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Volumn 23, Issue 10, 2017, Pages 1522-1532

Sodium-glucose cotransporter 2 inhibitors (SGLT2i): Their role in cardiometabolic risk management

Author keywords

Canagliflozin; Cardiovascular outcome trials; Cardiovascular risk factors; Dapagliflozin; Empagliflozin; Microvascular complications; Renoprotection; Sodium glucose cotransporter 2 inhibitors

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIDIABETIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CANAGLIFLOZIN; DAPAGLIFLOZIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; EMPAGLIFLOZIN; ERTUGLIFLOZIN; EZETIMIBE; FIBRIC ACID DERIVATIVE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IPRAGLIFLOZIN; LIPID; LIRAGLUTIDE; LUSEOGLIFLOZIN; METFORMIN; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; PLACEBO; REMOGLIFLOZIN; SERGLIFLOZIN ETABONATE; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SOTAGLIFLOZIN; TOFOGLIFLOZIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILDAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 85015145621     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612823666170113152742     Document Type: Review
Times cited : (52)

References (204)
  • 1
    • 84908254603 scopus 로고    scopus 로고
    • The role of the kidneys in glucose homeostasis in type 2 diabetes: Clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors
    • Wilding JP. The role of the kidneys in glucose homeostasis in type 2 diabetes: clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors. Metabolism 2014; 63(10): 1228-37.
    • (2014) Metabolism , vol.63 , Issue.10 , pp. 1228-1237
    • Wilding, J.P.1
  • 2
    • 83655193529 scopus 로고    scopus 로고
    • The role of the kidneys in glucose homeostasis: A new path towards normalizing glycaemia
    • DeFronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab 2012; 14(1): 5-14.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.1 , pp. 5-14
    • Defronzo, R.A.1    Davidson, J.A.2    Del Prato, S.3
  • 3
    • 84957709696 scopus 로고    scopus 로고
    • Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside
    • Mudaliar S, Polidori D, Zambrowicz B, Henry RR. Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside. Diabetes Care 2015; 38(12): 2344-53.
    • (2015) Diabetes Care , vol.38 , Issue.12 , pp. 2344-2353
    • Mudaliar, S.1    Polidori, D.2    Zambrowicz, B.3    Henry, R.R.4
  • 4
    • 84860391886 scopus 로고    scopus 로고
    • Kidney: Its impact on glucose homeostasis and hormonal regulation
    • Mitrakou A. Kidney: its impact on glucose homeostasis and hormonal regulation. Diabetes Res Clin Pract 2011; 93 Suppl 1: S66-72.
    • (2011) Diabetes Res Clin Pract , vol.93 , pp. S66-S72
    • Mitrakou, A.1
  • 5
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009; 58(4): 773-95.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 773-795
    • Defronzo, R.A.1
  • 6
    • 84875150979 scopus 로고    scopus 로고
    • Differentiating sodium-glucose cotransporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus
    • Washburn WN, Poucher SM. Differentiating sodium-glucose cotransporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus. Expert Opin Investig Drugs 2013; 22(4): 463-86.
    • (2013) Expert Opin Investig Drugs , vol.22 , Issue.4 , pp. 463-486
    • Washburn, W.N.1    Poucher, S.M.2
  • 7
    • 84978790852 scopus 로고    scopus 로고
    • Sodium-Glucose Cotransporter-2 Inhibition and the Glomerulus: A Review
    • Epub ahead of print
    • Kalra S, Singh V, Nagrale D. Sodium-Glucose Cotransporter-2 Inhibition and the Glomerulus: A Review. Adv Ther 2016 Jul 16. [Epub ahead of print]
    • Adv Ther 2016 Jul 16
    • Kalra, S.1    Singh, V.2    Nagrale, D.3
  • 8
    • 84902551594 scopus 로고    scopus 로고
    • SGLT2 inhibitors in the treatment of type 2 diabetes
    • Hasan FM, Alsahli M, Gerich JE. SGLT2 inhibitors in the treatment of type 2 diabetes. Diabetes Res Clin Pract 2014; 104(3): 297-22.
    • (2014) Diabetes Res Clin Pract , vol.104 , Issue.3 , pp. 297-322
    • Hasan, F.M.1    Alsahli, M.2    Gerich, J.E.3
  • 9
    • 85027928423 scopus 로고    scopus 로고
    • Sodium glucose co-transporter 2 (SGLT2) inhibitors: New among antidiabetic drugs
    • Opie LH. Sodium glucose co-transporter 2 (SGLT2) inhibitors: new among antidiabetic drugs. Cardiovasc Drugs Ther 2014; 28(4): 331-4.
    • (2014) Cardiovasc Drugs Ther , vol.28 , Issue.4 , pp. 331-334
    • Opie, L.H.1
  • 12
    • 84959239256 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors: An evidence-based practice approach to their use in the natural history of type 2 diabetes
    • Schwartz SS, Ahmed I. Sodium-glucose cotransporter 2 inhibitors: an evidence-based practice approach to their use in the natural history of type 2 diabetes. Curr Med Res Opin 2016; 32(5): 907-19.
    • (2016) Curr Med Res Opin , vol.32 , Issue.5 , pp. 907-919
    • Schwartz, S.S.1    Ahmed, I.2
  • 13
    • 84954514891 scopus 로고    scopus 로고
    • Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus
    • Watts NB, Bilezikian JP, Usiskin K, et al. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab 2016; 101(1): 157-66.
    • (2016) J Clin Endocrinol Metab , vol.101 , Issue.1 , pp. 157-166
    • Watts, N.B.1    Bilezikian, J.P.2    Usiskin, K.3
  • 14
    • 84994383020 scopus 로고    scopus 로고
    • Lack of Evidence for a Harmful Effect of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors on Fracture Risk among Type 2 Diabetes Patients: A Network and Cumulative Meta-Analysis of Randomized Controlled Trials
    • 2016 Jul 13. [Epub ahead of print]
    • Tang HL, Li DD, Zhang JJ, et al. Lack of Evidence for a Harmful Effect of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors on Fracture Risk among Type 2 Diabetes Patients: A Network and Cumulative Meta-Analysis of Randomized Controlled Trials. Diabetes Obes Metab 2016 Jul 13. [Epub ahead of print]
    • Diabetes Obes Metab
    • Tang, H.L.1    Li, D.D.2    Zhang, J.J.3
  • 17
    • 84923791994 scopus 로고    scopus 로고
    • Pharmacodynamics, efficacy and safety of sodiumglucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus
    • Scheen AJ. Pharmacodynamics, efficacy and safety of sodiumglucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs 2015; 75(1): 33-59.
    • (2015) Drugs , vol.75 , Issue.1 , pp. 33-59
    • Scheen, A.J.1
  • 18
    • 84981335309 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter-2 inhibitors and euglycemic ketoacidosis: Wisdom of hindsight
    • Singh AK. Sodium-glucose co-transporter-2 inhibitors and euglycemic ketoacidosis: Wisdom of hindsight. Indian J Endocrinol Metab 2015; 19(6): 722-30.
    • (2015) Indian J Endocrinol Metab , vol.19 , Issue.6 , pp. 722-730
    • Singh, A.K.1
  • 19
    • 84961591798 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors: Possible anti-atherosclerotic effects beyond glucose lowering
    • Yanai H, Katsuyama H, Hamasaki H, et al. Sodium-glucose cotransporter 2 inhibitors: possible anti-atherosclerotic effects beyond glucose lowering. J Clin Med Res 2016; 8(1): 10-4.
    • (2016) J Clin Med Res , vol.8 , Issue.1 , pp. 10-14
    • Yanai, H.1    Katsuyama, H.2    Hamasaki, H.3
  • 20
    • 84923510983 scopus 로고    scopus 로고
    • Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor
    • Lapuerta P, Zambrowicz B, Strumph P, Sands A. Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor. Diab Vasc Dis Res 2015; 12(2): 101-10.
    • (2015) Diab Vasc Dis Res , vol.12 , Issue.2 , pp. 101-110
    • Lapuerta, P.1    Zambrowicz, B.2    Strumph, P.3    Sands, A.4
  • 22
    • 84899904943 scopus 로고    scopus 로고
    • Renal sodium glucose cotransporter 2 inhibitors as a novel therapeutic approach to treatment of type 2 diabetes: Clinical data and mechanism of action
    • Fujita Y, Inagaki N. Renal sodium glucose cotransporter 2 inhibitors as a novel therapeutic approach to treatment of type 2 diabetes: Clinical data and mechanism of action. J Diabetes Investig 2014; 5(3): 265-75.
    • (2014) J Diabetes Investig , vol.5 , Issue.3 , pp. 265-275
    • Fujita, Y.1    Inagaki, N.2
  • 23
    • 84901577868 scopus 로고    scopus 로고
    • Cardiovascular risk stratification and management in pre-diabetes
    • Farch K, Vistisen D, Johansen NB, Jorgensen ME. Cardiovascular risk stratification and management in pre-diabetes. Curr Diab Rep 2014; 14(6): 493.
    • (2014) Curr Diab Rep , vol.14 , Issue.6 , pp. 493
    • Farch, K.1    Vistisen, D.2    Johansen, N.B.3    Jorgensen, M.E.4
  • 24
    • 84889255593 scopus 로고    scopus 로고
    • Pathogenesis and management of postprandial hyperglycemia: Role of incretin-based therapies
    • Gerich J. Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies. Int J Gen Med 2013; 6: 877-95.
    • (2013) Int J Gen Med , vol.6 , pp. 877-895
    • Gerich, J.1
  • 25
    • 84922191929 scopus 로고    scopus 로고
    • Increased glycemic variability and decrease of the postprandial glucose contribution to HbA1c in obese subjects across the glycemic continuum from normal glycemia to first time diagnosed diabetes
    • Fysekidis M, Cosson E, Banu I, Duteil R, Cyrille C, Valensi P. Increased glycemic variability and decrease of the postprandial glucose contribution to HbA1c in obese subjects across the glycemic continuum from normal glycemia to first time diagnosed diabetes. Metabolism 2014; 63(12): 1553-61.
    • (2014) Metabolism , vol.63 , Issue.12 , pp. 1553-1561
    • Fysekidis, M.1    Cosson, E.2    Banu, I.3    Duteil, R.4    Cyrille, C.5    Valensi, P.6
  • 26
    • 84872322553 scopus 로고    scopus 로고
    • Targeting the kidney and glucose excretion with dapagliflozin: Preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus
    • Whaley JM, Tirmenstein M, Reilly TP, et al. Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus. Diabetes Metab Syndr Obes 2012; 5: 135-48.
    • (2012) Diabetes Metab Syndr Obes , vol.5 , pp. 135-148
    • Whaley, J.M.1    Tirmenstein, M.2    Reilly, T.P.3
  • 27
    • 84894133232 scopus 로고    scopus 로고
    • Canagliflozin: A new class of antidiabetic agent targeting the sodium-glucose cotransporter
    • Toderika Y, Ferguson N. Canagliflozin: a new class of antidiabetic agent targeting the sodium-glucose cotransporter. Cardiol Rev 2014; 22(2): 97-104.
    • (2014) Cardiol Rev , vol.22 , Issue.2 , pp. 97-104
    • Toderika, Y.1    Ferguson, N.2
  • 28
    • 84964754662 scopus 로고    scopus 로고
    • Differential pharmacology and clinical utility of empagliflozin in type 2 diabetes
    • Munir KM, Davis SN. Differential pharmacology and clinical utility of empagliflozin in type 2 diabetes. Clin Pharmacol 2016; 8: 19-34.
    • (2016) Clin Pharmacol , vol.8 , pp. 19-34
    • Munir, K.M.1    Davis, S.N.2
  • 29
    • 84924328996 scopus 로고    scopus 로고
    • Effect of empagliflozin monotherapy on postprandial glucose and 24-hour glucose variability in Japanese patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled, 4-week study
    • Nishimura R, Tanaka Y, Koiwai K, et al. Effect of empagliflozin monotherapy on postprandial glucose and 24-hour glucose variability in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled, 4-week study. Cardiovasc Diabetol 2015; 14: 11.
