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Volumn 60, Issue 2, 2017, Pages 226-236

Glia: silent partners in energy homeostasis and obesity pathogenesis

Author keywords

Astrocytes; Brain; Central nervous system; Diabetes; Energy homeostasis; Glia; Hypothalamus; Inflammation; Microglia; Obesity; Review

Indexed keywords

LEPTIN;

EID: 85006354959     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4181-3     Document Type: Review
Times cited : (69)

References (108)
  • 1
    • 0034611732 scopus 로고    scopus 로고
    • Central nervous system control of food intake
    • COI: 1:CAS:528:DC%2BD3cXis1Grur4%3D, PID: 10766253
    • Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661–671
    • (2000) Nature , vol.404 , pp. 661-671
    • Schwartz, M.W.1    Woods, S.C.2    Porte, D.3    Seeley, R.J.4    Baskin, D.G.5
  • 2
    • 0034611681 scopus 로고    scopus 로고
    • Genetics of body-weight regulation
    • COI: 1:CAS:528:DC%2BD3cXis1Grtbw%3D, PID: 10766251
    • Barsh GS, Farooqi IS, O’Rahilly S (2000) Genetics of body-weight regulation. Nature 404:644–651
    • (2000) Nature , vol.404 , pp. 644-651
    • Barsh, G.S.1    Farooqi, I.S.2    O’Rahilly, S.3
  • 3
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • COI: 1:CAS:528:DyaK2MXisVGqsbs%3D, PID: 7984236
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 4
    • 84892741034 scopus 로고    scopus 로고
    • Reactive gliosis and the multicellular response to CNS damage and disease
    • COI: 1:CAS:528:DC%2BC2cXht1Gnsr8%3D, PID: 24462092
    • Burda JE, Sofroniew MV (2014) Reactive gliosis and the multicellular response to CNS damage and disease. Neuron 81:229–248
    • (2014) Neuron , vol.81 , pp. 229-248
    • Burda, J.E.1    Sofroniew, M.V.2
  • 5
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • COI: 1:CAS:528:DC%2BC38XkvFCltw%3D%3D, PID: 22201683
    • Thaler JP, Yi CX, Schur EA et al (2012) Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122:153–162
    • (2012) J Clin Invest , vol.122 , pp. 153-162
    • Thaler, J.P.1    Yi, C.X.2    Schur, E.A.3
  • 6
    • 84919847348 scopus 로고    scopus 로고
    • Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function
    • COI: 1:CAS:528:DC%2BC2cXitFKnurnN, PID: 25497089
    • Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK (2014) Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep 9:2124–2138
    • (2014) Cell Rep , vol.9 , pp. 2124-2138
    • Valdearcos, M.1    Robblee, M.M.2    Benjamin, D.I.3    Nomura, D.K.4    Xu, A.W.5    Koliwad, S.K.6
  • 7
    • 84922802034 scopus 로고    scopus 로고
    • Hypothalamic inflammation in the control of metabolic function
    • COI: 1:CAS:528:DC%2BC2MXls1Ckurg%3D, PID: 25668019
    • Valdearcos M, Xu AW, Koliwad SK (2015) Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol 77:131–160
    • (2015) Annu Rev Physiol , vol.77 , pp. 131-160
    • Valdearcos, M.1    Xu, A.W.2    Koliwad, S.K.3
  • 8
    • 84891719310 scopus 로고    scopus 로고
    • Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?
    • COI: 1:CAS:528:DC%2BC3sXht1Snu73L, PID: 23881189
    • Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW (2013) Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes 62:2629–2634
    • (2013) Diabetes , vol.62 , pp. 2629-2634
    • Thaler, J.P.1    Guyenet, S.J.2    Dorfman, M.D.3    Wisse, B.E.4    Schwartz, M.W.5
  • 9
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • COI: 1:CAS:528:DC%2BD28Xpslalu7c%3D, PID: 16988703
    • Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight. Nature 443:289–295
    • (2006) Nature , vol.443 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 10
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • PID: 16002529
    • De Souza CT, Araujo EP, Bordin S et al (2005) Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146:4192–4199
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3
  • 11
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • COI: 1:CAS:528:DC%2BD28XhtlShtrzK, PID: 17167474
    • Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860–867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 12
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • COI: 1:CAS:528:DC%2BD28XmvV2ltLo%3D, PID: 16823477
    • Shoelson SE, Lee J, Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116:1793–1801
    • (2006) J Clin Invest , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 13
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: modulation by nutrients and inflammation
    • COI: 1:CAS:528:DC%2BD1cXhtV2isb%2FE, PID: 18769626
    • Schenk S, Saberi M, Olefsky JM (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118:2992–3002
    • (2008) J Clin Invest , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 14
    • 84922780528 scopus 로고    scopus 로고
    • Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats
    • COI: 1:CAS:528:DC%2BC2cXhvFWku7%2FK, PID: 25303559
    • Li JM, Ge CX, Xu MX et al (2015) Betaine recovers hypothalamic neural injury by inhibiting astrogliosis and inflammation in fructose-fed rats. Mol Nutr Food Res 59:189–202
    • (2015) Mol Nutr Food Res , vol.59 , pp. 189-202
    • Li, J.M.1    Ge, C.X.2    Xu, M.X.3
  • 15
    • 77950216899 scopus 로고    scopus 로고
    • Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet
    • COI: 1:CAS:528:DC%2BC3cXks1Cmt7Y%3D, PID: 20176722
    • Grayson BE, Levasseur PR, Williams SM, Smith MS, Marks DL, Grove KL (2010) Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology 151:1622–1632
    • (2010) Endocrinology , vol.151 , pp. 1622-1632
    • Grayson, B.E.1    Levasseur, P.R.2    Williams, S.M.3    Smith, M.S.4    Marks, D.L.5    Grove, K.L.6
  • 16
    • 66149118129 scopus 로고    scopus 로고
    • Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
    • COI: 1:CAS:528:DC%2BD1MXlvFags7w%3D, PID: 19116375
    • Posey KA, Clegg DJ, Printz RL et al (2009) Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 296:E1003–E1012
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E1003-E1012
    • Posey, K.A.1    Clegg, D.J.2    Printz, R.L.3
  • 17
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
    • Milanski M, Degasperi G, Coope A et al (2009) Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 29:359–370
    • (2009) J Neurosci , vol.29 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3
  • 18
    • 84919674550 scopus 로고    scopus 로고
    • Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ERalpha
    • COI: 1:CAS:528:DC%2BC2cXhslOrtL3N, PID: 25373903
    • Morselli E, Fuente-Martin E, Finan B et al (2014) Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ERalpha. Cell Rep 9:633–645
    • (2014) Cell Rep , vol.9 , pp. 633-645
    • Morselli, E.1    Fuente-Martin, E.2    Finan, B.3
  • 19
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • COI: 1:CAS:528:DC%2BD1cXht1Gkt7nP, PID: 18854155
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D (2008) Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61–73
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 20
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • PID: 15271881
    • Munzberg H, Flier JS, Bjorbaek C (2004) Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880–4889
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 21
    • 70349484212 scopus 로고    scopus 로고
    • MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    • COI: 1:CAS:528:DC%2BD1MXhsFKltL3K, PID: 19808018
    • Kleinridders A, Schenten D, Konner AC et al (2009) MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10:249–259
    • (2009) Cell Metab , vol.10 , pp. 249-259
    • Kleinridders, A.1    Schenten, D.2    Konner, A.C.3
  • 22
    • 61849113209 scopus 로고    scopus 로고
    • Differential susceptibility to obesity between male, female and ovariectomized female mice
    • PID: 19220919
    • Hong J, Stubbins RE, Smith RR, Harvey AE, Nunez NP (2009) Differential susceptibility to obesity between male, female and ovariectomized female mice. Nutr J 8:11
    • (2009) Nutr J , vol.8 , pp. 11
    • Hong, J.1    Stubbins, R.E.2    Smith, R.R.3    Harvey, A.E.4    Nunez, N.P.5
  • 23
    • 84888134187 scopus 로고    scopus 로고
    • Hormones and diet, but not body weight, control hypothalamic microglial activity
    • PID: 24166765
    • Gao Y, Ottaway N, Schriever SC et al (2014) Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 62:17–25
    • (2014) Glia , vol.62 , pp. 17-25
    • Gao, Y.1    Ottaway, N.2    Schriever, S.C.3
  • 24
    • 84905018799 scopus 로고    scopus 로고
    • The opposing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats
    • PID: 24848869
    • Garcia-Caceres C, Fuente-Martin E, Diaz F et al (2014) The opposing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats. Endocrinology 155:2868–2880
    • (2014) Endocrinology , vol.155 , pp. 2868-2880
    • Garcia-Caceres, C.1    Fuente-Martin, E.2    Diaz, F.3
  • 25
    • 84865000323 scopus 로고    scopus 로고
    • Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet
    • PID: 22844271
    • Wang X, Ge A, Cheng M et al (2012) Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet. Exp Diabetes Res 2012:847246
    • (2012) Exp Diabetes Res , vol.2012 , pp. 847246
    • Wang, X.1    Ge, A.2    Cheng, M.3
  • 26
    • 55049084760 scopus 로고    scopus 로고
    • The mystery and magic of glia: a perspective on their roles in health and disease
    • COI: 1:CAS:528:DC%2BD1cXhsVahsr7J, PID: 18995817
    • Barres BA (2008) The mystery and magic of glia: a perspective on their roles in health and disease. Neuron 60:430–440
    • (2008) Neuron , vol.60 , pp. 430-440
    • Barres, B.A.1
  • 27
    • 84858076374 scopus 로고    scopus 로고
    • Genetic approaches to study glial cells in the rodent brain
    • PID: 22162024
    • Pfrieger FW, Slezak M (2012) Genetic approaches to study glial cells in the rodent brain. Glia 60:681–701
    • (2012) Glia , vol.60 , pp. 681-701
    • Pfrieger, F.W.1    Slezak, M.2
  • 28
    • 84957850437 scopus 로고    scopus 로고
    • Genetic manipulation of microglia during brain development and disease
    • COI: 1:CAS:528:DC%2BC2MXhs1SltbvP, PID: 26432479
    • Wieghofer P, Prinz M (2016) Genetic manipulation of microglia during brain development and disease. Biochim Biophys Acta 1862:299–309
    • (2016) Biochim Biophys Acta , vol.1862 , pp. 299-309
    • Wieghofer, P.1    Prinz, M.2
  • 29
    • 84946568131 scopus 로고    scopus 로고
    • Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions
