메뉴 건너뛰기




Volumn 38, Issue 10, 2015, Pages 598-608

The Molecular Constituents of the Blood-Brain Barrier

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD BRAIN BARRIER; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; ENDOTHELIUM CELL; MICROENVIRONMENT; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; HUMAN; METABOLISM;

EID: 84943237109     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2015.08.003     Document Type: Review
Times cited : (287)

References (80)
  • 1
    • 84937413991 scopus 로고    scopus 로고
    • Neuronal and vascular interactions
    • Andreone B.J., et al. Neuronal and vascular interactions. Annu. Rev. Neurosci. 2015, 38:25-46.
    • (2015) Annu. Rev. Neurosci. , vol.38 , pp. 25-46
    • Andreone, B.J.1
  • 2
    • 84889872057 scopus 로고    scopus 로고
    • Development, maintenance and disruption of the blood-brain barrier
    • Obermeier B., et al. Development, maintenance and disruption of the blood-brain barrier. Nat. Med. 2013, 19:1584-1596.
    • (2013) Nat. Med. , vol.19 , pp. 1584-1596
    • Obermeier, B.1
  • 4
    • 33444458070 scopus 로고
    • Ueber die Beziehungen von chemischer Constitution, Verteilung und pharmakologischer Wirkung
    • Hirschwald, (in German)
    • Ehrlich P. Ueber die Beziehungen von chemischer Constitution, Verteilung und pharmakologischer Wirkung. Gesammelte Arbeiten zur Immunitaetsforschung 1904, 574. Hirschwald, (in German).
    • (1904) Gesammelte Arbeiten zur Immunitaetsforschung , pp. 574
    • Ehrlich, P.1
  • 6
    • 42249086270 scopus 로고    scopus 로고
    • Science and fate: Lina Stern (1878-1968), a neurophysiologist and biochemist
    • Vein A.A. Science and fate: Lina Stern (1878-1968), a neurophysiologist and biochemist. J. Hist. Neurosci. 2008, 17:195-206.
    • (2008) J. Hist. Neurosci. , vol.17 , pp. 195-206
    • Vein, A.A.1
  • 7
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • Reese T.S., Karnovsky M.J. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol. 1967, 34:207-217.
    • (1967) J. Cell Biol. , vol.34 , pp. 207-217
    • Reese, T.S.1    Karnovsky, M.J.2
  • 8
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • Brightman M.W., Reese T.S. Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 1969, 40:648-677.
    • (1969) J. Cell Biol. , vol.40 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 9
    • 0018080931 scopus 로고
    • Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries
    • Betz A.L., Goldstein G.W. Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries. Science 1978, 202:225-227.
    • (1978) Science , vol.202 , pp. 225-227
    • Betz, A.L.1    Goldstein, G.W.2
  • 11
    • 84957794434 scopus 로고
    • Filtration, diffusion and molecular sieving through peripheral capillary membranes. A contribution to the pore theory of capillary permeability
    • Pappenheimer J.R. Filtration, diffusion and molecular sieving through peripheral capillary membranes. A contribution to the pore theory of capillary permeability. Am. J. Physiol. 1951, 167:1-34.
    • (1951) Am. J. Physiol. , vol.167 , pp. 1-34
    • Pappenheimer, J.R.1
  • 12
    • 84887403996 scopus 로고    scopus 로고
    • "Sealing off the CNS": cellular and molecular regulation of blood-brain barriergenesis
    • Siegenthaler J.A., et al. "Sealing off the CNS": cellular and molecular regulation of blood-brain barriergenesis. Curr. Opin. Neurobiol. 2013, 23:1057-1064.
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 1057-1064
    • Siegenthaler, J.A.1
  • 13
    • 84864760434 scopus 로고    scopus 로고
    • Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances
    • Liu W-Y., et al. Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances. CNS Neurosci. Ther. 2012, 18:609-615.