    • (2015) Cardiovasc Diabetol , vol.14 , pp. 11
    • Nishimura, R.1    Tanaka, Y.2    Koiwai, K.3
  • 30
    • 84899558137 scopus 로고    scopus 로고
    • Tofogliflozin 003 Study Group. Efficacy and safety of monotherapy with the novel sodium/ glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: A combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study
    • Kaku K, Watada H, Iwamoto Y, et al; Tofogliflozin 003 Study Group. Efficacy and safety of monotherapy with the novel sodium/ glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc Diabetol 2014; 13: 65.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 65
    • Kaku, K.1    Watada, H.2    Iwamoto, Y.3
  • 31
    • 84908048700 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic study of ipragliflozin in Japanese patients with type 2 diabetes mellitus: A randomized, double blind, placebocontrolled study
    • Kadokura T, Akiyama N, Kashiwagi A, et al. Pharmacokinetic and pharmacodynamic study of ipragliflozin in Japanese patients with type 2 diabetes mellitus: a randomized, double blind, placebocontrolled study. Diabetes Res Clin Pract 2014; 106(1): 50-6.
    • (2014) Diabetes Res Clin Pract , vol.106 , Issue.1 , pp. 50-56
    • Kadokura, T.1    Akiyama, N.2    Kashiwagi, A.3
  • 32
    • 84903557735 scopus 로고    scopus 로고
    • Efficacy and safety of luseogliflozin as monotherapy in Japanese patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled, phase 3 study
    • Seino Y, Sasaki T, Fukatsu A, Ubukata M, Sakai S, Samukawa Y. Efficacy and safety of luseogliflozin as monotherapy in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled, phase 3 study. Curr Med Res Opin 2014; 30(7): 1245-55.
    • (2014) Curr Med Res Opin , vol.30 , Issue.7 , pp. 1245-1255
    • Seino, Y.1    Sasaki, T.2    Fukatsu, A.3    Ubukata, M.4    Sakai, S.5    Samukawa, Y.6
  • 33
    • 84869998632 scopus 로고    scopus 로고
    • Dapagliflozin: A review of its use in type 2 diabetes mellitus
    • Plosker GL. Dapagliflozin: A review of its use in type 2 diabetes mellitus. Drugs 2012; 72(17): 2289-312.
    • (2012) Drugs , vol.72 , Issue.17 , pp. 2289-2312
    • Plosker, G.L.1
  • 34
    • 84947439430 scopus 로고    scopus 로고
    • Sodium-Glucose Cotransporter 2 Inhibitors in the Treatment of Type 2 Diabetes Mellitus
    • Vivian E. Sodium-Glucose Cotransporter 2 Inhibitors in the Treatment of Type 2 Diabetes Mellitus. Diabetes Educ 2015; 41(1 Suppl): 5S-18S.
    • (2015) Diabetes Educ , vol.41 , Issue.1 , pp. 5SS-18S
    • Vivian, E.1
  • 35
    • 84969915634 scopus 로고    scopus 로고
    • Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: Systematic review and network metaanalysis
    • Zaccardi F, Webb DR, Htike ZZ, Youssef D, Khunti K, Davies MJ. Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network metaanalysis. Diabetes Obes Metab 2016; 18(8): 783-94.
    • (2016) Diabetes Obes Metab , vol.18 , Issue.8 , pp. 783-794
    • Zaccardi, F.1    Webb, D.R.2    Htike, Z.Z.3    Youssef, D.4    Khunti, K.5    Davies, M.J.6
  • 36
    • 84918523582 scopus 로고    scopus 로고
    • Tofogliflozin: A highly selective SGLT2 inhibitor for the treatment of type 2 diabetes
    • Rosenwasser RF, Rosenwasser JN, Sutton D, Choksi R, Epstein B. Tofogliflozin: a highly selective SGLT2 inhibitor for the treatment of type 2 diabetes. Drugs Today (Barc) 2014; 50(11): 739-45.
    • (2014) Drugs Today (Barc) , vol.50 , Issue.11 , pp. 739-745
    • Rosenwasser, R.F.1    Rosenwasser, J.N.2    Sutton, D.3    Choksi, R.4    Epstein, B.5
  • 37
    • 84924799557 scopus 로고    scopus 로고
    • Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, in the treatment of type 2 diabetes
    • Hedrington MS, Davis SN. Ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, in the treatment of type 2 diabetes. Expert Opin Drug Metab Toxicol 2015; 11(4): 613-23.
    • (2015) Expert Opin Drug Metab Toxicol , vol.11 , Issue.4 , pp. 613-623
    • Hedrington, M.S.1    Davis, S.N.2
  • 38
    • 84961801299 scopus 로고    scopus 로고
    • Efficacy and safety of the SGLT2 inhibitor luseogliflozin in japanese patients with type 2 diabetes mellitus stratified according to baseline body mass index: Pooled analysis of data from 52-week phase III trials
    • Sakai S, Kaku K, Seino Y, et al. Efficacy and safety of the SGLT2 inhibitor luseogliflozin in japanese patients with type 2 diabetes mellitus stratified according to baseline body mass index: pooled analysis of data from 52-week phase III trials. Clin Ther 2016; 38(4): 843-862.e9.
    • (2016) Clin Ther , vol.38 , Issue.4
    • Sakai, S.1    Kaku, K.2    Seino, Y.3
  • 39
    • 84949293188 scopus 로고    scopus 로고
    • Sotagliflozin as a potential treatment for type 2 diabetes mellitus
    • Cariou B, Charbonnel B. Sotagliflozin as a potential treatment for type 2 diabetes mellitus. Expert Opin Investig Drugs 2015; 24(12): 1647-56.
    • (2015) Expert Opin Investig Drugs , vol.24 , Issue.12 , pp. 1647-1656
    • Cariou, B.1    Charbonnel, B.2
  • 40
    • 64549093267 scopus 로고    scopus 로고
    • Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats
    • Fujimori Y, Katsuno K, Ojima K, et al. Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats. Eur J Pharmacol 2009; 609(1-3): 148-54.
    • (2009) Eur J Pharmacol , vol.609 , Issue.1-3 , pp. 148-154
    • Fujimori, Y.1    Katsuno, K.2    Ojima, K.3
  • 41
    • 77953734934 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus
    • Hussey EK, Clark RV, Amin DM, et al. Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus. J Clin Pharmacol 2010; 50(6): 623-35.
    • (2010) J Clin Pharmacol , vol.50 , Issue.6 , pp. 623-635
    • Hussey, E.K.1    Clark, R.V.2    Amin, D.M.3
  • 42
    • 84928381216 scopus 로고    scopus 로고
    • Doseranging efficacy and safety study of ertugliflozin, a sodium-glucose co-transporter 2 inhibitor, in patients with type 2 diabetes on a background of metformin
    • Amin NB, Wang X, Jain SM, Lee DS, Nucci G, Rusnak JM. Doseranging efficacy and safety study of ertugliflozin, a sodium-glucose co-transporter 2 inhibitor, in patients with type 2 diabetes on a background of metformin. Diabetes Obes Metab 2015; 17(6): 591-8.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.6 , pp. 591-598
    • Amin, N.B.1    Wang, X.2    Jain, S.M.3    Lee, D.S.4    Nucci, G.5    Rusnak, J.M.6
  • 43
    • 84941600467 scopus 로고    scopus 로고
    • Remogliflozin etabonate: A novel SGLT2 inhibitor for treatment of diabetes mellitus
    • Mikhail N. Remogliflozin etabonate: a novel SGLT2 inhibitor for treatment of diabetes mellitus. Expert Opin Investig Drugs 2015; 24(10): 1381-7.
    • (2015) Expert Opin Investig Drugs , vol.24 , Issue.10 , pp. 1381-1387
    • Mikhail, N.1
  • 44
    • 84957981337 scopus 로고    scopus 로고
    • Long-term glycemic variability and risk of adverse outcomes: A systematic review and metaanalysis
    • Gorst C, Kwok CS, Aslam S, et al. Long-term glycemic variability and risk of adverse outcomes: a systematic review and metaanalysis. Diabetes Care 2015; 38(12): 2354-69.
    • (2015) Diabetes Care , vol.38 , Issue.12 , pp. 2354-2369
    • Gorst, C.1    Kwok, C.S.2    Aslam, S.3
  • 45
    • 84939810275 scopus 로고    scopus 로고
    • Glycemic variability: How do we measure it and why is it important?
    • Suh S, Kim JH. Glycemic variability: how do we measure it and why is it important? Diabetes Metab J 2015; 39(4): 273-82.
    • (2015) Diabetes Metab J , vol.39 , Issue.4 , pp. 273-282
    • Suh, S.1    Kim, J.H.2
  • 46
    • 84978148155 scopus 로고    scopus 로고
    • Substantial effects of luseogliflozin revealed by analyzing responses to postprandial hyperglycemia: Post hoc subanalyses of a randomized controlled study
    • Samukawa Y, Omiya H, Watase H, Nozaki K, Sakai S, Nishimura R. Substantial effects of luseogliflozin revealed by analyzing responses to postprandial hyperglycemia: post hoc subanalyses of a randomized controlled study. Adv Ther 2016; 33(7): 1215-30.
    • (2016) Adv Ther , vol.33 , Issue.7 , pp. 1215-1230
    • Samukawa, Y.1    Omiya, H.2    Watase, H.3    Nozaki, K.4    Sakai, S.5    Nishimura, R.6
  • 47
    • 84934442921 scopus 로고    scopus 로고
    • Exploring the potential of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: A randomized, double-blind, placebo-controlled pilot study
    • Henry RR, Rosenstock J, Edelman S, et al. Exploring the potential of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: a randomized, double-blind, placebo-controlled pilot study. Diabetes Care 2015; 38(3): 412-9.
    • (2015) Diabetes Care , vol.38 , Issue.3 , pp. 412-419
    • Henry, R.R.1    Rosenstock, J.2    Edelman, S.3
  • 48
    • 84952682963 scopus 로고    scopus 로고
    • Diurnal glycemic patterns during an 8-week open-label proof-of-concept trial of empagliflozin in type 1 diabetes
    • Perkins BA, Cherney DZ, Soleymanlou N, et al. Diurnal glycemic patterns during an 8-week open-label proof-of-concept trial of empagliflozin in type 1 diabetes. PLoS One 2015; 10(11): e0141085.
    • (2015) Plos One , vol.10 , Issue.11
    • Perkins, B.A.1    Cherney, D.Z.2    Soleymanlou, N.3
  • 49
    • 84899535874 scopus 로고    scopus 로고
    • The efficacy of dapagliflozin combined with hypoglycaemic drugs in treating type 2 diabetes mellitus: Meta-analysis of randomised controlled trials
    • Sun YN, Zhou Y, Chen X, Che WS, Leung SW. The efficacy of dapagliflozin combined with hypoglycaemic drugs in treating type 2 diabetes mellitus: meta-analysis of randomised controlled trials. BMJ Open 2014; 4(4): e004619.
    • (2014) BMJ Open , vol.4 , Issue.4
    • Sun, Y.N.1    Zhou, Y.2    Chen, X.3    Che, W.S.4    Leung, S.W.5
  • 50
    • 84929676338 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes: Systematic review and meta-analysis
    • Yang XP, Lai D, Zhong XY, Shen HP, Huang YL. Efficacy and safety of canagliflozin in subjects with type 2 diabetes: systematic review and meta-analysis. Eur J Clin Pharmacol 2014; 70(10): 1149-58.