    • PID: 26578855
    • Goodman T, Hajihosseini MK (2015) Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions. Front Neurosci 9:387
    • (2015) Front Neurosci , vol.9 , pp. 387
    • Goodman, T.1    Hajihosseini, M.K.2
  • 30
    • 79959873914 scopus 로고    scopus 로고
    • The development and application of optogenetics
    • COI: 1:CAS:528:DC%2BC3MXpvVyisrs%3D, PID: 21692661
    • Fenno L, Yizhar O, Deisseroth K (2011) The development and application of optogenetics. Annu Rev Neurosci 34:389–412
    • (2011) Annu Rev Neurosci , vol.34 , pp. 389-412
    • Fenno, L.1    Yizhar, O.2    Deisseroth, K.3
  • 31
    • 84904676650 scopus 로고    scopus 로고
    • Chemogenetic tools to interrogate brain functions
    • COI: 1:CAS:528:DC%2BC2cXhsVKgtL7E, PID: 25002280
    • Sternson SM, Roth BL (2014) Chemogenetic tools to interrogate brain functions. Annu Rev Neurosci 37:387–407
    • (2014) Annu Rev Neurosci , vol.37 , pp. 387-407
    • Sternson, S.M.1    Roth, B.L.2
  • 32
    • 84931028718 scopus 로고    scopus 로고
    • Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors
    • COI: 1:CAS:528:DC%2BC2MXntFKjur0%3D, PID: 25921535
    • Yang L, Qi Y, Yang Y (2015) Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors. Cell Rep 11:798–807
    • (2015) Cell Rep , vol.11 , pp. 798-807
    • Yang, L.1    Qi, Y.2    Yang, Y.3
  • 33
    • 78149435065 scopus 로고    scopus 로고
    • The myeloid cells of the central nervous system parenchyma
    • COI: 1:CAS:528:DC%2BC3cXhsVWjsLfP, PID: 21068834
    • Ransohoff RM, Cardona AE (2010) The myeloid cells of the central nervous system parenchyma. Nature 468:253–262
    • (2010) Nature , vol.468 , pp. 253-262
    • Ransohoff, R.M.1    Cardona, A.E.2
  • 34
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • COI: 1:CAS:528:DC%2BC3cXhtlKht7vP, PID: 20966214
    • Ginhoux F, Greter M, Leboeuf M et al (2010) Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330:841–845
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3
  • 35
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • COI: 1:CAS:528:DC%2BC3MXpsFKru7c%3D, PID: 21804537
    • Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM (2011) Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 14:1142–1149
    • (2011) Nat Neurosci , vol.14 , pp. 1142-1149
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    McNagny, K.M.4    Rossi, F.M.5
  • 36
    • 84888324248 scopus 로고    scopus 로고
    • The microglial sensome revealed by direct RNA sequencing
    • COI: 1:CAS:528:DC%2BC3sXhs1yhsrnE, PID: 24162652
    • Hickman SE, Kingery ND, Ohsumi TK et al (2013) The microglial sensome revealed by direct RNA sequencing. Nat Neurosci 16:1896–1905
    • (2013) Nat Neurosci , vol.16 , pp. 1896-1905
    • Hickman, S.E.1    Kingery, N.D.2    Ohsumi, T.K.3
  • 37
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • COI: 1:CAS:528:DC%2BC3cXlsVSgu7Y%3D, PID: 20303880
    • Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140:918–934
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 38
    • 84978120874 scopus 로고    scopus 로고
    • High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia
    • COI: 1:CAS:528:DC%2BC28XhtFCit7fF, PID: 27393312
    • Baufeld C, Osterloh A, Prokop S, Miller KR, Heppner FL (2016) High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia. Acta Neuropathol 132:361–375
    • (2016) Acta Neuropathol , vol.132 , pp. 361-375
    • Baufeld, C.1    Osterloh, A.2    Prokop, S.3    Miller, K.R.4    Heppner, F.L.5
  • 39
    • 84966550877 scopus 로고    scopus 로고
    • Adult NG2-Glia are required for median eminence-mediated leptin sensing and body weight control
    • COI: 1:CAS:528:DC%2BC28XntVOls7Y%3D, PID: 27166944
    • Djogo T, Robins SC, Schneider S et al (2016) Adult NG2-Glia are required for median eminence-mediated leptin sensing and body weight control. Cell Metab 23:797–810
    • (2016) Cell Metab , vol.23 , pp. 797-810
    • Djogo, T.1    Robins, S.C.2    Schneider, S.3
  • 40
    • 84926433834 scopus 로고    scopus 로고
    • Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior
    • COI: 1:CAS:528:DC%2BC2MXls1Klsr0%3D, PID: 25646713
    • Reis WL, Yi CX, Gao Y, Tschop MH, Stern JE (2015) Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior. Endocrinology 156:1303–1315
    • (2015) Endocrinology , vol.156 , pp. 1303-1315
    • Reis, W.L.1    Yi, C.X.2    Gao, Y.3    Tschop, M.H.4    Stern, J.E.5
  • 41
    • 84897478440 scopus 로고    scopus 로고
    • Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage
    • PID: 24352739
    • Sheridan GK, Murphy KJ (2013) Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage. Open Biol 3:130181
    • (2013) Open Biol , vol.3 , pp. 130181
    • Sheridan, G.K.1    Murphy, K.J.2
  • 42
    • 84875932665 scopus 로고    scopus 로고
    • Microglia, seen from the CX3CR1 angle
    • COI: 1:CAS:528:DC%2BC3sXhtlGjtbzO, PID: 23507975
    • Wolf Y, Yona S, Kim KW, Jung S (2013) Microglia, seen from the CX3CR1 angle. Front Cell Neurosci 7:26
    • (2013) Front Cell Neurosci , vol.7 , pp. 26
    • Wolf, Y.1    Yona, S.2    Kim, K.W.3    Jung, S.4
  • 43
    • 33745573660 scopus 로고    scopus 로고
    • Control of microglial neurotoxicity by the fractalkine receptor
