain Behav. Immun. 25 (2011), 1658–1667.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 1658-1667
    • Lu, J.1
  • 11
    • 84960841798 scopus 로고    scopus 로고
    • Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation
    • 11 Beilharz, J.E., et al. Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation. Behav. Brain Res. 306 (2016), 1–7.
    • (2016) Behav. Brain Res. , vol.306 , pp. 1-7
    • Beilharz, J.E.1
  • 12
    • 84983666580 scopus 로고    scopus 로고
    • High-fat diet feeding differentially affects the development of inflammation in the central nervous system
    • 12 Guillemot-Legris, O., High-fat diet feeding differentially affects the development of inflammation in the central nervous system. J. Neuroinflammation, 13, 2016, 206.
    • (2016) J. Neuroinflammation , vol.13 , pp. 206
    • Guillemot-Legris, O.1
  • 13
    • 79952677635 scopus 로고    scopus 로고
    • Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition
    • 13 Tapia-Gonzalez, S., Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition. J. Neuroendocrinol. 23 (2011), 365–370.
    • (2011) J. Neuroendocrinol. , vol.23 , pp. 365-370
    • Tapia-Gonzalez, S.1
  • 14
    • 84879108278 scopus 로고    scopus 로고
    • Obesity genomics: assessing the transferability of susceptibility loci across diverse populations
    • 14 Lu, Y., Loos, R.J., Obesity genomics: assessing the transferability of susceptibility loci across diverse populations. Genome Med., 5, 2013, 55.
    • (2013) Genome Med. , vol.5 , pp. 55
    • Lu, Y.1    Loos, R.J.2
  • 15
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • 15 Thaler, J.P., et al. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 122 (2012), 153–162.
    • (2012) J. Clin. Invest. , vol.122 , pp. 153-162
    • Thaler, J.P.1
  • 16
    • 78650472774 scopus 로고    scopus 로고
    • Toll-like receptors: linking inflammation to metabolism
    • 16 Konner, A.C., Bruning, J.C., Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol. Metab. 22 (2011), 16–23.
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 16-23
    • Konner, A.C.1    Bruning, J.C.2
  • 17
    • 80755152887 scopus 로고    scopus 로고
    • Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    • 17 Everard, A., et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 60 (2011), 2775–2786.
    • (2011) Diabetes , vol.60 , pp. 2775-2786
    • Everard, A.1
  • 18
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • 18 Cani, P.D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56 (2007), 1761–1772.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1
  • 19
    • 84863413720 scopus 로고    scopus 로고
    • A high-fat diet is associated with endotoxemia that originates from the gut
    • 19 Pendyala, S., et al. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenterology 142 (2012), 1100–1101.
    • (2012) Gastroenterology , vol.142 , pp. 1100-1101
    • Pendyala, S.1
  • 20
    • 84893663418 scopus 로고    scopus 로고
    • Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance
    • 20 Lee, B.C., Lee, J., Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim. Biophys. Acta 1842 (2014), 446–462.
    • (2014) Biochim. Biophys. Acta , vol.1842 , pp. 446-462
    • Lee, B.C.1    Lee, J.2
  • 21
    • 84961621666 scopus 로고    scopus 로고
    • Secret talk between adipose tissue and central nervous system via secreted factors – an emerging frontier in the neurodegenerative research
    • 21 Parimisetty, A., et al. Secret talk between adipose tissue and central nervous system via secreted factors – an emerging frontier in the neurodegenerative research. J. Neuroinflammation, 13, 2016, 67.
    • (2016) J. Neuroinflammation , vol.13 , pp. 67
    • Parimisetty, A.1
  • 22
    • 84943237109 scopus 로고    scopus 로고
    • The molecular constituents of the blood–brain barrier
    • 22 Chow, B.W., Gu, C., The molecular constituents of the blood–brain barrier. Trends Neurosci. 38 (2015), 598–608.
    • (2015) Trends Neurosci. , vol.38 , pp. 598-608
    • Chow, B.W.1    Gu, C.2
  • 23
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • 23 Louveau, A., et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523 (2015), 337–341.
    • (2015) Nature , vol.523 , pp. 337-341
    • Louveau, A.1
  • 24
    • 85001944856 scopus 로고    scopus 로고
    • Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice
    • 24 Stranahan, A.M., et al. Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice. J. Cereb. Blood Flow Metab. 36 (2016), 2108–2121.