    • (2012) CNS Neurosci. Ther. , vol.18 , pp. 609-615
    • Liu, W.-Y.1
  • 14
    • 63249132854 scopus 로고    scopus 로고
    • Tight junctions and the regulation of gene expression
    • Balda M.S., Matter K. Tight junctions and the regulation of gene expression. Biochim. Biophys. Acta 2009, 1788:761-767.
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 761-767
    • Balda, M.S.1    Matter, K.2
  • 15
    • 84943255434 scopus 로고    scopus 로고
    • Brain barriers: crosstalk between complex tight junctions and adherens junctions
    • Tietz S., Engelhardt B. Brain barriers: crosstalk between complex tight junctions and adherens junctions. J. Cell Biol. 2015, 209:493-506.
    • (2015) J. Cell Biol. , vol.209 , pp. 493-506
    • Tietz, S.1    Engelhardt, B.2
  • 16
    • 0037817352 scopus 로고    scopus 로고
    • Transcytosis: crossing cellular barriers
    • Tuma P.L., Hubbard A.L. Transcytosis: crossing cellular barriers. Physiol. Rev. 2003, 83:871-932.
    • (2003) Physiol. Rev. , vol.83 , pp. 871-932
    • Tuma, P.L.1    Hubbard, A.L.2
  • 17
    • 84880161805 scopus 로고    scopus 로고
    • Receptor-mediated endocytosis and brain delivery of therapeutic biologics
    • Xiao G., Gan L-S. Receptor-mediated endocytosis and brain delivery of therapeutic biologics. Int. J. Cell Biol. 2013, 2013:1-14.
    • (2013) Int. J. Cell Biol. , vol.2013 , pp. 1-14
    • Xiao, G.1    Gan, L.-S.2
  • 18
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel A.H., et al. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 1995, 96:1698-1705.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1
  • 19
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • Schinkel A.H., et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994, 77:491-502.
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1
  • 20
    • 22744440362 scopus 로고    scopus 로고
    • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    • Löscher W., Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog. Neurobiol. 2005, 76:22-76.
    • (2005) Prog. Neurobiol. , vol.76 , pp. 22-76
    • Löscher, W.1    Potschka, H.2
  • 21
    • 34547624611 scopus 로고    scopus 로고
    • Supply and demand in cerebral energy metabolism: the role of nutrient transporters
    • Simpson I.A., et al. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J. Cereb. Blood Flow Metab. 2007, 27:1766-1791.
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 1766-1791
    • Simpson, I.A.1
  • 22
    • 84875191169 scopus 로고    scopus 로고
    • Transporters of the blood-brain and blood-CSF interfaces in development and in the adult
    • Saunders N.R., et al. Transporters of the blood-brain and blood-CSF interfaces in development and in the adult. Mol. Aspects Med. 2013, 34:742-752.
    • (2013) Mol. Aspects Med. , vol.34 , pp. 742-752
    • Saunders, N.R.1
  • 23
    • 84938301217 scopus 로고    scopus 로고
    • A call for systematic research on solute carriers
    • César-Razquin A., et al. A call for systematic research on solute carriers. Cell 2015, 162:478-487.
    • (2015) Cell , vol.162 , pp. 478-487
    • César-Razquin, A.1
  • 24
    • 84869885852 scopus 로고    scopus 로고
    • Capture, crawl, cross: the T cell code to breach the blood-brain barriers
    • Engelhardt B., Ransohoff R.M. Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends Immunol. 2012, 33:579-589.
    • (2012) Trends Immunol. , vol.33 , pp. 579-589
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 25
    • 84866364390 scopus 로고    scopus 로고
    • The anatomical and cellular basis of immune surveillance in the central nervous system
    • Ransohoff R.M., Engelhardt B. The anatomical and cellular basis of immune surveillance in the central nervous system. Nat. Rev. Immunol. 2012, 12:623-635.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 623-635
    • Ransohoff, R.M.1    Engelhardt, B.2
  • 26
    • 84871921577 scopus 로고    scopus 로고
    • Immunologic privilege in the central nervous system and the blood-brain barrier
    • Muldoon L.L., et al. Immunologic privilege in the central nervous system and the blood-brain barrier. J. Cereb. Blood Flow Metab. 2013, 33:13-21.
