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Volumn 63, Issue 10, 2014, Pages 1228-1237

The role of the kidneys in glucose homeostasis in type 2 diabetes: Clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors

Author keywords

Kidneys; Sodium glucose co transporter 2 (SGLT2) inhibitor; Type 2 diabetes mellitus

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; GLUCOSE; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 84908254603     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.06.018     Document Type: Review
Times cited : (147)

References (81)
  • 1
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. from the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • R.A. Defronzo Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus Diabetes 58 2009 773 795
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 2
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications
    • J.E. Gerich Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications Diabet Med 27 2010 136 142
    • (2010) Diabet Med , vol.27 , pp. 136-142
    • Gerich, J.E.1
  • 3
    • 0028872833 scopus 로고
    • Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine
    • M. Stumvoll, U. Chintalapudi, and G. Perriello Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine J Clin Invest 96 1995 2528 2533
    • (1995) J Clin Invest , vol.96 , pp. 2528-2533
    • Stumvoll, M.1    Chintalapudi, U.2    Perriello, G.3
  • 4
    • 0034520399 scopus 로고    scopus 로고
    • Physiology of glucose homeostasis
    • J.E. Gerich Physiology of glucose homeostasis Diabetes Obes Metab 2 2000 345 350
    • (2000) Diabetes Obes Metab , vol.2 , pp. 345-350
    • Gerich, J.E.1
  • 5
    • 0035146344 scopus 로고    scopus 로고
    • Renal gluconeogenesis: Its importance in human glucose homeostasis
    • J.E. Gerich, C. Meyer, and H.J. Woerle Renal gluconeogenesis: its importance in human glucose homeostasis Diabetes Care 24 2001 382 391
    • (2001) Diabetes Care , vol.24 , pp. 382-391
    • Gerich, J.E.1    Meyer, C.2    Woerle, H.J.3
  • 6
    • 0032952105 scopus 로고    scopus 로고
    • Insulin regulation of renal glucose metabolism in humans
    • E. Cersosimo, P. Garlick, and J. Ferretti Insulin regulation of renal glucose metabolism in humans Am J Physiol 276 1999 E78 E84
    • (1999) Am J Physiol , vol.276 , pp. 78-E84
    • Cersosimo, E.1    Garlick, P.2    Ferretti, J.3
  • 7
    • 0032437590 scopus 로고    scopus 로고
    • Effects of physiological hyperinsulinemia on systemic, renal, and hepatic substrate metabolism
    • C. Meyer, J. Dostou, and V. Nadkarni Effects of physiological hyperinsulinemia on systemic, renal, and hepatic substrate metabolism Am J Physiol 275 1998 F915 F921
    • (1998) Am J Physiol , vol.275 , pp. 915-F921
    • Meyer, C.1    Dostou, J.2    Nadkarni, V.3
  • 8
    • 0141504365 scopus 로고    scopus 로고
    • Relative importance of liver, kidney, and substrates in epinephrine-induced increased gluconeogenesis in humans
    • C. Meyer, M. Stumvoll, and S. Welle Relative importance of liver, kidney, and substrates in epinephrine-induced increased gluconeogenesis in humans Am J Physiol Endocrinol Metab 285 2003 E819 E826
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. 819-E826
    • Meyer, C.1    Stumvoll, M.2    Welle, S.3
  • 9
  • 10
    • 0036084280 scopus 로고    scopus 로고
    • Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis
    • C. Meyer, J.M. Dostou, and S.L. Welle Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis Am J Physiol Endocrinol Metab 282 2002 E419 E427
    • (2002) Am J Physiol Endocrinol Metab , vol.282 , pp. 419-E427
    • Meyer, C.1    Dostou, J.M.2    Welle, S.L.3
  • 11
    • 0034997336 scopus 로고    scopus 로고
    • Renal Na(+)-glucose cotransporters
    • E.M. Wright Renal Na(+)-glucose cotransporters Am J Physiol Renal Physiol 280 2001 F10 F18
    • (2001) Am J Physiol Renal Physiol , vol.280 , pp. 10-F18
    • Wright, E.M.1
  • 12