    • (2016) J. Cereb. Blood Flow Metab. , vol.36 , pp. 2108-2121
    • Stranahan, A.M.1
  • 25
    • 84874046130 scopus 로고    scopus 로고
    • NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet
    • 25 Pepping, J.K., et al. NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Am. J. Physiol. Endocrinol. Metab. 304 (2013), E392–E404.
    • (2013) Am. J. Physiol. Endocrinol. Metab. , vol.304 , pp. E392-E404
    • Pepping, J.K.1
  • 26
    • 79957807811 scopus 로고    scopus 로고
    • Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation
    • 26 Nerurkar, P.V., et al. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J. Neuroinflammation, 8, 2011, 64.
    • (2011) J. Neuroinflammation , vol.8 , pp. 64
    • Nerurkar, P.V.1
  • 27
    • 84911074681 scopus 로고    scopus 로고
    • Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice
    • 27 Tucsek, Z., et al. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J. Gerontol. A Biol. Sci. Med. Sci. 69 (2014), 1339–1352.
    • (2014) J. Gerontol. A Biol. Sci. Med. Sci. , vol.69 , pp. 1339-1352
    • Tucsek, Z.1
  • 28
    • 84973115855 scopus 로고    scopus 로고
    • Nicotine attenuates disruption of blood–brain barrier induced by saturated-fat feeding in wild-type mice
    • 28 Elahy, M., et al. Nicotine attenuates disruption of blood–brain barrier induced by saturated-fat feeding in wild-type mice. Nicotine. Tob. Res. 17 (2015), 1436–1441.
    • (2015) Nicotine. Tob. Res. , vol.17 , pp. 1436-1441
    • Elahy, M.1
  • 29
    • 84879066709 scopus 로고    scopus 로고
    • Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood–brain barrier function in wild-type mice
    • 29 Takechi, R., et al. Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood–brain barrier function in wild-type mice. J. Neuroinflammation, 10, 2013, 73.
    • (2013) J. Neuroinflammation , vol.10 , pp. 73
    • Takechi, R.1
  • 30
    • 77954981010 scopus 로고    scopus 로고
    • The effects of a high-energy diet on hippocampal function and blood–brain barrier integrity in the rat
    • 30 Kanoski, S.E., et al. The effects of a high-energy diet on hippocampal function and blood–brain barrier integrity in the rat. J. Alzheimers Dis. 21 (2010), 207–219.
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 207-219
    • Kanoski, S.E.1
  • 31
    • 84898977561 scopus 로고    scopus 로고
    • Resveratrol attenuates high-fat diet-induced disruption of the blood–brain barrier and protects brain neurons from apoptotic insults
    • 31 Chang, H.C., et al. Resveratrol attenuates high-fat diet-induced disruption of the blood–brain barrier and protects brain neurons from apoptotic insults. J. Agric. Food Chem. 62 (2014), 3466–3475.
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 3466-3475
    • Chang, H.C.1
  • 32
    • 84955365718 scopus 로고    scopus 로고
    • Western diets induce blood–brain barrier leakage and alter spatial strategies in rats
    • 32 Hargrave, S.L., et al. Western diets induce blood–brain barrier leakage and alter spatial strategies in rats. Behav. Neurosci. 130 (2016), 123–135.
    • (2016) Behav. Neurosci. , vol.130 , pp. 123-135
    • Hargrave, S.L.1
  • 33
    • 84861933896 scopus 로고    scopus 로고
    • The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats
    • 33 Davidson, T.L., et al. The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats. Physiol. Behav. 107 (2012), 26–33.
    • (2012) Physiol. Behav. , vol.107 , pp. 26-33
    • Davidson, T.L.1
  • 34
    • 84989915450 scopus 로고    scopus 로고
    • Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles
    • 34 Balusu, S., et al. Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. EMBO Mol. Med. 8 (2016), 1162–1183.
    • (2016) EMBO Mol. Med. , vol.8 , pp. 1162-1183
    • Balusu, S.1
  • 35
    • 85011252777 scopus 로고    scopus 로고
    • Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin
    • 35 Bartolome, F., et al. Obesity and neuroinflammatory phenotype in mice lacking endothelial megalin. J. Neuroinflammation, 14, 2017, 26.
    • (2017) J. Neuroinflammation , vol.14 , pp. 26
    • Bartolome, F.1
  • 36
    • 84964595404 scopus 로고    scopus 로고
    • Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity
    • 36 Jais, A., et al. Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. Cell 165 (2016), 882–895.
    • (2016) Cell , vol.165 , pp. 882-895
    • Jais, A.1
  • 37
    • 84958970061 scopus 로고    scopus 로고
    • Functional polarization of neuroglia: implications in neuroinflammation and neurological disorders
    • 37 Jha, M.K., et al. Functional polarization of neuroglia: implications in neuroinflammation and neurological disorders. Biochem. Pharmacol. 103 (2016), 1–16.
