Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Cintra, Dennys E ^a   Ropelle, Eduardo R ^a   Moraes, Juliana C ^a   Pauli, José R ^a   Morari, Joseane ^a   de Souza, Claudio T ^a   Grimaldi, Renato ^a   Stahl, Marcela ^a   Carvalheira, José B ^a   Saad, Mario J ^a   Velloso, Licio A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; CARNITINE PALMITOYLTRANSFERASE I; G PROTEIN COUPLED RECEPTOR 120; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 6; LEPTIN; LINOLENIC ACID; LINSEED OIL; OLEIC ACID; OLIVE OIL; PROOPIOMELANOCORTIN; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNSATURATED FATTY ACID; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; EDIBLE OIL; FATTY ACID; G PROTEIN COUPLED RECEPTOR; NERVE PROTEIN; O3FAR1 PROTEIN, MOUSE; OMEGA 3 FATTY ACID; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE HOMEOSTASIS; HYPOTHALAMUS; INSULIN RESISTANCE; LIPID COMPOSITION; LIPID DIET; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OBESITY; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; THERMOGENESIS; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECT; EATING; FAT INTAKE; GENE EXPRESSION; GENETICS; IMMUNOBLOTTING; INFLAMMATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WEIGHT GAIN; WISTAR RAT;

LINUM USITATISSIMUM; RATTUS;

ANIMALS; DIETARY FATS; DIETARY FATS, UNSATURATED; EATING; FATTY ACIDS; FATTY ACIDS, OMEGA-3; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOBLOTTING; INFLAMMATION; INSULIN RESISTANCE; MALE; MICE; NERVE TISSUE PROTEINS; OBESITY; PLANT OILS; PRO-OPIOMELANOCORTIN; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WEIGHT GAIN;

EID: 84855971481     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030571     Document Type: Article

References (40)

1. Yang L, Hotamisligil GS, (2008) Stressing the brain, fattening the body. Cell 135: 20-22.
2. Velloso LA, Araujo EP, de Souza CT, (2008) Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation 15: 189-193.
3. Wisse BE, Schwartz MW, (2009) Does hypothalamic inflammation cause obesity? Cell Metab 10: 241-242.
4. De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, et al. (2005) Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146: 4192-4199.
5. Milanski M, Degasperi G, Coope A, Morari J, Denis R, et al. (2009) Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 29: 359-370.
6. Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, et al. (2009) High-fat diet induces apoptosis of hypothalamic neurons. PLoS One 4: e5045.
7. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, et al. (2008) Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 283: 14230-14241.
8. Zhang X, Zhang G, Zhang H, Karin M, Bai H, et al. (2008) Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135: 61-73.
9. Bjorbak C, Lavery HJ, Bates SH, Olson RK, Davis SM, et al. (2000) SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275: 40649-40657.
10. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, et al. (2004) Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10: 734-738.
11. Araujo EP, De Souza CT, Ueno M, Cintra DE, Bertolo MB, et al. (2007) Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. Endocrinology 148: 5991-5997.
12. Lee TH, Hoover RL, Williams JD, Sperling RI, Ravalese J, 3rd, et al. (1985) Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 312: 1217-1224.
13. Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, et al. (1989) The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320: 265-271.
14. Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, et al. (2009) A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4. J Nutr 139: 2351-2357.
15. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, et al. (1989) Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 68: 374-378.
16. Johnson AK, Epstein AN, (1975) The cerebral ventricles as the avenue for the dipsogenic action of intracranial angiotensin. Brain Res 86: 399-418.
17. Weinstein JR, Swarts S, Bishop C, Hanisch UK, Moller T, (2008) Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors. Glia 56: 16-26.
18. Martins EF, Miyasaka CK, Newsholme P, Curi R, Carpinelli AR, (2004) Changes of fatty acid composition in incubated rat pancreatic islets. Diabetes Metab 30: 21-27.
19. Bertelli DF, Araujo EP, Cesquini M, Stoppa GR, Gasparotto-Contessotto M, et al. (2006) Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology 147: 5385-5399.
20. Paxinos G, Watson CR, Emson PC, (1980) AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J Neurosci Methods 3: 129-149.
21. Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, et al. (2006) Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci 9: 901-906.
22. Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
23. Rivellese AA, Lilli S, (2003) Quality of dietary fatty acids, insulin sensitivity and type 2 diabetes. Biomed Pharmacother 57: 84-87.
24. De Souza CT, Araujo EP, Stoppiglia LF, Pauli JR, Ropelle E, et al. (2007) Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. Faseb J 21: 1153-1163.
25. Plum L, Belgardt BF, Bruning JC, (2006) Central insulin action in energy and glucose homeostasis. J Clin Invest 116: 1761-1766.
26. Myers MG Jr, (2004) Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 59: 287-304.
27. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, et al. (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142: 687-698.
28. Thaler JP, Choi SJ, Schwartz MW, Wisse BE Hypothalamic inflammation and energy homeostasis: resolving the paradox. Front Neuroendocrinol 31: 79-84.
29. Lam TK, Gutierrez-Juarez R, Pocai A, Bhanot S, Tso P, et al. (2007) Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med 13: 171-180.
30. Morgan K, Obici S, Rossetti L, (2004) Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J Biol Chem 279: 31139-31148.
31. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, et al. (2002) Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51: 271-275.
32. Arruda AP, Milanski M, Romanatto T, Solon C, Coope A, et al. Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology 151: 683-694.
33. Anderson KA, Ribar TJ, Lin F, Noeldner PK, Green MF, et al. (2008) Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab 7: 377-388.
34. Schwartz MW, Porte D Jr, (2005) Diabetes, obesity, and the brain. Science 307: 375-379.
35. Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, et al. (2009) Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 296: E1003-1012.
36. Bjornholm M, Munzberg H, Leshan RL, Villanueva EC, Bates SH, et al. (2007) Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest 117: 1354-1360.
37. Cotero VE, Routh VH, (2009) Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose. Am J Physiol Endocrinol Metab 296: E1101-1109.
38. Figlewicz DP, Benoit SC, (2009) Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol 296: R9-R19.
39. van den Pol AN, (2003) Weighing the role of hypothalamic feeding neurotransmitters. Neuron 40: 1059-1061.
40. Romanatto T, Roman EA, Arruda AP, Denis RG, Solon C, et al. (2009) Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem 284: 36213-36222.