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Volumn 18, Issue 8, 2016, Pages 783-794

Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis

Author keywords

canagliflozin; dapagliflozin; empagliflozin; meta analysis; review; SGLT2 inhibitor; systematic

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; PLACEBO; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SULFONYLUREA; 2-(3-(4-ETHOXYBENZYL)-4-CHLOROPHENYL)-6-HYDROXYMETHYLTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; ANTIDIABETIC AGENT; B CELL ACTIVATING FACTOR; BENZHYDRYL DERIVATIVE; GLUCOSE BLOOD LEVEL; GLUCOSIDE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 84969915634     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12670     Document Type: Article
Times cited : (393)

References (74)
  • 1
    • 64649104158 scopus 로고    scopus 로고
    • Banting lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
    • Defronzo RA. Banting lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009; 58: 773–795.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 2
    • 84901768284 scopus 로고    scopus 로고
    • Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes
    • Holman RR, Sourij H, Califf RM. Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes. Lancet 2014; 383: 2008–2017.
    • (2014) Lancet , vol.383 , pp. 2008-2017
    • Holman, R.R.1    Sourij, H.2    Califf, R.M.3
  • 3
    • 84925489733 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB et al. Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2015; 58: 429–442.
    • (2015) Diabetologia , vol.58 , pp. 429-442
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 4
    • 84914173984 scopus 로고    scopus 로고
    • Lowering plasma glucose concentration by inhibiting renal sodium-glucose cotransport
    • Abdul-Ghani MA, DeFronzo RA. Lowering plasma glucose concentration by inhibiting renal sodium-glucose cotransport. J Intern Med 2014; 276: 352–363.
    • (2014) J Intern Med , vol.276 , pp. 352-363
    • Abdul-Ghani, M.A.1    DeFronzo, R.A.2
  • 5
    • 84864283226 scopus 로고    scopus 로고
    • SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
    • Ferrannini E, Solini A. SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 2012; 8: 495–502.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 495-502
    • Ferrannini, E.1    Solini, A.2
  • 6
    • 51149095603 scopus 로고    scopus 로고
    • Use of indirect and mixed treatment comparisons for technology assessment
    • Sutton A, Ades AE, Cooper N, Abrams K. Use of indirect and mixed treatment comparisons for technology assessment. Pharmacoeconomics 2008; 26: 753–767.
    • (2008) Pharmacoeconomics , vol.26 , pp. 753-767
    • Sutton, A.1    Ades, A.E.2    Cooper, N.3    Abrams, K.4
  • 7
    • 84896381773 scopus 로고    scopus 로고
    • Indirect treatment comparison/network meta-analysis study questionnaire to assess relevance and credibility to inform health care decision making: an ISPOR-AMCP-NPC Good Practice Task Force report
    • Jansen JP, Trikalinos T, Cappelleri JC et al. Indirect treatment comparison/network meta-analysis study questionnaire to assess relevance and credibility to inform health care decision making: an ISPOR-AMCP-NPC Good Practice Task Force report. Value Health 2014; 17: 157–173.
    • (2014) Value Health , vol.17 , pp. 157-173
    • Jansen, J.P.1    Trikalinos, T.2    Cappelleri, J.C.3
  • 8
    • 84925548115 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62: 1006–1012.
    • (2009) J Clin Epidemiol , vol.62 , pp. 1006-1012
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 9
    • 79959960493 scopus 로고    scopus 로고
    • Conducting indirect-treatment-comparison and network-meta-analysis studies: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 2
    • Hoaglin DC, Hawkins N, Jansen JP et al. Conducting indirect-treatment-comparison and network-meta-analysis studies: report of the ISPOR Task Force on Indirect Treatment Comparisons Good Research Practices: part 2. Value Health 2011; 14: 429–437.
    • (2011) Value Health , vol.14 , pp. 429-437
    • Hoaglin, D.C.1    Hawkins, N.2    Jansen, J.P.3
  • 10
    • 84932084410 scopus 로고    scopus 로고
    • The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations
    • Hutton B, Salanti G, Caldwell DM et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 2015; 162: 777–784.