    • (2016) Biochem. Pharmacol. , vol.103 , pp. 1-16
    • Jha, M.K.1
  • 38
    • 84898912868 scopus 로고    scopus 로고
    • Microglial cell activation increases saturated and decreases monounsaturated fatty acid content, but both lipid species are proinflammatory
    • 38 Button, E.B., et al. Microglial cell activation increases saturated and decreases monounsaturated fatty acid content, but both lipid species are proinflammatory. Lipids 49 (2014), 305–316.
    • (2014) Lipids , vol.49 , pp. 305-316
    • Button, E.B.1
  • 39
    • 84862928989 scopus 로고    scopus 로고
    • Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling
    • 39 Wang, Z., et al. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling. Br. J. Nutr. 107 (2012), 229–241.
    • (2012) Br. J. Nutr. , vol.107 , pp. 229-241
    • Wang, Z.1
  • 40
    • 84855971481 scopus 로고    scopus 로고
    • Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity
    • 40 Cintra, D.E., et al. Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One, 7, 2012, e30571.
    • (2012) PLoS One , vol.7 , pp. e30571
    • Cintra, D.E.1
  • 41
    • 84862812857 scopus 로고    scopus 로고
    • Saturated long-chain fatty acids activate inflammatory signaling in astrocytes
    • 41 Gupta, S., et al. Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J. Neurochem. 120 (2012), 1060–1071.
    • (2012) J. Neurochem. , vol.120 , pp. 1060-1071
    • Gupta, S.1
  • 42
    • 84919847348 scopus 로고    scopus 로고
    • Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function
    • 42 Valdearcos, M., et al. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 9 (2014), 2124–2138.
    • (2014) Cell Rep. , vol.9 , pp. 2124-2138
    • Valdearcos, M.1
  • 43
    • 84904747301 scopus 로고    scopus 로고
    • A role for human brain pericytes in neuroinflammation
    • 43 Jansson, D., et al. A role for human brain pericytes in neuroinflammation. J. Neuroinflammation, 11, 2014, 104.
    • (2014) J. Neuroinflammation , vol.11 , pp. 104
    • Jansson, D.1
  • 44
    • 84894459903 scopus 로고    scopus 로고
    • Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro
    • 44 Pieper, C., et al. Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro. Brain Res. 1550 (2014), 1–8.
    • (2014) Brain Res. , vol.1550 , pp. 1-8
    • Pieper, C.1
  • 45
    • 84880328646 scopus 로고    scopus 로고
    • Pericytes support neutrophil transmigration via interleukin-8 across a porcine co-culture model of the blood–brain barrier
    • 45 Pieper, C., et al. Pericytes support neutrophil transmigration via interleukin-8 across a porcine co-culture model of the blood–brain barrier. Brain Res. 1524 (2013), 1–11.
    • (2013) Brain Res. , vol.1524 , pp. 1-11
    • Pieper, C.1
  • 46
    • 85006354959 scopus 로고    scopus 로고
    • Glia: silent partners in energy homeostasis and obesity pathogenesis
    • 46 Douglass, J.D., et al. Glia: silent partners in energy homeostasis and obesity pathogenesis. Diabetologia 60 (2017), 226–236.
    • (2017) Diabetologia , vol.60 , pp. 226-236
    • Douglass, J.D.1
  • 47
    • 84888867859 scopus 로고    scopus 로고
    • Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system
    • 47 Buckman, L.B., et al. Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain Behav. Immun. 35 (2014), 33–42.
    • (2014) Brain Behav. Immun. , vol.35 , pp. 33-42
    • Buckman, L.B.1
  • 48
    • 84978120874 scopus 로고    scopus 로고
    • High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia
    • 48 Baufeld, C., et al. High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia. Acta Neuropathol. 132 (2016), 361–375.
    • (2016) Acta Neuropathol. , vol.132 , pp. 361-375
    • Baufeld, C.1
  • 49
    • 84954357678 scopus 로고    scopus 로고
    • High-fat diet induced anxiety and anhedonia: impact on brain homeostasis and inflammation
    • 49 Dutheil, S., et al. High-fat diet induced anxiety and anhedonia: impact on brain homeostasis and inflammation. Neuropsychopharmacology 41 (2016), 1874–1887.
