메뉴 건너뛰기




Volumn 19, Issue 17, 2013, Pages 3124-3131

The role of fibrate treatment in dyslipidemia: An overview

Author keywords

Cardiovascular risk; Diabetes; Dyslipidemia; Fibrates

Indexed keywords

ADIPOCYTOKINE; ATORVASTATIN; ATORVASTATIN PLUS FENOFIBRATE; BEZAFIBRATE; CIPROFIBRATE; COLESEVELAM; EZETIMIBE; FENOFIBRATE; FENOFIBRATE PLUS PRAVASTATIN; FIBRATE PLUS STATINS; FIBRIC ACID DERIVATIVE; FIBRINOGEN; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PLACEBO; PRAVASTATIN; SIMVASTATIN; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84878652813     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319170020     Document Type: Review
Times cited : (115)

References (137)
  • 1
    • 0003661910 scopus 로고    scopus 로고
    • Organization WH, 2012; Available from
    • Organization WH. World Health Statistics. 2012; Available from: http://www.who.int/gho/publications/world_health_statistics/EN_ WHS2012_Full.pdf.
    • (2012) World Health Statistics
  • 2
    • 84862193216 scopus 로고    scopus 로고
    • Management of cardiovascular risk: The importance of meeting lipid targets
    • Gotto AM, Jr., Moon JE. Management of cardiovascular risk: the importance of meeting lipid targets. The American journal of cardiology. 2012; 110(1 Suppl): 3A-14A.
    • (2012) The American journal of cardiology. , vol.110 , Issue.1 SUPPL.
    • Gotto Jr., A.M.1    Moon, J.E.2
  • 4
    • 84862119222 scopus 로고    scopus 로고
    • European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
    • Perk J, De Backer G, Gohlke H, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). European heart journal. 2012; 33(13): 1635-701.
    • (2012) European heart journal. , vol.33 , Issue.13 , pp. 1635-1701
    • Perk, J.1    de Backer, G.2    Gohlke, H.3
  • 5
    • 84858773518 scopus 로고    scopus 로고
    • Should raising highdensity lipoprotein cholesterol be a matter of debate?
    • Athyros VG, Katsiki N, Karagiannis A, et al. Should raising highdensity lipoprotein cholesterol be a matter of debate? J Cardiovasc Med (Hagerstown). 2012; 13(4): 254-9.
    • (2012) J Cardiovasc Med (Hagerstown). , vol.13 , Issue.4 , pp. 254-259
    • Athyros, V.G.1    Katsiki, N.2    Karagiannis, A.3
  • 7
    • 34248183098 scopus 로고    scopus 로고
    • Management of hypertriglyceridemia
    • Oh RC, Lanier JB. Management of hypertriglyceridemia. American family physician. 2007; 75(9): 1365-71.
    • (2007) American family physician. , vol.75 , Issue.9 , pp. 1365-1371
    • Oh, R.C.1    Lanier, J.B.2
  • 9
    • 79955582390 scopus 로고    scopus 로고
    • Assessment and clinical relevance of non-fasting and postprandial triglycerides: An expert panel statement
    • Kolovou GD, Mikhailidis DP, Kovar J, et al. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Current vascular pharmacology. 2011; 9(3): 258-70.
    • (2011) Current vascular pharmacology. , vol.9 , Issue.3 , pp. 258-270
    • Kolovou, G.D.1    Mikhailidis, D.P.2    Kovar, J.3
  • 10
    • 79151484278 scopus 로고    scopus 로고
    • Management of dyslipidemias with fibrates, alone and in combination with statins: Role of delayed-release fenofibric acid
    • Moutzouri E, Kei A, Elisaf MS, et al. Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid. Vascular health and risk management. 2010; 6: 525-39.
    • (2010) Vascular health and risk management. , vol.6 , pp. 525-539
    • Moutzouri, E.1    Kei, A.2    Elisaf, M.S.3
  • 11
    • 0028817459 scopus 로고
    • Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates
    • Staels B, Vu-Dac N, Kosykh VA, et al. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. The Journal of clinical investigation. 1995; 95(2): 705-12.
    • (1995) The Journal of clinical investigation. , vol.95 , Issue.2 , pp. 705-712
    • Staels, B.1    Vu-Dac, N.2    Kosykh, V.A.3
  • 12
    • 0032506273 scopus 로고    scopus 로고
    • Mechanism of action of fibrates on lipid and lipoprotein metabolism
    • Staels B, Dallongeville J, Auwerx J, et al. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation. 1998; 98(19): 2088-93.
    • (1998) Circulation. , vol.98 , Issue.19 , pp. 2088-2093
    • Staels, B.1    Dallongeville, J.2    Auwerx, J.3
  • 13
    • 0344581292 scopus 로고    scopus 로고
    • Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: Relevance for human health and disease
    • Boitier E, Gautier JC, Roberts R. Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. Comparative hepatology. 2003; 2(1): 3.
    • (2003) Comparative hepatology. , vol.2 , Issue.1 , pp. 3
    • Boitier, E.1    Gautier, J.C.2    Roberts, R.3
  • 14
    • 84862858211 scopus 로고    scopus 로고
    • Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): A patent review (2008-present)
    • Lamers C, Schubert-Zsilavecz M, Merk D. Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present). Expert opinion on therapeutic patents. 2012; 22(7): 803-41.
    • (2012) Expert opinion on therapeutic patents. , vol.22 , Issue.7 , pp. 803-841
    • Lamers, C.1    Schubert-Zsilavecz, M.2    Merk, D.3
  • 15
    • 33846623798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
    • Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation. 2007; 115(4): 518-33.
    • (2007) Circulation. , vol.115 , Issue.4 , pp. 518-533
    • Brown, J.D.1    Plutzky, J.2
  • 16
    • 80054761005 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and atherosclerosis
    • Soskic SS, Dobutovic BD, Sudar EM, et al. Peroxisome proliferator-activated receptors and atherosclerosis. Angiology. 2011; 62(7): 523-34.
    • (2011) Angiology. , vol.62 , Issue.7 , pp. 523-534
    • Soskic, S.S.1    Dobutovic, B.D.2    Sudar, E.M.3
  • 17
    • 84868306994 scopus 로고    scopus 로고
    • Sex-Specific Differences in Type 2 Diabetes Mellitus and Dyslipidemia Therapy: PPAR Agonists
    • Benz V, Kintscher U, Foryst-Ludwig A. Sex-Specific Differences in Type 2 Diabetes Mellitus and Dyslipidemia Therapy: PPAR Agonists. Handbook of experimental pharmacology. 2012; (214): 387-410.
    • (2012) Handbook of experimental pharmacology. , Issue.214 , pp. 387-410
    • Benz, V.1    Kintscher, U.2    Foryst-Ludwig, A.3
  • 18
    • 84860919318 scopus 로고    scopus 로고
    • Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1beta and inhibited by peroxisome proliferator activated receptor alpha agonist
    • Clockaerts S, Bastiaansen-Jenniskens YM, Feijt C, et al. Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1beta and inhibited by peroxisome proliferator activated receptor alpha agonist. Annals of the rheumatic diseases. 2012; 71(6): 1012-8.
    • (2012) Annals of the rheumatic diseases. , vol.71 , Issue.6 , pp. 1012-1018
    • Clockaerts, S.1    Bastiaansen-Jenniskens, Y.M.2    Feijt, C.3
  • 19
    • 0020533327 scopus 로고
    • Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects
    • Heller F, Harvengt C. Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects. European journal of clinical pharmacology. 1983; 25(1): 57-63.