    • (2015) Ann Intern Med , vol.162 , pp. 777-784
    • Hutton, B.1    Salanti, G.2    Caldwell, D.M.3
  • 11
    • 84859001212 scopus 로고    scopus 로고
    • The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
    • Higgins JP, Altman DG, Gøtzsche PC et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; 343: d5928.
    • (2011) BMJ , vol.343 , pp. d5928
    • Higgins, J.P.1    Altman, D.G.2    Gøtzsche, P.C.3
  • 13
    • 84940314614 scopus 로고    scopus 로고
    • Available from, Accessed 15 February 2016
    • Multiple-Treatments Meta-Analysis. Using STATA for network meta-analysis. Available from URL: http://www.mtm.uoi.gr/index.php/stata-routines-for-network-meta-analysis. Accessed 15 February 2016.
    • Using STATA for network meta-analysis
  • 14
    • 79960824714 scopus 로고    scopus 로고
    • Multivariate random-effects meta-regression: updates to mvmeta
    • White IR. Multivariate random-effects meta-regression: updates to mvmeta. Stata J 2011; 11: 255–270.
    • (2011) Stata J , vol.11 , pp. 255-270
    • White, I.R.1
  • 15
    • 84875612338 scopus 로고    scopus 로고
    • Consistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regression
    • White IR, Barrett JK, Jackson D, Higgins JP. Consistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regression. Res Synth Methods 2012; 3: 111–125.
    • (2012) Res Synth Methods , vol.3 , pp. 111-125
    • White, I.R.1    Barrett, J.K.2    Jackson, D.3    Higgins, J.P.4
  • 18
    • 78650509651 scopus 로고    scopus 로고
    • Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial
    • Salanti G, Ades AE, Ioannidis JP. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol 2011; 64: 163–171.
    • (2011) J Clin Epidemiol , vol.64 , pp. 163-171
    • Salanti, G.1    Ades, A.E.2    Ioannidis, J.P.3
  • 19
    • 84905565481 scopus 로고    scopus 로고
    • A design-by-treatment interaction model for network meta-analysis with random inconsistency effects
    • Jackson D, Barrett JK, Rice S, White IR, Higgins JP. A design-by-treatment interaction model for network meta-analysis with random inconsistency effects. Stat Med 2014; 33: 3639–3654.
    • (2014) Stat Med , vol.33 , pp. 3639-3654
    • Jackson, D.1    Barrett, J.K.2    Rice, S.3    White, I.R.4    Higgins, J.P.5
  • 20
    • 84931957000 scopus 로고    scopus 로고
    • Long-term treatment with empagliflozin as add-on to oral antidiabetes therapy in Japanese patients with type 2 diabetes mellitus
    • Araki E, Tanizawa Y, Tanaka Y et al. Long-term treatment with empagliflozin as add-on to oral antidiabetes therapy in Japanese patients with type 2 diabetes mellitus. Diabetes Obes Metab 2015; 17: 665–674.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 665-674
    • Araki, E.1    Tanizawa, Y.2    Tanaka, Y.3
  • 21
    • 84866003015 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in drug-naive patients with diabetes: a randomized-controlled trial of low-dose range
    • Bailey CJ, Iqbal N, T'Joen C, List JF. Dapagliflozin monotherapy in drug-naive patients with diabetes: a randomized-controlled trial of low-dose range. Diabetes Obes Metab 2012; 14: 951–959.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 951-959
    • Bailey, C.J.1    Iqbal, N.2    T'Joen, C.3    List, J.F.4
  • 22
    • 84873960885 scopus 로고    scopus 로고
    • Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial
    • Bailey CJ, Gross JL, Hennicken D, Iqbal N, Mansfield TA, List JF. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med 2013; 11: 43.
    • (2013) BMC Med , vol.11 , pp. 43
    • Bailey, C.J.1    Gross, J.L.2    Hennicken, D.3    Iqbal, N.4    Mansfield, T.A.5    List, J.F.6
  • 23
    • 84924708763 scopus 로고    scopus 로고
    • Efficacy and safety of dapagliflozin monotherapy in people with Type 2 diabetes: a randomized double-blind placebo-controlled 102-week trial
    • Bailey CJ, Morales Villegas EC, Woo V et al. Efficacy and safety of dapagliflozin monotherapy in people with Type 2 diabetes: a randomized double-blind placebo-controlled 102-week trial. Diabet Med 2015; 32: 531–541.