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , pp. 13-21
    • Muldoon, L.L.1
  • 27
    • 84928213789 scopus 로고    scopus 로고
    • The molecular, cellular, and morphological components of blood-brain barrier development during embryogenesis
    • Hagan N., Ben-Zvi A. The molecular, cellular, and morphological components of blood-brain barrier development during embryogenesis. Semin. Cell Dev. Biol. 2014, 38:7-15.
    • (2014) Semin. Cell Dev. Biol. , vol.38 , pp. 7-15
    • Hagan, N.1    Ben-Zvi, A.2
  • 28
    • 0019798883 scopus 로고
    • Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras
    • Stewart P.A., Wiley M.J. Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras. Dev. Biol. 1981, 84:183-192.
    • (1981) Dev. Biol. , vol.84 , pp. 183-192
    • Stewart, P.A.1    Wiley, M.J.2
  • 29
    • 56749104928 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature
    • Stenman J.M., et al. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 2008, 322:1247-1250.
    • (2008) Science , vol.322 , pp. 1247-1250
    • Stenman, J.M.1
  • 30
    • 56149124382 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling controls development of the blood-brain barrier
    • Liebner S., et al. Wnt/β-catenin signaling controls development of the blood-brain barrier. J. Cell Biol. 2008, 183:409-417.
    • (2008) J. Cell Biol. , vol.183 , pp. 409-417
    • Liebner, S.1
  • 31
    • 58849119932 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    • Daneman R., et al. Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:641-646.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 641-646
    • Daneman, R.1
  • 32
    • 84870897220 scopus 로고    scopus 로고
    • Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity
    • Wang Y., et al. Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. Cell 2012, 151:1332-1344.
    • (2012) Cell , vol.151 , pp. 1332-1344
    • Wang, Y.1
  • 33
    • 84907008498 scopus 로고    scopus 로고
    • Canonical WNT signaling components in vascular development and barrier formation
    • Zhou Y., et al. Canonical WNT signaling components in vascular development and barrier formation. J. Clin. Invest. 2014, 124:3825-3846.
    • (2014) J. Clin. Invest. , vol.124 , pp. 3825-3846
    • Zhou, Y.1
  • 34
    • 84908481545 scopus 로고    scopus 로고
    • Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling
    • Zhou Y., Nathans J. Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Dev. Cell 2014, 31:248-256.
    • (2014) Dev. Cell , vol.31 , pp. 248-256
    • Zhou, Y.1    Nathans, J.2
  • 35
    • 78149399666 scopus 로고    scopus 로고
    • Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124
    • Kuhnert F., et al. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 2010, 330:985-989.
    • (2010) Science , vol.330 , pp. 985-989
    • Kuhnert, F.1
  • 36
    • 84920917936 scopus 로고    scopus 로고
    • GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling
    • Posokhova E., et al. GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling. Cell Rep. 2015, 10:123-130.
    • (2015) Cell Rep. , vol.10 , pp. 123-130
    • Posokhova, E.1
  • 37
    • 79952596356 scopus 로고    scopus 로고
    • Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor
    • Anderson K.D., et al. Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:2807-2812.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 2807-2812
    • Anderson, K.D.1
  • 38
    • 79955029851 scopus 로고    scopus 로고
    • GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier
    • Cullen M., et al. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:5759-5764.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 5759-5764
    • Cullen, M.1
  • 39
    • 84933043937 scopus 로고    scopus 로고
    • Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis
    • Published online June 8, 2015
    • Vanhollebeke B., et al. Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Elife 2015, Published online June 8, 2015. 10.7554/eLife.06489.
    • (2015) Elife
    • Vanhollebeke, B.1
  • 40
    • 84855838132 scopus 로고    scopus 로고
    • Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice
    • Chen J., et al. Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS ONE 2012, 7:e30203.
    • (2012) PLoS ONE , vol.7 , pp. e30203
    • Chen, J.1
  • 41
    • 84856978029 scopus 로고    scopus 로고
    • Death receptors DR6 and TROY regulate brain vascular development
    • Tam S.J., et al. Death receptors DR6 and TROY regulate brain vascular development. Dev. Cell 2012, 22:403-417.