    • (2014) Eur J Clin Pharmacol , vol.70 , Issue.10 , pp. 1149-1158
    • Yang, X.P.1    Lai, D.2    Zhong, X.Y.3    Shen, H.P.4    Huang, Y.L.5
  • 51
    • 84912533839 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin for type 2 diabetes: A systematic review and metaanalysis
    • Liakos A, Karagiannis T, Athanasiadou E, et al. Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and metaanalysis. Diabetes Obes Metab 2014; 16(10): 984-93.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.10 , pp. 984-993
    • Liakos, A.1    Karagiannis, T.2    Athanasiadou, E.3
  • 52
    • 84942258962 scopus 로고    scopus 로고
    • A novel and selective sodiumglucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus
    • Ikeda S, Takano Y, Cynshi O, et al. A novel and selective sodiumglucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus. Diabetes Obes Metab 2015; 17(10): 984-93.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.10 , pp. 984-993
    • Ikeda, S.1    Takano, Y.2    Cynshi, O.3
  • 53
    • 85047287316 scopus 로고    scopus 로고
    • Ipragliflozin: A novel sodium-glucose cotransporter 2 inhibitor developed in Japan
    • Ohkura T. Ipragliflozin: A novel sodium-glucose cotransporter 2 inhibitor developed in Japan. World J Diabetes 2015; 6(1): 136-44.
    • (2015) World J Diabetes , vol.6 , Issue.1 , pp. 136-144
    • Ohkura, T.1
  • 54
    • 84910685028 scopus 로고    scopus 로고
    • Luseogliflozin for the treatment of type 2 diabetes
    • Seino Y. Luseogliflozin for the treatment of type 2 diabetes. Expert Opin Pharmacother 2014; 15(18): 2741-9.
    • (2014) Expert Opin Pharmacother , vol.15 , Issue.18 , pp. 2741-2749
    • Seino, Y.1
  • 55
    • 84919478361 scopus 로고    scopus 로고
    • Randomized trial showing efficacy and safety of twice-daily remogliflozin etabonate for the treatment of type 2 diabetes
    • Sykes AP, O’Connor-Semmes R, Dobbins R, et al. Randomized trial showing efficacy and safety of twice-daily remogliflozin etabonate for the treatment of type 2 diabetes. Diabetes Obes Metab 2015; 17(1): 94-7.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.1 , pp. 94-97
    • Sykes, A.P.1    O’connor-Semmes, R.2    Dobbins, R.3
  • 56
    • 84923502372 scopus 로고    scopus 로고
    • Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy
    • Rosenstock J, Cefalu WT, Lapuerta P, et al. Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy. Diabetes Care 2015; 38(3): 431-8.
    • (2015) Diabetes Care , vol.38 , Issue.3 , pp. 431-438
    • Rosenstock, J.1    Cefalu, W.T.2    Lapuerta, P.3
  • 57
    • 77953801665 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: A randomized double-blind study
    • Hussey EK, Dobbins RL, Stoltz RR, et al. Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: a randomized double-blind study. J Clin Pharmacol 2010; 50(6): 636-46.
    • (2010) J Clin Pharmacol , vol.50 , Issue.6 , pp. 636-646
    • Hussey, E.K.1    Dobbins, R.L.2    Stoltz, R.R.3
  • 58
    • 84916880876 scopus 로고    scopus 로고
    • Dapagliflozin for the treatment of type 2 diabetes: A review of the literature
    • Saeed MA, Narendran P. Dapagliflozin for the treatment of type 2 diabetes: a review of the literature. Drug Des Devel Ther 2014; 8: 2493-505.
    • (2014) Drug Des Devel Ther , vol.8 , pp. 2493-2505
    • Saeed, M.A.1    Narendran, P.2
  • 59
    • 84978388879 scopus 로고    scopus 로고
    • Effects of canagliflozin on body weight and body composition in patients with type 2 diabetes over 104 weeks
    • Blonde L, Stenlof K, Fung A, Xie J, Canovatchel W, Meininger G. Effects of canagliflozin on body weight and body composition in patients with type 2 diabetes over 104 weeks. Postgrad Med 2016; 128(4): 371-80.
    • (2016) Postgrad Med , vol.128 , Issue.4 , pp. 371-380
    • Blonde, L.1    Stenlof, K.2    Fung, A.3    Xie, J.4    Canovatchel, W.5    Meininger, G.6
  • 60
    • 84898791935 scopus 로고    scopus 로고
    • Efficacy and safety of sodium glucose co-transport-2 inhibitors in type 2 diabetes: A meta-analysis of randomized clinical trials
    • Monami M, Nardini C, Mannucci E. Efficacy and safety of sodium glucose co-transport-2 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 2014; 16(5): 457-66.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.5 , pp. 457-466
    • Monami, M.1    Nardini, C.2    Mannucci, E.3
  • 61
    • 78649499568 scopus 로고    scopus 로고
    • Dapagliflozin: More than just another oral glucose-lowering agent?
    • Katsiki N, Papanas N, Mikhailidis DP. Dapagliflozin: more than just another oral glucose-lowering agent? Expert Opin Investig Drugs 2010; 19(12): 1581-9.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.12 , pp. 1581-1589
    • Katsiki, N.1    Papanas, N.2    Mikhailidis, D.P.3
  • 62
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • Bolinder J, Ljunggren Ö, Kullberg J, et al. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab 2012; 97(3): 1020-31.
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.3 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, Ö.2    Kullberg, J.3
  • 63
    • 85010880320 scopus 로고    scopus 로고
    • Abnormal peri-organ or intra-organ fat (APIFat) deposition: An underestimated predictor of vascular risk?
    • 2016 Jul 22. [Epub ahead of print] PubMed PMID: 27456108
    • Katsiki N, Athyros VG, Mikhailidis DP. Abnormal peri-organ or intra-organ fat (APIFat) deposition: an underestimated predictor of vascular risk? Curr Vasc Pharmacol 2016 Jul 22. [Epub ahead of print] PubMed PMID: 27456108.
    • Curr Vasc Pharmacol
    • Katsiki, N.1    Athyros, V.G.2    Mikhailidis, D.P.3
  • 65
    • 84929001601 scopus 로고    scopus 로고
    • Abdominal obesity: A marker of ectopic fat accumulation
    • Smith U. Abdominal obesity: a marker of ectopic fat accumulation. J Clin Invest 2015; 125(5): 1790-2.
    • (2015) J Clin Invest , vol.125 , Issue.5 , pp. 1790-1792
    • Smith, U.1
  • 66
    • 84958158486 scopus 로고    scopus 로고
    • Empagliflozin reduces body weight and indices of adipose distribution in patients with type 2 diabetes mellitus
    • Neeland IJ, McGuire DK, Chilton R, et al. Empagliflozin reduces body weight and indices of adipose distribution in patients with type 2 diabetes mellitus. Diab Vasc Dis Res 2016; 13(2): 119-26.
    • (2016) Diab Vasc Dis Res , vol.13 , Issue.2 , pp. 119-126
    • Neeland, I.J.1    McGuire, D.K.2    Chilton, R.3
  • 67
    • 84930580913 scopus 로고    scopus 로고
    • Update on long-term efficacy and safety of dapagliflozin in patients with type 2 diabetes mellitus
    • Liakos A, Karagiannis T, Bekiari E, Boura P, Tsapas A. Update on long-term efficacy and safety of dapagliflozin in patients with type 2 diabetes mellitus. Ther Adv Endocrinol Metab 2015; 6(2): 61-7.
    • (2015) Ther Adv Endocrinol Metab , vol.6 , Issue.2 , pp. 61-67
    • Liakos, A.1    Karagiannis, T.2    Bekiari, E.3    Boura, P.4    Tsapas, A.5
  • 68
    • 84893682957 scopus 로고    scopus 로고
    • SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats
    • Yokono M, Takasu T, Hayashizaki Y, et al. SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats. Eur J Pharmacol 2014; 727: 66-74.
    • (2014) Eur J Pharmacol , vol.727 , pp. 66-74
    • Yokono, M.1    Takasu, T.2    Hayashizaki, Y.3
  • 69
    • 84976521931 scopus 로고    scopus 로고
    • Ipragliflozin effectively reduced visceral fat in Japanese patients with type 2 diabetes under adequate diet therapy
    • Yamamoto C, Miyoshi H, Ono K, et al. Ipragliflozin effectively reduced visceral fat in Japanese patients with type 2 diabetes under adequate diet therapy. Endocr J 2016; 63(6): 589-96.
    • (2016) Endocr J , vol.63 , Issue.6 , pp. 589-596
    • Yamamoto, C.1    Miyoshi, H.2    Ono, K.3
  • 70
    • 84988939761 scopus 로고    scopus 로고
    • Efficacy and Safety of Ipragliflozin in Japanese Patients With Type 2 Diabetes: Interim Outcome of the ASSIGN-K Study
    • Iizuka T, Iemitsu K, Takihata M, et al. Efficacy and Safety of Ipragliflozin in Japanese Patients With Type 2 Diabetes: Interim Outcome of the ASSIGN-K Study. J Clin Med Res 2016; 8(2): 116-25.
    • (2016) J Clin Med Res , vol.8 , Issue.2 , pp. 116-125
    • Iizuka, T.1    Iemitsu, K.2    Takihata, M.3
  • 71
    • 84973667631 scopus 로고    scopus 로고
    • Risk of type 2 diabetes in patients with nonalcoholic fatty liver disease: Causal association or epiphenomenon?
    • Targher G, Marchesini G, Byrne CD. Risk of type 2 diabetes in patients with nonalcoholic fatty liver disease: Causal association or epiphenomenon? Diabetes Metab 2016; 42(3): 142-56.
    • (2016) Diabetes Metab , vol.42 , Issue.3 , pp. 142-156
    • Targher, G.1    Marchesini, G.2    Byrne, C.D.3
  • 72
    • 84964331001 scopus 로고    scopus 로고
    • Treatment of patients with type 2 diabetes and nonalcoholic fatty liver disease: Current approaches and future directions
    • Cusi K. Treatment of patients with type 2 diabetes and nonalcoholic fatty liver disease: current approaches and future directions. Diabetologia 2016; 59(6): 1112-20.
    • (2016) Diabetologia , vol.59 , Issue.6 , pp. 1112-1120
    • Cusi, K.1
  • 74
    • 84969961723 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and dyslipidemia: An update
    • Katsiki N, Mikhailidis DP, Mantzoros CS. Non-alcoholic fatty liver disease and dyslipidemia: An update. Metabolism 2016; 65(8): 1109-23.
    • (2016) Metabolism , vol.65 , Issue.8 , pp. 1109-1123
    • Katsiki, N.1    Mikhailidis, D.P.2    Mantzoros, C.S.3
  • 75
    • 84930860402 scopus 로고    scopus 로고
    • Mikhailidis DP. Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update
    • Athyros VG, Tziomalos K, Katsiki N, Doumas M, Karagiannis A, Mikhailidis DP. Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update. World J Gastroenterol 2015; 21(22): 6820-34.
    • (2015) World J Gastroenterol , vol.21 , Issue.22 , pp. 6820-6834
    • Athyros, V.G.1    Tziomalos, K.2    Katsiki, N.3    Doumas, M.4    Karagiannis, A.5
  • 76
    • 84979220732 scopus 로고    scopus 로고
    • Empagliflozin (An SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes
    • Jojima T, Tomotsune T, Iijima T, Akimoto K, Suzuki K, Aso Y. Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes. Diabetol Metab Syndr 2016; 8: 45.
    • (2016) Diabetol Metab Syndr , vol.8 , pp. 45
    • Jojima, T.1    Tomotsune, T.2    Iijima, T.3    Akimoto, K.4    Suzuki, K.5    Aso, Y.6
  • 77
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • Liang Y, Arakawa K, Ueta K, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One 2012; 7(2): e30555.
    • (2012) Plos One , vol.7 , Issue.2
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3
  • 78
    • 84961615237 scopus 로고    scopus 로고
    • Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction
    • Komiya C, Tsuchiya K, Shiba K, et al. Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction. PLoS One 2016; 11(3): e0151511.
