메뉴 건너뛰기




Volumn 15, Issue 1, 2016, Pages

Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: A meta-analysis

Author keywords

Cardiovascular; Cardiovascular risk; Dapagliflozin; Major adverse cardiovascular events; Meta analysis; SGLT2 inhibitors; Type 2 diabetes

Indexed keywords

DAPAGLIFLOZIN; 2-(3-(4-ETHOXYBENZYL)-4-CHLOROPHENYL)-6-HYDROXYMETHYLTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLUCOSIDE; SODIUM GLUCOSE COTRANSPORTER;

EID: 84958548824     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-016-0356-y     Document Type: Article
Times cited : (158)

References (67)
  • 2
    • 84936750939 scopus 로고    scopus 로고
    • (8) Cardiovascular disease and risk management
    • American Diabetes Association. (8) Cardiovascular disease and risk management. Diabetes Care. 2015;38(Suppl):S49-57.
    • (2015) Diabetes Care , vol.38 , pp. S49-S57
  • 4
    • 79551673658 scopus 로고    scopus 로고
    • Strategies for optimizing glycemic control and cardiovascular prognosis in patients with type 2 diabetes mellitus
    • O'Keefe JH, Abuannadi M, Lavie CJ, Bell DS. Strategies for optimizing glycemic control and cardiovascular prognosis in patients with type 2 diabetes mellitus. Mayo Clin Proc. 2011;86(2):128-38.
    • (2011) Mayo Clin Proc , vol.86 , Issue.2 , pp. 128-138
    • O'Keefe, J.H.1    Abuannadi, M.2    Lavie, C.J.3    Bell, D.S.4
  • 5
    • 55149125150 scopus 로고    scopus 로고
    • Glycated haemoglobin and cardiovascular outcomes in people with Type 2 diabetes: a large prospective cohort study
    • Elley CR, Kenealy T, Robinson E, Drury PL. Glycated haemoglobin and cardiovascular outcomes in people with Type 2 diabetes: a large prospective cohort study. Diabet Med. 2008;25(11):1295-301.
    • (2008) Diabet Med , vol.25 , Issue.11 , pp. 1295-1301
    • Elley, C.R.1    Kenealy, T.2    Robinson, E.3    Drury, P.L.4
  • 6
    • 4644336398 scopus 로고    scopus 로고
    • Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk
    • Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med. 2004;141(6):413-20.
    • (2004) Ann Intern Med , vol.141 , Issue.6 , pp. 413-420
    • Khaw, K.T.1    Wareham, N.2    Bingham, S.3    Luben, R.4    Welch, A.5    Day, N.6
  • 7
    • 84901768284 scopus 로고    scopus 로고
    • Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes
    • Holman RR, Sourij H, Califf RM. Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes. Lancet. 2014;383(9933):2008-17.
    • (2014) Lancet , vol.383 , Issue.9933 , pp. 2008-2017
    • Holman, R.R.1    Sourij, H.2    Califf, R.M.3
  • 11
    • 68349130799 scopus 로고    scopus 로고
    • Prevention of cardiovascular disease through glycemic control in type 2 diabetes: a meta-analysis of randomized clinical trials
    • Mannucci E, Monami M, Lamanna C, Gori F, Marchionni N. Prevention of cardiovascular disease through glycemic control in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis. 2009;19(9):604-12.
    • (2009) Nutr Metab Cardiovasc Dis , vol.19 , Issue.9 , pp. 604-612
    • Mannucci, E.1    Monami, M.2    Lamanna, C.3    Gori, F.4    Marchionni, N.5
  • 12
    • 79960959816 scopus 로고    scopus 로고
    • Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials
    • Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, Erpeldinger S, Wright JM, Gueyffier F, Cornu C. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ. 2011;343:d4169.
    • (2011) BMJ , vol.343 , pp. d4169
    • Boussageon, R.1    Bejan-Angoulvant, T.2    Saadatian-Elahi, M.3    Lafont, S.4    Bergeonneau, C.5    Kassai, B.6    Erpeldinger, S.7    Wright, J.M.8    Gueyffier, F.9    Cornu, C.10
  • 14
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364-79.
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6    Peters, A.L.7    Tsapas, A.8    Wender, R.9    Matthews, D.R.10
  • 15
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38(1):140-9.