    • (2012) Dev. Cell , vol.22 , pp. 403-417
    • Tam, S.J.1
  • 42
    • 84901269974 scopus 로고    scopus 로고
    • Mfsd2a is critical for the formation and function of the blood-brain barrier
    • Ben-Zvi A., et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature 2014, 509:507-511.
    • (2014) Nature , vol.509 , pp. 507-511
    • Ben-Zvi, A.1
  • 43
    • 84900992748 scopus 로고    scopus 로고
    • Blood-brain barrier: a dual life of MFSD2A?
    • Zhao Z., Zlokovic B.V. Blood-brain barrier: a dual life of MFSD2A?. Neuron 2014, 82:728-730.
    • (2014) Neuron , vol.82 , pp. 728-730
    • Zhao, Z.1    Zlokovic, B.V.2
  • 44
    • 84901267568 scopus 로고    scopus 로고
    • Physiology: double function at the blood-brain barrier
    • Betsholtz C. Physiology: double function at the blood-brain barrier. Nature 2014, 509:432-433.
    • (2014) Nature , vol.509 , pp. 432-433
    • Betsholtz, C.1
  • 45
    • 84901260638 scopus 로고    scopus 로고
    • Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
    • Nguyen L.N., et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 2014, 509:503-506.
    • (2014) Nature , vol.509 , pp. 503-506
    • Nguyen, L.N.1
  • 46
    • 79951979686 scopus 로고    scopus 로고
    • Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
    • Lafourcade M., et al. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat. Neurosci. 2011, 14:345-350.
    • (2011) Nat. Neurosci. , vol.14 , pp. 345-350
    • Lafourcade, M.1
  • 47
    • 84933040235 scopus 로고    scopus 로고
    • Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome
    • Guemez-Gamboa A., et al. Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nat. Genet. 2015, 47:809-813.
    • (2015) Nat. Genet. , vol.47 , pp. 809-813
    • Guemez-Gamboa, A.1
  • 48
    • 84933064751 scopus 로고    scopus 로고
    • A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome
    • Alakbarzade V., et al. A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. Nat. Genet. 2015, 47:814-817.
    • (2015) Nat. Genet. , vol.47 , pp. 814-817
    • Alakbarzade, V.1
  • 49
    • 84925594369 scopus 로고    scopus 로고
    • GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
    • Winkler E.A., et al. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat. Neurosci. 2015, 18:521-530.
    • (2015) Nat. Neurosci. , vol.18 , pp. 521-530
    • Winkler, E.A.1
  • 50
    • 78650887526 scopus 로고    scopus 로고
    • Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo
    • Zheng P-P., et al. Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo. Ann. Neurol. 2010, 68:835-844.
    • (2010) Ann. Neurol. , vol.68 , pp. 835-844
    • Zheng, P.-P.1
  • 51
    • 84925353016 scopus 로고    scopus 로고
    • LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation
    • Sohet F., et al. LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. J. Cell Biol. 2015, 208:703-711.
    • (2015) J. Cell Biol. , vol.208 , pp. 703-711
    • Sohet, F.1
  • 52
    • 78149456928 scopus 로고    scopus 로고
    • The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells
    • Daneman R., et al. The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS ONE 2010, 5:e13741.
    • (2010) PLoS ONE , vol.5 , pp. e13741
    • Daneman, R.1
  • 53
    • 54449093230 scopus 로고    scopus 로고
    • Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice
    • Yen F.T., et al. Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice. J. Biol. Chem. 2008, 283:25650-25659.
    • (2008) J. Biol. Chem. , vol.283 , pp. 25650-25659
    • Yen, F.T.1
  • 54
    • 0037648580 scopus 로고    scopus 로고
    • Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    • Nitta T., et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol. 2003, 161:653-660.
    • (2003) J. Cell Biol. , vol.161 , pp. 653-660
    • Nitta, T.1
  • 55
    • 84455205524 scopus 로고    scopus 로고
    • The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    • Alvarez J.I., et al. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 2011, 334:1727-1731.