    • (2015) Diabet Med , vol.32 , pp. 531-541
    • Bailey, C.J.1    Morales Villegas, E.C.2    Woo, V.3
  • 24
    • 84964240560 scopus 로고    scopus 로고
    • Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55–80 years with type 2 diabetes
    • Bode B, Stenlöf K, Harris S et al. Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55–80 years with type 2 diabetes. Diabetes Obes Metab 2015; 17: 294–303.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 294-303
    • Bode, B.1    Stenlöf, K.2    Harris, S.3
  • 25
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • Bolinder J, Ljunggren Ö, Johansson L et al. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab 2014; 16: 159–169.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 159-169
    • Bolinder, J.1    Ljunggren, Ö.2    Johansson, L.3
  • 26
    • 84945175811 scopus 로고    scopus 로고
    • Dapagliflozin's effects on glycemia and cardiovascular risk factors in high-risk patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension
    • Cefalu WT, Leiter LA, de Bruin TW, Gause-Nilsson I, Sugg J, Parikh SJ. Dapagliflozin's effects on glycemia and cardiovascular risk factors in high-risk patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension. Diabetes Care 2015; 38: 1218–1227.
    • (2015) Diabetes Care , vol.38 , pp. 1218-1227
    • Cefalu, W.T.1    Leiter, L.A.2    de Bruin, T.W.3    Gause-Nilsson, I.4    Sugg, J.5    Parikh, S.J.6
  • 27
    • 84928176749 scopus 로고    scopus 로고
    • Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin
    • DeFronzo RA, Lewin A, Patel S et al. Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin. Diabetes Care 2015; 38: 384–393.
    • (2015) Diabetes Care , vol.38 , pp. 384-393
    • DeFronzo, R.A.1    Lewin, A.2    Patel, S.3
  • 28
    • 84928426587 scopus 로고    scopus 로고
    • Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data
    • Del Prato S, Nauck M, Durán-Garcia S et al. Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data. Diabetes Obes Metab 2015; 17: 581–590.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 581-590
    • Del Prato, S.1    Nauck, M.2    Durán-Garcia, S.3
  • 29
    • 84891851923 scopus 로고    scopus 로고
    • Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    • Ferrannini E, Berk A, Hantel S et al. Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care 2013; 36: 4015–4021.
    • (2013) Diabetes Care , vol.36 , pp. 4015-4021
    • Ferrannini, E.1    Berk, A.2    Hantel, S.3
  • 30
    • 84898791440 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone
    • Forst T, Guthrie R, Goldenberg R et al. Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes on background metformin and pioglitazone. Diabetes Obes Metab 2014; 16: 467–477.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 467-477
    • Forst, T.1    Guthrie, R.2    Goldenberg, R.3
  • 31
    • 84943200890 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin plus sulphonylurea in patients with type 2 diabetes
    • Haering HU, Merker L, Christiansen AV et al. Empagliflozin as add-on to metformin plus sulphonylurea in patients with type 2 diabetes. Diabetes Res Clin Pract 2015; 110: 82–90.
    • (2015) Diabetes Res Clin Pract , vol.110 , pp. 82-90
    • Haering, H.U.1    Merker, L.2    Christiansen, A.V.3
  • 32
    • 84860218907 scopus 로고    scopus 로고
    • Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
    • Henry RR, Murray AV, Marmolejo MH, Hennicken D, Ptaszynska A, List JF. Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract 2012; 66: 446–456.
    • (2012) Int J Clin Pract , vol.66 , pp. 446-456
    • Henry, R.R.1    Murray, A.V.2    Marmolejo, M.H.3    Hennicken, D.4    Ptaszynska, A.5    List, J.F.6
  • 33
    • 84904207974 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled with diet and exercise: a 24-week, randomized, double-blind, placebo-controlled, phase III study
    • Inagaki N, Kondo K, Yoshinari T, Takahashi N, Susuta Y, Kuki H. Efficacy and safety of canagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled with diet and exercise: a 24-week, randomized, double-blind, placebo-controlled, phase III study. Expert Opin Pharmacother 2014; 15: 1501–1515.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 1501-1515
    • Inagaki, N.1    Kondo, K.2    Yoshinari, T.3    Takahashi, N.4    Susuta, Y.5    Kuki, H.6
  • 34
    • 84896701131 scopus 로고    scopus 로고
    • Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study
    • Jabbour SA, Hardy E, Sugg J, Parikh S. Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study. Diabetes Care 2014; 37: 740–750.
