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Volumn 294, Issue 5541, 2001, Pages 369-374
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Observation of covalent intermediates in an enzyme mechanism at atomic resolution
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Author keywords
[No Author keywords available]
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Indexed keywords
CATALYSIS;
MUTAGENESIS;
NUCLEAR MAGNETIC RESONANCE;
PROTONS;
X RAY ANALYSIS;
ENZYMOLOGY;
ENZYME KINETICS;
DEXTRO 2 DEOXYRIBOSE 5 PHOSPHATE ALDOLASE;
ENZYME;
SCHIFF BASE;
UNCLASSIFIED DRUG;
BIOCHEMISTRY;
ENZYME;
NUCLEAR MAGNETIC RESONANCE;
ARTICLE;
ATOM;
COMPLEX FORMATION;
ENZYME MECHANISM;
ENZYME STRUCTURE;
PRIORITY JOURNAL;
PROTON NUCLEAR MAGNETIC RESONANCE;
PROTON TRANSPORT;
SITE DIRECTED MUTAGENESIS;
STEREOCHEMISTRY;
STRUCTURE ANALYSIS;
ALDEHYDE-LYASES;
AMINO ACID SUBSTITUTION;
BINDING SITES;
CATALYSIS;
CHEMISTRY, PHYSICAL;
CRYSTALLIZATION;
CRYSTALLOGRAPHY, X-RAY;
ESCHERICHIA COLI;
HYDROGEN BONDING;
HYDROGEN-ION CONCENTRATION;
LIGANDS;
LYSINE;
MODELS, CHEMICAL;
MUTAGENESIS, SITE-DIRECTED;
MUTATION;
NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;
PROTEIN CONFORMATION;
PROTEIN FOLDING;
PROTEIN STRUCTURE, TERTIARY;
PROTONS;
RIBOSEMONOPHOSPHATES;
SCHIFF BASES;
WATER;
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EID: 0035850820
PISSN: 00368075
EISSN: None
Source Type: Journal
DOI: 10.1126/science.1063601 Document Type: Article |
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Times cited : (267)
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References (62)
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