    • (2011) Science , vol.334 , pp. 1727-1731
    • Alvarez, J.I.1
  • 56
    • 0036468157 scopus 로고    scopus 로고
    • Sonic hedgehog in CNS development: one signal, multiple outputs
    • Martí E., Bovolenta P. Sonic hedgehog in CNS development: one signal, multiple outputs. Trends Neurosci. 2002, 25:89-96.
    • (2002) Trends Neurosci. , vol.25 , pp. 89-96
    • Martí, E.1    Bovolenta, P.2
  • 57
    • 84911884131 scopus 로고    scopus 로고
    • The gut microbiota influences blood-brain barrier permeability in mice
    • 263ra158
    • Braniste V., et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci. Transl. Med. 2014, 6:263ra158.
    • (2014) Sci. Transl. Med. , vol.6
    • Braniste, V.1
  • 58
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao E.Y., et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013, 155:1451-1463.
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 59
    • 84981188004 scopus 로고    scopus 로고
    • Microbiota and the control of blood-tissue barriers
    • Published online May 29, 2015
    • Al-Asmakh M., Hedin L. Microbiota and the control of blood-tissue barriers. Tissue Barriers 2015, Published online May 29, 2015. 10.1080/21688370.2015.1039691.
    • (2015) Tissue Barriers
    • Al-Asmakh, M.1    Hedin, L.2
  • 60
    • 77954618806 scopus 로고    scopus 로고
    • Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis
    • Brouwer M.C., et al. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin. Microbiol. Rev. 2010, 23:467-492.
    • (2010) Clin. Microbiol. Rev. , vol.23 , pp. 467-492
    • Brouwer, M.C.1
  • 61
    • 84858060614 scopus 로고    scopus 로고
    • Defense at the border: the blood-brain barrier versus bacterial foreigners
    • van Sorge N.M., Doran K.S. Defense at the border: the blood-brain barrier versus bacterial foreigners. Future Microbiol. 2012, 7:383-394.
    • (2012) Future Microbiol. , vol.7 , pp. 383-394
    • van Sorge, N.M.1    Doran, K.S.2
  • 62
    • 84930385063 scopus 로고    scopus 로고
    • Bacterial induction of Snail1 contributes to blood-brain barrier disruption
    • Kim B.J., et al. Bacterial induction of Snail1 contributes to blood-brain barrier disruption. J. Clin. Invest. 2015, 125:2473-2483.
    • (2015) J. Clin. Invest. , vol.125 , pp. 2473-2483
    • Kim, B.J.1
  • 63
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • Zhang Y., et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 2014, 34:11929-11947.
    • (2014) J. Neurosci. , vol.34 , pp. 11929-11947
    • Zhang, Y.1
  • 64
    • 0023137260 scopus 로고
    • The microcirculation of rat circumventricular organs and pituitary gland
    • Gross P.M., et al. The microcirculation of rat circumventricular organs and pituitary gland. Brain Res. Bull. 1987, 18:73-85.
    • (1987) Brain Res. Bull. , vol.18 , pp. 73-85
    • Gross, P.M.1
  • 65
    • 0027211759 scopus 로고
    • Sensory circumventricular organs and brain homeostatic pathways
    • Johnson A.K., Gross P.M. Sensory circumventricular organs and brain homeostatic pathways. FASEB J. 1993, 7:678-686.
    • (1993) FASEB J. , vol.7 , pp. 678-686
    • Johnson, A.K.1    Gross, P.M.2
  • 66
    • 0017276160 scopus 로고
    • Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood
    • Broadwell R.D., Brightman M.W. Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J. Comp. Neurol. 1976, 166:257-283.
    • (1976) J. Comp. Neurol. , vol.166 , pp. 257-283
    • Broadwell, R.D.1    Brightman, M.W.2
  • 67
    • 84910047887 scopus 로고    scopus 로고
    • Dissecting gene expression at the blood-brain barrier
    • Huntley M.A., et al. Dissecting gene expression at the blood-brain barrier. Front. Neurosci. 2014, 8:355.