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • E.M. Wright, B.A. Hirayama, and D.F. Loo Active sugar transport in health and disease J Intern Med 261 2007 32 43
    • (2007) J Intern Med , vol.261 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 13
    • 67349189212 scopus 로고    scopus 로고
    • Renal sodium-glucose transport: Role in diabetes mellitus and potential clinical implications
    • G.L. Bakris, V.A. Fonseca, and K. Sharma Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications Kidney Int 75 2009 1272 1277
    • (2009) Kidney Int , vol.75 , pp. 1272-1277
    • Bakris, G.L.1    Fonseca, V.A.2    Sharma, K.3
  • 14
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • M.A. Abdul-Ghani, L. Norton, and R.A. Defronzo Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes Endocr Rev 32 2011 515 531
    • (2011) Endocr Rev , vol.32 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 15
    • 0037267005 scopus 로고    scopus 로고
    • Glucose transporters (GLUT and SGLT): Expanded families of sugar transport proteins
    • I.S. Wood, and P. Trayhurn Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins Br J Nutr 89 2003 3 9
    • (2003) Br J Nutr , vol.89 , pp. 3-9
    • Wood, I.S.1    Trayhurn, P.2
  • 16
    • 67649359913 scopus 로고    scopus 로고
    • From victim to ally: The kidney as an emerging target for the treatment of diabetes mellitus
    • H. Bays From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus Curr Med Res Opin 25 2009 671 681
    • (2009) Curr Med Res Opin , vol.25 , pp. 671-681
    • Bays, H.1
  • 17
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • E.M. Wright, D.D. Loo, and B.A. Hirayama Biology of human sodium glucose transporters Physiol Rev 91 2011 733 794
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 18
    • 75149196250 scopus 로고    scopus 로고
    • Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus
    • S. Nair, and J.P. Wilding Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus J Clin Endocrinol Metab 95 2010 34 42
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 34-42
    • Nair, S.1    Wilding, J.P.2
  • 19
    • 79651473537 scopus 로고    scopus 로고
    • Renal glucose reabsorption inhibitors to treat diabetes
    • C.J. Bailey Renal glucose reabsorption inhibitors to treat diabetes Trends Pharmacol Sci 32 2011 63 71
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 63-71
    • Bailey, C.J.1
  • 20
    • 84877865378 scopus 로고    scopus 로고
    • Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: Results of a randomized, placebo-controlled study
    • D. Polidori, S. Sha, and S. Mudaliar Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study Diabetes Care 36 2013 2154 2161
    • (2013) Diabetes Care , vol.36 , pp. 2154-2161
    • Polidori, D.1    Sha, S.2    Mudaliar, S.3
  • 21
    • 84877710926 scopus 로고    scopus 로고
    • Validation of a novel method for determining the renal threshold for glucose excretion in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus
    • D. Polidori, S. Sha, and A. Ghosh Validation of a novel method for determining the renal threshold for glucose excretion in untreated and canagliflozin-treated subjects with type 2 diabetes mellitus J Clin Endocrinol Metab 98 2013 E867 E871
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 867-E871
    • Polidori, D.1    Sha, S.2    Ghosh, A.3
  • 22
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • Y. Liang, K. Arakawa, and K. Ueta Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models PLoS One 7 2012 e30555
    • (2012) PLoS One , vol.7 , pp. 30555
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3
  • 24
    • 33748064644 scopus 로고    scopus 로고
    • Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes - Results of a hyperglycaemic glucose clamp study
    • K. Rave, L. Nosek, and J. Posner Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes - results of a hyperglycaemic glucose clamp study Nephrol Dial Transplant 21 2006 2166 2171
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 2166-2171