    • (2016) Plos One , vol.11 , Issue.3
    • Komiya, C.1    Tsuchiya, K.2    Shiba, K.3
  • 79
    • 84905446525 scopus 로고    scopus 로고
    • Tofogliflozin, a sodium/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models
    • Suzuki M, Takeda M, Kito A, et al. Tofogliflozin, a sodium/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models. Nutr Diabetes 2014; 4: e125.
    • (2014) Nutr Diabetes , vol.4
    • Suzuki, M.1    Takeda, M.2    Kito, A.3
  • 80
    • 84960517126 scopus 로고    scopus 로고
    • Tofogliflozin improves insulin resistance in skeletal muscle and accelerates lipolysis in adipose tissue in male mice
    • Obata A, Kubota N, Kubota T, et al. Tofogliflozin improves insulin resistance in skeletal muscle and accelerates lipolysis in adipose tissue in male mice. Endocrinology 2016; 157(3): 1029-42.
    • (2016) Endocrinology , vol.157 , Issue.3 , pp. 1029-1042
    • Obata, A.1    Kubota, N.2    Kubota, T.3
  • 81
    • 84946474255 scopus 로고    scopus 로고
    • Remogliflozin etabonate improves fatty liver disease in diet-induced obese male mice
    • Nakano S, Katsuno K, Isaji M, et al. Remogliflozin etabonate improves fatty liver disease in diet-induced obese male mice. J Clin Exp Hepatol 2015; 5(3): 190-8.
    • (2015) J Clin Exp Hepatol , vol.5 , Issue.3 , pp. 190-198
    • Nakano, S.1    Katsuno, K.2    Isaji, M.3
  • 82
    • 84947786115 scopus 로고    scopus 로고
    • Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus
    • Qiang S, Nakatsu Y, Seno Y, et al. Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus. Diabetol Metab Syndr 2015; 7: 104.
    • (2015) Diabetol Metab Syndr , vol.7 , pp. 104
    • Qiang, S.1    Nakatsu, Y.2    Seno, Y.3
  • 84
    • 84860183617 scopus 로고    scopus 로고
    • A novel approach to control hyperglycemia in type 2 diabetes: Sodium glucose cotransport (SGLT) inhibitors: Systematic review and meta-analysis of randomized trials
    • Musso G, Gambino R, Cassader M, Pagano G. A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose cotransport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Ann Med 2012; 44(4): 375-93.
    • (2012) Ann Med , vol.44 , Issue.4 , pp. 375-393
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 85
    • 84898854471 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: A systematic review and meta-analysis
    • Baker WL, Smyth LR, Riche DM, Bourret EM, Chamberlin KW, White WB. Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J Am Soc Hypertens 2014; 8(4): 262-75.e9.
    • (2014) J am Soc Hypertens , vol.8 , Issue.4
    • Baker, W.L.1    Smyth, L.R.2    Riche, D.M.3    Bourret, E.M.4    Chamberlin, K.W.5    White, W.B.6
  • 86
    • 84943187885 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter-2 inhibitors and blood pressure decrease: A valuable effect of a novel antidiabetic class?
    • Imprialos KP, Sarafidis PA, Karagiannis AI. Sodium-glucose cotransporter-2 inhibitors and blood pressure decrease: a valuable effect of a novel antidiabetic class? J Hypertens 2015; 33(11): 2185-97.
    • (2015) J Hypertens , vol.33 , Issue.11 , pp. 2185-2197
    • Imprialos, K.P.1    Sarafidis, P.A.2    Karagiannis, A.I.3
  • 87
    • 84981717952 scopus 로고    scopus 로고
    • Baseline characteristics and interim (3-month) efficacy and safety data from STELLALONG TERM, a long-term post-marketing surveillance study of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice
    • 2016 Jul 27. [Epub ahead of print]
    • Maegawa H, Tobe K, Tabuchi H, Nakamura I. Baseline characteristics and interim (3-month) efficacy and safety data from STELLALONG TERM, a long-term post-marketing surveillance study of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice. Expert Opin Pharmacother 2016 Jul 27. [Epub ahead of print]
    • Expert Opin Pharmacother
    • Maegawa, H.1    Tobe, K.2    Tabuchi, H.3    Nakamura, I.4
  • 88
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • Zambrowicz B, Freiman J, Brown PM, et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther 2012; 92(2): 158-69.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.2 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3
  • 89
    • 84959460390 scopus 로고    scopus 로고
    • Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: A randomised, double-blind, placebo-controlled, phase 3 study
    • Weber MA, Mansfield TA, Cain VA, Iqbal N, Parikh S, Ptaszynska A. Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Diabetes Endocrinol 2016; 4(3): 211-20.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , Issue.3 , pp. 211-220
    • Weber, M.A.1    Mansfield, T.A.2    Cain, V.A.3    Iqbal, N.4    Parikh, S.5    Ptaszynska, A.6
  • 90
    • 84958125420 scopus 로고    scopus 로고
    • Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade
    • Weber MA, Mansfield TA, Alessi F, Iqbal N, Parikh S, Ptaszynska A. Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade. Blood Press 2016; 25(2): 93-103.
    • (2016) Blood Press , vol.25 , Issue.2 , pp. 93-103
    • Weber, M.A.1    Mansfield, T.A.2    Alessi, F.3    Iqbal, N.4    Parikh, S.5    Ptaszynska, A.6
  • 91
    • 84953638180 scopus 로고    scopus 로고
    • Reductions in mean 24-hour ambulatory blood pressure after 6-week treatment with canagliflozin in patients with type 2 diabetes mellitus and hypertension
    • Townsend RR, Machin I, Ren J, et al. Reductions in mean 24-hour ambulatory blood pressure after 6-week treatment with canagliflozin in patients with type 2 diabetes mellitus and hypertension. J Clin Hypertens (Greenwich) 2016; 18(1): 43-52.
    • (2016) J Clin Hypertens (Greenwich) , vol.18 , Issue.1 , pp. 43-52
    • Townsend, R.R.1    Machin, I.2    Ren, J.3
  • 92
    • 84928196614 scopus 로고    scopus 로고
    • EMPA-REG BP Investigators. Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension
    • Tikkanen I, Narko K, Zeller C, et al; EMPA-REG BP Investigators. Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension. Diabetes Care 2015; 38(3): 420-8.
    • (2015) Diabetes Care , vol.38 , Issue.3 , pp. 420-428
    • Tikkanen, I.1    Narko, K.2    Zeller, C.3
  • 93
    • 84962154687 scopus 로고    scopus 로고
    • 4B.01: Contrasting influences of renal function on blood pressure and hba1c reductions with empagliflozin in patients with type 2 diabetes and hypertension
    • Cherney D, Cooper M, Tikkanen I, et al. 4B.01: Contrasting influences of renal function on blood pressure and hba1c reductions with empagliflozin in patients with type 2 diabetes and hypertension. J Hypertens 2015; 33 (Suppl 1): e53.
    • (2015) J Hypertens , vol.33
    • Cherney, D.1    Cooper, M.2    Tikkanen, I.3
  • 94
    • 84923108094 scopus 로고    scopus 로고
    • SGLT2 inhibitors: Their potential reduction in blood pressure
    • Maliha G, Townsend RR. SGLT2 inhibitors: their potential reduction in blood pressure. J Am Soc Hypertens 2015; 9(1): 48-53.
    • (2015) J am Soc Hypertens , vol.9 , Issue.1 , pp. 48-53
    • Maliha, G.1    Townsend, R.R.2
  • 95
    • 84957441669 scopus 로고    scopus 로고
    • Potential role of sodium glucose cotransporter 2 inhibitors in the treatment of hypertension
    • Tikkanen I, Chilton R, Johansen OE. Potential role of sodium glucose cotransporter 2 inhibitors in the treatment of hypertension. Curr Opin Nephrol Hypertens 2016; 25(2): 81-6.
    • (2016) Curr Opin Nephrol Hypertens , vol.25 , Issue.2 , pp. 81-86
    • Tikkanen, I.1    Chilton, R.2    Johansen, O.E.3
  • 96
    • 84874168561 scopus 로고    scopus 로고
    • Hygia Project Investigators. Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes
    • Ayala DE, Moya A, Crespo JJ, et al; Hygia Project Investigators. Circadian pattern of ambulatory blood pressure in hypertensive patients with and without type 2 diabetes. Chronobiol Int 2013; 30(1-2): 99-115.
    • (2013) Chronobiol Int , vol.30 , Issue.1-2 , pp. 99-115
    • Ayala, D.E.1    Moya, A.2    Crespo, J.J.3
  • 97
    • 84976340181 scopus 로고    scopus 로고
    • A case of type 2 diabetes with a change from a non-dipper to a dipper blood pressure pattern by dapagliflozin
    • Mori H, Okada Y, Kawaguchi M, Tanaka Y. A case of type 2 diabetes with a change from a non-dipper to a dipper blood pressure pattern by dapagliflozin. J UOEH 2016; 38(2): 149-53.
    • (2016) J UOEH , vol.38 , Issue.2 , pp. 149-153
    • Mori, H.1    Okada, Y.2    Kawaguchi, M.3    Tanaka, Y.4
  • 98
    • 84961223678 scopus 로고    scopus 로고
    • Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome
    • Rahman A, Kittikulsuth W, Fujisawa Y, et al. Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome. J Hypertens 2016; 34(5): 893-906.
    • (2016) J Hypertens , vol.34 , Issue.5 , pp. 893-906
    • Rahman, A.1    Kittikulsuth, W.2    Fujisawa, Y.3
  • 99
    • 85020850154 scopus 로고    scopus 로고
    • 4B.03: Empagliflozin reduces systolic blood pressure in dipper and non-dipper patients with type 2 diabetes and hypertension
    • Chilton R, Tikkanen I, Crowe S, et al. 4B.03: Empagliflozin reduces systolic blood pressure in dipper and non-dipper patients with type 2 diabetes and hypertension. J Hypertens 2015; 33 Suppl 1: e53.
    • J Hypertens 2015; 33 Suppl , vol.1
    • Chilton, R.1    Tikkanen, I.2    Crowe, S.3
  • 100
    • 85009081205 scopus 로고    scopus 로고
    • Empagliflozin for type 2 diabetes mellitus: An overview of phase 3 clinical trials
    • 2016 Jun 13. [Epub ahead of print]
    • Levine MJ. Empagliflozin for type 2 diabetes mellitus: an overview of phase 3 clinical trials. Curr Diabetes Rev 2016 Jun 13. [Epub ahead of print]
    • Curr Diabetes Rev
    • Levine, M.J.1
  • 101
    • 84938687573 scopus 로고    scopus 로고
    • Dapagliflozin lowers blood pressure in hypertensive and nonhypertensive patients with type 2 diabetes
    • Sjöström CD, Johansson P, Ptaszynska A, List J, Johnsson E. Dapagliflozin lowers blood pressure in hypertensive and nonhypertensive patients with type 2 diabetes. Diab Vasc Dis Res 2015; 12(5): 352-8.
    • (2015) Diab Vasc Dis Res , vol.12 , Issue.5 , pp. 352-358
    • Sjöström, C.D.1    Johansson, P.2    Ptaszynska, A.3    List, J.4    Johnsson, E.5
  • 102
    • 84944800184 scopus 로고    scopus 로고
    • EMPA REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman B, Wanner C, Lachin JM, et al, EMPA REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015; 373: 2117-28.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 103
    • 85012981869 scopus 로고    scopus 로고
    • Aspects of hyperglycemia contribution to arterial stiffness and cardiovascular complications in patients with type 1 diabetes
    • Mar 7. pii: 1932296816636894. [Epub ahead of print]
    • Gordin D, Groop PH. Aspects of hyperglycemia contribution to arterial stiffness and cardiovascular complications in patients with type 1 diabetes. J Diabetes Sci Technol 2016 Mar 7. pii: 1932296816636894. [Epub ahead of print]
    • (2016) J Diabetes Sci Technol
    • Gordin, D.1    Groop, P.H.2
  • 104
    • 84937126409 scopus 로고    scopus 로고
    • The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society
    • Vlachopoulos C, Xaplanteris P, Aboyans V, et al. The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis 2015; 241(2): 507-32.
