Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

Nature Chemistry

Volumn 9, Issue 1, 2017, Pages 50-56

  Obexer, Richard ^a   Godina, Alexei ^a,b   Garrabou, Xavier ^a   Mittl, Peer R E ^c   Baker, David ^d   Griffiths, Andrew D ^b   Hilvert, Donald ^a  

^a ETH ZURICH   (Switzerland)

^b PSL RESEARCH UNIVERSITY   (France)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3-HYDROXYBUTANAL; ALDEHYDE; FRUCTOSE BISPHOSPHATE ALDOLASE;

AMINO ACID SEQUENCE; CATALYSIS; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE LIBRARY; GENETICS; MICROFLUIDICS; MOLECULAR MODEL; PLASMID; PROCEDURES; PROTEIN ENGINEERING; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ALDEHYDES; AMINO ACID SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; FRUCTOSE-BISPHOSPHATE ALDOLASE; GENE LIBRARY; MICROFLUIDICS; MODELS, MOLECULAR; PLASMIDS; PROTEIN ENGINEERING; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 85015318933     PISSN: 17554330     EISSN: 17554349     Source Type: Journal    
DOI: 10.1038/nchem.2596     Document Type: Article

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