    • Rave, K.1    Nosek, L.2    Posner, J.3
  • 25
    • 0031128195 scopus 로고    scopus 로고
    • Renal threshold for glucose in non-insulin-dependent diabetic patients
    • B. Ruhnau, O.K. Faber, and K. Borch-Johnsen Renal threshold for glucose in non-insulin-dependent diabetic patients Diabetes Res Clin Pract 36 1997 27 33
    • (1997) Diabetes Res Clin Pract , vol.36 , pp. 27-33
    • Ruhnau, B.1    Faber, O.K.2    Borch-Johnsen, K.3
  • 26
    • 70349567392 scopus 로고    scopus 로고
    • Renal glucose excretion and tubular reabsorption rate related to blood glucose in subjects with type 2 diabetes with a critical reappraisal of the "renal glucose threshold" model
    • S. Wolf, K. Rave, and L. Heinemann Renal glucose excretion and tubular reabsorption rate related to blood glucose in subjects with type 2 diabetes with a critical reappraisal of the "renal glucose threshold" model Horm Metab Res 41 2009 600 604
    • (2009) Horm Metab Res , vol.41 , pp. 600-604
    • Wolf, S.1    Rave, K.2    Heinemann, L.3
  • 27
    • 80052818523 scopus 로고    scopus 로고
    • Canagliflozin lowers the renal threshold for glucose excretion in lean, obese and type 2 diabetic subjects [abstract]
    • D. Polidori, S. Sha, and T. Sarich Canagliflozin lowers the renal threshold for glucose excretion in lean, obese and type 2 diabetic subjects [abstract] Diabetologia 53 2010 S350
    • (2010) Diabetologia , vol.53 , pp. 350
    • Polidori, D.1    Sha, S.2    Sarich, T.3
  • 28
    • 84860252876 scopus 로고    scopus 로고
    • Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    • D. Devineni, L. Morrow, and M. Hompesch Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin Diabetes Obes Metab 14 2012 539 545
    • (2012) Diabetes Obes Metab , vol.14 , pp. 539-545
    • Devineni, D.1    Morrow, L.2    Hompesch, M.3
  • 29
    • 64749094872 scopus 로고
    • Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
    • S.J. Farber, E.Y. Berger, and D.P. Earle Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose J Clin Invest 30 1951 125 129
    • (1951) J Clin Invest , vol.30 , pp. 125-129
    • Farber, S.J.1    Berger, E.Y.2    Earle, D.P.3
  • 30
    • 0015122757 scopus 로고
    • Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects
    • C.E. Mogensen Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects Scand J Clin Lab Invest 28 1971 101 109
    • (1971) Scand J Clin Lab Invest , vol.28 , pp. 101-109
    • Mogensen, C.E.1
  • 31
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • H. Rahmoune, P.W. Thompson, and J.M. Ward Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes Diabetes 54 2005 3427 3434
    • (2005) Diabetes , vol.54 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3
  • 32
    • 0035879385 scopus 로고    scopus 로고
    • Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat
    • S. Vestri, M.M. Okamoto, and H.S. de Freitas Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat J Membr Biol 182 2001 105 112
    • (2001) J Membr Biol , vol.182 , pp. 105-112
    • Vestri, S.1    Okamoto, M.M.2    De Freitas, H.S.3
  • 33
    • 38549182041 scopus 로고    scopus 로고
    • Na(+)-glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: Involvement of hepatocyte nuclear factor-1alpha expression and activity
    • H.S. Freitas, G.F. Anhe, and K.F. Melo Na(+)-glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity Endocrinology 149 2008 717 724
    • (2008) Endocrinology , vol.149 , pp. 717-724
    • Freitas, H.S.1    Anhe, G.F.2    Melo, K.F.3
  • 34
    • 57949111356 scopus 로고    scopus 로고
    • Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats
    • N.M. Tabatabai, M. Sharma, and S.S. Blumenthal Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats Diabetes Res Clin Pract 83 2009 e27 e30
    • (2009) Diabetes Res Clin Pract , vol.83 , pp. 27-e30
    • Tabatabai, N.M.1    Sharma, M.2    Blumenthal, S.S.3
  • 35
    • 0036627887 scopus 로고    scopus 로고
    • Is hepatic glucose production increased in type 2 diabetes mellitus?