    • (2015) Atherosclerosis , vol.241 , Issue.2 , pp. 507-532
    • Vlachopoulos, C.1    Xaplanteris, P.2    Aboyans, V.3
  • 105
    • 84957601632 scopus 로고    scopus 로고
    • Diabetes mellitus, arterial wall, and cardiovascular risk assessment
    • Kozakova M, Palombo C. Diabetes mellitus, arterial wall, and cardiovascular risk assessment. Int J Environ Res Public Health 2016; 13(2): 201.
    • (2016) Int J Environ Res Public Health , vol.13 , Issue.2 , pp. 201
    • Kozakova, M.1    Palombo, C.2
  • 106
    • 82955194914 scopus 로고    scopus 로고
    • Thinking beyond traditional cardiovascular risk factors: The role of arterial stiffness in targeting residual risk
    • Katsiki N, Koumaras C, Athyros VG, Karagiannis A. Thinking beyond traditional cardiovascular risk factors: the role of arterial stiffness in targeting residual risk. Angiology 2012; 63(1): 9-11.
    • (2012) Angiology , vol.63 , Issue.1 , pp. 9-11
    • Katsiki, N.1    Koumaras, C.2    Athyros, V.G.3    Karagiannis, A.4
  • 107
    • 84961627544 scopus 로고    scopus 로고
    • Cardiovascular outcomes of sodium-glucose cotransporter 2 inhibitors: A comprehensive review of clinical and preclinical studies
    • Ghosh RK, Bandyopadhyay D, Hajra A, Biswas M, Gupta A. Cardiovascular outcomes of sodium-glucose cotransporter 2 inhibitors: A comprehensive review of clinical and preclinical studies. Int J Cardiol 2016; 212: 29-36.
    • (2016) Int J Cardiol , vol.212 , pp. 29-36
    • Ghosh, R.K.1    Bandyopadhyay, D.2    Hajra, A.3    Biswas, M.4    Gupta, A.5
  • 108
    • 84937525356 scopus 로고    scopus 로고
    • A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans
    • Michel MC, Mayoux E, Vallon V. A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans. Naunyn Schmiedebergs Arch Pharmacol 2015; 388(8): 801-16.
    • (2015) Naunyn Schmiedebergs Arch Pharmacol , vol.388 , Issue.8 , pp. 801-816
    • Michel, M.C.1    Mayoux, E.2    Vallon, V.3
  • 109
    • 84892959743 scopus 로고    scopus 로고
    • The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
    • Cherney DZ, Perkins BA, Soleymanlou N, et al. The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus. Cardiovasc Diabetol 2014; 13: 28.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 28
    • Cherney, D.Z.1    Perkins, B.A.2    Soleymanlou, N.3
  • 110
    • 84969300904 scopus 로고    scopus 로고
    • 4B.02: The sodium glucose cotransporter 2 inhibitor empagliflozin reduces blood pressure and markers of arterial stiffness and vascular resistance in type 2 diabetes
    • Chilton R, Tikkanen I, Cannon CP, et al. 4B.02: The sodium glucose cotransporter 2 inhibitor empagliflozin reduces blood pressure and markers of arterial stiffness and vascular resistance in type 2 diabetes. J Hypertens 2015; 33 (Suppl 1): e53.
    • (2015) J Hypertens , vol.33
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3
  • 111
    • 85044195018 scopus 로고    scopus 로고
    • Therapeutic modification of arterial stiffness: An update and comprehensive review
    • Wu CF, Liu PY, Wu TJ, Hung Y, Yang SP, Lin GM. Therapeutic modification of arterial stiffness: An update and comprehensive review. World J Cardiol 2015; 7(11): 742-53.
    • (2015) World J Cardiol , vol.7 , Issue.11 , pp. 742-753
    • Wu, C.F.1    Liu, P.Y.2    Wu, T.J.3    Hung, Y.4    Yang, S.P.5    Lin, G.M.6
  • 112
    • 84905116036 scopus 로고    scopus 로고
    • Pioglitazone improves the cardio-ankle vascular index in patients with type 2 diabetes mellitus treated with metformin
    • Ohira M, Yamaguchi T, Saiki A, et al. Pioglitazone improves the cardio-ankle vascular index in patients with type 2 diabetes mellitus treated with metformin. Diabetes Metab Syndr Obes 2014; 7: 313-9.
    • (2014) Diabetes Metab Syndr Obes , vol.7 , pp. 313-319
    • Ohira, M.1    Yamaguchi, T.2    Saiki, A.3
  • 113
    • 84963976386 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors improve arterial stiffness, blood pressure, lipid profile and inflammation parameters in patients with type 2 diabetes mellitus
    • Duvnjak L, Blaslov K. Dipeptidyl peptidase-4 inhibitors improve arterial stiffness, blood pressure, lipid profile and inflammation parameters in patients with type 2 diabetes mellitus. Diabetol Metab Syndr 2016; 8: 26.
    • (2016) Diabetol Metab Syndr , vol.8 , pp. 26
    • Duvnjak, L.1    Blaslov, K.2
  • 114
    • 84863791439 scopus 로고    scopus 로고
    • The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients
    • Koren S, Shemesh-Bar L, Tirosh A, et al. The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients. Diabetes Technol Ther 2012; 14(7): 561-7.
    • (2012) Diabetes Technol Ther , vol.14 , Issue.7 , pp. 561-567
    • Koren, S.1    Shemesh-Bar, L.2    Tirosh, A.3
  • 115
    • 84927633440 scopus 로고    scopus 로고
    • Effect of vildagliptin on hsCRP and arterial stiffness in patients with type 2 diabetes mellitus
    • Zografou I, Sampanis C, Gkaliagkousi E, et al. Effect of vildagliptin on hsCRP and arterial stiffness in patients with type 2 diabetes mellitus. Hormones (Athens) 2015; 14(1): 118-25.
    • (2015) Hormones (Athens) , vol.14 , Issue.1 , pp. 118-125
    • Zografou, I.1    Sampanis, C.2    Gkaliagkousi, E.3
  • 116
    • 69849104827 scopus 로고    scopus 로고
    • Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients
    • Kiyici S, Ersoy C, Kaderli A, et al. Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients. Diabetes Res Clin Pract 2009; 86(1): 44-50.
    • (2009) Diabetes Res Clin Pract , vol.86 , Issue.1 , pp. 44-50
    • Kiyici, S.1    Ersoy, C.2    Kaderli, A.3
  • 117
    • 84861323191 scopus 로고    scopus 로고
    • Role of antihypertensive drugs in arterial ’de-stiffening’ and central pulsatile hemodynamics
    • Koumaras C, Tzimou M, Stavrinou E, et al. Role of antihypertensive drugs in arterial ’de-stiffening’ and central pulsatile hemodynamics. Am J Cardiovasc Drugs 2012; 12(3): 143-56.
    • (2012) Am J Cardiovasc Drugs , vol.12 , Issue.3 , pp. 143-156
    • Koumaras, C.1    Tzimou, M.2    Stavrinou, E.3
  • 118
    • 84894103242 scopus 로고    scopus 로고
    • Effects of reninangiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness
    • Koumaras C, Tziomalos K, Stavrinou E, et al. Effects of reninangiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness. J Am Soc Hypertens 2014; 8(2): 74-82.
    • (2014) J am Soc Hypertens , vol.8 , Issue.2 , pp. 74-82
    • Koumaras, C.1    Tziomalos, K.2    Stavrinou, E.3
  • 119
    • 84964200241 scopus 로고    scopus 로고
    • Halting arterial aging in patients with cardiovascular disease: Hypolipidemic and antihypertensive therapy
    • Papademetriou V, Katsiki N, Doumas M, Faselis C. Halting arterial aging in patients with cardiovascular disease: hypolipidemic and antihypertensive therapy. Curr Pharm Des 2014; 20(40): 6339-49.
    • (2014) Curr Pharm Des , vol.20 , Issue.40 , pp. 6339-6349
    • Papademetriou, V.1    Katsiki, N.2    Doumas, M.3    Faselis, C.4
  • 120
    • 77956778810 scopus 로고    scopus 로고
    • Effect of ezetimibe monotherapy on lipid metabolism and arterial stiffness assessed by cardioankle vascular index in type 2 diabetic patients
    • Miyashita Y, Endo K, Saiki A, et al. Effect of ezetimibe monotherapy on lipid metabolism and arterial stiffness assessed by cardioankle vascular index in type 2 diabetic patients. J Atheroscler Thromb 2010; 17(10): 1070-6.
    • (2010) J Atheroscler Thromb , vol.17 , Issue.10 , pp. 1070-1076
    • Miyashita, Y.1    Endo, K.2    Saiki, A.3
  • 121
    • 84975698839 scopus 로고    scopus 로고
    • EMPA-REG OUTCOMER trial investigators. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: Results of the EMPA-REG OUTCOMER trial
    • Fitchett D, Zinman B, Wanner C, et al; EMPA-REG OUTCOMER trial investigators. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOMER trial. Eur Heart J 2016; 37(19): 1526-34.
    • (2016) Eur Heart J , vol.37 , Issue.19 , pp. 1526-1534
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3
  • 122
    • 84928407115 scopus 로고    scopus 로고
    • Adverse effects and safety of SGLT-2 inhibitors
    • Halimi S, Vergès B. Adverse effects and safety of SGLT-2 inhibitors. Diabetes Metab 2014; 40(6 Suppl 1): S28-34.
    • (2014) Diabetes Metab , vol.40 , Issue.6 , pp. S28-S34
    • Halimi, S.1    Vergès, B.2
  • 123
    • 84944597723 scopus 로고    scopus 로고
    • Durability and tolerability of dapagliflozin over 52 weeks as addon to metformin and sulphonylurea in type 2 diabetes
    • Matthaei S, Bowering K, Rohwedder K, Sugg J, Parikh S, Johnsson E. Durability and tolerability of dapagliflozin over 52 weeks as addon to metformin and sulphonylurea in type 2 diabetes. Diabetes Obes Metab 2015; 17(11): 1075–1084.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.11 , pp. 1075-1084
    • Matthaei, S.1    Bowering, K.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5    Johnsson, E.6
  • 124
    • 84964240560 scopus 로고    scopus 로고
    • Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes
    • Bode B, Stenlof K, Harris S, et al. Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes. Diabetes Obes Metab 2015; 17(3): 294-303.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.3 , pp. 294-303
    • Bode, B.1    Stenlof, K.2    Harris, S.3
  • 125
    • 84906924894 scopus 로고    scopus 로고
    • Safety and tolerability of canagliflozin in patients with type 2 diabetes mellitus: Pooled analysis of phase 3 study results
    • Usiskin K, Kline I, Fung A, Mayer C, Meininger G. Safety and tolerability of canagliflozin in patients with type 2 diabetes mellitus: pooled analysis of phase 3 study results. Postgrad Med 2014; 126(3): 16-34.
    • (2014) Postgrad Med , vol.126 , Issue.3 , pp. 16-34
    • Usiskin, K.1    Kline, I.2    Fung, A.3    Mayer, C.4    Meininger, G.5
  • 126
    • 84964773926 scopus 로고    scopus 로고
    • SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study
    • Abdul-Ghani M, Del Prato S, Chilton R, DeFronzo RA. SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study. Diabetes Care 2016; 39(5): 717-25.
    • (2016) Diabetes Care , vol.39 , Issue.5 , pp. 717-725
    • Abdul-Ghani, M.1    Del Prato, S.2    Chilton, R.3    Defronzo, R.A.4
  • 127
    • 84885171560 scopus 로고    scopus 로고
    • The clinical efficacy and safety of sodium glucose cotransporter-2 inhibitors in adults with type 2 diabetes mellitus
    • Riser Taylor S, Harris KB. The clinical efficacy and safety of sodium glucose cotransporter-2 inhibitors in adults with type 2 diabetes mellitus. Pharmacotherapy 2013; 33(9): 984-99.