    • (1983) European journal of clinical pharmacology. , vol.25 , Issue.1 , pp. 57-63
    • Heller, F.1    Harvengt, C.2
  • 20
    • 0024474642 scopus 로고
    • Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration
    • Malmendier CL, Lontie JF, Delcroix C, et al. Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration. Atherosclerosis. 1989; 77(2-3): 139-49.
    • (1989) Atherosclerosis. , vol.77 , Issue.2-3 , pp. 139-149
    • Malmendier, C.L.1    Lontie, J.F.2    Delcroix, C.3
  • 21
    • 0030766476 scopus 로고    scopus 로고
    • Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alphadeficient mice
    • Peters JM, Hennuyer N, Staels B, et al. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alphadeficient mice. The Journal of biological chemistry. 1997; 272(43): 27307-12.
    • (1997) The Journal of biological chemistry. , vol.272 , Issue.43 , pp. 27307-27312
    • Peters, J.M.1    Hennuyer, N.2    Staels, B.3
  • 22
    • 0027459606 scopus 로고
    • An enzymatic explanation of the differential effects of oleate and gemfibrozil on cultured hepatocyte triacylglycerol and phosphatidylcholine biosynthesis and secretion
    • Lamb RG, Koch JC, Bush SR. An enzymatic explanation of the differential effects of oleate and gemfibrozil on cultured hepatocyte triacylglycerol and phosphatidylcholine biosynthesis and secretion. Biochimica et biophysica acta. 1993; 1165(3): 299-305.
    • (1993) Biochimica et biophysica acta. , vol.1165 , Issue.3 , pp. 299-305
    • Lamb, R.G.1    Koch, J.C.2    Bush, S.R.3
  • 24
    • 0027243757 scopus 로고
    • Effect of gemfibrozil and lovastatin on postprandial lipoprotein clearance in the hypoalphalipoproteinemia and hypertriglyceridemia syndrome
    • Simo IE, Yakichuk JA, Ooi TC. Effect of gemfibrozil and lovastatin on postprandial lipoprotein clearance in the hypoalphalipoproteinemia and hypertriglyceridemia syndrome. Atherosclerosis. 1993; 100(1): 55-64.
    • (1993) Atherosclerosis. , vol.100 , Issue.1 , pp. 55-64
    • Simo, I.E.1    Yakichuk, J.A.2    Ooi, T.C.3
  • 25
    • 0025651990 scopus 로고
    • Postprandial lipemia, fenofibrate and coronary artery disease
    • Simpson HS, Williamson CM, Olivecrona T, et al. Postprandial lipemia, fenofibrate and coronary artery disease. Atherosclerosis. 1990; 85(2-3): 193-202.
    • (1990) Atherosclerosis. , vol.85 , Issue.2-3 , pp. 193-202
    • Simpson, H.S.1    Williamson, C.M.2    Olivecrona, T.3
  • 26
    • 0029058733 scopus 로고
    • Postprandial lipoprotein clearance in type 2 diabetes: Fenofibrate effects
    • Cavallero E, Piolot A, Jacotot B. Postprandial lipoprotein clearance in type 2 diabetes: fenofibrate effects. Diabete & metabolisme. 1995; 21(2): 118-20.
    • (1995) Diabete & metabolisme. , vol.21 , Issue.2 , pp. 118-120
    • Cavallero, E.1    Piolot, A.2    Jacotot, B.3
  • 27
    • 0030658022 scopus 로고    scopus 로고
    • Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
    • Martin G, Schoonjans K, Lefebvre AM, et al. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. The Journal of biological chemistry. 1997; 272(45): 28210-7.
    • (1997) The Journal of biological chemistry. , vol.272 , Issue.45 , pp. 28210-28217
    • Martin, G.1    Schoonjans, K.2    Lefebvre, A.M.3
  • 28
    • 0029144018 scopus 로고
    • Induction of the acylcoenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
    • Schoonjans K, Watanabe M, Suzuki H, et al. Induction of the acylcoenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. The Journal of biological chemistry. 1995; 270(33): 19269-76.
    • (1995) The Journal of biological chemistry. , vol.270 , Issue.33 , pp. 19269-19276
    • Schoonjans, K.1    Watanabe, M.2    Suzuki, H.3
  • 29
    • 0016441118 scopus 로고
    • Inhibition of hormone-stimulated lipolysis by clofibrate. A possible mechanism for its hypolipidemic action
    • D'Costa MA, Angel A. Inhibition of hormone-stimulated lipolysis by clofibrate. A possible mechanism for its hypolipidemic action. The Journal of clinical investigation. 1975; 55(1): 138-48.
    • (1975) The Journal of clinical investigation. , vol.55 , Issue.1 , pp. 138-148
    • D'Costa, M.A.1    Angel, A.2
  • 31
    • 0027258425 scopus 로고
    • Identification of multiple dense LDL subfractions with enhanced susceptibility to in vitro oxidation among hypertriglyceridemic subjects. Normalization after clofibrate treatment
    • de Graaf J, Hendriks JC, Demacker PN, et al. Identification of multiple dense LDL subfractions with enhanced susceptibility to in vitro oxidation among hypertriglyceridemic subjects. Normalization after clofibrate treatment. Arteriosclerosis and thrombosis: a journal of vascular biology / American Heart Association. 1993; 13(5): 712-9.
    • (1993) Arteriosclerosis and thrombosis: A journal of vascular biology / American Heart Association. , vol.13 , Issue.5 , pp. 712-719
    • de Graaf, J.1    Hendriks, J.C.2    Demacker, P.N.3
  • 32
    • 0028816578 scopus 로고
    • Effect of gemfibrozil on the concentration and composition of very low density and low density lipoprotein subfractions in hypertriglyceridemic patients
    • Dachet C, Cavallero E, Martin C, et al. Effect of gemfibrozil on the concentration and composition of very low density and low density lipoprotein subfractions in hypertriglyceridemic patients. Atherosclerosis. 1995; 113(1): 1-9.
    • (1995) Atherosclerosis. , vol.113 , Issue.1 , pp. 1-9
    • Dachet, C.1    Cavallero, E.2    Martin, C.3
  • 33
    • 0025873036 scopus 로고
    • Low density lipoprotein density and composition in hypercholesterolaemic men treated with HMG CoA reductase inhibitors and gemfibrozil
    • Tilly-Kiesi M, Tikkanen MJ. Low density lipoprotein density and composition in hypercholesterolaemic men treated with HMG CoA reductase inhibitors and gemfibrozil. Journal of internal medicine. 1991; 229(5): 427-34.
    • (1991) Journal of internal medicine. , vol.229 , Issue.5 , pp. 427-434
    • Tilly-Kiesi, M.1    Tikkanen, M.J.2
  • 34
    • 0028905504 scopus 로고
    • Effect of gemfibrozil treatment in hypercholesterolemia on low density lipoprotein (LDL) subclass distribution and LDL-cell interaction
    • Franceschini G, Lovati MR, Manzoni C, et al. Effect of gemfibrozil treatment in hypercholesterolemia on low density lipoprotein (LDL) subclass distribution and LDL-cell interaction. Atherosclerosis. 1995; 114(1): 61-71.
    • (1995) Atherosclerosis. , vol.114 , Issue.1 , pp. 61-71
    • Franceschini, G.1    Lovati, M.R.2    Manzoni, C.3
  • 35
    • 0026284533 scopus 로고
    • Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia
    • Mann CJ, Yen FT, Grant AM, et al. Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. The Journal of clinical investigation. 1991; 88(6): 2059-66.