    • COI: 1:CAS:528:DC%2BD28XmtFCmsbw%3D, PID: 16732273
    • Cardona AE, Pioro EP, Sasse ME et al (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 9:917–924
    • (2006) Nat Neurosci , vol.9 , pp. 917-924
    • Cardona, A.E.1    Pioro, E.P.2    Sasse, M.E.3
  • 44
    • 84862777755 scopus 로고    scopus 로고
    • CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity
    • COI: 1:CAS:528:DC%2BC38Xns12itro%3D, PID: 22252034
    • Morris DL, Oatmen KE, Wang T, DelProposto JL, Lumeng CN (2012) CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity. Obesity 20:1189–1199
    • (2012) Obesity , vol.20 , pp. 1189-1199
    • Morris, D.L.1    Oatmen, K.E.2    Wang, T.3    DelProposto, J.L.4    Lumeng, C.N.5
  • 45
    • 84898548414 scopus 로고    scopus 로고
    • The fractalkine/Cx3CR1 system is implicated in the development of metabolic visceral adipose tissue inflammation in obesity
    • COI: 1:CAS:528:DC%2BC2cXisFequ7o%3D, PID: 24456845
    • Polyak A, Ferenczi S, Denes A et al (2014) The fractalkine/Cx3CR1 system is implicated in the development of metabolic visceral adipose tissue inflammation in obesity. Brain Behav Immun 38:25–35
    • (2014) Brain Behav Immun , vol.38 , pp. 25-35
    • Polyak, A.1    Ferenczi, S.2    Denes, A.3
  • 46
    • 84908638565 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity
    • COI: 1:CAS:528:DC%2BC2cXhvVyhu7fM, PID: 24947351
    • Morari J, Anhe GF, Nascimento LF et al (2014) Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity. Diabetes 63:3770–3784
    • (2014) Diabetes , vol.63 , pp. 3770-3784
    • Morari, J.1    Anhe, G.F.2    Nascimento, L.F.3
  • 47
    • 84947435413 scopus 로고    scopus 로고
    • Metabolic effects of CX3CR1 deficiency in diet-induced obese mice
    • PID: 26393344
    • Shah R, O’Neill SM, Hinkle C et al (2015) Metabolic effects of CX3CR1 deficiency in diet-induced obese mice. PLoS One 10:e0138317
    • (2015) PLoS One , vol.10
    • Shah, R.1    O’Neill, S.M.2    Hinkle, C.3
  • 48
    • 84876213020 scopus 로고    scopus 로고
    • The fractalkine/CX3CR1 system regulates beta cell function and insulin secretion
    • COI: 1:CAS:528:DC%2BC3sXlvVCkurk%3D, PID: 23582329
    • Lee YS, Morinaga H, Kim JJ et al (2013) The fractalkine/CX3CR1 system regulates beta cell function and insulin secretion. Cell 153:413–425
    • (2013) Cell , vol.153 , pp. 413-425
    • Lee, Y.S.1    Morinaga, H.2    Kim, J.J.3
  • 49
    • 0030723388 scopus 로고    scopus 로고
    • Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
    • COI: 1:CAS:528:DyaK2sXnsFGltL0%3D, PID: 9390561
    • Imai T, Hieshima K, Haskell C et al (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91:521–530
    • (1997) Cell , vol.91 , pp. 521-530
    • Imai, T.1    Hieshima, K.2    Haskell, C.3
  • 50
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • COI: 1:CAS:528:DC%2BD3cXjt1CmtrY%3D, PID: 10805752
    • Jung S, Aliberti J, Graemmel P et al (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20:4106–4114
    • (2000) Mol Cell Biol , vol.20 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3
  • 51
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
    • COI: 1:CAS:528:DC%2BC3sXhvV2hsb%2FE, PID: 24316888
    • Butovsky O, Jedrychowski MP, Moore CS et al (2014) Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 17:131–143
    • (2014) Nat Neurosci , vol.17 , pp. 131-143
    • Butovsky, O.1    Jedrychowski, M.P.2    Moore, C.S.3
  • 52
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • Zhang Y, Chen K, Sloan SA et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34:11929–11947
    • (2014) J Neurosci , vol.34 , pp. 11929-11947
    • Zhang, Y.1    Chen, K.2    Sloan, S.A.3
  • 53
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: biology and pathology
    • PID: 20012068
    • Sofroniew MV, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119:7–35
    • (2010) Acta Neuropathol , vol.119 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 54
    • 84981295660 scopus 로고    scopus 로고
    • Astrocytic insulin signaling couples brain glucose uptake with nutrient availability
    • COI: 1:CAS:528:DC%2BC28XhtlCrtL%2FI, PID: 27518562
    • Garcia-Caceres C, Quarta C, Varela L et al (2016) Astrocytic insulin signaling couples brain glucose uptake with nutrient availability. Cell 166:867–880
    • (2016) Cell , vol.166 , pp. 867-880
    • Garcia-Caceres, C.1    Quarta, C.2    Varela, L.3
  • 55
    • 13344286293 scopus 로고    scopus 로고
    • Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
    • COI: 1:CAS:528:DyaK28XhvFyltrg%3D, PID: 8785064
    • Rothstein JD, Dykes-Hoberg M, Pardo CA et al (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16:675–686
    • (1996) Neuron , vol.16 , pp. 675-686
    • Rothstein, J.D.1    Dykes-Hoberg, M.2    Pardo, C.A.3
  • 56
    • 0022907958 scopus 로고
    • Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes
    • COI: 1:CAS:528:DyaL28Xls12ntb4%3D, PID: 3018177
    • Cataldo AM, Broadwell RD (1986) Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes. J Neurocytol 15:511–524
    • (1986) J Neurocytol , vol.15 , pp. 511-524
    • Cataldo, A.M.1    Broadwell, R.D.2
  • 57
    • 0028157201 scopus 로고