    • (2013) Pharmacotherapy , vol.33 , Issue.9 , pp. 984-999
    • Riser Taylor, S.1    Harris, K.B.2
  • 128
    • 84930825790 scopus 로고    scopus 로고
    • Dapagliflozin improves glycemic control and reduces body weight as add-on therapy to metformin plus sulfonylurea: A 24-week randomized, double-blind clinical trial
    • Matthaei S, Bowering K, Rohwedder K, Grohl A, Parikh S. Dapagliflozin improves glycemic control and reduces body weight as add-on therapy to metformin plus sulfonylurea: a 24-week randomized, double-blind clinical trial. Diabetes Care 2015; 38(3): 365-372
    • (2015) Diabetes Care , vol.38 , Issue.3 , pp. 365-372
    • Matthaei, S.1    Bowering, K.2    Rohwedder, K.3    Grohl, A.4    Parikh, S.5
  • 129
    • 84982292524 scopus 로고    scopus 로고
    • An overview of the effect of sodium glucose cotransporter 2 inhibitor monotherapy on glycemic and other clinical laboratory parameters in type 2 diabetes patients
    • Wang Y, Hu X, Liu X, Wang Z. An overview of the effect of sodium glucose cotransporter 2 inhibitor monotherapy on glycemic and other clinical laboratory parameters in type 2 diabetes patients. Ther Clin Risk Manag 2016; 12: 1113-31.
    • (2016) Ther Clin Risk Manag , vol.12 , pp. 1113-1131
    • Wang, Y.1    Hu, X.2    Liu, X.3    Wang, Z.4
  • 130
    • 84964608804 scopus 로고    scopus 로고
    • Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
    • Ferrannini E, Baldi S, Frascerra S, et al. Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes. Diabetes 2016; 65(5): 1190-5.
    • (2016) Diabetes , vol.65 , Issue.5 , pp. 1190-1195
    • Ferrannini, E.1    Baldi, S.2    Frascerra, S.3
  • 131
    • 84975789692 scopus 로고    scopus 로고
    • Empagliflozin, via Switching Metabolism Toward Lipid Utilization, Moderately Increases LDL Cholesterol Levels Through Reduced LDL Catabolism
    • Briand F, Mayoux E, Brousseau E, et al. Empagliflozin, via Switching Metabolism Toward Lipid Utilization, Moderately Increases LDL Cholesterol Levels Through Reduced LDL Catabolism. Diabetes 2016; 65(7): 2032-8.
    • (2016) Diabetes , vol.65 , Issue.7 , pp. 2032-2038
    • Briand, F.1    Mayoux, E.2    Brousseau, E.3
  • 132
    • 84948567431 scopus 로고    scopus 로고
    • Effects of baseline blood pressure and low-density lipoprotein cholesterol on safety and efficacy of canagliflozin in japanese patients with type 2 diabetes mellitus
    • Inagaki N, Goda M, Yokota S, Maruyama N, Iijima H. Effects of baseline blood pressure and low-density lipoprotein cholesterol on safety and efficacy of canagliflozin in japanese patients with type 2 diabetes mellitus. Adv Ther 2015; 32(11): 1085-103.
    • (2015) Adv Ther , vol.32 , Issue.11 , pp. 1085-1103
    • Inagaki, N.1    Goda, M.2    Yokota, S.3    Maruyama, N.4    Iijima, H.5
  • 133
    • 84925238699 scopus 로고    scopus 로고
    • Achieving lipid targets in primary care settings
    • Katsiki N, Athyros VG, Karagiannis A. Achieving lipid targets in primary care settings. Curr Med Res Opin 2014; 30(10): 1971-4.
    • (2014) Curr Med Res Opin , vol.30 , Issue.10 , pp. 1971-1974
    • Katsiki, N.1    Athyros, V.G.2    Karagiannis, A.3
  • 134
    • 84875303002 scopus 로고    scopus 로고
    • Lipoprotein subfractions in metabolic syndrome and obesity: Clinical significance and therapeutic approaches
    • Nikolic D, Katsiki N, Montalto G, Isenovic ER, Mikhailidis DP, Rizzo M. Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches. Nutrients 2013; 5(3): 928-48.
    • (2013) Nutrients , vol.5 , Issue.3 , pp. 928-948
    • Nikolic, D.1    Katsiki, N.2    Montalto, G.3    Isenovic, E.R.4    Mikhailidis, D.P.5    Rizzo, M.6
  • 135
    • 80051769525 scopus 로고    scopus 로고
    • European panel on low density lipoprotein (LDL) subclasses: A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: Executive summary
    • Mikhailidis DP, Elisaf M, Rizzo M, et al. “European panel on low density lipoprotein (LDL) subclasses”: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: executive summary. Curr Vasc Pharmacol 2011; 9(5): 531-2.
    • (2011) Curr Vasc Pharmacol , vol.9 , Issue.5 , pp. 531-532
    • Mikhailidis, D.P.1    Elisaf, M.2    Rizzo, M.3
  • 136
    • 80051725784 scopus 로고    scopus 로고
    • European panel on low density lipoprotein (LDL) subclasses: A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses
    • Mikhailidis DP, Elisaf M, Rizzo M, et al. “European panel on low density lipoprotein (LDL) subclasses”: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses. Curr Vasc Pharmacol 2011; 9(5): 533-71.
    • (2011) Curr Vasc Pharmacol , vol.9 , Issue.5 , pp. 533-571
    • Mikhailidis, D.P.1    Elisaf, M.2    Rizzo, M.3
  • 137
    • 84925884366 scopus 로고    scopus 로고
    • The role of statins in the treatment of type 2 diabetes mellitus: An update
    • Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP. The role of statins in the treatment of type 2 diabetes mellitus: an update. Curr Pharm Des 2014; 20(22): 3665-74.
    • (2014) Curr Pharm Des , vol.20 , Issue.22 , pp. 3665-3674
    • Katsiki, N.1    Athyros, V.G.2    Karagiannis, A.3    Mikhailidis, D.P.4
  • 140
    • 52249118511 scopus 로고    scopus 로고
    • The differential effects of thiazolidinediones on atherogenic dyslipidemia in type 2 diabetes: What is the clinical significance?
    • Rizzo M, Christ ER, Rini GB, Spinas GA, Berneis K. The differential effects of thiazolidinediones on atherogenic dyslipidemia in type 2 diabetes: what is the clinical significance? Expert Opin Pharmacother 2008; 9(13): 2295-303.
    • (2008) Expert Opin Pharmacother , vol.9 , Issue.13 , pp. 2295-2303
    • Rizzo, M.1    Christ, E.R.2    Rini, G.B.3    Spinas, G.A.4    Berneis, K.5
  • 141
    • 84920007637 scopus 로고    scopus 로고
    • Effect of liraglutide administration and a calorie-restricted diet on lipoprotein profile in overweight/obese persons with prediabetes
    • Ariel D, Kim SH, Abbasi F, Lamendola CA, Liu A, Reaven GM. Effect of liraglutide administration and a calorie-restricted diet on lipoprotein profile in overweight/obese persons with prediabetes. Nutr Metab Cardiovasc Dis 2014; 24(12): 1317-22.
    • (2014) Nutr Metab Cardiovasc Dis , vol.24 , Issue.12 , pp. 1317-1322
    • Ariel, D.1    Kim, S.H.2    Abbasi, F.3    Lamendola, C.A.4    Liu, A.5    Reaven, G.M.6
  • 142
    • 84904742980 scopus 로고    scopus 로고
    • Characteristics other than the diagnostic criteria associated with metabolic syndrome: An overview
    • Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP. Characteristics other than the diagnostic criteria associated with metabolic syndrome: an overview. Curr Vasc Pharmacol 2014; 12(4): 627-41.
    • (2014) Curr Vasc Pharmacol , vol.12 , Issue.4 , pp. 627-641
    • Katsiki, N.1    Athyros, V.G.2    Karagiannis, A.3    Mikhailidis, D.P.4
  • 143
    • 79955582390 scopus 로고    scopus 로고
    • Assessment and clinical relevance of non-fasting and postprandial triglycerides: An expert panel statement
    • Kolovou GD, Mikhailidis DP, Kovar J, et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol 2011; 9(3): 258-70.
    • (2011) Curr Vasc Pharmacol , vol.9 , Issue.3 , pp. 258-270
    • Kolovou, G.D.1    Mikhailidis, D.P.2    Kovar, J.3
  • 145
    • 84872483502 scopus 로고    scopus 로고
    • Postprandial hypertriglyceridemia and cardiovascular disease: Current and future therapies
    • Chan DC, Pang J, Romic G, Watts GF. Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies. Curr Atheroscler Rep 2013; 15(3): 309.
    • (2013) Curr Atheroscler Rep , vol.15 , Issue.3 , pp. 309
    • Chan, D.C.1    Pang, J.2    Romic, G.3    Watts, G.F.4
  • 146
    • 84882282651 scopus 로고    scopus 로고
    • Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: From risk factors to clinical outcomes
    • Scheen AJ. Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomes. Postgrad Med 2013; 125(3): 7-20.
    • (2013) Postgrad Med , vol.125 , Issue.3 , pp. 7-20
    • Scheen, A.J.1
  • 147
    • 59849092050 scopus 로고    scopus 로고
    • The effects of medications used for the management of diabetes and obesity on postprandial lipid metabolism
    • Eleftheriadou I, Grigoropoulou P, Katsilambros N, Tentolouris N. The effects of medications used for the management of diabetes and obesity on postprandial lipid metabolism. Curr Diabetes Rev 2008; 4(4): 340-56.
    • (2008) Curr Diabetes Rev , vol.4 , Issue.4 , pp. 340-356
    • Eleftheriadou, I.1    Grigoropoulou, P.2    Katsilambros, N.3    Tentolouris, N.4
  • 148
    • 84949843720 scopus 로고    scopus 로고
    • Liraglutide and cardiometabolic effects: More than just another antiobesity drug?
    • Katsiki N, Christou GA, Kiortsis DN. Liraglutide and cardiometabolic effects: more than just another antiobesity drug? Curr Vasc Pharmacol 2016; 14(1): 76-9.
    • (2016) Curr Vasc Pharmacol , vol.14 , Issue.1 , pp. 76-79
    • Katsiki, N.1    Christou, G.A.2    Kiortsis, D.N.3
  • 149
    • 80051725784 scopus 로고    scopus 로고
    • European panel on low density lipoprotein (LDL) subclasses: A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses
    • Mikhailidis DP, Elisaf M, Rizzo M, et al. “European panel on low density lipoprotein (LDL) subclasses”: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses. Curr Vasc Pharmacol 2011; 9(5): 533-71.
    • (2011) Curr Vasc Pharmacol , vol.9 , Issue.5 , pp. 533-571
    • Mikhailidis, D.P.1    Elisaf, M.2    Rizzo, M.3
  • 150
    • 80051769525 scopus 로고    scopus 로고
    • European panel on low density lipoprotein (LDL) subclasses: A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: Executive summary
    • Mikhailidis DP, Elisaf M, Rizzo M, et al. “European panel on low density lipoprotein (LDL) subclasses”: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: executive summary. Curr Vasc Pharmacol 2011; 9(5): 531-2.
    • (2011) Curr Vasc Pharmacol , vol.9 , Issue.5 , pp. 531-532
    • Mikhailidis, D.P.1    Elisaf, M.2    Rizzo, M.3
  • 151
    • 79955582390 scopus 로고    scopus 로고
    • Assessment and clinical relevance of non-fasting and postprandial triglycerides: An expert panel statement
    • Kolovou GD, Mikhailidis DP, Kovar J, et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol 2011; 9(3): 258-70.