    • (2015) Diabetes Care , vol.38 , Issue.1 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6    Peters, A.L.7    Tsapas, A.8    Wender, R.9    Matthews, D.R.10
  • 16
    • 84891839210 scopus 로고    scopus 로고
    • Clinical and economic benefits associated with the achievement of both HbA1c and LDL cholesterol goals in veterans with type 2 diabetes
    • Shi L, Ye X, Lu M, Wu EQ, Sharma H, Thomason D, Fonseca VA. Clinical and economic benefits associated with the achievement of both HbA1c and LDL cholesterol goals in veterans with type 2 diabetes. Diabetes Care. 2013;36(10):3297-304.
    • (2013) Diabetes Care , vol.36 , Issue.10 , pp. 3297-3304
    • Shi, L.1    Ye, X.2    Lu, M.3    Wu, E.Q.4    Sharma, H.5    Thomason, D.6    Fonseca, V.A.7
  • 17
    • 84882254968 scopus 로고    scopus 로고
    • The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988-2010
    • Stark Casagrande S, Fradkin JE, Saydah SH, Rust KF, Cowie CC. The prevalence of meeting A1C, blood pressure, and LDL goals among people with diabetes, 1988-2010. Diabetes Care. 2013;36(8):2271-9.
    • (2013) Diabetes Care , vol.36 , Issue.8 , pp. 2271-2279
    • Stark Casagrande, S.1    Fradkin, J.E.2    Saydah, S.H.3    Rust, K.F.4    Cowie, C.C.5
  • 18
    • 84958586996 scopus 로고    scopus 로고
    • SPC: Forxiga 5 mg & 10 mg film coated tablets. Accessed 30 Oct 2015.
    • AstraZeneca UK Limited. SPC: Forxiga 5 mg & 10 mg film coated tablets. 2015. http://www.medicines.org.uk/EMC/medicine/27188. Accessed 30 Oct 2015.
    • (2015)
  • 19
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List JF, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care. 2009;32(4):650-7.
    • (2009) Diabetes Care , vol.32 , Issue.4 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 20
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment
    • Wilding JP, Norwood P, T'Joen C, Bastien A, List JF, Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment. Diabetes Care. 2009;32(9):1656-62.
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1656-1662
    • Wilding, J.P.1    Norwood, P.2    T'Joen, C.3    Bastien, A.4    List, J.F.5    Fiedorek, F.T.6
  • 21
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375(9733):2223-33.
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 22
    • 84860218907 scopus 로고    scopus 로고
    • Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
    • Henry RR, Murray AV, Marmolejo MH, Hennicken D, Ptaszynska A, List JF. Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract. 2012;66(5):446-56.
    • (2012) Int J Clin Pract , vol.66 , Issue.5 , pp. 446-456
    • Henry, R.R.1    Murray, A.V.2    Marmolejo, M.H.3    Hennicken, D.4    Ptaszynska, A.5    List, J.F.6
  • 23
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del Prato S, Meier JJ, Duran-Garcia S, Rohwedder K, Elze M, Parikh SJ. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34(9):2015-22.
    • (2011) Diabetes Care , vol.34 , Issue.9 , pp. 2015-2022
    • Nauck, M.A.1    Prato, S.2    Meier, J.J.3    Duran-Garcia, S.4    Rohwedder, K.5    Elze, M.6    Parikh, S.J.7
  • 24
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K, Yoon KH, Hruba V, Elze M, Langkilde AM, Parikh S. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2011;13(10):928-38.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.10 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Elze, M.4    Langkilde, A.M.5    Parikh, S.6
  • 25
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int. 2014;85(4):962-71.
    • (2014) Kidney Int , vol.85 , Issue.4 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3    List, J.F.4
  • 26
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care. 2012;35(7):1473-8.
    • (2012) Diabetes Care , vol.35 , Issue.7 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 27
    • 84892488179 scopus 로고    scopus 로고
    • Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years
    • Wilding JP, Woo V, Rohwedder K, Sugg J, Parikh S. Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years. Diabetes Obes Metab. 2014;16(2):124-36.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.2 , pp. 124-136
    • Wilding, J.P.1    Woo, V.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5
  • 28
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • Bolinder J, Ljunggren O, Johansson L, Wilding J, Langkilde AM, Sjostrom CD, Sugg J, Parikh S. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab. 2014;16(2):159-69.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.2 , pp. 159-169
    • Bolinder, J.1    Ljunggren, O.2    Johansson, L.3    Wilding, J.4    Langkilde, A.M.5    Sjostrom, C.D.6    Sugg, J.7    Parikh, S.8
  • 29
    • 84896701131 scopus 로고    scopus 로고
    • Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study
    • Jabbour SA, Hardy E, Sugg J, Parikh S. Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study. Diabetes Care. 2014;37(3):740-50.