    • Glucose transporter 2 (GLUT 2): expression in specific brain nuclei
    • COI: 1:CAS:528:DyaK2cXitFegsr8%3D, PID: 8199863
    • Leloup C, Arluison M, Lepetit N et al (1994) Glucose transporter 2 (GLUT 2): expression in specific brain nuclei. Brain Res 638:221–226
    • (1994) Brain Res , vol.638 , pp. 221-226
    • Leloup, C.1    Arluison, M.2    Lepetit, N.3
  • 58
    • 33947428261 scopus 로고    scopus 로고
    • Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*, S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)pro pyl]-1H-indole-2-carboxamide)
    • COI: 1:CAS:528:DC%2BD2sXktVSks7Y%3D, PID: 17251391
    • Suh SW, Bergher JP, Anderson CM, Treadway JL, Fosgerau K, Swanson RA (2007) Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*, S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)pro pyl]-1H-indole-2-carboxamide). J Pharmacol Exp Ther 321:45–50
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 45-50
    • Suh, S.W.1    Bergher, J.P.2    Anderson, C.M.3    Treadway, J.L.4    Fosgerau, K.5    Swanson, R.A.6
  • 59
    • 12244300930 scopus 로고    scopus 로고
    • Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
    • COI: 1:CAS:528:DC%2BD2MXltlCmtg%3D%3D, PID: 15578727
    • Brown AM, Sickmann HM, Fosgerau K et al (2005) Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter. J Neurosci Res 79:74–80
    • (2005) J Neurosci Res , vol.79 , pp. 74-80
    • Brown, A.M.1    Sickmann, H.M.2    Fosgerau, K.3
  • 60
    • 0037497019 scopus 로고    scopus 로고
    • Glycogen regulation and functional role in mouse white matter
    • COI: 1:CAS:528:DC%2BD3sXlslWnsbY%3D, PID: 12679378
    • Brown AM, Tekkok SB, Ransom BR (2003) Glycogen regulation and functional role in mouse white matter. J Physiol 549:501–512
    • (2003) J Physiol , vol.549 , pp. 501-512
    • Brown, A.M.1    Tekkok, S.B.2    Ransom, B.R.3
  • 61
    • 83255192949 scopus 로고    scopus 로고
    • Lactate produced by glycogenolysis in astrocytes regulates memory processing
    • COI: 1:CAS:528:DC%2BC38XhsFWqtw%3D%3D, PID: 22180782
    • Newman LA, Korol DL, Gold PE (2011) Lactate produced by glycogenolysis in astrocytes regulates memory processing. PLoS One 6:e28427
    • (2011) PLoS One , vol.6
    • Newman, L.A.1    Korol, D.L.2    Gold, P.E.3
  • 62
    • 79952305803 scopus 로고    scopus 로고
    • Astrocyte-neuron lactate transport is required for long-term memory formation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqt7Y%3D, PID: 21376239
    • Suzuki A, Stern SA, Bozdagi O et al (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144:810–823
    • (2011) Cell , vol.144 , pp. 810-823
    • Suzuki, A.1    Stern, S.A.2    Bozdagi, O.3
  • 63
    • 84897885703 scopus 로고    scopus 로고
    • Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids
    • PID: 24379353
    • Le Foll C, Dunn-Meynell AA, Miziorko HM, Levin BE (2014) Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids. Diabetes 63:1259–1269
    • (2014) Diabetes , vol.63 , pp. 1259-1269
    • Le Foll, C.1    Dunn-Meynell, A.A.2    Miziorko, H.M.3    Levin, B.E.4
  • 64
    • 84984799822 scopus 로고    scopus 로고
    • Fatty acid-induced astrocyte ketone production and the control of food intake
    • PID: 27122369
    • Le Foll C, Levin BE (2016) Fatty acid-induced astrocyte ketone production and the control of food intake. Am J Physiol Regul Integr Comp Physiol 310:R1186–R1192
    • (2016) Am J Physiol Regul Integr Comp Physiol , vol.310 , pp. R1186-R1192
    • Le Foll, C.1    Levin, B.E.2
  • 65
    • 30444460361 scopus 로고    scopus 로고
    • Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors
    • PID: 15968634
    • Cheunsuang O, Morris R (2005) Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia 52:228–233
    • (2005) Glia , vol.52 , pp. 228-233
    • Cheunsuang, O.1    Morris, R.2
  • 66
    • 84868629649 scopus 로고    scopus 로고
    • Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes
    • COI: 1:CAS:528:DC%2BC38Xhs1Cis7fK, PID: 23064363
    • Fuente-Martin E, Garcia-Caceres C, Granado M et al (2012) Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. J Clin Invest 122:3900–3913
    • (2012) J Clin Invest , vol.122 , pp. 3900-3913
    • Fuente-Martin, E.1    Garcia-Caceres, C.2    Granado, M.3
  • 67
    • 84903382613 scopus 로고    scopus 로고
    • Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
    • COI: 1:CAS:528:DC%2BC2cXovFCgt7k%3D, PID: 24880214
    • Kim JG, Suyama S, Koch M et al (2014) Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci 17:908–910
    • (2014) Nat Neurosci , vol.17 , pp. 908-910
    • Kim, J.G.1    Suyama, S.2    Koch, M.3
  • 68
    • 85007329158 scopus 로고    scopus 로고
    • Leptin potentiates astrogenesis in the developing hypothalamus
    • COI: 1:CAS:528:DC%2BC2MXhsVyitbvO, PID: 26629411
    • Rottkamp DM, Rudenko IA, Maier MT et al (2015) Leptin potentiates astrogenesis in the developing hypothalamus. Mol Metab 4:881–889
    • (2015) Mol Metab , vol.4 , pp. 881-889
    • Rottkamp, D.M.1    Rudenko, I.A.2    Maier, M.T.3
  • 69
    • 65249150732 scopus 로고    scopus 로고
    • Obesity induces functional astrocytic leptin receptors in hypothalamus
    • Hsuchou H, He Y, Kastin AJ et al (2009) Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain: J Neurol 132:889–902