    • (2011) Curr Vasc Pharmacol , vol.9 , Issue.3 , pp. 258-270
    • Kolovou, G.D.1    Mikhailidis, D.P.2    Kovar, J.3
  • 154
    • 84929957143 scopus 로고    scopus 로고
    • Hyperuricaemia in cardiovascular diseases: A passive or an active player?
    • Katsiki N, Mikhailidis DP. Hyperuricaemia in cardiovascular diseases: a passive or an active player? Med Princ Pract 2015; 24(3): 269-70.
    • (2015) Med Princ Pract , vol.24 , Issue.3 , pp. 269-270
    • Katsiki, N.1    Mikhailidis, D.P.2
  • 157
  • 158
    • 84977572114 scopus 로고    scopus 로고
    • Efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes stratified by body mass index: A subgroup analysis of five randomized clinical trials
    • Kashiwagi A, Yoshida S, Nakamura I, et al. Efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes stratified by body mass index: A subgroup analysis of five randomized clinical trials. J Diabetes Investig 2016; 7(4): 544-54.
    • (2016) J Diabetes Investig , vol.7 , Issue.4 , pp. 544-554
    • Kashiwagi, A.1    Yoshida, S.2    Nakamura, I.3
  • 159
    • 79960411842 scopus 로고    scopus 로고
    • Hyperuricaemia and non-alcoholic fatty liver disease (NAFLD): A relationship with implications for vascular risk?
    • Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP. Hyperuricaemia and non-alcoholic fatty liver disease (NAFLD): a relationship with implications for vascular risk? Curr Vasc Pharmacol 2011; 9(6): 698-705.
    • (2011) Curr Vasc Pharmacol , vol.9 , Issue.6 , pp. 698-705
    • Katsiki, N.1    Athyros, V.G.2    Karagiannis, A.3    Mikhailidis, D.P.4
  • 161
    • 84903528312 scopus 로고    scopus 로고
    • Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice
    • Terami N, Ogawa D, Tachibana H, et al. Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS One 2014; 9(6): e100777.
    • (2014) Plos One , vol.9 , Issue.6
    • Terami, N.1    Ogawa, D.2    Tachibana, H.3
  • 162
    • 84911942671 scopus 로고    scopus 로고
    • The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity
    • Oelze M, Kröller-Schön S, Welschof P, et al. The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity. PLoS One 2014; 9(11): e112394.
    • (2014) Plos One , vol.9 , Issue.11
    • Oelze, M.1    Kröller-Schön, S.2    Welschof, P.3
  • 163
    • 84971663895 scopus 로고    scopus 로고
    • The effects of empagliflozin, an SGLT2 inhibitor, on pancreatic β-cell mass and glucose homeostasis in type 1 diabetes
    • Cheng ST, Chen L, Li SY, Mayoux E, Leung PS. The effects of empagliflozin, an SGLT2 inhibitor, on pancreatic β-cell mass and glucose homeostasis in type 1 diabetes. PLoS One 2016; 11(1): e0147391.
    • (2016) Plos One , vol.11 , Issue.1
    • Cheng, S.T.1    Chen, L.2    Li, S.Y.3    Mayoux, E.4    Leung, P.S.5
  • 164
    • 84873497173 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibition in human kidney proximal tubular cells--renoprotection in diabetic nephropathy?
    • Panchapakesan U, Pegg K, Gross S, et al. Effects of SGLT2 inhibition in human kidney proximal tubular cells--renoprotection in diabetic nephropathy? PLoS One 2013; 8(2): e54442.
    • (2013) Plos One , vol.8 , Issue.2
    • Panchapakesan, U.1    Pegg, K.2    Gross, S.3
  • 165
    • 84961057126 scopus 로고    scopus 로고
    • Tofogliflozin, a highly selective inhibitor of SGLT2 blocks proinflammatory and proapoptotic effects of glucose overload on proximal tubular cells partly by suppressing oxidative stress generation
    • Ishibashi Y, Matsui T, Yamagishi S. Tofogliflozin, a highly selective inhibitor of SGLT2 blocks proinflammatory and proapoptotic effects of glucose overload on proximal tubular cells partly by suppressing oxidative stress generation. Horm Metab Res 2016; 48(3): 191-5.
    • (2016) Horm Metab Res , vol.48 , Issue.3 , pp. 191-195
    • Ishibashi, Y.1    Matsui, T.2    Yamagishi, S.3
  • 166
    • 84885476895 scopus 로고    scopus 로고
    • Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
    • Tahara A, Kurosaki E, Yokono M, et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol 2013; 715(1-3): 246-55.
    • (2013) Eur J Pharmacol , vol.715 , Issue.1-3 , pp. 246-255
    • Tahara, A.1    Kurosaki, E.2    Yokono, M.3
  • 167
    • 84902536157 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin induced type 1 diabetic rats
    • Tahara A, Kurosaki E, Yokono M, et al. Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin induced type 1 diabetic rats. J Pharm Pharmacol 2014; 66(7): 975-87.
    • (2014) J Pharm Pharmacol , vol.66 , Issue.7 , pp. 975-987
    • Tahara, A.1    Kurosaki, E.2    Yokono, M.3
  • 168
    • 84975501232 scopus 로고    scopus 로고
    • Changes in levels of biomarkers associated with adipocyte function and insulin and glucagon kinetics during treatment with dapagliflozin among obese type 2 diabetes mellitus patients
    • Jun, [Epub ahead of print]
    • Okamoto A, Yokokawa H, Sanada H, Naito T. Changes in levels of biomarkers associated with adipocyte function and insulin and glucagon kinetics during treatment with dapagliflozin among obese type 2 diabetes mellitus patients. Drugs R D 2016 Jun 22. [Epub ahead of print]
    • (2016) Drugs R D , pp. 22
    • Okamoto, A.1    Yokokawa, H.2    Sanada, H.3    Naito, T.4
  • 169
    • 84994180780 scopus 로고    scopus 로고
    • EMPA-REG OUTCOME investigators. Empagliflozin and progression of kidney disease in type 2 diabetes
    • Wanner C, Inzucchi SE, Lachin JM, et al; EMPA-REG OUTCOME investigators. empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med.2016; 375(4): 323-34.
    • (2016) N Engl J Med , vol.375 , Issue.4 , pp. 323-334
    • Wanner, C.1    Inzucchi, S.E.2    Lachin, J.M.3
  • 170
    • 84970027946 scopus 로고    scopus 로고
    • The effect of dapagliflozin on renal function in patients with type 2 diabetes
    • Kohan DE, Fioretto P, Johnsson K, Parikh S, Ptaszynska A, Ying L. The effect of dapagliflozin on renal function in patients with type 2 diabetes. J Nephrol 2016; 29(3): 391-400.
    • (2016) J Nephrol , vol.29 , Issue.3 , pp. 391-400
    • Kohan, D.E.1    Fioretto, P.2    Johnsson, K.3    Parikh, S.4    Ptaszynska, A.5    Ying, L.6
  • 171
    • 84961806532 scopus 로고    scopus 로고
    • Cystatin C-and creatinine-based estimates of glomerular filtration rate in dapagliflozin phase 3 clinical trials
    • Mende C, Katz A. Cystatin C-and creatinine-based estimates of glomerular filtration rate in dapagliflozin phase 3 clinical trials. Diabetes Ther 2016; 7(1): 139-51.
    • (2016) Diabetes Ther , vol.7 , Issue.1 , pp. 139-151
    • Mende, C.1    Katz, A.2
  • 172
    • 84977071302 scopus 로고    scopus 로고
    • Impact of age and estimated glomerular filtration rate on the glycemic efficacy and safety of canagliflozin: A pooled analysis of clinical studies
    • Gilbert RE, Weir MR, Fioretto P, et al. Impact of age and estimated glomerular filtration rate on the glycemic efficacy and safety of canagliflozin: a pooled analysis of clinical studies. Can J Diabetes 2016; 40(3): 247-57.
    • (2016) Can J Diabetes , vol.40 , Issue.3 , pp. 247-257
    • Gilbert, R.E.1    Weir, M.R.2    Fioretto, P.3
  • 173
    • 84957581904 scopus 로고    scopus 로고
    • Impact of reduced renal function on the glucose-lowering effects of luseogliflozin, a selective sglt2 inhibitor, assessed by continuous Glucose Monitoring in Japanese Patients with Type 2 Diabetes Mellitus
    • Jinnouchi H, Nozaki K, Watase H, Omiya H, Sakai S, Samukawa Y. Impact of reduced renal function on the glucose-lowering effects of luseogliflozin, a selective sglt2 inhibitor, assessed by continuous Glucose Monitoring in Japanese Patients with Type 2 Diabetes Mellitus. Adv Ther 2016; 33(3): 460-79.
    • (2016) Adv Ther , vol.33 , Issue.3 , pp. 460-479
    • Jinnouchi, H.1    Nozaki, K.2    Watase, H.3    Omiya, H.4    Sakai, S.5    Samukawa, Y.6
  • 174
    • 84920772335 scopus 로고    scopus 로고
    • LX4211 therapy reduces postprandial glucose levels in patients with type 2 diabetes mellitus and renal impairment despite low urinary glucose excretion
    • Zambrowicz B, Lapuerta P, Strumph P, et al. LX4211 therapy reduces postprandial glucose levels in patients with type 2 diabetes mellitus and renal impairment despite low urinary glucose excretion. Clin Ther 2015; 37(1): 71-82.e12.
    • (2015) Clin Ther , vol.37 , Issue.1
    • Zambrowicz, B.1    Lapuerta, P.2    Strumph, P.3
  • 175
    • 84964010047 scopus 로고    scopus 로고
    • The kidney and type 2 diabetes mellitus: Therapeutic implications of SGLT2 inhibitors
    • Weir MR. The kidney and type 2 diabetes mellitus: therapeutic implications of SGLT2 inhibitors. Postgrad Med 2016; 128(3): 290-8.
    • (2016) Postgrad Med , vol.128 , Issue.3 , pp. 290-298
    • Weir, M.R.1
  • 176
    • 85010952053 scopus 로고    scopus 로고
    • Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers
    • Heerspink HJ, Johnsson E, Gause-Nilsson I, Cain VA, Sjostrom CD. Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers. Diabetes Obes Metab 2016; 18(6): 590-7.
    • (2016) Diabetes Obes Metab , vol.18 , Issue.6 , pp. 590-597
    • Heerspink, H.J.1    Johnsson, E.2    Gause-Nilsson, I.3    Cain, V.A.4    Sjostrom, C.D.5
  • 177
    • 84974816065 scopus 로고    scopus 로고
    • Dapagliflozin reduces albuminuria over 2 years in patients with type 2 diabetes mellitus and renal impairment
    • Fioretto P, Stefansson BV, Johnsson E, Cain VA, Sjostrom CD. Dapagliflozin reduces albuminuria over 2 years in patients with type 2 diabetes mellitus and renal impairment. Diabetologia 2016; 59(9): 2036-9.
    • (2016) Diabetologia , vol.59 , Issue.9 , pp. 2036-2039
    • Fioretto, P.1    Stefansson, B.V.2    Johnsson, E.3    Cain, V.A.4    Sjostrom, C.D.5
  • 178
    • 84996493998 scopus 로고    scopus 로고
    • Canagliflozin slows progression of renal function decline independently of glycemic effects
    • Aug 18. pii: ASN.2016030278. [Epub ahead of print]
    • Heerspink HJ, Desai M, Jardine M, Balis D, Meininger G, Perkovic V. Canagliflozin slows progression of renal function decline independently of glycemic effects. J Am Soc Nephrol 2016 Aug 18. pii: ASN.2016030278. [Epub ahead of print]
    • (2016) J am Soc Nephrol
    • Heerspink, H.J.1    Desai, M.2    Jardine, M.3    Balis, D.4    Meininger, G.5    Perkovic, V.6
  • 179
    • 84975153660 scopus 로고    scopus 로고
    • The effect of sodium glucose cotransporter 2 inhibition with empagliflozin on microalbuminuria and macroalbuminuria in patients with type 2 diabetes
    • Cherney D, Lund SS, Perkins BA, et al. The effect of sodium glucose cotransporter 2 inhibition with empagliflozin on microalbuminuria and macroalbuminuria in patients with type 2 diabetes. Diabetologia 2016; 59(9): 1860-70.