    • (1991) The Journal of clinical investigation. , vol.88 , Issue.6 , pp. 2059-2066
    • Mann, C.J.1    Yen, F.T.2    Grant, A.M.3
  • 36
    • 0029119082 scopus 로고
    • Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor
    • Vu-Dac N, Schoonjans K, Kosykh V, et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. The Journal of clinical investigation. 1995; 96(2): 741-50.
    • (1995) The Journal of clinical investigation. , vol.96 , Issue.2 , pp. 741-750
    • Vu-Dac, N.1    Schoonjans, K.2    Kosykh, V.3
  • 37
    • 8944252340 scopus 로고    scopus 로고
    • Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice
    • Berthou L, Duverger N, Emmanuel F, et al. Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice. The Journal of clinical investigation. 1996; 97(11): 2408-16.
    • (1996) The Journal of clinical investigation. , vol.97 , Issue.11 , pp. 2408-2416
    • Berthou, L.1    Duverger, N.2    Emmanuel, F.3
  • 38
    • 0028036723 scopus 로고
    • Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element
    • Vu-Dac N, Schoonjans K, Laine B, et al. Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element. The Journal of biological chemistry. 1994; 269(49): 31012-8.
    • (1994) The Journal of biological chemistry. , vol.269 , Issue.49 , pp. 31012-31018
    • Vu-Dac, N.1    Schoonjans, K.2    Laine, B.3
  • 39
    • 0026631526 scopus 로고
    • A multicenter comparison of the effects of simvastatin and fenofibrate therapy in severe primary hypercholesterolemia, with particular emphasis on lipoproteins defined by their apolipoprotein composition
    • Bard JM, Parra HJ, Camare R, et al. A multicenter comparison of the effects of simvastatin and fenofibrate therapy in severe primary hypercholesterolemia, with particular emphasis on lipoproteins defined by their apolipoprotein composition. Metabolism: clinical and experimental. 1992; 41(5): 498-503.
    • (1992) Metabolism: Clinical and experimental. , vol.41 , Issue.5 , pp. 498-503
    • Bard, J.M.1    Parra, H.J.2    Camare, R.3
  • 40
    • 0024312635 scopus 로고
    • Lipoprotein composition changes induced by fenofibrate in dysbetalipoproteinemia type III
    • Lussier-Cacan S, Bard JM, Boulet L, et al. Lipoprotein composition changes induced by fenofibrate in dysbetalipoproteinemia type III. Atherosclerosis. 1989; 78(2-3): 167-82.
    • (1989) Atherosclerosis. , vol.78 , Issue.2-3 , pp. 167-182
    • Lussier-Cacan, S.1    Bard, J.M.2    Boulet, L.3
  • 41
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, et al. Mechanisms of fatty acid-induced inhibition of glucose uptake. The Journal of clinical investigation. 1994; 93(6): 2438-46.
    • (1994) The Journal of clinical investigation. , vol.93 , Issue.6 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3
  • 42
    • 0042822095 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: Comparison with PPAR-gamma activation
    • Koh EH, Kim MS, Park JY, et al. Peroxisome proliferatoractivated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003; 52(9): 2331-7.
    • (2003) Diabetes. , vol.52 , Issue.9 , pp. 2331-2337
    • Koh, E.H.1    Kim, M.S.2    Park, J.Y.3
  • 43
    • 2442711384 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptors and atherogenesis: Regulators of gene expression in vascular cells
    • Marx N, Duez H, Fruchart JC, et al. Peroxisome proliferatoractivated receptors and atherogenesis: regulators of gene expression in vascular cells. Circulation research. 2004; 94(9): 1168-78.
    • (2004) Circulation research. , vol.94 , Issue.9 , pp. 1168-1178
    • Marx, N.1    Duez, H.2    Fruchart, J.C.3
  • 44
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, et al. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of clinical investigation. 1995; 95(5): 2409-15.
    • (1995) The Journal of clinical investigation. , vol.95 , Issue.5 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3
  • 46
    • 77956342929 scopus 로고    scopus 로고
    • The novel role of fenofibrate in preventing nicotine-and sodium arsenite-induced vascular endothelial dysfunction in the rat
    • Kaur J, Reddy K, Balakumar P. The novel role of fenofibrate in preventing nicotine-and sodium arsenite-induced vascular endothelial dysfunction in the rat. Cardiovascular toxicology. 2010; 10(3): 227-38.
    • (2010) Cardiovascular toxicology. , vol.10 , Issue.3 , pp. 227-238
    • Kaur, J.1    Reddy, K.2    Balakumar, P.3
  • 48
    • 84855557895 scopus 로고    scopus 로고
    • Treatment of hypertriglyceridemia with fibric acid derivatives: Impact on lipid subfractions and translation into a reduction in cardiovascular events
    • McCullough PA, Ahmed AB, Zughaib MT, et al. Treatment of hypertriglyceridemia with fibric acid derivatives: impact on lipid subfractions and translation into a reduction in cardiovascular events. Reviews in cardiovascular medicine. 2011; 12(4): 173-85.
    • (2011) Reviews in cardiovascular medicine. , vol.12 , Issue.4 , pp. 173-185
    • McCullough, P.A.1    Ahmed, A.B.2    Zughaib, M.T.3
  • 49
    • 78649644672 scopus 로고    scopus 로고
    • Prevention of cardiovascular disease utilizing fibrates--a pooled meta-analysis
    • Loomba RS, Arora R. Prevention of cardiovascular disease utilizing fibrates--a pooled meta-analysis. American journal of therapeutics. 2010; 17(6): e182-8.
    • (2010) American journal of therapeutics. , vol.17 , Issue.6
    • Loomba, R.S.1    Arora, R.2
  • 50
    • 78149332747 scopus 로고    scopus 로고
    • Apolipoprotein B genetic variants modify the response to fenofibrate: A GOLDN study
    • Wojczynski MK, Gao G, Borecki I, et al. Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study. Journal of lipid research. 2010; 51(11): 3316-23.
    • (2010) Journal of lipid research. , vol.51 , Issue.11 , pp. 3316-3323
    • Wojczynski, M.K.1    Gao, G.2    Borecki, I.3
  • 51
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primaryprevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primaryprevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. The New England journal of medicine. 1987; 317(20): 1237-45.
    • (1987) The New England journal of medicine. , vol.317 , Issue.20 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Haapa, K.3
  • 52
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Rubins HB, Robins SJ, Collins D, et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. The New England journal of medicine. 1999; 341(6): 410-8.
    • (1999) The New England journal of medicine. , vol.341 , Issue.6 , pp. 410-418
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 53
    • 0037121346 scopus 로고    scopus 로고
    • Bezafibrate in men with lower extremity arterial disease: Randomised controlled trial
    • Meade T, Zuhrie R, Cook C, et al. Bezafibrate in men with lower extremity arterial disease: randomised controlled trial. BMJ. 2002; 325(7373): 1139.
    • (2002) BMJ. , vol.325 , Issue.7373 , pp. 1139
    • Meade, T.1    Zuhrie, R.2    Cook, C.3
  • 54
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • Keech A, Simes RJ, Barter P, et al. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet. 2005; 366(9500): 1849-61.
    • (2005) Lancet. , vol.366 , Issue.9500 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3
  • 55
    • 0029845294 scopus 로고    scopus 로고
    • Secondary preventive potential of lipid-lowering drugs. The Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT)
    • de Faire U, Ericsson CG, Grip L, et al. Secondary preventive potential of lipid-lowering drugs. The Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT). European heart journal. 1996; 17 Suppl F: 37-42.
