Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: Structural analysis of reaction intermediates

Biochemistry

Volumn 44, Issue 11, 2005, Pages 4222-4229

  Lorentzen, Esben ^a   Siebers, Bettina ^b   Hensel, Reinhard ^b   Pohl, Ehmke ^a,c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYMES; PROTONS; REACTION KINETICS;

CARBON-CARBON CLEAVAGE; GLYCOLYTIC ENZYME; PROTON DONOR; SCHIFF BASE;

FRUCTOSE;

AMINE; ASPARTIC ACID; DIHYDROXYACETONE PHOSPHATE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUTAMIC ACID; GLYCERALDEHYDE 3 PHOSPHATE; LYSINE; METHANOLAMINE; SCHIFF BASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME MECHANISM; GLYCOLYSIS; PRIORITY JOURNAL; PROTON TRANSPORT; R FACTOR; REACTION ANALYSIS; STRUCTURE ANALYSIS; THERMOPROTEUS TENAX;

ARCHAEAL PROTEINS; ASPARTIC ACID; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; FRUCTOSE-BISPHOSPHATE ALDOLASE; GLUTAMIC ACID; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMOPROTEUS; TYROSINE;

EID: 15544366696     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048192o     Document Type: Article

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