    • (2014) Diabetes Care , vol.37 , Issue.3 , pp. 740-750
    • Jabbour, S.A.1    Hardy, E.2    Sugg, J.3    Parikh, S.4
  • 30
    • 84945175811 scopus 로고    scopus 로고
    • Dapagliflozin's effects on glycemia and cardiovascular risk factors in high-risk patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension
    • Cefalu WT, Leiter LA, de Bruin TW, Gause-Nilsson I, Sugg J, Parikh SJ. Dapagliflozin's effects on glycemia and cardiovascular risk factors in high-risk patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension. Diabetes Care. 2015;38(7):1218-27.
    • (2015) Diabetes Care , vol.38 , Issue.7 , pp. 1218-1227
    • Cefalu, W.T.1    Leiter, L.A.2    Bruin, T.W.3    Gause-Nilsson, I.4    Sugg, J.5    Parikh, S.J.6
  • 31
    • 84904466033 scopus 로고    scopus 로고
    • Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension
    • Leiter LA, Cefalu WT, de Bruin TW, Gause-Nilsson I, Sugg J, Parikh SJ. Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension. J Am Geriatr Soc. 2014;62(7):1252-62.
    • (2014) J Am Geriatr Soc , vol.62 , Issue.7 , pp. 1252-1262
    • Leiter, L.A.1    Cefalu, W.T.2    Bruin, T.W.3    Gause-Nilsson, I.4    Sugg, J.5    Parikh, S.J.6
  • 32
    • 84914181817 scopus 로고    scopus 로고
    • Efficacy and safety of dapagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise
    • Kaku K, Kiyosue A, Inoue S, Ueda N, Tokudome T, Yang J, Langkilde AM. Efficacy and safety of dapagliflozin monotherapy in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise. Diabetes Obes Metab. 2014;16(11):1102-10.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.11 , pp. 1102-1110
    • Kaku, K.1    Kiyosue, A.2    Inoue, S.3    Ueda, N.4    Tokudome, T.5    Yang, J.6    Langkilde, A.M.7
  • 33
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial
    • Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care. 2010;33(10):2217-24.
    • (2010) Diabetes Care , vol.33 , Issue.10 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 34
    • 84866003015 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in drug-naive patients with diabetes: a randomized-controlled trial of low-dose range
    • Bailey CJ, Iqbal N, T'Joen C, List JF. Dapagliflozin monotherapy in drug-naive patients with diabetes: a randomized-controlled trial of low-dose range. Diabetes Obes Metab. 2012;14(10):951-9.
    • (2012) Diabetes Obes Metab , vol.14 , Issue.10 , pp. 951-959
    • Bailey, C.J.1    Iqbal, N.2    T'Joen, C.3    List, J.F.4
  • 35
    • 84880850027 scopus 로고    scopus 로고
    • Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab. 2013;15(9):853-62.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.9 , pp. 853-862
    • Lambers Heerspink, H.J.1    de Zeeuw, D.2    Wie, L.3    Leslie, B.4    List, J.5
  • 37
    • 84892368256 scopus 로고    scopus 로고
    • Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study
    • Ji L, Ma J, Li H, Mansfield TA, T'Joen CL, Iqbal N, Ptaszynska A, List JF. Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study. Clin Ther. 2014;36(1):84-100.
    • (2014) Clin Ther , vol.36 , Issue.1 , pp. 84-100
    • Ji, L.1    Ma, J.2    Li, H.3    Mansfield, T.A.4    T'Joen, C.L.5    Iqbal, N.6    Ptaszynska, A.7    List, J.F.8
  • 38
    • 84876335563 scopus 로고    scopus 로고
    • Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial
    • Kaku K, Inoue S, Matsuoka O, Kiyosue A, Azuma H, Hayashi N, Tokudome T, Langkilde AM, Parikh S. Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus in Japanese patients with inadequate glycaemic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2013;15(5):432-40.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.5 , pp. 432-440
    • Kaku, K.1    Inoue, S.2    Matsuoka, O.3    Kiyosue, A.4    Azuma, H.5    Hayashi, N.6    Tokudome, T.7    Langkilde, A.M.8    Parikh, S.9
  • 39
    • 84895484977 scopus 로고    scopus 로고
    • Dapagliflozin treatment for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
    • Zhang M, Zhang L, Wu B, Song H, An Z, Li S. Dapagliflozin treatment for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Res Rev. 2014;30(3):204-21.
    • (2014) Diabetes Metab Res Rev , vol.30 , Issue.3 , pp. 204-221
    • Zhang, M.1    Zhang, L.2    Wu, B.3    Song, H.4    An, Z.5    Li, S.6
  • 41
    • 84958586997 scopus 로고    scopus 로고
    • Guidance for industry: diabetes mellitus-evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. Accessed 30 Oct 2015.