    • (2016) Neuropsychopharmacology , vol.41 , pp. 1874-1887
    • Dutheil, S.1
  • 50
    • 84990213792 scopus 로고    scopus 로고
    • Neuroprotective effects of endurance exercise against high-fat diet-induced hippocampal neuroinflammation
    • 50 Kang, E.B., et al. Neuroprotective effects of endurance exercise against high-fat diet-induced hippocampal neuroinflammation. J. Neuroendocrinol., 28, 2016, 12385.
    • (2016) J. Neuroendocrinol. , vol.28 , pp. 12385
    • Kang, E.B.1
  • 51
    • 84861846116 scopus 로고    scopus 로고
    • Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet
    • 51 Jeon, B.T., et al. Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet. Diabetes 61 (2012), 1444–1454.
    • (2012) Diabetes , vol.61 , pp. 1444-1454
    • Jeon, B.T.1
  • 52
    • 84885036188 scopus 로고    scopus 로고
    • α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet
    • 52 Miao, Y., et al. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet. Int. J. Mol. Med. 32 (2013), 1179–1186.
    • (2013) Int. J. Mol. Med. , vol.32 , pp. 1179-1186
    • Miao, Y.1
  • 53
    • 84969506648 scopus 로고    scopus 로고
    • The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise
    • 53 Cai, M., et al. The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise. Brain Behav. Immun. 57 (2016), 347–359.
    • (2016) Brain Behav. Immun. , vol.57 , pp. 347-359
    • Cai, M.1
  • 54
    • 84908376800 scopus 로고    scopus 로고
    • Obesity in aging exacerbates blood–brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease
    • 54 Tucsek, Z., et al. Obesity in aging exacerbates blood–brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J. Gerontol. A Biol. Sci. Med. Sci. 69 (2014), 1212–1226.
    • (2014) J. Gerontol. A Biol. Sci. Med. Sci. , vol.69 , pp. 1212-1226
    • Tucsek, Z.1
  • 55
    • 84896267444 scopus 로고    scopus 로고
    • Improvements in hippocampal-dependent memory and microglial infiltration with calorie restriction and gastric bypass surgery, but not with vertical sleeve gastrectomy
    • 55 Grayson, B.E., et al. Improvements in hippocampal-dependent memory and microglial infiltration with calorie restriction and gastric bypass surgery, but not with vertical sleeve gastrectomy. Int. J. Obes. 38 (2014), 349–356.
    • (2014) Int. J. Obes. , vol.38 , pp. 349-356
    • Grayson, B.E.1
  • 56
    • 84878524645 scopus 로고    scopus 로고
    • Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus
    • 56 Rivera, P., et al. Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus. PLoS One, 8, 2013, e64750.
    • (2013) PLoS One , vol.8 , pp. e64750
    • Rivera, P.1
  • 57
    • 84999828494 scopus 로고    scopus 로고
    • A high fat diet-induced decrease in hippocampal newly-born neurons of male mice is exacerbated by mild psychological stress using a communication box
    • 57 Murata, Y., et al. A high fat diet-induced decrease in hippocampal newly-born neurons of male mice is exacerbated by mild psychological stress using a communication box. J. Affect. Disord. 209 (2016), 209–216.
    • (2016) J. Affect. Disord. , vol.209 , pp. 209-216
    • Murata, Y.1
  • 58
    • 84940705163 scopus 로고    scopus 로고
    • Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity
    • 58 Hao, S., et al. Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity. Brain Behav. Immun. 51 (2016), 230–239.
    • (2016) Brain Behav. Immun. , vol.51 , pp. 230-239
    • Hao, S.1
  • 59
    • 84981723089 scopus 로고    scopus 로고
    • Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex
    • 59 Carlin, J.L., et al. Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex. Brain Behav. Immun. 58 (2016), 82–90.
    • (2016) Brain Behav. Immun. , vol.58 , pp. 82-90
    • Carlin, J.L.1
  • 60
    • 84983746074 scopus 로고    scopus 로고
    • Chronic rhein treatment improves recognition memory in high-fat diet-induced obese male mice
    • 60 Wang, S., et al. Chronic rhein treatment improves recognition memory in high-fat diet-induced obese male mice. J. Nutr. Biochem. 36 (2016), 42–50.
    • (2016) J. Nutr. Biochem. , vol.36 , pp. 42-50
    • Wang, S.1
  • 61
    • 77249153620 scopus 로고    scopus 로고
    • Cognitive impairment following high fat diet consumption is associated with brain inflammation
    • 61 Pistell, P.J., et al. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J. Neuroimmunol. 219 (2010), 25–32.