    • (2014) Diabetes Care , vol.37 , pp. 740-750
    • Jabbour, S.A.1    Hardy, E.2    Sugg, J.3    Parikh, S.4
  • 35
    • 84892368256 scopus 로고    scopus 로고
    • Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study
    • Ji L, Ma J, Li H et al. Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study. Clin Ther 2014; 36: 84–100.
    • (2014) Clin Ther , vol.36 , pp. 84-100
    • Ji, L.1    Ma, J.2    Li, H.3
  • 36
    • 84936928500 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin monotherapy for 52 weeks in Japanese patients with type 2 diabetes: a randomized, double-blind, parallel-group study
    • Kadowaki T, Haneda M, Inagaki N et al. Efficacy and safety of empagliflozin monotherapy for 52 weeks in Japanese patients with type 2 diabetes: a randomized, double-blind, parallel-group study. Adv Ther 2015; 32: 306–318.
    • (2015) Adv Ther , vol.32 , pp. 306-318
    • Kadowaki, T.1    Haneda, M.2    Inagaki, N.3
  • 37
    • 84914181817 scopus 로고    scopus 로고
    • Efficacy and safety of dapagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise
    • Kaku K, Kiyosue A, Inoue S et al. Efficacy and safety of dapagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise. Diabetes Obes Metab 2014; 16: 1102–1110.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1102-1110
    • Kaku, K.1    Kiyosue, A.2    Inoue, S.3
  • 38
    • 84940575211 scopus 로고    scopus 로고
    • Empagliflozin as add-on therapy to pioglitazone with or without metformin in patients with type 2 diabetes mellitus
    • Kovacs CS, Seshiah V, Merker L et al. Empagliflozin as add-on therapy to pioglitazone with or without metformin in patients with type 2 diabetes mellitus. Clin Ther 2015; 37: 1773–1788.
    • (2015) Clin Ther , vol.37 , pp. 1773-1788
    • Kovacs, C.S.1    Seshiah, V.2    Merker, L.3
  • 39
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial
    • Lavalle-González FJ, Januszewicz A, Davidson J et al. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial. Diabetologia 2013; 56: 2582–2592.
    • (2013) Diabetologia , vol.56 , pp. 2582-2592
    • Lavalle-González, F.J.1    Januszewicz, A.2    Davidson, J.3
  • 40
    • 84904466033 scopus 로고    scopus 로고
    • Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension
    • Leiter LA, Cefalu WT, de Bruin TW, Gause-Nilsson I, Sugg J, Parikh SJ. Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension. J Am Geriatr Soc 2014; 62: 1252–1262.
    • (2014) J Am Geriatr Soc , vol.62 , pp. 1252-1262
    • Leiter, L.A.1    Cefalu, W.T.2    de Bruin, T.W.3    Gause-Nilsson, I.4    Sugg, J.5    Parikh, S.J.6
  • 41
    • 84940110139 scopus 로고    scopus 로고
    • Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study
    • Leiter LA, Yoon KH, Arias P et al. Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study. Diabetes Care 2015; 38: 355–364.
    • (2015) Diabetes Care , vol.38 , pp. 355-364
    • Leiter, L.A.1    Yoon, K.H.2    Arias, P.3
  • 42
    • 84928199102 scopus 로고    scopus 로고
    • Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes
    • Lewin A, DeFronzo RA, Patel S et al. Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes. Diabetes Care 2015; 38: 394–402.