    • (1996) European heart journal. , vol.17 , Issue.SUPPL. F , pp. 37-42
    • de Faire, U.1    Ericsson, C.G.2    Grip, L.3
  • 56
    • 0342506477 scopus 로고    scopus 로고
    • Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group
    • Frick MH, Syvanne M, Nieminen MS, et al. Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group. Circulation. 1997; 96(7): 2137-43.
    • (1997) Circulation. , vol.96 , Issue.7 , pp. 2137-2143
    • Frick, M.H.1    Syvanne, M.2    Nieminen, M.S.3
  • 57
    • 0037426396 scopus 로고    scopus 로고
    • Relationships between low-density lipoprotein particle size, plasma lipoproteins, and progression of coronary artery disease: The Diabetes Atherosclerosis Intervention Study (DAIS)
    • Vakkilainen J, Steiner G, Ansquer JC, et al. Relationships between low-density lipoprotein particle size, plasma lipoproteins, and progression of coronary artery disease: the Diabetes Atherosclerosis Intervention Study (DAIS). Circulation. 2003; 107(13): 1733-7.
    • (2003) Circulation. , vol.107 , Issue.13 , pp. 1733-1737
    • Vakkilainen, J.1    Steiner, G.2    Ansquer, J.C.3
  • 58
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) study
    • Group BS. Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation. 2000; 102(1): 21-7.
    • (2000) Circulation. , vol.102 , Issue.1 , pp. 21-27
    • Group, B.S.1
  • 59
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
    • Jun M, Foote C, Lv J, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet. 2010; 375(9729): 1875-84.
    • (2010) Lancet. , vol.375 , Issue.9729 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3
  • 60
    • 0034782713 scopus 로고    scopus 로고
    • Are high density lipoprotein (HDL) and triglyceride levels relevant in stroke prevention?
    • Rizos E, Mikhailidis DP. Are high density lipoprotein (HDL) and triglyceride levels relevant in stroke prevention? Cardiovascular research. 2001; 52(2): 199-207.
    • (2001) Cardiovascular research. , vol.52 , Issue.2 , pp. 199-207
    • Rizos, E.1    Mikhailidis, D.P.2
  • 61
    • 84888438122 scopus 로고    scopus 로고
    • The Effect of Fenofibrate on Lymphocyte Release of Proinflammatory Cytokines and Systemic Inflammation in Simvastatin-Treated Patients with Atherosclerosis and Early Glucose Metabolism Disturbances
    • Krysiak R, Gdula-Dymek A, Okopien B. The Effect of Fenofibrate on Lymphocyte Release of Proinflammatory Cytokines and Systemic Inflammation in Simvastatin-Treated Patients with Atherosclerosis and Early Glucose Metabolism Disturbances. Basic & clinical pharmacology & toxicology. 2012.
    • (2012) Basic & clinical pharmacology & toxicology.
    • Krysiak, R.1    Gdula-Dymek, A.2    Okopien, B.3
  • 63
    • 84855950126 scopus 로고    scopus 로고
    • Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia
    • Koh KK, Quon MJ, Shin KC, et al. Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia. Atherosclerosis. 2012; 220(2): 537-44.
    • (2012) Atherosclerosis. , vol.220 , Issue.2 , pp. 537-544
    • Koh, K.K.1    Quon, M.J.2    Shin, K.C.3
  • 64
    • 79952268700 scopus 로고    scopus 로고
    • Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin-induced diabetic rats
    • Olukman M, Sezer ED, Ulker S, et al. Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin-induced diabetic rats. Experimental diabetes research. 2010; 2010: 828531.
    • (2010) Experimental diabetes research. , vol.2010 , pp. 828531
    • Olukman, M.1    Sezer, E.D.2    Ulker, S.3
  • 65
    • 79151482401 scopus 로고    scopus 로고
    • Effects of fenofibrate on plasma oxidized LDL and 8-isoprostane in a sub-cohort of GOLDN participants
    • Dong Y, Steffen BT, Cao J, et al. Effects of fenofibrate on plasma oxidized LDL and 8-isoprostane in a sub-cohort of GOLDN participants. Atherosclerosis. 2011; 214(2): 422-5.
    • (2011) Atherosclerosis. , vol.214 , Issue.2 , pp. 422-425
    • Dong, Y.1    Steffen, B.T.2    Cao, J.3
  • 66
    • 34548645400 scopus 로고    scopus 로고
    • Fenofibrate: A novel formulation (Triglide) in the treatment of lipid disorders: A review
    • Tziomalos K, Athyros VG. Fenofibrate: a novel formulation (Triglide) in the treatment of lipid disorders: a review. International journal of nanomedicine. 2006; 1(2): 129-47.
    • (2006) International journal of nanomedicine. , vol.1 , Issue.2 , pp. 129-147
    • Tziomalos, K.1    Athyros, V.G.2
  • 67
    • 80054758169 scopus 로고    scopus 로고
    • Adipokines and vascular risk in type 2 diabetes mellitus
    • Katsiki N, Yovos JG, Gotzamani-Psarrakou A, et al. Adipokines and vascular risk in type 2 diabetes mellitus. Angiology. 2011; 62(8): 601-4.
    • (2011) Angiology. , vol.62 , Issue.8 , pp. 601-604
    • Katsiki, N.1    Yovos, J.G.2    Gotzamani-Psarrakou, A.3
  • 68
    • 81855228289 scopus 로고    scopus 로고
    • Pharmacological effects of lipid-lowering drugs on circulating adipokines
    • Wanders D, Plaisance EP, Judd RL. Pharmacological effects of lipid-lowering drugs on circulating adipokines. World journal of diabetes. 2010; 1(4): 116-28.
    • (2010) World journal of diabetes. , vol.1 , Issue.4 , pp. 116-128
    • Wanders, D.1    Plaisance, E.P.2    Judd, R.L.3
  • 69
    • 79952667048 scopus 로고    scopus 로고
    • Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus
    • Katsiki N, Mikhailidis DP, Gotzamani-Psarrakou A, et al. Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus. Expert opinion on therapeutic targets. 2011; 15(4): 401-20.
    • (2011) Expert opinion on therapeutic targets. , vol.15 , Issue.4 , pp. 401-420
    • Katsiki, N.1    Mikhailidis, D.P.2    Gotzamani-Psarrakou, A.3
  • 70
    • 78650828581 scopus 로고    scopus 로고
    • Effects of fenofibrate therapy on circulating adipocytokines in patients with primary hypertriglyceridemia
    • Koh KK, Quon MJ, Lim S, et al. Effects of fenofibrate therapy on circulating adipocytokines in patients with primary hypertriglyceridemia. Atherosclerosis. 2011; 214(1): 144-7.
    • (2011) Atherosclerosis. , vol.214 , Issue.1 , pp. 144-147
    • Koh, K.K.1    Quon, M.J.2    Lim, S.3
  • 73
    • 82255175318 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor-alpha activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: Possible neuroprotective mechanisms
    • Bhateja DK, Dhull DK, Gill A, et al. Peroxisome proliferatoractivated receptor-alpha activation attenuates 3-nitropropionic acid induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms. European journal of pharmacology. 2012; 674(1): 33-43.