    • H. Beck-Nielsen, O. Hother-Nielsen, and P. Staehr Is hepatic glucose production increased in type 2 diabetes mellitus? Curr Diab Rep 2 2002 231 236
    • (2002) Curr Diab Rep , vol.2 , pp. 231-236
    • Beck-Nielsen, H.1    Hother-Nielsen, O.2    Staehr, P.3
  • 36
    • 0025891622 scopus 로고
    • Glucose/galactose malabsorption caused by a defect in the Na +/glucose cotransporter
    • E. Turk, B. Zabel, and S. Mundlos Glucose/galactose malabsorption caused by a defect in the Na +/glucose cotransporter Nature 350 1991 354 356
    • (1991) Nature , vol.350 , pp. 354-356
    • Turk, E.1    Zabel, B.2    Mundlos, S.3
  • 37
    • 56749160374 scopus 로고    scopus 로고
    • Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion
    • J. Calado, Y. Sznajer, and D. Metzger Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion Nephrol Dial Transplant 23 2008 3874 3879
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3874-3879
    • Calado, J.1    Sznajer, Y.2    Metzger, D.3
  • 38
    • 10744229025 scopus 로고    scopus 로고
    • Molecular analysis of the SGLT2 gene in patients with renal glucosuria
    • R. Santer, M. Kinner, and C.L. Lassen Molecular analysis of the SGLT2 gene in patients with renal glucosuria J Am Soc Nephrol 14 2003 2873 2882
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2873-2882
    • Santer, R.1    Kinner, M.2    Lassen, C.L.3
  • 39
    • 75749094398 scopus 로고    scopus 로고
    • Familial renal glucosuria and SGLT2: From a Mendelian trait to a therapeutic target
    • R. Santer, and J. Calado Familial renal glucosuria and SGLT2: from a Mendelian trait to a therapeutic target Clin J Am Soc Nephrol 5 2010 133 141
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 133-141
    • Santer, R.1    Calado, J.2
  • 40
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • B. Zambrowicz, J. Freiman, and P.M. Brown LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial Clin Pharmacol Ther 92 2012 158 169
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3
  • 42
    • 84908234321 scopus 로고    scopus 로고
    • Summary of Product Characteristics
    • Bristol-Myers Squibb/AstraZeneca EEIG Middlesex, United Kingdom
    • Summary of Product Characteristics Forxiga 5 mg and 10 mg film-coated tablets 2012 Bristol-Myers Squibb/AstraZeneca EEIG Middlesex, United Kingdom
    • (2012) Forxiga 5 Mg and 10 Mg Film-coated Tablets
  • 43
    • 84877922239 scopus 로고    scopus 로고
    • Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data
    • E. Kurosaki, and H. Ogasawara Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data Pharmacol Ther 139 2013 51 59
    • (2013) Pharmacol Ther , vol.139 , pp. 51-59
    • Kurosaki, E.1    Ogasawara, H.2
  • 44
    • 84872733237 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects
    • Z. Miao, G. Nucci, and N. Amin Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects Drug Metab Dispos 41 2013 445 456
    • (2013) Drug Metab Dispos , vol.41 , pp. 445-456
    • Miao, Z.1    Nucci, G.2    Amin, N.3
  • 45
    • 84879795546 scopus 로고    scopus 로고
    • A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
    • E. Ferrannini, L. Seman, and E. Seewaldt-Becker A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes Diabetes Obes Metab 15 2013 721 728
    • (2013) Diabetes Obes Metab , vol.15 , pp. 721-728
    • Ferrannini, E.1    Seman, L.2    Seewaldt-Becker, E.3
  • 48
    • 84880320337 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus
    • D. Devineni, C.R. Curtin, and D. Polidori Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus J Clin Pharmacol 53 2013 601 610
    • (2013) J Clin Pharmacol , vol.53 , pp. 601-610
    • Devineni, D.1    Curtin, C.R.2    Polidori, D.3
  • 49
    • 79956331954 scopus 로고    scopus 로고
    • Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects
    • S. Sha, D. Devineni, and A. Ghosh Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects Diabetes Obes Metab 13 2011 669 672
    • (2011) Diabetes Obes Metab , vol.13 , pp. 669-672
    • Sha, S.1    Devineni, D.2    Ghosh, A.3
  • 50
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • J. Rosenstock, N. Aggarwal, and D. Polidori Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes Diabetes Care 35 2012 1232 1238
    • (2012) Diabetes Care , vol.35 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3
  • 52
    • 84887501877 scopus 로고    scopus 로고
    • Canagliflozin (CANA), a sodium glucose co-transporter 2 (SGLT2) inhibitor, reduces post-meal glucose excursion in patients with type 2 diabetes mellitus (T2DM) by a non-renal mechanism [abstract]
    • P. Stein, J.K. Berg, and L. Morrow Canagliflozin (CANA), a sodium glucose co-transporter 2 (SGLT2) inhibitor, reduces post-meal glucose excursion in patients with type 2 diabetes mellitus (T2DM) by a non-renal mechanism [abstract] Diabetes 61 2012
    • (2012) Diabetes , vol.61
    • Stein, P.1    Berg, J.K.2    Morrow, L.3
  • 53
    • 77956319973 scopus 로고    scopus 로고
    • Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus
    • S. Nomura, S. Sakamaki, and M. Hongu Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus J Med Chem 53 2010 6355 6360
    • (2010) J Med Chem , vol.53 , pp. 6355-6360
    • Nomura, S.1    Sakamaki, S.2    Hongu, M.3
  • 54
    • 84880543926 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: A randomized trial
    • B. Bode, K. Stenlöf, and D. Sullivan Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: a randomized trial Hosp Pract 41 2013 72 84
    • (2013) Hosp Pract , vol.41 , pp. 72-84
    • Bode, B.1    Stenlöf, K.2    Sullivan, D.3
  • 55
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • W.T. Cefalu, L.A. Leiter, and K.-H. Yoon Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial Lancet 382 2013 941 950
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.-H.3
  • 56
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week, randomized trial
    • G. Schernthaner, J.L. Gross, and J. Rosenstock Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week, randomized trial Diabetes Care 36 2013 2508 2515
    • (2013) Diabetes Care , vol.36 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 57
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • K. Stenlöf, W.T. Cefalu, and K.-A. Kim Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise Diabetes Obes Metab 15 2013 372 382
    • (2013) Diabetes Obes Metab , vol.15 , pp. 372-382
    • Stenlöf, K.1    Cefalu, W.T.2    Kim, K.-A.3
  • 58
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • J.F. Yale, G. Bakris, and B. Cariou Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease Diabetes Obes Metab 15 2013 463 473
    • (2013) Diabetes Obes Metab , vol.15 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 59
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: A randomised trial
    • F.J. Lavalle-González, A. Januszewicz, and J. Davidson Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial Diabetologia 56 2013 2582 2592
    • (2013) Diabetologia , vol.56 , pp. 2582-2592
    • Lavalle-González, F.J.1    Januszewicz, A.2    Davidson, J.3
  • 60
    • 84888059660 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: A randomised trial
    • J.P. Wilding, G. Charpentier, and P. Hollander Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial Int J Clin Pract 67 2013 1267 1282
    • (2013) Int J Clin Pract , vol.67 , pp. 1267-1282
    • Wilding, J.P.1    Charpentier, G.2    Hollander, P.3
  • 61
    • 84893482692 scopus 로고    scopus 로고
    • Canagliflozin (CANA) demonstrates durable glycemic improvements over 104 weeks versus glimepiride (GLIM) in subjects with type 2 diabetes mellitus (T2DM) on metformin (MET) [abstract]
    • W.T. Cefalu, L.A. Leiter, and K.-H. Yoon Canagliflozin (CANA) demonstrates durable glycemic improvements over 104 weeks versus glimepiride (GLIM) in subjects with type 2 diabetes mellitus (T2DM) on metformin (MET) [abstract] Diabetes 62 2013 LB18
    • (2013) Diabetes , vol.62 , pp. 18
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.-H.3
  • 62
    • 67349180574 scopus 로고    scopus 로고
    • Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    • B. Komoroski, N. Vachharajani, and D. Boulton Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects Clin Pharmacol Ther 85 2009 520 526
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 520-526
    • Komoroski, B.1    Vachharajani, N.2    Boulton, D.3
  • 63
    • 67349275999 scopus 로고    scopus 로고
    • Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    • B. Komoroski, N. Vachharajani, and Y. Feng Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus Clin Pharmacol Ther 85 2009 513 519
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 513-519
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3
  • 64
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
    • E. Ferrannini, S.J. Ramos, and A. Salsali Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial Diabetes Care 33 2010 2217 2224
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3
  • 65
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • C.J. Bailey, J.L. Gross, and A. Pieters Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial Lancet 375 2010 2223 2233
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3
  • 66
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
    • K. Strojek, K.H. Yoon, and V. Hruba Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial Diabetes Obes Metab 13 2011 928 938
    • (2011) Diabetes Obes Metab , vol.13 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3
  • 67
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, on hemoglobin A1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • J. Rosenstock, M. Vico, and L. Wei Effects of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, on hemoglobin A1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy Diabetes Care 35 2012 1473 1478
    • (2012) Diabetes Care , vol.35 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3
  • 68
    • 84892646750 scopus 로고    scopus 로고