    • (2015) Diabetes Care , vol.38 , pp. 394-402
    • Lewin, A.1    DeFronzo, R.A.2    Patel, S.3
  • 43
    • 84944597723 scopus 로고    scopus 로고
    • Durability and tolerability of dapagliflozin over 52 weeks as add-on to metformin and sulphonylurea in type 2 diabetes
    • Matthaei S, Bowering K, Rohwedder K, Sugg J, Parikh S, Johnsson E. Durability and tolerability of dapagliflozin over 52 weeks as add-on to metformin and sulphonylurea in type 2 diabetes. Diabetes Obes Metab 2015; 17: 1075–1084.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1075-1084
    • Matthaei, S.1    Bowering, K.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5    Johnsson, E.6
  • 44
    • 84983201802 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin in people with type 2 diabetes
    • Merker L, Häring HU, Christiansen AV et al. Empagliflozin as add-on to metformin in people with type 2 diabetes. Diabet Med 2015; 32: 1555–1567.
    • (2015) Diabet Med , vol.32 , pp. 1555-1567
    • Merker, L.1    Häring, H.U.2    Christiansen, A.V.3
  • 45
    • 84930844091 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin, an inhibitor of sodium-glucose cotransporter 2, when used in conjunction with insulin therapy in patients with type 2 diabetes
    • Neal B, Perkovic V, de Zeeuw D et al. Efficacy and safety of canagliflozin, an inhibitor of sodium-glucose cotransporter 2, when used in conjunction with insulin therapy in patients with type 2 diabetes. Diabetes Care 2015; 38: 403–411.
    • (2015) Diabetes Care , vol.38 , pp. 403-411
    • Neal, B.1    Perkovic, V.2    de Zeeuw, D.3
  • 46
    • 84908332537 scopus 로고    scopus 로고
    • Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial
    • Ridderstrale M, Andersen KR, Zeller C, Kim G, Woerle HJ, Broedl UC. Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial. Lancet Diabetes Endocrinol 2014; 2: 691–700.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 691-700
    • Ridderstrale, M.1    Andersen, K.R.2    Zeller, C.3    Kim, G.4    Woerle, H.J.5    Broedl, U.C.6
  • 47
    • 84885954870 scopus 로고    scopus 로고
    • Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial
    • Roden M, Weng J, Eilbracht J et al. Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol 2013; 1: 208–219.
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 208-219
    • Roden, M.1    Weng, J.2    Eilbracht, J.3
  • 48
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycaemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycaemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care 2012; 35: 1473–1478.
    • (2012) Diabetes Care , vol.35 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 49
    • 84903511385 scopus 로고    scopus 로고
    • Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycaemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes
    • Rosenstock J, Jelaska A, Frappin G et al. Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycaemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes. Diabetes Care 2014; 37: 1815–1823.
    • (2014) Diabetes Care , vol.37 , pp. 1815-1823
    • Rosenstock, J.1    Jelaska, A.2    Frappin, G.3
  • 50
    • 84942294658 scopus 로고    scopus 로고
    • Impact of empagliflozin added-on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: a 78-week randomized, double-blind, placebo-controlled trial
    • Rosenstock J, Jelaska A, Zeller C, Kim G, Broedl UC, Woerle HJ. Impact of empagliflozin added-on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: a 78-week randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab 2015; 17: 936–948.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 936-948
    • Rosenstock, J.1    Jelaska, A.2    Zeller, C.3    Kim, G.4    Broedl, U.C.5    Woerle, H.J.6
  • 51
    • 84928201032 scopus 로고    scopus 로고
    • Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin
    • Rosenstock J, Hansen L, Zee P et al. Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin. Diabetes Care 2015; 38: 376–383.
    • (2015) Diabetes Care , vol.38 , pp. 376-383
    • Rosenstock, J.1    Hansen, L.2    Zee, P.3
  • 52
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial
    • Schernthaner G, Gross JL, Rosenstock J et al. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial. Diabetes Care 2013; 36: 2508–2515.
    • (2013) Diabetes Care , vol.36 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 53
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlöf K, Cefalu WT, Kim KA et al. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab 2013; 15: 372–382.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 372-382
    • Stenlöf, K.1    Cefalu, W.T.2    Kim, K.A.3
  • 54
    • 84915809485 scopus 로고    scopus 로고
    • Dapagliflozin added to glimepiride in patients with type 2 diabetes mellitus sustains glycemic control and weight loss over 48 weeks: a randomized, double-blind, parallel-group, placebo-controlled trial
    • Strojek K, Yoon KH, Hruba V, Sugg J, Langkilde AM, Parikh S. Dapagliflozin added to glimepiride in patients with type 2 diabetes mellitus sustains glycemic control and weight loss over 48 weeks: a randomized, double-blind, parallel-group, placebo-controlled trial. Diabetes Ther 2014; 5: 267–283.