    • (2012) European journal of pharmacology. , vol.674 , Issue.1 , pp. 33-43
    • Bhateja, D.K.1    Dhull, D.K.2    Gill, A.3
  • 74
    • 70449535878 scopus 로고    scopus 로고
    • Withdrawal of fenofibrate treatment partially abrogates preventive neuroprotection in stroke via loss of vascular protection
    • Ouk T, Laprais M, Bastide M, et al. Withdrawal of fenofibrate treatment partially abrogates preventive neuroprotection in stroke via loss of vascular protection. Vascular pharmacology. 2009; 51(5-6): 323-30.
    • (2009) Vascular pharmacology. , vol.51 , Issue.5-6 , pp. 323-330
    • Ouk, T.1    Laprais, M.2    Bastide, M.3
  • 75
    • 84862734043 scopus 로고    scopus 로고
    • Fenofibrate-a potential systemic treatment for diabetic retinopathy?
    • Wong TY, Simo R, Mitchell P. Fenofibrate-a potential systemic treatment for diabetic retinopathy? American journal of ophthalmology. 2012; 154(1): 6-12.
    • (2012) American journal of ophthalmology. , vol.154 , Issue.1 , pp. 6-12
    • Wong, T.Y.1    Simo, R.2    Mitchell, P.3
  • 76
    • 65649142619 scopus 로고    scopus 로고
    • Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): A prespecified analysis of a randomised controlled trial
    • Rajamani K, Colman PG, Li LP, et al. Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial. Lancet. 2009; 373(9677): 1780-8.
    • (2009) Lancet. , vol.373 , Issue.9677 , pp. 1780-1788
    • Rajamani, K.1    Colman, P.G.2    Li, L.P.3
  • 77
    • 84865413263 scopus 로고    scopus 로고
    • Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience
    • Bonds DE, Craven TE, Buse J, et al. Fenofibrate-associated changes in renal function and relationship to clinical outcomes among individuals with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) experience. Diabetologia. 2012; 55(6): 1641-50.
    • (2012) Diabetologia. , vol.55 , Issue.6 , pp. 1641-1650
    • Bonds, D.E.1    Craven, T.E.2    Buse, J.3
  • 78
    • 84862076457 scopus 로고    scopus 로고
    • Reversibility of fenofibrate therapy-induced renal function impairment in ACCORD type 2 diabetic participants
    • Mychaleckyj JC, Craven T, Nayak U, et al. Reversibility of fenofibrate therapy-induced renal function impairment in ACCORD type 2 diabetic participants. Diabetes care. 2012; 35(5): 1008-14.
    • (2012) Diabetes care. , vol.35 , Issue.5 , pp. 1008-1014
    • Mychaleckyj, J.C.1    Craven, T.2    Nayak, U.3
  • 79
    • 84858216690 scopus 로고    scopus 로고
    • Benefits and safety of longterm fenofibrate therapy in people with type 2 diabetes and renal impairment: The FIELD Study
    • Ting RD, Keech AC, Drury PL, et al. Benefits and safety of longterm fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study. Diabetes care. 2012; 35(2): 218-25.
    • (2012) Diabetes care. , vol.35 , Issue.2 , pp. 218-225
    • Ting, R.D.1    Keech, A.C.2    Drury, P.L.3
  • 80
    • 0036128228 scopus 로고    scopus 로고
    • Are high-density lipoprotein and triglyceride levels important in secondary prevention: Impressions from the BIP and VA-HIT trials
    • Rizos E, Mikhailidis DP. Are high-density lipoprotein and triglyceride levels important in secondary prevention: impressions from the BIP and VA-HIT trials. Int J Cardiol. 2002; 82(3): 199-207
    • (2002) Int J Cardiol. , vol.82 , Issue.3 , pp. 199-207
    • Rizos, E.1    Mikhailidis, D.P.2
  • 81
    • 84861143622 scopus 로고    scopus 로고
    • The effect of EPA and DHA on metabolic syndrome patients: A systematic review of randomised controlled trials
    • Lopez-Huertas E. The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. The British journal of nutrition. 2012; 107 Suppl 2: S185-94.
    • (2012) The British journal of nutrition. , vol.107 , Issue.SUPPL. 2
    • Lopez-Huertas, E.1
  • 82
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis
    • Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007; 369(9567): 1090-8.
    • (2007) Lancet. , vol.369 , Issue.9567 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3
  • 83
    • 49749128376 scopus 로고    scopus 로고
    • Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS)
    • Saito Y, Yokoyama M, Origasa H, et al. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis. 2008; 200(1): 135-40.
    • (2008) Atherosclerosis. , vol.200 , Issue.1 , pp. 135-140
    • Saito, Y.1    Yokoyama, M.2    Origasa, H.3
  • 84
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSIPrevenzione trial Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSIPrevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet. 1999; 354(9177): 447-55.
    • (1999) Lancet. , vol.354 , Issue.9177 , pp. 447-455
  • 85
    • 84866070612 scopus 로고    scopus 로고
    • Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: A systematic review and meta-analysis
    • Rizos EC, Ntzani EE, Bika E, et al. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA: the journal of the American Medical Association. 2012; 308(10): 1024-33.
    • (2012) JAMA: The journal of the American Medical Association. , vol.308 , Issue.10 , pp. 1024-1033
    • Rizos, E.C.1    Ntzani, E.E.2    Bika, E.3
  • 86
    • 0036636769 scopus 로고    scopus 로고
    • Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia
    • Athyros VG, Papageorgiou AA, Athyrou VV, et al. Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hyperlipidemia. Diabetes care. 2002; 25(7): 1198-202.
    • (2002) Diabetes care. , vol.25 , Issue.7 , pp. 1198-1202
    • Athyros, V.G.1    Papageorgiou, A.A.2    Athyrou, V.V.3
  • 89
    • 77953264127 scopus 로고    scopus 로고
    • Efficacy and safety of rosuvastatin and fenofibric acid combination therapy versus simvastatin monotherapy in patients with hypercholesterolemia and hypertriglyceridemia: A randomized, double-blind study
    • Roth EM, McKenney JM, Kelly MT, et al. Efficacy and safety of rosuvastatin and fenofibric acid combination therapy versus simvastatin monotherapy in patients with hypercholesterolemia and hypertriglyceridemia: a randomized, double-blind study. American journal of cardiovascular drugs: drugs, devices, and other interventions. 2010; 10(3): 175-86.
    • (2010) American journal of cardiovascular drugs: Drugs, devices, and other interventions. , vol.10 , Issue.3 , pp. 175-186
    • Roth, E.M.1    McKenney, J.M.2    Kelly, M.T.3
  • 90
    • 62549159657 scopus 로고    scopus 로고
    • Efficacy and safety of fenofibric acid in combination with a statin in patients with mixed dyslipidemia: Pooled analysis of three phase 3, 12-week randomized, controlled studies
    • Jones PH, Davidson MH, Goldberg AC, et al. Efficacy and safety of fenofibric acid in combination with a statin in patients with mixed dyslipidemia: Pooled analysis of three phase 3, 12-week randomized, controlled studies. Journal of clinical lipidology. 2009; 3(2): 125-37.
    • (2009) Journal of clinical lipidology. , vol.3 , Issue.2 , pp. 125-137
    • Jones, P.H.1    Davidson, M.H.2    Goldberg, A.C.3
  • 91
    • 59049086841 scopus 로고    scopus 로고
    • Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia
    • Goldberg AC, Bays HE, Ballantyne CM, et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia. The American journal of cardiology. 2009; 103(4): 515-22.
    • (2009) The American journal of cardiology. , vol.103 , Issue.4 , pp. 515-522
    • Goldberg, A.C.1    Bays, H.E.2    Ballantyne, C.M.3
  • 92
    • 10444268083 scopus 로고    scopus 로고
    • Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: A 12-month, randomized, double-blind, controlled trial
    • Derosa G, Cicero AE, Bertone G, et al. Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial. Clinical therapeutics. 2004; 26(10): 1599-607.