    • (2009) Brain: J Neurol , vol.132 , pp. 889-902
    • Hsuchou, H.1    He, Y.2    Kastin, A.J.3
  • 70
    • 84878586125 scopus 로고
    • Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity
    • Jayaram B, Pan W, Wang Y et al (1985) (2013) Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity. J Appl Physiol 114:734–741
    • (1985) J Appl Physiol , vol.114 , pp. 734-741
    • Jayaram, B.1    Pan, W.2    Wang, Y.3
  • 71
    • 84963647541 scopus 로고    scopus 로고
    • Ghrelin regulates glucose and glutamate transporters in hypothalamic astrocytes
    • COI: 1:CAS:528:DC%2BC28Xlt1Gnt7Y%3D, PID: 27026049
    • Fuente-Martin E, Garcia-Caceres C, Argente-Arizon P et al (2016) Ghrelin regulates glucose and glutamate transporters in hypothalamic astrocytes. Sci Rep 6:23673
    • (2016) Sci Rep , vol.6 , pp. 23673
    • Fuente-Martin, E.1    Garcia-Caceres, C.2    Argente-Arizon, P.3
  • 72
    • 84961637999 scopus 로고    scopus 로고
    • Astrocytes regulate GLP-1 receptor-mediated effects on energy balance
    • Reiner DJ, Mietlicki-Baase EG, McGrath LE et al (2016) Astrocytes regulate GLP-1 receptor-mediated effects on energy balance. J Neurosci 36:3531–3540
    • (2016) J Neurosci , vol.36 , pp. 3531-3540
    • Reiner, D.J.1    Mietlicki-Baase, E.G.2    McGrath, L.E.3
  • 73
    • 84992130085 scopus 로고    scopus 로고
    • Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
    • PID: 27751234
    • Chen N, Sugihara H, Kim J et al (2016) Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding. Elife 5, e18716
    • (2016) Elife , vol.5
    • Chen, N.1    Sugihara, H.2    Kim, J.3
  • 74
    • 84879836964 scopus 로고    scopus 로고
    • High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes
    • COI: 1:CAS:528:DC%2BC3sXmtV2ntL4%3D, PID: 23548599
    • Guyenet SJ, Nguyen HT, Hwang BH, Schwartz MW, Baskin DG, Thaler JP (2013) High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes. Brain Res 1512:97–105
    • (2013) Brain Res , vol.1512 , pp. 97-105
    • Guyenet, S.J.1    Nguyen, H.T.2    Hwang, B.H.3    Schwartz, M.W.4    Baskin, D.G.5    Thaler, J.P.6
  • 75
    • 84920722615 scopus 로고    scopus 로고
    • Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice
    • COI: 1:CAS:528:DC%2BC2cXhsl2ltbzF, PID: 25685690
    • Buckman LB, Thompson MM, Lippert RN, Blackwell TS, Yull FE, Ellacott KL (2015) Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Mol Metab 4:58–63
    • (2015) Mol Metab , vol.4 , pp. 58-63
    • Buckman, L.B.1    Thompson, M.M.2    Lippert, R.N.3    Blackwell, T.S.4    Yull, F.E.5    Ellacott, K.L.6
  • 76
    • 84874156024 scopus 로고    scopus 로고
    • Regional astrogliosis in the mouse hypothalamus in response to obesity
    • COI: 1:CAS:528:DC%2BC3sXjtFSjsLk%3D, PID: 23047490
    • Buckman LB, Thompson MM, Moreno HN, Ellacott KL (2013) Regional astrogliosis in the mouse hypothalamus in response to obesity. J Comp Neurol 521:1322–1333
    • (2013) J Comp Neurol , vol.521 , pp. 1322-1333
    • Buckman, L.B.1    Thompson, M.M.2    Moreno, H.N.3    Ellacott, K.L.4
  • 77
    • 84905014938 scopus 로고    scopus 로고
    • Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study
    • PID: 24914942
    • Berkseth KE, Guyenet SJ, Melhorn SJ et al (2014) Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study. Endocrinology 155:2858–2867
    • (2014) Endocrinology , vol.155 , pp. 2858-2867
    • Berkseth, K.E.1    Guyenet, S.J.2    Melhorn, S.J.3
  • 78
    • 84880652456 scopus 로고    scopus 로고
    • Longer T(2) relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity
    • COI: 1:CAS:528:DC%2BC3sXhtV2jurrN, PID: 23548614
    • Lee D, Thaler JP, Berkseth KE, Melhorn SJ, Schwartz MW, Schur EA (2013) Longer T(2) relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity. Am J Physiol Endocrinol Metab 304:E1245–E1250
    • (2013) Am J Physiol Endocrinol Metab , vol.304 , pp. E1245-E1250
    • Lee, D.1    Thaler, J.P.2    Berkseth, K.E.3    Melhorn, S.J.4    Schwartz, M.W.5    Schur, E.A.6
  • 79
    • 84946011612 scopus 로고    scopus 로고
    • Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans
    • COI: 1:CAS:528:DC%2BC2MXhvVSls7fI, PID: 26530930
    • Schur EA, Melhorn SJ, Oh SK et al (2015) Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans. Obesity 23:2142–2148
    • (2015) Obesity , vol.23 , pp. 2142-2148
    • Schur, E.A.1    Melhorn, S.J.2    Oh, S.K.3
  • 80
    • 84871888415 scopus 로고    scopus 로고
    • High calorie diet triggers hypothalamic angiopathy
    • COI: 1:CAS:528:DC%2BC3sXht12iurrK, PID: 24024123
    • Yi CX, Gericke M, Kruger M et al (2012) High calorie diet triggers hypothalamic angiopathy. Mol Metab 1:95–100
    • (2012) Mol Metab , vol.1 , pp. 95-100
    • Yi, C.X.1    Gericke, M.2    Kruger, M.3
  • 81
    • 84939893166 scopus 로고    scopus 로고
    • Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence
    • Bull C, Freitas KC, Zou S et al (2014) Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence. Neuropsychopharmacol 39:2835–2845
    • (2014) Neuropsychopharmacol , vol.39 , pp. 2835-2845
    • Bull, C.1    Freitas, K.C.2    Zou, S.3
  • 82
    • 77957053600 scopus 로고    scopus 로고
    • Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
    • COI: 1:CAS:528:DC%2BC3cXhtVKqu7zI, PID: 20679202
    • Horvath TL, Sarman B, Garcia-Caceres C et al (2010) Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci U S A 107:14875–14880
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14875-14880
    • Horvath, T.L.1    Sarman, B.2    Garcia-Caceres, C.3
  • 84
    • 0029294583 scopus 로고
    • The human blood-brain barrier glucose transporter (GLUT1) is a glucose transporter of gray matter astrocytes
    • COI: 1:STN:280:DyaK2MzktVartw%3D%3D, PID: 7615345
    • Morgello S, Uson RR, Schwartz EJ, Haber RS (1995) The human blood-brain barrier glucose transporter (GLUT1) is a glucose transporter of gray matter astrocytes. Glia 14:43–54
    • (1995) Glia , vol.14 , pp. 43-54
    • Morgello, S.1    Uson, R.R.2    Schwartz, E.J.3    Haber, R.S.4
  • 85
    • 0042303943 scopus 로고    scopus 로고
    • Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing
    • PID: 12859684
    • Garcia M, Millan C, Balmaceda-Aguilera C et al (2003) Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing. J Neurochem 86:709–724
    • (2003) J Neurochem , vol.86 , pp. 709-724
    • Garcia, M.1    Millan, C.2    Balmaceda-Aguilera, C.3
  • 86
    • 77956257822 scopus 로고    scopus 로고
    • Glial glucokinase expression in adult and post-natal development of the hypothalamic region
    • PID: 20531973
    • Millan C, Martinez F, Cortes-Campos C et al (2010) Glial glucokinase expression in adult and post-natal development of the hypothalamic region. ASN Neuro 2:e00035
    • (2010) ASN Neuro , vol.2
    • Millan, C.1    Martinez, F.2    Cortes-Campos, C.3
  • 87
    • 79551571718 scopus 로고    scopus 로고
    • MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction
    • COI: 1:CAS:528:DC%2BC3MXhvVKksLs%3D, PID: 21297988
    • Cortes-Campos C, Elizondo R, Llanos P, Uranga RM, Nualart F, Garcia MA (2011) MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction. PLoS One 6:e16411
    • (2011) PLoS One , vol.6
    • Cortes-Campos, C.1    Elizondo, R.2    Llanos, P.3    Uranga, R.M.4    Nualart, F.5    Garcia, M.A.6
  • 88
    • 84875883939 scopus 로고    scopus 로고
    • Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting
    • COI: 1:CAS:528:DC%2BC3sXltFCrur8%3D, PID: 23562080
    • Langlet F, Levin BE, Luquet S et al (2013) Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab 17:607–617
    • (2013) Cell Metab , vol.17 , pp. 607-617
    • Langlet, F.1    Levin, B.E.2    Luquet, S.3
  • 89
    • 84893434815 scopus 로고    scopus 로고
    • Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
    • COI: 1:CAS:528:DC%2BC2cXhvFGqsbg%3D, PID: 24506870
    • Balland E, Dam J, Langlet F et al (2014) Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab 19:293–301
    • (2014) Cell Metab , vol.19 , pp. 293-301
    • Balland, E.1    Dam, J.2    Langlet, F.3
  • 90
    • 84862776637 scopus 로고    scopus 로고
    • Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
    • COI: 1:CAS:528:DC%2BC38XksVegtL8%3D, PID: 22446882
    • Lee DA, Bedont JL, Pak T et al (2012) Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci 15:700–702
    • (2012) Nat Neurosci , vol.15 , pp. 700-702
    • Lee, D.A.1    Bedont, J.L.2    Pak, T.3
  • 91
    • 84882865862 scopus 로고    scopus 로고
    • Alpha-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors
    • COI: 1:STN:280:DC%2BC3sjmtVGgsA%3D%3D, PID: 23804023
    • Robins SC, Stewart I, McNay DE et al (2013) Alpha-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors. Nat Commun 4:2049
    • (2013) Nat Commun , vol.4 , pp. 2049
    • Robins, S.C.1    Stewart, I.2    McNay, D.E.3
  • 92
    • 84860557656 scopus 로고    scopus 로고
    • Obesity in patients with acute lymphoblastic leukemia in childhood
    • PID: 22284631
    • Iughetti L, Bruzzi P, Predieri B, Paolucci P (2012) Obesity in patients with acute lymphoblastic leukemia in childhood. Ital J Pediatr 38:4
    • (2012) Ital J Pediatr , vol.38 , pp. 4
    • Iughetti, L.1    Bruzzi, P.2    Predieri, B.3    Paolucci, P.4
  • 93
    • 0023412021 scopus 로고
    • Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen
    • Levine JM, Stallcup WB (1987) Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen. J Neurosci 7:2721–2731
    • (1987) J Neurosci , vol.7 , pp. 2721-2731
    • Levine, J.M.1    Stallcup, W.B.2
  • 94
    • 84930872206 scopus 로고    scopus 로고
    • NG2-glia and their functions in the central nervous system
    • COI: 1:STN:280:DC%2BC2MfntFegsA%3D%3D, PID: 26010717
    • Dimou L, Gallo V (2015) NG2-glia and their functions in the central nervous system. Glia 63:1429–1451
    • (2015) Glia , vol.63 , pp. 1429-1451
    • Dimou, L.1    Gallo, V.2
  • 95
    • 65549104473 scopus 로고    scopus 로고
    • Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology
    • PID: 18837053
    • Rhee W, Ray S, Yokoo H et al (2009) Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: implications for glioma histogenesis and biology. Glia 57:510–523
    • (2009) Glia , vol.57 , pp. 510-523
    • Rhee, W.1    Ray, S.2    Yokoo, H.3
  • 96
    • 75949085273 scopus 로고    scopus 로고
    • NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain
    • PID: 19486010