    • (2014) Diabetes Ther , vol.5 , pp. 267-283
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Sugg, J.4    Langkilde, A.M.5    Parikh, S.6
  • 55
    • 84888059660 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial
    • Wilding JP, Charpentier G, Hollander P et al. Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial. Int J Clin Pract 2013; 67: 1267–1282.
    • (2013) Int J Clin Pract , vol.67 , pp. 1267-1282
    • Wilding, J.P.1    Charpentier, G.2    Hollander, P.3
  • 56
    • 84892488179 scopus 로고    scopus 로고
    • Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years
    • Wilding JP, Woo V, Rohwedder K, Sugg J, Parikh S. Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years. Diabetes Obes Metab 2014; 16: 124–136.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 124-136
    • Wilding, J.P.1    Woo, V.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5
  • 57
    • 84958650333 scopus 로고    scopus 로고
    • Randomized, double-blind, phase 3 trial of triple therapy with dapagliflozin add-on to saxagliptin plus metformin in type 2 diabetes
    • Mathieu C, Ranetti AE, Li D et al. Randomized, double-blind, phase 3 trial of triple therapy with dapagliflozin add-on to saxagliptin plus metformin in type 2 diabetes. Diabetes Care 2015; 38: 2009–2017.
    • (2015) Diabetes Care , vol.38 , pp. 2009-2017
    • Mathieu, C.1    Ranetti, A.E.2    Li, D.3
  • 58
    • 84898789114 scopus 로고    scopus 로고
    • Dapagliflozin compared with other oral anti-diabetes treatments when added to metformin monotherapy: a systematic review and network meta-analysis
    • Goring S, Hawkins N, Wygant G et al. Dapagliflozin compared with other oral anti-diabetes treatments when added to metformin monotherapy: a systematic review and network meta-analysis. Diabetes Obes Metab 2014; 16: 433–442.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 433-442
    • Goring, S.1    Hawkins, N.2    Wygant, G.3
  • 59
    • 84978864899 scopus 로고    scopus 로고
    • Network meta-analysis (NMA) to assess relative efficacy measured as percentage of patients treated to HbA1c target with canagliflozin in patients with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin and sulphonylurea (MET + SU)
    • Taieb V, Pacou M, Schroeder M, Schubert A, Nielsen AT. Network meta-analysis (NMA) to assess relative efficacy measured as percentage of patients treated to HbA1c target with canagliflozin in patients with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin and sulphonylurea (MET + SU). Value Health 2015; 18: A598.
    • (2015) Value Health , vol.18 , pp. A598
    • Taieb, V.1    Pacou, M.2    Schroeder, M.3    Schubert, A.4    Nielsen, A.T.5
  • 60
    • 84978864899 scopus 로고    scopus 로고
    • Bayesian network meta-analysis (NMA) to assess the relative efficacy of canagliflozin in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with insulin
    • Taieb V, Pacou M, Schroeder M, Nielsen AT, Neslusan C, Schubert A. Bayesian network meta-analysis (NMA) to assess the relative efficacy of canagliflozin in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with insulin. Value Health 2015; 18: A598.
    • (2015) Value Health , vol.18 , pp. A598
    • Taieb, V.1    Pacou, M.2    Schroeder, M.3    Nielsen, A.T.4    Neslusan, C.5    Schubert, A.6
  • 61
    • 84978864899 scopus 로고    scopus 로고
    • A network meta-analysis (NMA) to assess the longer-term relative efficacy of canagliflozin in patients with type 2 diabetes inadequately controlled on metformin
    • Taieb V, Pacou M, Schroeder M, Nielsen AT, Schubert A, Neslusan C. A network meta-analysis (NMA) to assess the longer-term relative efficacy of canagliflozin in patients with type 2 diabetes inadequately controlled on metformin. Value Health 2015; 18: A598.