    • (2004) Clinical therapeutics. , vol.26 , Issue.10 , pp. 1599-1607
    • Derosa, G.1    Cicero, A.E.2    Bertone, G.3
  • 93
    • 77956343549 scopus 로고    scopus 로고
    • Efficacy and safety of adding fenofibrate 160 mg in high-risk patients with mixed hyperlipidemia not controlled by pravastatin 40 mg monotherapy
    • Farnier M, Ducobu J, Bryniarski L. Efficacy and safety of adding fenofibrate 160 mg in high-risk patients with mixed hyperlipidemia not controlled by pravastatin 40 mg monotherapy. The American journal of cardiology. 2010; 106(6): 787-92.
    • (2010) The American journal of cardiology. , vol.106 , Issue.6 , pp. 787-792
    • Farnier, M.1    Ducobu, J.2    Bryniarski, L.3
  • 94
    • 80054696508 scopus 로고    scopus 로고
    • Long-term safety and efficacy of fenofibrate/pravastatin combination therapy in high risk patients with mixed hyperlipidemia not controlled by pravastatin monotherapy
    • Farnier M, Ducobu J, Bryniarski L. Long-term safety and efficacy of fenofibrate/pravastatin combination therapy in high risk patients with mixed hyperlipidemia not controlled by pravastatin monotherapy. Current medical research and opinion. 2011; 27(11): 2165-73.
    • (2011) Current medical research and opinion. , vol.27 , Issue.11 , pp. 2165-2173
    • Farnier, M.1    Ducobu, J.2    Bryniarski, L.3
  • 95
    • 74549173160 scopus 로고    scopus 로고
    • Efficacy and tolerability of atorvastatin/fenofibrate fixed-dose combination tablet compared with atorvastatin and fenofibrate monotherapies in patients with dyslipidemia: A 12-week, multicenter, double-blind, randomized, parallel-group study
    • Davidson MH, Rooney MW, Drucker J, et al. Efficacy and tolerability of atorvastatin/fenofibrate fixed-dose combination tablet compared with atorvastatin and fenofibrate monotherapies in patients with dyslipidemia: a 12-week, multicenter, double-blind, randomized, parallel-group study. Clinical therapeutics. 2009; 31(12): 2824-38.
    • (2009) Clinical therapeutics. , vol.31 , Issue.12 , pp. 2824-2838
    • Davidson, M.H.1    Rooney, M.W.2    Drucker, J.3
  • 96
    • 84861865181 scopus 로고    scopus 로고
    • Pravastatin and fenofibrate in combination (Pravafenix(R) for the treatment of high-risk patients with mixed hyperlipidemia
    • Farnier M. Pravastatin and fenofibrate in combination (Pravafenix(R) for the treatment of high-risk patients with mixed hyperlipidemia. Expert review of cardiovascular therapy. 2012; 10(5): 565-75.
    • (2012) Expert review of cardiovascular therapy. , vol.10 , Issue.5 , pp. 565-575
    • Farnier, M.1
  • 98
    • 84859871458 scopus 로고    scopus 로고
    • Cardiovascular events in patients received combined fibrate/statin treatment versus statin monotherapy: Acute Coronary Syndrome Israeli Surveys data
    • Tenenbaum A, Medvedofsky D, Fisman EZ, et al. Cardiovascular events in patients received combined fibrate/statin treatment versus statin monotherapy: Acute Coronary Syndrome Israeli Surveys data. PloS one. 2012; 7(4): e35298.
    • (2012) PloS one. , vol.7 , Issue.4
    • Tenenbaum, A.1    Medvedofsky, D.2    Fisman, E.Z.3
  • 99
  • 100
    • 11144239674 scopus 로고    scopus 로고
    • Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin
    • Jones PH, Davidson MH. Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin. The American journal of cardiology. 2005; 95(1): 120-2.
    • (2005) The American journal of cardiology. , vol.95 , Issue.1 , pp. 120-122
    • Jones, P.H.1    Davidson, M.H.2
  • 103
    • 18744365508 scopus 로고    scopus 로고
    • Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia
    • Farnier M, Freeman MW, Macdonell G, et al. Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia. European heart journal. 2005; 26(9): 897-905.
    • (2005) European heart journal. , vol.26 , Issue.9 , pp. 897-905
    • Farnier, M.1    Freeman, M.W.2    McDonell, G.3
  • 105
    • 74049091227 scopus 로고    scopus 로고
    • Combined therapy in the treatment of dyslipidemia
    • Reiner Z. Combined therapy in the treatment of dyslipidemia. Fundamental & clinical pharmacology. 2010; 24(1): 19-28.
    • (2010) Fundamental & clinical pharmacology. , vol.24 , Issue.1 , pp. 19-28
    • Reiner, Z.1
  • 106
    • 56849101891 scopus 로고    scopus 로고
    • Update on the clinical utility of fenofibrate in mixed dyslipidemias: Mechanisms of action and rational prescribing
    • Farnier M. Update on the clinical utility of fenofibrate in mixed dyslipidemias: mechanisms of action and rational prescribing. Vascular health and risk management. 2008; 4(5): 991-1000.
    • (2008) Vascular health and risk management. , vol.4 , Issue.5 , pp. 991-1000
    • Farnier, M.1
  • 107
    • 42549095738 scopus 로고    scopus 로고
    • Colesevelam hydrochloride in clinical practice: A new approach in the treatment of hypercholesterolaemia
    • Florentin M, Liberopoulos EN, Mikhailidis DP, et al. Colesevelam hydrochloride in clinical practice: a new approach in the treatment of hypercholesterolaemia. Current medical research and opinion. 2008; 24(4): 995-1009.
    • (2008) Current medical research and opinion. , vol.24 , Issue.4 , pp. 995-1009
    • Florentin, M.1    Liberopoulos, E.N.2    Mikhailidis, D.P.3
  • 108
    • 25444497513 scopus 로고    scopus 로고
    • Safety and efficacy of colesevelam hydrochloride in combination with fenofibrate for the treatment of mixed hyperlipidemia
    • McKenney J, Jones M, Abby S. Safety and efficacy of colesevelam hydrochloride in combination with fenofibrate for the treatment of mixed hyperlipidemia. Current medical research and opinion. 2005; 21(9): 1403-12.
    • (2005) Current medical research and opinion. , vol.21 , Issue.9 , pp. 1403-1412
    • McKenney, J.1    Jones, M.2    Abby, S.3
  • 109
    • 29144456017 scopus 로고    scopus 로고
    • Effect of orlistat, micronised fenofibrate and their combination on metabolic parameters in overweight and obese patients with the metabolic syndrome: The FenOrli study
    • Filippatos TD, Kiortsis DN, Liberopoulos EN, et al. Effect of orlistat, micronised fenofibrate and their combination on metabolic parameters in overweight and obese patients with the metabolic syndrome: the FenOrli study. Current medical research and opinion. 2005; 21(12): 1997-2006.
    • (2005) Current medical research and opinion. , vol.21 , Issue.12 , pp. 1997-2006
    • Filippatos, T.D.1    Kiortsis, D.N.2    Liberopoulos, E.N.3
  • 111
    • 79960088422 scopus 로고    scopus 로고
    • Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: Results of "heart positive, " a randomized, controlled trial
    • Balasubramanyam A, Coraza I, Smith EO, et al. Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of "heart positive, " a randomized, controlled trial. The Journal of clinical endocrinology and metabolism. 2011; 96(7): 2236-47.