    • (2010) J. Neuroimmunol. , vol.219 , pp. 25-32
    • Pistell, P.J.1
  • 62
    • 84907920449 scopus 로고    scopus 로고
    • Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function
    • 62 Jayaraman, A., et al. Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function. J. Neuroinflammation, 11, 2014, 162.
    • (2014) J. Neuroinflammation , vol.11 , pp. 162
    • Jayaraman, A.1
  • 63
    • 11844263385 scopus 로고    scopus 로고
    • High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex
    • 63 Zhang, X., et al. High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex. Exp. Neurol. 191 (2005), 318–325.
    • (2005) Exp. Neurol. , vol.191 , pp. 318-325
    • Zhang, X.1
  • 64
    • 84955084496 scopus 로고    scopus 로고
    • Resistance training prevents the cardiovascular changes caused by high-fat diet
    • 64 Speretta, G.F., et al. Resistance training prevents the cardiovascular changes caused by high-fat diet. Life Sci. 146 (2016), 154–162.
    • (2016) Life Sci. , vol.146 , pp. 154-162
    • Speretta, G.F.1
  • 65
    • 85002194804 scopus 로고    scopus 로고
    • Behavioral changes in male mice fed a high-fat diet are associated with IL-1beta expression in specific brain regions
    • 65 Almeida-Suhett, C.P., et al. Behavioral changes in male mice fed a high-fat diet are associated with IL-1beta expression in specific brain regions. Physiol. Behav. 169 (2016), 130–140.
    • (2016) Physiol. Behav. , vol.169 , pp. 130-140
    • Almeida-Suhett, C.P.1
  • 66
    • 84976406800 scopus 로고    scopus 로고
    • Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet
    • 66 Bernier, M., et al. Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet. Aging 8 (2016), 899–916.
    • (2016) Aging , vol.8 , pp. 899-916
    • Bernier, M.1
  • 67
    • 84939571088 scopus 로고    scopus 로고
    • Brain and behavioral perturbations in rats following Western diet access
    • 67 Hargrave, S.L., et al. Brain and behavioral perturbations in rats following Western diet access. Appetite 93 (2015), 35–43.
    • (2015) Appetite , vol.93 , pp. 35-43
    • Hargrave, S.L.1
  • 68
    • 84908651577 scopus 로고    scopus 로고
    • Obesity and neuroinflammation: a pathway to cognitive impairment
    • 68 Miller, A.A., Spencer, S.J., Obesity and neuroinflammation: a pathway to cognitive impairment. Brain Behav. Immun. 42 (2014), 10–21.
    • (2014) Brain Behav. Immun. , vol.42 , pp. 10-21
    • Miller, A.A.1    Spencer, S.J.2
  • 69
    • 79952483902 scopus 로고    scopus 로고
    • Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity
    • 69 Kanoski, S.E., Davidson, T.L., Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol. Behav. 103 (2011), 59–68.
    • (2011) Physiol. Behav. , vol.103 , pp. 59-68
    • Kanoski, S.E.1    Davidson, T.L.2
  • 70
    • 84901334114 scopus 로고    scopus 로고
    • Blood–brain barrier disruption: mechanistic links between Western diet consumption and dementia
    • 70 Hsu, T.M., Kanoski, S.E., Blood–brain barrier disruption: mechanistic links between Western diet consumption and dementia. Front. Aging Neurosci., 6, 2014, 88.
    • (2014) Front. Aging Neurosci. , vol.6 , pp. 88
    • Hsu, T.M.1    Kanoski, S.E.2
  • 71
    • 84995459599 scopus 로고    scopus 로고
    • Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice
    • 71 Klaus, F., et al. Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice. Brain Behav. Immun. 58 (2016), 310–326.
    • (2016) Brain Behav. Immun. , vol.58 , pp. 310-326
    • Klaus, F.1
  • 72
    • 84927747505 scopus 로고    scopus 로고
    • Neurochemical and electrophysiological deficits in the ventral hippocampus and selective behavioral alterations caused by high-fat diet in female C57BL/6 mice
    • 72 Krishna, S., et al. Neurochemical and electrophysiological deficits in the ventral hippocampus and selective behavioral alterations caused by high-fat diet in female C57BL/6 mice. Neuroscience 297 (2015), 170–181.
    • (2015) Neuroscience , vol.297 , pp. 170-181
    • Krishna, S.1
  • 73
    • 84921969632 scopus 로고    scopus 로고
    • Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory
    • 73 Camer, D., et al. Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory. Prog. Neuropsychopharmacol. Biol. Psychiatry 59 (2015), 68–75.