    • (2015) Value Health , vol.18 , pp. A598
    • Taieb, V.1    Pacou, M.2    Schroeder, M.3    Nielsen, A.T.4    Schubert, A.5    Neslusan, C.6
  • 62
    • 84960433486 scopus 로고    scopus 로고
    • SGLT-2 receptor inhibitors for treating patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
    • Shyangdan DS, Uthman OA, Waugh N. SGLT-2 receptor inhibitors for treating patients with type 2 diabetes mellitus: a systematic review and network meta-analysis. BMJ Open 2016; 6: e009417.
    • (2016) BMJ Open , vol.6
    • Shyangdan, D.S.1    Uthman, O.A.2    Waugh, N.3
  • 63
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman B, Wanner C, Lachin JM et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015; 373: 2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 64
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)–a randomized placebo-controlled trial
    • Neal B, Perkovic V, de Zeeuw D et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)–a randomized placebo-controlled trial. Am Heart J 2013; 166: 217–223.
    • (2013) Am Heart J , vol.166 , pp. 217-223
    • Neal, B.1    Perkovic, V.2    de Zeeuw, D.3
  • 65
    • 84978843801 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from: Accessed 15 February 2016
    • ClinicalTrials.gov. Available from URL: https://clinicaltrials.gov/ct2/show/NCT01730534. Accessed 15 February 2016.
  • 66
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med 2007; 261: 32–43.
    • (2007) J Intern Med , vol.261 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 67
    • 83655184724 scopus 로고    scopus 로고
    • Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
    • Grempler R, Thomas L, Eckhardt M et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab 2012; 14: 83–90.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 83-90
    • Grempler, R.1    Thomas, L.2    Eckhardt, M.3
  • 68
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • Zambrowicz B, Freiman J, Brown PM et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther 2012; 92: 158–169.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3
  • 69
    • 84923502372 scopus 로고    scopus 로고
    • Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy
    • Rosenstock J, Cefalu WT, Lapuerta P et al. Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of SGLT1 and SGLT2, in patients with type 2 diabetes on metformin monotherapy. Diabetes Care 2015; 38: 431–438.
    • (2015) Diabetes Care , vol.38 , pp. 431-438
    • Rosenstock, J.1    Cefalu, W.T.2    Lapuerta, P.3
  • 70
    • 84962339296 scopus 로고    scopus 로고
    • Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition
    • Peters AL, Buschur EO, Buse JB, Cohan P, Diner JC, Hirsch IB. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care 2015; 38: 1687–1693.
    • (2015) Diabetes Care , vol.38 , pp. 1687-1693
    • Peters, A.L.1    Buschur, E.O.2    Buse, J.B.3    Cohan, P.4    Diner, J.C.5    Hirsch, I.B.6
  • 71
    • 84962381148 scopus 로고    scopus 로고
    • Diabetic ketoacidosis and related events in the canagliflozin type 2 diabetes clinical program
    • Erondu N, Desai M, Ways K, Meininger G. Diabetic ketoacidosis and related events in the canagliflozin type 2 diabetes clinical program. Diabetes Care 2015; 38: 1680–1686.
    • (2015) Diabetes Care , vol.38 , pp. 1680-1686
    • Erondu, N.1    Desai, M.2    Ways, K.3    Meininger, G.4
  • 72
    • 72649106871 scopus 로고    scopus 로고
    • Available from: Accessed 15 February 2016
    • Food and Drug Administration. Available from URL: http://www.fda.gov/downloads/Drugs/DrugSafety/UCM461790.pdf. Accessed 15 February 2016.
    • Food and Drug Administration.
  • 73
    • 84954514891 scopus 로고    scopus 로고
    • Effects of canagliflozin on fracture risk in patients with type 2 diabetes mellitus
    • Watts NB, Bilezikian JP, Usiskin K et al. Effects of canagliflozin on fracture risk in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2016; 101: 157–166.
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 157-166
    • Watts, N.B.1    Bilezikian, J.P.2    Usiskin, K.3
  • 74
    • 84962613532 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
    • [Epub before print]
    • Wu JHY, Foote C, Blomster J et al. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2016 [Epub before print]. DOI: 10.1016/S2213-8587(16)00052-8.
    • (2016) Lancet Diabetes Endocrinol
    • Wu, J.H.Y.1    Foote, C.2    Blomster, J.3


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