    • Geha S, Pallud J, Junier MP et al (2010) NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain. Brain Pathol 20:399–411
    • (2010) Brain Pathol , vol.20 , pp. 399-411
    • Geha, S.1    Pallud, J.2    Junier, M.P.3
  • 97
    • 57749172539 scopus 로고    scopus 로고
    • Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
    • COI: 1:CAS:528:DC%2BD1MXpt12m, PID: 19096367
    • Nishiyama A, Komitova M, Suzuki R, Zhu X (2009) Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat Rev Neurosci 10:9–22
    • (2009) Nat Rev Neurosci , vol.10 , pp. 9-22
    • Nishiyama, A.1    Komitova, M.2    Suzuki, R.3    Zhu, X.4
  • 98
    • 84905015966 scopus 로고    scopus 로고
    • Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus
    • COI: 1:CAS:528:DC%2BC3sXhslehsbfN, PID: 24205170
    • Robins SC, Trudel E, Rotondi O et al (2013) Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus. PLoS One 8:e78236
    • (2013) PLoS One , vol.8
    • Robins, S.C.1    Trudel, E.2    Rotondi, O.3
  • 99
    • 79954490068 scopus 로고    scopus 로고
    • Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging
    • COI: 1:CAS:528:DC%2BC3MXltVWruro%3D, PID: 21494606
    • Mueller K, Anwander A, Moller HE et al (2011) Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging. PLoS One 6:e18544
    • (2011) PLoS One , vol.6
    • Mueller, K.1    Anwander, A.2    Moller, H.E.3
  • 100
    • 79952006211 scopus 로고    scopus 로고
    • Obesity is associated with reduced white matter integrity in otherwise healthy adults
    • PID: 21183934
    • Stanek KM, Grieve SM, Brickman AM et al (2011) Obesity is associated with reduced white matter integrity in otherwise healthy adults. Obesity 19:500–504
    • (2011) Obesity , vol.19 , pp. 500-504
    • Stanek, K.M.1    Grieve, S.M.2    Brickman, A.M.3
  • 101
    • 84889652068 scopus 로고    scopus 로고
    • Obesity is associated with white matter atrophy: a combined diffusion tensor imaging and voxel-based morphometric study
    • PID: 23512884
    • Karlsson HK, Tuulari JJ, Hirvonen J et al (2013) Obesity is associated with white matter atrophy: a combined diffusion tensor imaging and voxel-based morphometric study. Obesity 21:2530–2537
    • (2013) Obesity , vol.21 , pp. 2530-2537
    • Karlsson, H.K.1    Tuulari, J.J.2    Hirvonen, J.3
  • 102
    • 84860707186 scopus 로고    scopus 로고
    • Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study
    • COI: 1:STN:280:DC%2BC38zlsF2msw%3D%3D
    • Yokum S, Ng J, Stice E (2012) Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study. Int J Obes 36:656–664
    • (2012) Int J Obes , vol.36 , pp. 656-664
    • Yokum, S.1    Ng, J.2    Stice, E.3
  • 103
    • 84922672553 scopus 로고    scopus 로고
    • Orbitofrontal cortex volume and brain reward response in obesity
    • COI: 1:STN:280:DC%2BC2cbisFKqsw%3D%3D
    • Shott ME, Cornier MA, Mittal VA et al (2015) Orbitofrontal cortex volume and brain reward response in obesity. Int J Obes 39:214–221
    • (2015) Int J Obes , vol.39 , pp. 214-221
    • Shott, M.E.1    Cornier, M.A.2    Mittal, V.A.3
  • 104
    • 84927566096 scopus 로고    scopus 로고
    • Hypothalamic damage is associated with inflammatory markers and worse cognitive performance in obese subjects
    • COI: 1:CAS:528:DC%2BC2MXjtVWqur0%3D, PID: 25423565
    • Puig J, Blasco G, Daunis IEJ et al (2015) Hypothalamic damage is associated with inflammatory markers and worse cognitive performance in obese subjects. J Clin Endocrinol Metab 100:E276–E281
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. E276-E281
    • Puig, J.1    Blasco, G.2    Daunis, I.E.J.3
  • 105
    • 79151485914 scopus 로고    scopus 로고
    • Obesity-mediated inflammation may damage the brain circuit that regulates food intake
    • COI: 1:CAS:528:DC%2BC3MXpsFaltQ%3D%3D, PID: 21146506
    • Cazettes F, Cohen JI, Yau PL, Talbot H, Convit A (2011) Obesity-mediated inflammation may damage the brain circuit that regulates food intake. Brain Res 1373:101–109
    • (2011) Brain Res , vol.1373 , pp. 101-109
    • Cazettes, F.1    Cohen, J.I.2    Yau, P.L.3    Talbot, H.4    Convit, A.5
  • 106
    • 84894464622 scopus 로고    scopus 로고
    • The human side of microglia
    • COI: 1:CAS:528:DC%2BC2cXisVOqug%3D%3D, PID: 24388427
    • Smith AM, Dragunow M (2014) The human side of microglia. Trends Neurosci 37:125–135
    • (2014) Trends Neurosci , vol.37 , pp. 125-135
    • Smith, A.M.1    Dragunow, M.2
  • 107
    • 84953709732 scopus 로고    scopus 로고
    • Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse
    • COI: 1:CAS:528:DC%2BC2MXitVSksb%2FO, PID: 26687838
    • Zhang Y, Sloan SA, Clarke LE et al (2016) Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. Neuron 89:37–53
    • (2016) Neuron , vol.89 , pp. 37-53
    • Zhang, Y.1    Sloan, S.A.2    Clarke, L.E.3
  • 108
    • 84875185145 scopus 로고    scopus 로고
    • Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
    • COI: 1:CAS:528:DC%2BC3sXktFWltLc%3D, PID: 23472873
    • Han X, Chen M, Wang F et al (2013) Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 12:342–353
    • (2013) Cell Stem Cell , vol.12 , pp. 342-353
    • Han, X.1    Chen, M.2    Wang, F.3


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