    • (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.59 , pp. 68-75
    • Camer, D.1
  • 74
    • 84867744341 scopus 로고    scopus 로고
    • Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice
    • 74 Boitard, C., et al. Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice. Hippocampus 22 (2012), 2095–2100.
    • (2012) Hippocampus , vol.22 , pp. 2095-2100
    • Boitard, C.1
  • 75
    • 84998881969 scopus 로고    scopus 로고
    • Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations
    • 75 Boitard, C., et al. Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations. Front. Behav. Neurosci., 10, 2016, 225.
    • (2016) Front. Behav. Neurosci. , vol.10 , pp. 225
    • Boitard, C.1
  • 76
    • 84925172043 scopus 로고    scopus 로고
    • Chronic high fat feeding increases anxiety-like behaviour and reduces transcript abundance of glucocorticoid signalling genes in the hippocampus of female rats
    • 76 Sivanathan, S., et al. Chronic high fat feeding increases anxiety-like behaviour and reduces transcript abundance of glucocorticoid signalling genes in the hippocampus of female rats. Behav. Brain Res. 286 (2015), 265–270.
    • (2015) Behav. Brain Res. , vol.286 , pp. 265-270
    • Sivanathan, S.1
  • 77
    • 0037151258 scopus 로고    scopus 로고
    • Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice
    • 77 Carola, V., et al. Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice. Behav. Brain Res. 134 (2002), 49–57.
    • (2002) Behav. Brain Res. , vol.134 , pp. 49-57
    • Carola, V.1
  • 78
    • 43049083275 scopus 로고    scopus 로고
    • Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice
    • 78 Lalonde, R., Strazielle, C., Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice. J. Neurosci. Methods 171 (2008), 48–52.
    • (2008) J. Neurosci. Methods , vol.171 , pp. 48-52
    • Lalonde, R.1    Strazielle, C.2
  • 79
    • 84921320404 scopus 로고    scopus 로고
    • Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats
    • 79 Hsu, T.M., et al. Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus 25 (2015), 227–239.
    • (2015) Hippocampus , vol.25 , pp. 227-239
    • Hsu, T.M.1
  • 80
    • 84942990663 scopus 로고    scopus 로고
    • Brain morphology links systemic inflammation to cognitive function in midlife adults
    • 80 Marsland, A.L., et al. Brain morphology links systemic inflammation to cognitive function in midlife adults. Brain Behav. Immun. 48 (2015), 195–204.
    • (2015) Brain Behav. Immun. , vol.48 , pp. 195-204
    • Marsland, A.L.1
  • 81
    • 84973922617 scopus 로고    scopus 로고
    • Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects
    • 81 Lasselin, J., et al. Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects. Brain Behav. Immun. 58 (2016), 63–68.
    • (2016) Brain Behav. Immun. , vol.58 , pp. 63-68
    • Lasselin, J.1
  • 82
    • 77950256167 scopus 로고    scopus 로고
    • Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function
    • 82 Wersching, H., et al. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology 74 (2010), 1022–1029.
    • (2010) Neurology , vol.74 , pp. 1022-1029
    • Wersching, H.1
  • 83
    • 84860389076 scopus 로고    scopus 로고
    • C-reactive protein is related to memory and medial temporal brain volume in older adults
    • 83 Bettcher, B.M., et al. C-reactive protein is related to memory and medial temporal brain volume in older adults. Brain Behav. Immun. 26 (2012), 103–108.
    • (2012) Brain Behav. Immun. , vol.26 , pp. 103-108
    • Bettcher, B.M.1
  • 84
    • 84992179956 scopus 로고    scopus 로고
    • The effect of short-term exposure to energy-matched diets enriched in fat or sugar on memory, gut microbiota and markers of brain inflammation and plasticity
    • 84 Beilharz, J.E., et al. The effect of short-term exposure to energy-matched diets enriched in fat or sugar on memory, gut microbiota and markers of brain inflammation and plasticity. Brain Behav. Immun. 57 (2016), 304–313.
    • (2016) Brain Behav. Immun. , vol.57 , pp. 304-313
    • Beilharz, J.E.1
  • 85
    • 79960841144 scopus 로고    scopus 로고
    • Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents
    • 85 Lavin, D.N., et al. Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents. Obesity 19 (2011), 1586–1594.
    • (2011) Obesity , vol.19 , pp. 1586-1594
    • Lavin, D.N.1
  • 86
    • 84942989648 scopus 로고    scopus 로고
    • Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet
    • 86 Strekalova, T., et al. Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet. Brain Behav. Immun. 48 (2015), 42–47.