    • (2011) The Journal of clinical endocrinology and metabolism. , vol.96 , Issue.7 , pp. 2236-2247
    • Balasubramanyam, A.1    Coraza, I.2    Smith, E.O.3
  • 112
    • 58949105022 scopus 로고    scopus 로고
    • Effect of combination nicotinic acid and gemfibrozil treatment on intermediate density lipoprotein, and subclasses of low density lipoprotein and high density lipoprotein in patients with combined hyperlipidemia
    • Superko HR, Garrett BC, King SB, 3rd, et al. Effect of combination nicotinic acid and gemfibrozil treatment on intermediate density lipoprotein, and subclasses of low density lipoprotein and high density lipoprotein in patients with combined hyperlipidemia. The American journal of cardiology. 2009; 103(3): 387-92.
    • (2009) The American journal of cardiology. , vol.103 , Issue.3 , pp. 387-392
    • Superko, H.R.1    Garrett, B.C.2    King III, S.B.3
  • 113
    • 0020060090 scopus 로고
    • Identification of multiple subclasses of plasma low density lipoproteins in normal humans
    • Krauss RM, Burke DJ. Identification of multiple subclasses of plasma low density lipoproteins in normal humans. Journal of lipid research. 1982; 23(1): 97-104.
    • (1982) Journal of lipid research. , vol.23 , Issue.1 , pp. 97-104
    • Krauss, R.M.1    Burke, D.J.2
  • 114
    • 33748443205 scopus 로고    scopus 로고
    • Should we measure routinely the LDL peak particle size?
    • Rizzo M, Berneis K. Should we measure routinely the LDL peak particle size? International journal of cardiology. 2006; 107(2): 166-70.
    • (2006) International journal of cardiology. , vol.107 , Issue.2 , pp. 166-170
    • Rizzo, M.1    Berneis, K.2
  • 115
    • 31144471875 scopus 로고    scopus 로고
    • Lipid triad or atherogenic lipoprotein phenotype: A role in cardiovascular prevention?
    • Rizzo M, Berneis K. Lipid triad or atherogenic lipoprotein phenotype: a role in cardiovascular prevention? Journal of atherosclerosis and thrombosis. 2005; 12(5): 237-9.
    • (2005) Journal of atherosclerosis and thrombosis. , vol.12 , Issue.5 , pp. 237-239
    • Rizzo, M.1    Berneis, K.2
  • 116
    • 35348812759 scopus 로고    scopus 로고
    • Who needs to care about small, dense lowdensity lipoproteins?
    • Rizzo M, Berneis K. Who needs to care about small, dense lowdensity lipoproteins? International journal of clinical practice. 2007; 61(11): 1949-56.
    • (2007) International journal of clinical practice. , vol.61 , Issue.11 , pp. 1949-1956
    • Rizzo, M.1    Berneis, K.2
  • 117
    • 33846639147 scopus 로고    scopus 로고
    • Value of lowdensity lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: The EPIC-Norfolk Prospective Population Study
    • El Harchaoui K, van der Steeg WA, Stroes ES, et al. Value of lowdensity lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. Journal of the American College of Cardiology. 2007; 49(5): 547-53.
    • (2007) Journal of the American College of Cardiology. , vol.49 , Issue.5 , pp. 547-553
    • El Harchaoui, K.1    van der Steeg, W.A.2    Stroes, E.S.3
  • 118
    • 34249067115 scopus 로고    scopus 로고
    • The clinical significance of the size of lowdensity-lipoproteins and the modulation of subclasses by fibrates
    • Rizzo M, Berneis K. The clinical significance of the size of lowdensity-lipoproteins and the modulation of subclasses by fibrates. Current medical research and opinion. 2007; 23(5): 1103-11.
    • (2007) Current medical research and opinion. , vol.23 , Issue.5 , pp. 1103-1111
    • Rizzo, M.1    Berneis, K.2
  • 119
    • 27144471841 scopus 로고    scopus 로고
    • Gemfibrozil reduces small low-density lipoprotein more in normolipemic subjects classified as low-density lipoprotein pattern B compared with pattern A
    • Superko HR, Berneis KK, Williams PT, et al. Gemfibrozil reduces small low-density lipoprotein more in normolipemic subjects classified as low-density lipoprotein pattern B compared with pattern A. The American journal of cardiology. 2005; 96(9): 1266-72.
    • (2005) The American journal of cardiology. , vol.96 , Issue.9 , pp. 1266-1272
    • Superko, H.R.1    Berneis, K.K.2    Williams, P.T.3
  • 120
    • 0026597808 scopus 로고
    • Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment
    • Manninen V, Tenkanen L, Koskinen P, et al. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation. 1992; 85(1): 37-45.
    • (1992) Circulation. , vol.85 , Issue.1 , pp. 37-45
    • Manninen, V.1    Tenkanen, L.2    Koskinen, P.3
  • 121
    • 34548062085 scopus 로고    scopus 로고
    • Effects of statins, fibrates, rosuvastatin, and ezetimibe beyond cholesterol: The modulation of LDL size and subclasses in high-risk patients
    • Rizzo M, Rini GB, Berneis K. Effects of statins, fibrates, rosuvastatin, and ezetimibe beyond cholesterol: the modulation of LDL size and subclasses in high-risk patients. Advances in therapy. 2007; 24(3): 575-82.
    • (2007) Advances in therapy. , vol.24 , Issue.3 , pp. 575-582
    • Rizzo, M.1    Rini, G.B.2    Berneis, K.3
  • 122
    • 80051725784 scopus 로고    scopus 로고
    • "European panel on low density lipoprotein (LDL) subclasses": A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses
    • Mikhailidis DP, Elisaf M, Rizzo M, et al. "European panel on low density lipoprotein (LDL) subclasses": a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses. Current vascular pharmacology. 2011; 9(5): 533-71.
    • (2011) Current vascular pharmacology. , vol.9 , Issue.5 , pp. 533-571
    • Mikhailidis, D.P.1    Elisaf, M.2    Rizzo, M.3
  • 123
    • 80051769525 scopus 로고    scopus 로고
    • "European panel on low density lipoprotein (LDL) subclasses": A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: Executive summary
    • Mikhailidis DP, Elisaf M, Rizzo M, et al. "European panel on low density lipoprotein (LDL) subclasses": a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: executive summary. Current vascular pharmacology. 2011; 9(5): 531-2.
    • (2011) Current vascular pharmacology. , vol.9 , Issue.5 , pp. 531-532
    • Mikhailidis, D.P.1    Elisaf, M.2    Rizzo, M.3
  • 124
    • 0027359719 scopus 로고
    • Independent associations between plasma lipoprotein subfraction levels and the course of coronary artery disease in the St. Thomas' Atherosclerosis Regression Study (STARS)
    • Watts GF, Mandalia S, Brunt JN, et al. Independent associations between plasma lipoprotein subfraction levels and the course of coronary artery disease in the St. Thomas' Atherosclerosis Regression Study (STARS). Metabolism: clinical and experimental. 1993; 42(11): 1461-7.
    • (1993) Metabolism: Clinical and experimental. , vol.42 , Issue.11 , pp. 1461-1467
    • Watts, G.F.1    Mandalia, S.2    Brunt, J.N.3
  • 125
    • 33645741889 scopus 로고    scopus 로고
    • Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    • Otvos JD, Collins D, Freedman DS, et al. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation. 2006; 113(12): 1556-63.