    • Center for Drug Evaluation and Research (CDER). Guidance for industry: diabetes mellitus-evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. 2008. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071627.pdf. Accessed 30 Oct 2015.
    • (2008)
  • 42
    • 84958586998 scopus 로고    scopus 로고
    • Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus
    • European Medicines Agency. Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus. 2012. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/06/WC500129256.pdf. Accessed 30 Oct 2015.
    • (2012)
  • 46
    • 84958586999 scopus 로고    scopus 로고
    • The evaluation of lixisenatide in acute coronary syndrome-the results of ELIXA
    • Presented at the 75th Scientific Sessions of the American Diabetes Association June 5-9, 2015, Boston, MA;
    • Riddle MC. The evaluation of lixisenatide in acute coronary syndrome-the results of ELIXA. Presented at the 75th Scientific Sessions of the American Diabetes Association June 5-9, 2015, Boston, MA; 2015.
    • (2015)
    • Riddle, M.C.1
  • 48
    • 84958587000 scopus 로고    scopus 로고
    • Clinicaltrials.gov. Multicenter trial to evaluate the effect of dapagliflozin on the incidence of cardiovascular events (DECLARE-TIMI58). Accessed 08 Jan 2016.
    • Clinicaltrials.gov. Multicenter trial to evaluate the effect of dapagliflozin on the incidence of cardiovascular events (DECLARE-TIMI58). https://clinicaltrials.gov/ct2/show/NCT01730534. Accessed 08 Jan 2016.
  • 50
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)-a randomized placebo-controlled trial
    • Neal B, Perkovic V, de Zeeuw D, Mahaffey KW, Fulcher G, Stein P, Desai M, Shaw W, Jiang J, Vercruysse F, et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)-a randomized placebo-controlled trial. Am Heart J. 2013;166(2):217-23.
    • (2013) Am Heart J , vol.166 , Issue.2 , pp. 217-223
    • Neal, B.1    Perkovic, V.2    Zeeuw, D.3    Mahaffey, K.W.4    Fulcher, G.5    Stein, P.6    Desai, M.7    Shaw, W.8    Jiang, J.9    Vercruysse, F.10
  • 51
    • 84958587001 scopus 로고    scopus 로고
    • Abstract 11105: cardiovascular safety of the SGLT2 inhibitor dapagliflozin: meta-analysis with >6000 patient-years exposure
    • Presented at the American Heart Association 2013 Scientific Sessions, Dallas, TX, November 16-20, 2013;
    • Langkilde AM, Johansson P, Ptaszynska A, Johnsson E. Abstract 11105: cardiovascular safety of the SGLT2 inhibitor dapagliflozin: meta-analysis with >6000 patient-years exposure. Presented at the American Heart Association 2013 Scientific Sessions, Dallas, TX, November 16-20, 2013; 2013.
    • (2013)
    • Langkilde, A.M.1    Johansson, P.2    Ptaszynska, A.3    Johnsson, E.4
  • 52
    • 84862823213 scopus 로고    scopus 로고
    • Variation of fasting plasma glucose: a predictor of mortality in patients with type 2 diabetes
    • Lin CC, Li CI, Yang SY, Liu CS, Chen CC, Fuh MM, Chen W, Li TC. Variation of fasting plasma glucose: a predictor of mortality in patients with type 2 diabetes. Am J Med. 2012;125(4):416e9-18.
    • (2012) Am J Med , vol.125 , Issue.4 , pp. 416e9-419e18
    • Lin, C.C.1    Li, C.I.2    Yang, S.Y.3    Liu, C.S.4    Chen, C.C.5    Fuh, M.M.6    Chen, W.7    Li, T.C.8
  • 53
    • 84891780161 scopus 로고    scopus 로고
    • Glycemic variability: both sides of the story
    • Ceriello A, Kilpatrick ES. Glycemic variability: both sides of the story. Diabetes Care. 2013;36(Suppl 2):S272-5.
    • (2013) Diabetes Care , vol.36 , pp. S272-S275
    • Ceriello, A.1    Kilpatrick, E.S.2
  • 54
    • 79959774659 scopus 로고    scopus 로고
    • Postprandial hyperglycemia and glycemic variability: should we care?
    • Standl E, Schnell O, Ceriello A. Postprandial hyperglycemia and glycemic variability: should we care? Diabetes Care. 2011;34(Suppl 2):S120-7.