    • (2015) Brain Behav. Immun. , vol.48 , pp. 42-47
    • Strekalova, T.1
  • 87
    • 84960847764 scopus 로고    scopus 로고
    • Cognitive effects of intentional weight loss in elderly obese individuals with mild cognitive impairment
    • 87 Horie, N.C., et al. Cognitive effects of intentional weight loss in elderly obese individuals with mild cognitive impairment. J. Clin. Endocrinol. Metab 101 (2016), 1104–1112.
    • (2016) J. Clin. Endocrinol. Metab , vol.101 , pp. 1104-1112
    • Horie, N.C.1
  • 88
    • 84885000646 scopus 로고    scopus 로고
    • Effects of exercise and diet change on cognition function and synaptic plasticity in high fat diet induced obese rats
    • 88 Woo, J., et al. Effects of exercise and diet change on cognition function and synaptic plasticity in high fat diet induced obese rats. Lipids Health Dis., 12, 2013, 144.
    • (2013) Lipids Health Dis. , vol.12 , pp. 144
    • Woo, J.1
  • 89
    • 84866705627 scopus 로고    scopus 로고
    • From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
    • 89 Williams, K.W., Elmquist, J.K., From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nat. Neurosci. 15 (2012), 1350–1355.
    • (2012) Nat. Neurosci. , vol.15 , pp. 1350-1355
    • Williams, K.W.1    Elmquist, J.K.2
  • 90
    • 72449161077 scopus 로고    scopus 로고
    • Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit
    • 90 Sainsbury, A., Zhang, L., Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit. Mol. Cell Endocrinol. 316 (2010), 109–119.
    • (2010) Mol. Cell Endocrinol. , vol.316 , pp. 109-119
    • Sainsbury, A.1    Zhang, L.2
  • 91
    • 84940460124 scopus 로고    scopus 로고
    • One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice
    • 91 Waise, T.M., et al. One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice. Biochem. Biophys. Res. Commun. 464 (2015), 1157–1162.
    • (2015) Biochem. Biophys. Res. Commun. , vol.464 , pp. 1157-1162
    • Waise, T.M.1
  • 92
    • 84935052674 scopus 로고    scopus 로고
    • Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
    • 92 Naznin, F., et al. Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation. J. Endocrinol. 226 (2015), 81–92.
    • (2015) J. Endocrinol. , vol.226 , pp. 81-92
    • Naznin, F.1
  • 93
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • 93 Zhang, X., et al. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135 (2008), 61–73.
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1
  • 94
    • 84874156024 scopus 로고    scopus 로고
    • Regional astrogliosis in the mouse hypothalamus in response to obesity
    • 94 Buckman, L.B., et al. Regional astrogliosis in the mouse hypothalamus in response to obesity. J. Comp. Neurol. 521 (2013), 1322–1333.
    • (2013) J. Comp. Neurol. , vol.521 , pp. 1322-1333
    • Buckman, L.B.1
  • 95
    • 84861918690 scopus 로고    scopus 로고
    • Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
    • 95 Milanski, M., et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 61 (2012), 1455–1462.
    • (2012) Diabetes , vol.61 , pp. 1455-1462
    • Milanski, M.1
  • 96
    • 84937515151 scopus 로고    scopus 로고
    • New insights into the resolution of inflammation
    • 96 Gilroy, D., De, M.R., New insights into the resolution of inflammation. Semin. Immunol. 27 (2015), 161–168.
    • (2015) Semin. Immunol. , vol.27 , pp. 161-168
    • Gilroy, D.1    De, M.R.2
  • 97
    • 84904536784 scopus 로고    scopus 로고
    • ‘Neuroinflammation’ differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared
    • 97 Filiou, M.D., et al. ‘Neuroinflammation’ differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared. Neurogenetics 15 (2014), 201–212.
    • (2014) Neurogenetics , vol.15 , pp. 201-212
    • Filiou, M.D.1
  • 98
    • 84890986568 scopus 로고    scopus 로고
    • Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
    • 98 Xanthos, D.N., Sandkuhler, J., Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nat. Rev. Neurosci. 15 (2014), 43–53.
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 43-53
    • Xanthos, D.N.1    Sandkuhler, J.2
  • 99
    • 53549094159 scopus 로고    scopus 로고
    • Defining ‘neuroinflammation’
    • 99 O'Callaghan, J.P., Defining ‘neuroinflammation’. Ann. N. Y. Acad. Sci. 1139 (2008), 318–330.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1139 , pp. 318-330
    • O'Callaghan, J.P.1
  • 100
    • 81755173570 scopus 로고    scopus 로고
    • Role of microglia in CNS inflammation
    • 100 Graeber, M.B., et al. Role of microglia in CNS inflammation. FEBS Lett. 585 (2011), 3798–3805.