    • (2014) Front. Neurosci. , vol.8 , pp. 355
    • Huntley, M.A.1
  • 68
    • 84900314611 scopus 로고    scopus 로고
    • CRISPR-Cas systems for editing, regulating and targeting genomes
    • Sander J.D., Joung J.K. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat. Biotechnol. 2014, 32:347-355.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 347-355
    • Sander, J.D.1    Joung, J.K.2
  • 69
    • 79955459709 scopus 로고    scopus 로고
    • In vitro models of the blood-brain barrier
    • Wilhelm I., et al. In vitro models of the blood-brain barrier. Acta Neurobiol. Exp. (Wars.) 2011, 71:113-128.
    • (2011) Acta Neurobiol. Exp. (Wars.) , vol.71 , pp. 113-128
    • Wilhelm, I.1
  • 70
    • 79960279229 scopus 로고    scopus 로고
    • Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models
    • Hatherell K., et al. Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models. J. Neurosci. Methods 2011, 199:223-229.
    • (2011) J. Neurosci. Methods , vol.199 , pp. 223-229
    • Hatherell, K.1
  • 71
    • 84881180266 scopus 로고    scopus 로고
    • Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro
    • Paolinelli R., et al. Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS ONE 2013, 8:e70233.
    • (2013) PLoS ONE , vol.8 , pp. e70233
    • Paolinelli, R.1
  • 72
    • 84864874302 scopus 로고    scopus 로고
    • Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
    • Lippmann E.S., et al. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat. Biotechnol. 2012, 30:783-791.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 783-791
    • Lippmann, E.S.1
  • 73
    • 84894641836 scopus 로고    scopus 로고
    • A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
    • Lippmann E.S., et al. A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Sci. Rep. 2014, 4:4160.
    • (2014) Sci. Rep. , vol.4 , pp. 4160
    • Lippmann, E.S.1
  • 74
    • 84868573143 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier
    • Pardridge W.M. Drug transport across the blood-brain barrier. J. Cereb. Blood Flow Metab. 2012, 32:1959-1972.
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 1959-1972
    • Pardridge, W.M.1
  • 75
    • 34547642139 scopus 로고    scopus 로고
    • Blood-brain barrier transport of therapeutics via receptor-mediation
    • Jones A.R., Shusta E.V. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm. Res. 2007, 24:1759-1771.
    • (2007) Pharm. Res. , vol.24 , pp. 1759-1771
    • Jones, A.R.1    Shusta, E.V.2
  • 76
    • 84879968745 scopus 로고    scopus 로고
    • Developing therapeutic antibodies for neurodegenerative disease
    • Yu Y.J., Watts R.J. Developing therapeutic antibodies for neurodegenerative disease. Neurotherapeutics 2013, 10:459-472.
    • (2013) Neurotherapeutics , vol.10 , pp. 459-472
    • Yu, Y.J.1    Watts, R.J.2
  • 77
    • 84891804917 scopus 로고    scopus 로고
    • Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
    • Niewoehner J., et al. Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle. Neuron 2014, 81:49-60.
    • (2014) Neuron , vol.81 , pp. 49-60
    • Niewoehner, J.1
  • 78
    • 84863952172 scopus 로고    scopus 로고
    • Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques
    • McDannold N., et al. Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques. Cancer Res. 2012, 72:3652-3663.
    • (2012) Cancer Res. , vol.72 , pp. 3652-3663
    • McDannold, N.1
  • 79
    • 84926518652 scopus 로고    scopus 로고
    • Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood-brain barrier opening in vivo
    • Samiotaki G., et al. Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood-brain barrier opening in vivo. J. Cereb. Blood Flow Metab. 2015, 35:611-622.
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 611-622
    • Samiotaki, G.1
  • 80
    • 80054027552 scopus 로고    scopus 로고
    • Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier
    • Paes K.T., et al. Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier. Invest. Ophthalmol. Vis. Sci. 2011, 52:6452-6461.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 6452-6461
    • Paes, K.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.