    • (2011) Diabetes Care , vol.34 , pp. S120-S127
    • Standl, E.1    Schnell, O.2    Ceriello, A.3
  • 58
    • 84881416448 scopus 로고    scopus 로고
    • Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis
    • Goto A, Arah OA, Goto M, Terauchi Y, Noda M. Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis. BMJ. 2013;347:f4533.
    • (2013) BMJ , vol.347 , pp. f4533
    • Goto, A.1    Arah, O.A.2    Goto, M.3    Terauchi, Y.4    Noda, M.5
  • 60
    • 84891760955 scopus 로고    scopus 로고
    • Cardiovascular outcome studies with novel antidiabetes agents: scientific and operational considerations
    • Hirshberg B, Katz A. Cardiovascular outcome studies with novel antidiabetes agents: scientific and operational considerations. Diabetes Care. 2013;36(Suppl 2):S253-8.
    • (2013) Diabetes Care , vol.36 , pp. S253-S258
    • Hirshberg, B.1    Katz, A.2
  • 61
    • 84945206560 scopus 로고    scopus 로고
    • Efficacy and safety of dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in diabetes mellitus
    • Fioretto P, Giaccari A, Sesti G. Efficacy and safety of dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in diabetes mellitus. Cardiovasc Diabetol. 2015;14:142.
    • (2015) Cardiovasc Diabetol , vol.14 , pp. 142
    • Fioretto, P.1    Giaccari, A.2    Sesti, G.3
  • 62
    • 84959460390 scopus 로고    scopus 로고
    • Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study
    • Weber MA, Mansfield TA, Cain VA, Iqbal N, Parikh S, Ptaszynska A. Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Diabetes Endocrinol. 2015. doi: 10.1016/S2213-8587(15)00417-9.
    • (2015) Lancet Diabetes Endocrinol
    • Weber, M.A.1    Mansfield, T.A.2    Cain, V.A.3    Iqbal, N.4    Parikh, S.5    Ptaszynska, A.6
  • 63
    • 84958125420 scopus 로고    scopus 로고
    • Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade
    • Weber MA, Mansfield TA, Alessi F, Iqbal N, Parikh S, Ptaszynska A. Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin-angiotensin system blockade. Blood Press. 2016;25(2):93-103. doi: 10.3109/08037051.2015.1116258.
    • (2016) Blood Press , vol.25 , Issue.2 , pp. 93-103
    • Weber, M.A.1    Mansfield, T.A.2    Alessi, F.3    Iqbal, N.4    Parikh, S.5    Ptaszynska, A.6
  • 64
    • 84979549409 scopus 로고    scopus 로고
    • Dapagliflozin reduces albuminuria over 2 years in diabetic patients with renal impairment
    • 1A. Abstr. TH-OR001.
    • Fioretto P, Stefansson BV, Johnsson EKA, Cain VA, Sjostrom D. Dapagliflozin reduces albuminuria over 2 years in diabetic patients with renal impairment. J Am Soc Nephrol. 2015;26:1A. Abstr. TH-OR001.
    • (2015) J Am Soc Nephrol , pp. 26
    • Fioretto, P.1    Stefansson, B.V.2    Johnsson, E.K.A.3    Cain, V.A.4    Sjostrom, D.5
  • 65
    • 84945194519 scopus 로고    scopus 로고
    • Dapagliflozin reduces albuminuria on top of renin-angiotensin system blockade in hypertensive diabetic patients
    • Abstr. 1176-P.
    • Lambers-Heerspink H, Johnsson E, Gause-Nilsson I, Johansson K, Sjostrom CD. Dapagliflozin reduces albuminuria on top of renin-angiotensin system blockade in hypertensive diabetic patients. Diabetes. 2015;64(Suppl 1):A303. Abstr. 1176-P.
    • (2015) Diabetes , vol.64 , pp. A303
    • Lambers-Heerspink, H.1    Johnsson, E.2    Gause-Nilsson, I.3    Johansson, K.4    Sjostrom, C.D.5
  • 66
    • 84964696031 scopus 로고    scopus 로고
    • Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice
    • Lin B, Koibuchi N, Hasegawa Y, Sueta D, Toyama K, Uekawa K, Ma M, Nakagawa T, Kusaka H, Kim-Mitsuyama S. Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice. Cardiovasc Diabetol. 2014;13:148.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 148
    • Lin, B.1    Koibuchi, N.2    Hasegawa, Y.3    Sueta, D.4    Toyama, K.5    Uekawa, K.6    Ma, M.7    Nakagawa, T.8    Kusaka, H.9    Kim-Mitsuyama, S.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.