Characterization, kinetics, and crystal structures of fructose-1,6- bisphosphate aldolase from the human parasite, Giardia lamblia

Journal of Biological Chemistry

Volumn 282, Issue 7, 2007, Pages 4859-4867

  Galkin, Andrey ^a   Kulakova, Liudmila ^a   Melamud, Eugene ^a   Li, Ling ^b   Wu, Chun ^b,d   Mariano, Patrick ^b   Dunaway Mariano, Debra ^b   Nash, Theodore E ^c   Herzberg, Osnat ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d Mount Marty College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GIARDIA LAMBLIA; GIARDIA TROPHOZOITES; GLYCOLYTIC PATHWAY ENZYMES; HUMAN PARASITE;

AMINO ACIDS; BIOASSAY; CATALYST ACTIVITY; CRYSTAL STRUCTURE; PHOSPHATES; PROTOZOA;

ENZYME KINETICS;

CARBOHYDRATE DERIVATIVE; CARBONYL DERIVATIVE; DEXTRO FRUCTOSE 1,6 BISPHOSPHATE; DEXTRO TAGATOSE 1,6 BISPHOSPHATE; ESCHERICHIA COLI PROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; HOMODIMER; HYDROXAMIC ACID; OXYGEN; PARASITE ANTIBODY; PHOSPHORUS DERIVATIVE; PROTOZOAL PROTEIN; TAGATOSE 1,6 DIPHOSPHATE ALDOLASE; UNCLASSIFIED DRUG; ZINC; ENZYME INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING COMPETITION; CATALYSIS; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBUNIT; ENZYME SYNTHESIS; ESCHERICHIA COLI; GIARDIA LAMBLIA; IMMUNOFLUORESCENCE TEST; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TROPHOZOITE; ANIMAL; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GIARDIASIS; HUMAN; KINETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; GIARDIA; GIARDIA INTESTINALIS; MAMMALIA; PROTOZOA;

ANIMALS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; FRUCTOSE-BISPHOSPHATE ALDOLASE; GIARDIA LAMBLIA; GIARDIASIS; HUMANS; KINETICS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; SUBSTRATE SPECIFICITY; ZINC;

EID: 33947519204     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609534200     Document Type: Article

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