    • (2006) Circulation. , vol.113 , Issue.12 , pp. 1556-1563
    • Otvos, J.D.1    Collins, D.2    Freedman, D.S.3
  • 126
    • 0028340315 scopus 로고
    • Effects of bezafibrate therapy on subfractions of plasma low-density lipoprotein and high-density lipoprotein, and on activities of lecithin:Cholesterol acyltransferase and cholesteryl ester transfer protein in patients with hyperlipoproteinemia
    • Homma Y, Ozawa H, Kobayashi T, et al. Effects of bezafibrate therapy on subfractions of plasma low-density lipoprotein and high-density lipoprotein, and on activities of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in patients with hyperlipoproteinemia. Atherosclerosis. 1994; 106(2): 191-201.
    • (1994) Atherosclerosis. , vol.106 , Issue.2 , pp. 191-201
    • Homma, Y.1    Ozawa, H.2    Kobayashi, T.3
  • 127
    • 19344366802 scopus 로고    scopus 로고
    • Effects of bezafibrate on lipoprotein subclasses and inflammatory markers in patients with hypertriglyceridemia--a nuclear magnetic resonance study
    • Ikewaki K, Noma K, Tohyama J, et al. Effects of bezafibrate on lipoprotein subclasses and inflammatory markers in patients with hypertriglyceridemia--a nuclear magnetic resonance study. International journal of cardiology. 2005; 101(3): 441-7.
    • (2005) International journal of cardiology. , vol.101 , Issue.3 , pp. 441-447
    • Ikewaki, K.1    Noma, K.2    Tohyama, J.3
  • 128
    • 0032533219 scopus 로고    scopus 로고
    • Treatment effects on serum lipoprotein lipids, apolipoproteins and low density lipoprotein particle size and relationships of lipoprotein variables to progression of coronary artery disease in the Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT)
    • Ruotolo G, Ericsson CG, Tettamanti C, et al. Treatment effects on serum lipoprotein lipids, apolipoproteins and low density lipoprotein particle size and relationships of lipoprotein variables to progression of coronary artery disease in the Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT). Journal of the American College of Cardiology. 1998; 32(6): 1648-56.
    • (1998) Journal of the American College of Cardiology. , vol.32 , Issue.6 , pp. 1648-1656
    • Ruotolo, G.1    Ericsson, C.G.2    Tettamanti, C.3
  • 129
    • 0021344798 scopus 로고
    • The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: Results of NHLBI Type II Coronary Intervention Study
    • Levy RI, Brensike JF, Epstein SE, et al. The influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: results of NHLBI Type II Coronary Intervention Study. Circulation. 1984; 69(2): 325-37.
    • (1984) Circulation. , vol.69 , Issue.2 , pp. 325-337
    • Levy, R.I.1    Brensike, J.F.2    Epstein, S.E.3
  • 130
    • 0027285331 scopus 로고
    • Ciprofibrate therapy normalises the atherogenic low-density lipoprotein subspecies profile in combined hyperlipidemia
    • Bruckert E, Dejager S, Chapman MJ. Ciprofibrate therapy normalises the atherogenic low-density lipoprotein subspecies profile in combined hyperlipidemia. Atherosclerosis. 1993; 100(1): 91-102.
    • (1993) Atherosclerosis. , vol.100 , Issue.1 , pp. 91-102
    • Bruckert, E.1    Dejager, S.2    Chapman, M.J.3
  • 131
    • 0030463802 scopus 로고    scopus 로고
    • Effects of simvastatin and ciprofibrate alone and in combination on lipid profile, plasma fibrinogen and low density lipoprotein particle structure and distribution in patients with familial combined hyperlipidaemia and coronary artery disease
    • Kontopoulos AG, Athyros VG, Papageorgiou AA, et al. Effects of simvastatin and ciprofibrate alone and in combination on lipid profile, plasma fibrinogen and low density lipoprotein particle structure and distribution in patients with familial combined hyperlipidaemia and coronary artery disease. Coronary artery disease. 1996; 7(11): 843-50.
    • (1996) Coronary artery disease. , vol.7 , Issue.11 , pp. 843-850
    • Kontopoulos, A.G.1    Athyros, V.G.2    Papageorgiou, A.A.3
  • 132
    • 28044453286 scopus 로고    scopus 로고
    • Lipoprotein-associated phospholipase A2 activity is a marker of small, dense LDL particles in human plasma
    • Gazi I, Lourida ES, Filippatos T, et al. Lipoprotein-associated phospholipase A2 activity is a marker of small, dense LDL particles in human plasma. Clinical chemistry. 2005; 51(12): 2264-73.
    • (2005) Clinical chemistry. , vol.51 , Issue.12 , pp. 2264-2273
    • Gazi, I.1    Lourida, E.S.2    Filippatos, T.3
  • 133
    • 82055186813 scopus 로고    scopus 로고
    • Therapeutic modulation of lipoprotein-associated phospholipase A2 (Lp-PLA2)
    • Tselepis AF, Rizzo M, Goudevenos IA. Therapeutic modulation of lipoprotein-associated phospholipase A2 (Lp-PLA2). Current pharmaceutical design. 2011; 17(33): 3656-61.
    • (2011) Current pharmaceutical design. , vol.17 , Issue.33 , pp. 3656-3661
    • Tselepis, A.F.1    Rizzo, M.2    Goudevenos, I.A.3
  • 134
    • 34447314752 scopus 로고    scopus 로고
    • The effect of orlistat and fenofibrate, alone or in combination, on small dense LDL and lipoprotein-associated phospholipase A2 in obese patients with metabolic syndrome
    • Filippatos TD, Gazi IF, Liberopoulos EN, et al. The effect of orlistat and fenofibrate, alone or in combination, on small dense LDL and lipoprotein-associated phospholipase A2 in obese patients with metabolic syndrome. Atherosclerosis. 2007; 193(2): 428-37.
    • (2007) Atherosclerosis. , vol.193 , Issue.2 , pp. 428-437
    • Filippatos, T.D.1    Gazi, I.F.2    Liberopoulos, E.N.3
  • 135
    • 0041641604 scopus 로고    scopus 로고
    • Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins
    • Tsimihodimos V, Kakafika A, Tambaki AP, et al. Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins. Journal of lipid research. 2003; 44(5): 927-34.
    • (2003) Journal of lipid research. , vol.44 , Issue.5 , pp. 927-934
    • Tsimihodimos, V.1    Kakafika, A.2    Tambaki, A.P.3
  • 136
    • 77956745760 scopus 로고    scopus 로고
    • Effect of non-statin lipid lowering and anti-obesity drugs on LDL subfractions in patients with mixed dyslipidaemia
    • Florentin M, Tselepis AD, Elisaf MS, et al. Effect of non-statin lipid lowering and anti-obesity drugs on LDL subfractions in patients with mixed dyslipidaemia. Current vascular pharmacology. 2010; 8(6): 820-30.
    • (2010) Current vascular pharmacology. , vol.8 , Issue.6 , pp. 820-830
    • Florentin, M.1    Tselepis, A.D.2    Elisaf, M.S.3
  • 137
    • 82055198043 scopus 로고    scopus 로고
    • There is more to predicting vascular disease than just established risk factors
    • Rizzo M, Mikhailidis DP. There is more to predicting vascular disease than just established risk factors. Current pharmaceutical design. 2011; 17(33): 3608-10.
    • (2011) Current pharmaceutical design. , vol.17 , Issue.33 , pp. 3608-3610
    • Rizzo, M.1    Mikhailidis, D.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.