    • (2011) FEBS Lett. , vol.585 , pp. 3798-3805
    • Graeber, M.B.1
  • 101
    • 84946011612 scopus 로고    scopus 로고
    • Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans
    • 101 Schur, E.A., et al. Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans. Obesity 23 (2015), 2142–2148.
    • (2015) Obesity , vol.23 , pp. 2142-2148
    • Schur, E.A.1
  • 102
    • 84884821465 scopus 로고    scopus 로고
    • Frontal cortical thinning and subcortical volume reductions in early adulthood obesity
    • 102 Marques-Iturria, I., Frontal cortical thinning and subcortical volume reductions in early adulthood obesity. Psychiatry Res. 214 (2013), 109–115.
    • (2013) Psychiatry Res. , vol.214 , pp. 109-115
    • Marques-Iturria, I.1
  • 103
    • 84887228868 scopus 로고    scopus 로고
    • Abdominal obesity and lower gray matter volume: a Mendelian randomization study
    • 103 Debette, S., et al. Abdominal obesity and lower gray matter volume: a Mendelian randomization study. Neurobiol. Aging 35 (2014), 378–386.
    • (2014) Neurobiol. Aging , vol.35 , pp. 378-386
    • Debette, S.1
  • 104
    • 77149176577 scopus 로고    scopus 로고
    • Brain structure and obesity
    • 104 Raji, C.A., et al. Brain structure and obesity. Hum. Brain Mapp. 31 (2010), 353–364.
    • (2010) Hum. Brain Mapp. , vol.31 , pp. 353-364
    • Raji, C.A.1
  • 105
    • 84939625730 scopus 로고    scopus 로고
    • Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples
    • 105 Janowitz, D., et al. Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples. Neuroimage 122 (2015), 149–157.
    • (2015) Neuroimage , vol.122 , pp. 149-157
    • Janowitz, D.1
  • 106
    • 84889652068 scopus 로고    scopus 로고
    • Obesity is associated with white matter atrophy: a combined diffusion tensor imaging and voxel-based morphometric study
    • 106 Karlsson, H.K., et al. Obesity is associated with white matter atrophy: a combined diffusion tensor imaging and voxel-based morphometric study. Obesity 21 (2013), 2530–2537.
    • (2013) Obesity , vol.21 , pp. 2530-2537
    • Karlsson, H.K.1
  • 107
    • 84873713360 scopus 로고    scopus 로고
    • Late-life obesity is associated with smaller global and regional gray matter volumes: a voxel-based morphometric study
    • 107 Brooks, S.J., et al. Late-life obesity is associated with smaller global and regional gray matter volumes: a voxel-based morphometric study. Int. J. Obes. 37 (2013), 230–236.
    • (2013) Int. J. Obes. , vol.37 , pp. 230-236
    • Brooks, S.J.1
  • 108
    • 84964329169 scopus 로고    scopus 로고
    • Increased body mass index is associated with specific regional alterations in brain structure
    • 108 Medic, N., et al. Increased body mass index is associated with specific regional alterations in brain structure. Int. J. Obes. 40 (2016), 1177–1182.
    • (2016) Int. J. Obes. , vol.40 , pp. 1177-1182
    • Medic, N.1
  • 109
    • 84908636943 scopus 로고    scopus 로고
    • Brain structure and cognitive correlates of body mass index in healthy older adults
    • 109 Bolzenius, J.D., et al. Brain structure and cognitive correlates of body mass index in healthy older adults. Behav. Brain Res. 278 (2015), 342–347.
    • (2015) Behav. Brain Res. , vol.278 , pp. 342-347
    • Bolzenius, J.D.1
  • 110
    • 84887076229 scopus 로고    scopus 로고
    • Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats
    • 110 Castro, G., et al. Diet-induced obesity induces endoplasmic reticulum stress and insulin resistance in the amygdala of rats. FEBS Open Bio 3 (2013), 443–449.
    • (2013) FEBS Open Bio , vol.3 , pp. 443-449
    • Castro, G.1
  • 111
    • 84904126101 scopus 로고    scopus 로고
    • Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats
    • 111 Boitard, C., et al. Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats. Brain Behav. Immun. 40 (2014), 9–17.
    • (2014) Brain Behav. Immun. , vol.40 , pp. 9-17
    • Boitard, C.1


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