    • (2016) Diabetologia , vol.59 , Issue.9 , pp. 1860-1870
    • Cherney, D.1    Lund, S.S.2    Perkins, B.A.3
  • 180
    • 84930214161 scopus 로고    scopus 로고
    • Empagliflozin, an inhibitor of sodium-glucose cotransporter 2 exerts antiinflammatory and antifibrotic effects on experimental diabetic nephropathy partly by suppressing AGEs-receptor axis
    • Ojima A, Matsui T, Nishino Y, Nakamura N, Yamagishi S. Empagliflozin, an inhibitor of sodium-glucose cotransporter 2 exerts antiinflammatory and antifibrotic effects on experimental diabetic nephropathy partly by suppressing AGEs-receptor axis. Horm Metab Res 2015; 47(9): 686-92.
    • (2015) Horm Metab Res , vol.47 , Issue.9 , pp. 686-692
    • Ojima, A.1    Matsui, T.2    Nishino, Y.3    Nakamura, N.4    Yamagishi, S.5
  • 181
    • 84918531200 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter-2 inhibition and the potential for renal protection in diabetic nephropathy
    • Škrtić M, Cherney DZ. Sodium-glucose cotransporter-2 inhibition and the potential for renal protection in diabetic nephropathy. Curr Opin Nephrol Hypertens 2015; 24(1): 96-103.
    • (2015) Curr Opin Nephrol Hypertens , vol.24 , Issue.1 , pp. 96-103
    • Škrtić, M.1    Cherney, D.Z.2
  • 182
    • 84958548824 scopus 로고    scopus 로고
    • Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: A meta-analysis
    • Sonesson C, Johansson PA, Johnsson E, Gause-Nilsson I. Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis. Cardiovasc Diabetol 2016; 15: 37.
    • (2016) Cardiovasc Diabetol , vol.15 , pp. 37
    • Sonesson, C.1    Johansson, P.A.2    Johnsson, E.3    Gause-Nilsson, I.4
  • 183
    • 84932619134 scopus 로고    scopus 로고
    • Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in diabetic patients: A meta-analysis
    • Savarese G, Perrone-Filardi P, D’Amore C, et al. Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in diabetic patients: A meta-analysis. Int J Cardiol 2015; 181: 239-44.
    • (2015) Int J Cardiol , vol.181 , pp. 239-244
    • Savarese, G.1    Perrone-Filardi, P.2    D’amore, C.3
  • 184
    • 84962613532 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: A systematic review and meta-analysis
    • Wu JH, Foote C, Blomster J, Toyama T, Perkovic V, Sundstrom J, Neal B. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2016; 4(5): 411-9.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , Issue.5 , pp. 411-419
    • Wu, J.H.1    Foote, C.2    Blomster, J.3    Toyama, T.4    Perkovic, V.5    Sundstrom, J.6    Neal, B.7
  • 185
    • 84866424717 scopus 로고    scopus 로고
    • High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes
    • Boonman-de Winter LJ, Rutten FH, Cramer MJ, et al. High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes. Diabetologia 2012; 55(8): 2154-62.
    • (2012) Diabetologia , vol.55 , Issue.8 , pp. 2154-2162
    • Boonman-De Winter, L.J.1    Rutten, F.H.2    Cramer, M.J.3
  • 186
    • 77949790713 scopus 로고    scopus 로고
    • Prevalence, clinical characteristics and outcome in patients with chronic heart failure and diabetes
    • Shi C, Wang LJ, Hu DF, et al. Prevalence, clinical characteristics and outcome in patients with chronic heart failure and diabetes. Chin Med J (Engl) 2010; 123(6): 646-50.
    • (2010) Chin Med J (Engl) , vol.123 , Issue.6 , pp. 646-650
    • Shi, C.1    Wang, L.J.2    Hu, D.F.3
  • 187
    • 84942939218 scopus 로고    scopus 로고
    • Glycemia Lowering and Risk for Heart Failure: Recent Evidence from Studies of Dipeptidyl Peptidase Inhibition
    • Zhong J, Goud A, Rajagopalan S. Glycemia Lowering and Risk for Heart Failure: Recent Evidence from Studies of Dipeptidyl Peptidase Inhibition. Circ Heart Fail 2015; 8(4): 819-25.
    • (2015) Circ Heart Fail , vol.8 , Issue.4 , pp. 819-825
    • Zhong, J.1    Goud, A.2    Rajagopalan, S.3
  • 188
    • 84879207411 scopus 로고    scopus 로고
    • Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: Systematic review of observational studies involving 34, 000 patients
    • Eurich DT, Weir DL, Majumdar SR, et al. Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34, 000 patients. Circ Heart Fail 2013; 6: 395–402.
    • (2013) Circ Heart Fail , vol.6 , pp. 395-402
    • Eurich, D.T.1    Weir, D.L.2    Majumdar, S.R.3
  • 189
    • 84971280392 scopus 로고    scopus 로고
    • Heart failure considerations of antihyperglycemic medications for type 2 diabetes
    • Standl E, Schnell O, McGuire DK. Heart failure considerations of antihyperglycemic medications for type 2 diabetes. Circ Res 2016; 118(11): 1830-43.
    • (2016) Circ Res , vol.118 , Issue.11 , pp. 1830-1843
    • Standl, E.1    Schnell, O.2    McGuire, D.K.3
  • 190
    • 84883765959 scopus 로고    scopus 로고
    • SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al; SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013; 369(14): 1317-26.
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 191
    • 84883745765 scopus 로고    scopus 로고
    • EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • White WB, Cannon CP, Heller SR, et al. EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 2013; 369: 1327–1335.
    • (2013) N Engl J Med , vol.369 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 192
    • 84930085787 scopus 로고    scopus 로고
    • EXAMINE Investigators. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: A multicentre, randomised, double-blind trial
    • Zannad F, Cannon CP, Cushman WC, et al. EXAMINE Investigators. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet 2015; 385: 2067-2076.
    • (2015) Lancet , vol.385 , pp. 2067-2076
    • Zannad, F.1    Cannon, C.P.2    Cushman, W.C.3
  • 193
    • 84937053742 scopus 로고    scopus 로고
    • TECOS Study Group. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
    • 193] Green JB, Bethel MA, Armstrong PW, et al. TECOS Study Group. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med 2015; 373: 232-242.
    • (2015) N Engl J Med , vol.373 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3
  • 194
    • 84960100350 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: Systematic review and metaanalysis of randomised and observational studies
    • Li L, Li S, Deng K, et al. Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and metaanalysis of randomised and observational studies. BMJ 2016; 352: i610.
    • (2016) BMJ , vol.352 , pp. 610
    • Li, L.1    Li, S.2    Deng, K.3
  • 195
    • 84904007147 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: Meta-analysis of randomized clinical trials with 55, 141 participants
    • Wu S, Hopper I, Skiba M, Krum H. Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: meta-analysis of randomized clinical trials with 55, 141 participants. Cardiovasc Ther 2014; 32(4): 147-58.
    • (2014) Cardiovasc Ther , vol.32 , Issue.4 , pp. 147-158
    • Wu, S.1    Hopper, I.2    Skiba, M.3    Krum, H.4
  • 196
    • 85007452917 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists and heart failure in type 2 diabetes: Systematic review and metaanalysis of randomized and observational studies
    • Li L, Li S, Liu J, et al. Glucagon-like peptide-1 receptor agonists and heart failure in type 2 diabetes: systematic review and metaanalysis of randomized and observational studies. BMC Cardiovasc Disord 2016; 16: 91.
    • (2016) BMC Cardiovasc Disord , vol.16 , pp. 91
    • Li, L.1    Li, S.2    Liu, J.3
  • 197
    • 84978839381 scopus 로고    scopus 로고
    • LEADER steering committee; LEADER trial investigators. Liraglutide and cardiovascular outcomes in type 2 diabetes
    • Marso SP, Daniels GH, Brown-Frandsen K, et al; LEADER steering committee; LEADER trial investigators. liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2016; 375(4): 311-22.
    • (2016) N Engl J Med , vol.375 , Issue.4 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Brown-Frandsen, K.3
  • 198
    • 85007418008 scopus 로고    scopus 로고
    • Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: The CANDLE trial
    • Tanaka A, Inoue T, Kitakaze M, et al. Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial. Cardiovasc Diabetol 2016; 15: 57.
    • (2016) Cardiovasc Diabetol , vol.15 , pp. 57
    • Tanaka, A.1    Inoue, T.2    Kitakaze, M.3
  • 199
    • 84943517417 scopus 로고    scopus 로고
    • Diuretic effects of sodiumglucose cotransporter 2 inhibitor in patients with type 2 diabetes mellitus and heart failure
    • Takeuchi T, Dohi K, Omori T, et al. Diuretic effects of sodiumglucose cotransporter 2 inhibitor in patients with type 2 diabetes mellitus and heart failure. Int J Cardiol 2015; 201: 1-3.
    • (2015) Int J Cardiol , vol.201 , pp. 1-3
    • Takeuchi, T.1    Dohi, K.2    Omori, T.3
  • 200
    • 84964507777 scopus 로고    scopus 로고
    • SGLT2 Inhibition and cardiovascular events: Why did EMPA-REG Outcomes surprise and what were the likely mechanisms?
    • Sattar N, McLaren J, Kristensen SL, Preiss D, McMurray JJ. SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms? Diabetologia 2016; 59(7): 1333-9.
    • (2016) Diabetologia , vol.59 , Issue.7 , pp. 1333-1339
    • Sattar, N.1    McLaren, J.2    Kristensen, S.L.3    Preiss, D.4    McMurray, J.J.5
  • 201
    • 84975840750 scopus 로고    scopus 로고
    • Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
    • Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? a unifying hypothesis. Diabetes Care 2016; 39(7): 1115-22.
    • (2016) Diabetes Care , vol.39 , Issue.7 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 202
    • 84922005208 scopus 로고    scopus 로고
    • Dapagliflozin reduces the amplitude of shortening and Ca(2+) transient in ventricular myocytes from streptozotocininduced diabetic rats
    • Hamouda NN, Sydorenko V, Qureshi MA, Alkaabi JM, Oz M, Howarth FC. Dapagliflozin reduces the amplitude of shortening and Ca(2+) transient in ventricular myocytes from streptozotocininduced diabetic rats. Mol Cell Biochem 2015; 400(1-2): 57-68.
    • (2015) Mol Cell Biochem , vol.400 , Issue.1-2 , pp. 57-68
    • Hamouda, N.N.1    Sydorenko, V.2    Qureshi, M.A.3    Alkaabi, J.M.4    Oz, M.5    Howarth, F.C.6
  • 203
    • 84876665073 scopus 로고    scopus 로고
    • The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study
    • Ring A, Brand T, Macha S, et al. The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study. Cardiovasc Diabetol 2013; 12: 70.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 70
    • Ring, A.1    Brand, T.2    Macha, S.3
  • 204
    • 80052805929 scopus 로고    scopus 로고
    • Evaluation of the effect of dapagliflozin on cardiac repolarization: A thorough QT/QTc study
    • Carlson GF, Tou CK, Parikh S, Birmingham BK, Butler K. Evaluation of the effect of dapagliflozin on cardiac repolarization: a thorough QT/QTc study. Diabetes Ther 2011; 2(3): 123-32
    • (2011) Diabetes Ther , vol.2 , Issue.3 , pp. 123-132
    • Carlson, G.F.1    Tou, C.K.2    Parikh, S.3    Birmingham, B.K.4    Butler, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.