    • Durability of dapagliflozin vs glipizide as add-on therapies in T2DM inadequately controlled on metformin: 4-year data [abstract]
    • S. Del Prato, M.A. Nauck, and S. Duran-Garcia Durability of dapagliflozin vs. glipizide as add-on therapies in T2DM inadequately controlled on metformin: 4-year data [abstract] Diabetes 62 2013 LB17
    • (2013) Diabetes , vol.62 , pp. 17
    • Del Prato, S.1    Nauck, M.A.2    Duran-Garcia, S.3
  • 69
    • 84897019959 scopus 로고    scopus 로고
    • Urinary tract infection in randomized Phase III studies of canagliflozin, a sodium glucose co-transporter 2 inhibitor
    • L.E. Nicolle, G. Capuano, and A. Fung Urinary tract infection in randomized Phase III studies of canagliflozin, a sodium glucose co-transporter 2 inhibitor Postgrad Med 126 2014 7 17
    • (2014) Postgrad Med , vol.126 , pp. 7-17
    • Nicolle, L.E.1    Capuano, G.2    Fung, A.3
  • 70
    • 84883810898 scopus 로고    scopus 로고
    • Urinary tract infections in patients with diabetes treated with dapagliflozin
    • K.M. Johnsson, A. Ptaszynska, and B. Schmitz Urinary tract infections in patients with diabetes treated with dapagliflozin J Diabetes Complications 27 2013 473 478
    • (2013) J Diabetes Complications , vol.27 , pp. 473-478
    • Johnsson, K.M.1    Ptaszynska, A.2    Schmitz, B.3
  • 71
    • 84883799810 scopus 로고    scopus 로고
    • Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin
    • K.M. Johnsson, A. Ptaszynska, and B. Schmitz Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin J Diabetes Complications 27 2013 479 484
    • (2013) J Diabetes Complications , vol.27 , pp. 479-484
    • Johnsson, K.M.1    Ptaszynska, A.2    Schmitz, B.3
  • 72
    • 84900823374 scopus 로고    scopus 로고
    • Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • P. Nyirjesy, J.D. Sobel, and A. Fung Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studies Curr Med Res Opin 30 2014 1109 1119
    • (2014) Curr Med Res Opin , vol.30 , pp. 1109-1119
    • Nyirjesy, P.1    Sobel, J.D.2    Fung, A.3
  • 73
    • 84875175116 scopus 로고    scopus 로고
    • Effect of dapagliflozin on renal function [abstract]
    • A. Ptaszynska, A.-G. Chalamandaris, and J.E. Sugg Effect of dapagliflozin on renal function [abstract] Diabetes 61 2012 1098-P
    • (2012) Diabetes , vol.61 , pp. 1098-P
    • Ptaszynska, A.1    Chalamandaris, A.-G.2    Sugg, J.E.3
  • 74
    • 84873960885 scopus 로고    scopus 로고
    • Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled 102-week trial
    • C.J. Bailey, J.L. Gross, and D. Hennicken Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial BMC Med 11 2013 43
    • (2013) BMC Med , vol.11 , pp. 43
    • Bailey, C.J.1    Gross, J.L.2    Hennicken, D.3
  • 75
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • E. Ferrannini, E. Muscelli, and S. Frascerra Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients J Clin Invest 124 2014 499 508
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 76
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • A. Merovci, C. Solis-Herrera, and G. Daniele Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production J Clin Invest 124 2014 509 514
    • (2014) J Clin Invest , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 77
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • M.A. Nauck, P.S. Del, and J.J. Meier Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial Diabetes Care 34 2011 2015 2022
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.A.1    Del, P.S.2    Meier, J.J.3
  • 78
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • J. Bolinder, O. Ljunggren, and J. Kullberg Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin J Clin Endocrinol Metab 97 2012 1020 1031
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, O.2    Kullberg, J.3
  • 79
    • 84908062899 scopus 로고    scopus 로고
    • Exploring the potential of dapagliflozin in type 1 diabetes: Phase 2a pilot study [abstract]
    • R.R. Henry, J. Rosenstock, and A.-G. Chalamandaris Exploring the potential of dapagliflozin in type 1 diabetes: phase 2a pilot study [abstract] Diabetes 62 2013 LB20
    • (2013) Diabetes , vol.62 , pp. 20
    • Henry, R.R.1    Rosenstock, J.2    Chalamandaris, A.-G.3
  • 80
    • 84899105421 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: Results of an 8-week open-label proof-of-concept trial
    • B.A. Perkins, D.Z. Cherney, and H. Partridge Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial Diabetes Care 37 2014 1480 1483
    • (2014) Diabetes Care , vol.37 , pp. 1480-1483
    • Perkins, B.A.1    Cherney, D.Z.2    Partridge, H.3
  • 81
    • 84891865819 scopus 로고    scopus 로고
    • Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
    • R.A. Defronzo, M. Hompesch, and S. Kasichayanula Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes Diabetes Care 36 2013 3169 3176
    • (2013) Diabetes Care , vol.36 , pp. 3169-3176
    • Defronzo, R.A.1    Hompesch, M.2    Kasichayanula, S.3


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