Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation

Hormone and Metabolic Research

Volumn 48, Issue 3, 2016, Pages 191-195

  Ishibashi, Y ^a   Matsui, T ^a   Yamagishi, S ^a  

^a KURUME UNIVERSITY   (Japan)

Author keywords

antioxidants; apoptosis; diabetic nephropathy

Indexed keywords

ACETYLCYSTEINE; GLUCOSE; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; TOFOGLIFLOZIN; 6-((4-ETHYLPHENYL)METHYL)-3',4',5',6'-TETRAHYDRO-6'-(HYDROXYMETHYL)SPIRO(ISOBENZOFURAN-1(3H),2'-(2H)PYRAN)-3',4',5'-TRIOL; BENZHYDRYL DERIVATIVE; GLUCOSIDE; MESSENGER RNA; SODIUM GLUCOSE COTRANSPORTER 2;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IC50; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY;

APOPTOSIS; BENZHYDRYL COMPOUNDS; CELL LINE; CHEMOKINE CCL2; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSIDES; HUMANS; INFLAMMATION; KIDNEY TUBULES, PROXIMAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SODIUM-GLUCOSE TRANSPORTER 2;

EID: 84961057126     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0035-1555791     Document Type: Article

References (31)

1. th edition revision 2014 International Diabetes Federation Brussels, Belgium: 2014
2. Yamagishi S., Fukami K., Ueda S., Okuda S. Molecular mechanisms of diabetic nephropathy and its therapeutic intervention. Curr Drug Targets: 2007; 8 952 959
3. Karnib H. H., Ziyadeh F. N. The cardiorenal syndrome in diabetes mellitus. Diabetes Res Clin Pract: 2010; 89 201 208
4. Alsaad K. O., Herzenberg A. M. Distinguishing diabetic nephropathy from other causes of glomerulosclerosis: an update. J Clin Pathol: 2007; 60 18 26
5. Taft J. L., Nolan C. J., Yeung S. P., Hewitson T. D., Martin F. I. Clinical and histological correlations of decline in renal function in diabetic patients with proteinuria. Diabetes: 1994; 43 1046 1051
6. Ziyadeh F. N., Goldfarb S. The renal tubulointerstitium in diabetes mellitus. Kidney Int: 1991; 39 464 475
7. Yamagishi S., Imaizumi T. Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des: 2005; 11 2279 2299
8. Chan G. C., Tang S. C. Diabetic nephropathy: landmark clinical trials and tribulations. Nephrol Dial Transplant: 2015; 10.1093/ndt/gfu411 [in Press]
9. +/glucose cotransporters in renal proximal tubule cells. Kidney Int: 2007; 72 527 535
10. Sabolic I., Vrhovac I., Eror D. B., Gerasimova M., Rose M., Breljak D., Ljubojevic M., Brzica H., Sebastiani A., Thal S. C., Sauvant C., Kipp H., Vallon V., Koepsell H. Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol: 2012; 302 C1174 C1188
11. Santer R., Calado J. Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol: 2010; 5 133 141
12. Bailey C. J., Gross J. L., Pieters A., Bastien A., List J. F. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, double-blind, placebo-controlled trial. Lancet: 2010; 375 2223 2233
13. Ojima A., Matsui T., Nishino Y., Nakamura N., Yamagishi S. Empagliflozin, an Inhibitor of Sodium-Glucose Cotransporter 2 Exerts Anti-Inflammatory and Antifibrotic Effects on Experimental Diabetic Nephropathy Partly by Suppressing AGEs-Receptor Axis. Horm Metab Res: 2015; 10.1055/s-0034-1395609 [in Press]
14. Suzuki M., Honda K., Fukazawa M., Ozawa K., Hagita H., Kawai T., Takeda M., Yata T., Kawai M., Fukuzawa T., Kobayashi T., Sato T., Kawabe Y., Ikeda S. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther: 2012; 341 692 701
15. Ojima A., Ishibashi Y., Matsui T., Maeda S., Nishino Y., Takeuchi M., Fukami K., Yamagishi S. Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression. Am J Pathol: 2013; 182 132 141
16. Maeda S., Matsui T., Takeuchi M., Yamagishi S. Sodium-glucose cotransporter 2-mediated oxidative stress augments advanced glycation end products-induced tubular cell apoptosis. Diabetes Metab Res Rev: 2013; 29 406 412
17. Matsui T., Yamagishi S., Takeuchi M., Ueda S., Fukami K., Okuda S. Irbesartan inhibits advanced glycation end product (AGE)-induced proximal tubular cell injury in vitro by suppressing receptor for AGEs (RAGE) expression. Pharmacol Res: 2010; 61 34 39
18. Panchapakesan U., Pegg K., Gross S., Komala M. G., Mudaliar H., Forbes J., Pollock C., Mather A. Effects of SGLT2 inhibition in human kidney proximal tubular cells - renoprotection in diabetic nephropathy? PLoS One: 2013; 8 e54442
19. Farber S. J., Berger E. Y., Earle D. P. Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose. J Clin Invest: 1951; 30 125 129
20. Mogensen C. E. Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand J Clin Lab Invest: 1971; 28 101 109
21. Rahmoune H., Thompson P. W., Ward J. M., Smith C. D., Hong G., Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes: 2005; 54 3427 3434
22. Banba N., Nakamura T., Matsumura M., Kuroda H., Hattori Y., Ksai K. Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int: 2000; 58 684 960
23. Ojima A., Ishibashi Y., Matsui T., Maeda S., Nishino Y., Takeuchi M., Fukami K., Yamagishi S. Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression. Am J Pathol: 2013; 182 132 141
24. Morii T., Fujita H., Narita T., Shimotomai T., Fujishima H., Yoshioka N., Imai H., Kakei M., Ito S. Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy. J Diabetes Complications: 2003; 17 11 15
25. Chow F. Y., Nikolic-Paterson D. J., Ma F. Y., Ozols E., Rollins B. J., Tesch G. H. Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. Diabetologia: 2007; 50 471 480
26. Ye S. D., Zheng M., Zhao L. L., Qian Y., Yao X. M., Ren A., Li S. M., Jing C. Y. Intensive insulin therapy decreases urinary MCP-1 and ICAM-1 excretions in incipient diabetic nephropathy. Eur J Clin Invest: 2009; 39 980 985
27. Brezniceanu M. L., Lau C. J., Godin N., Chénier I., Duclos A., Ethier J., Filep J. G., Ingelfinger J. R., Zhang S. L., Chan J. S. Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. J Am Soc Nephrol: 2010; 2 943 954
28. White K. E., Marshall S. M., Bilous R. W. Prevalence of atubular glomeruli in type 2 diabetic patients with nephropathy. Nephrol Dial Transplant: 2008; 23 3539 3545
29. Schwab D., Portron A., Backholer Z., Lausecker B., Kawashima K. A novel double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [14C] tofogliflozin after oral administration and concomitant intravenous microdose administration of [13C] tofogliflozin in humans. Clin Pharmacokinet: 2013; 52 463 473
30. Vallon V., Rose M., Gerasimova M., Satriano J., Platt K. A., Koepsell H., Cunard R., Sharma K., Thomson S. C., Rieg T. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol: 2013; 304 F156 F167
31. Barbosa Júnior Ade A., Zhou H., Hültenschmidt D., Totovic V., Jurilj N., Pfeifer U. Inhibition of cellular autophagy in proximal tubular cells of the kidney in streptozotocin-diabetic and uninephrectomized rats. Virchows Arch B Cell Pathol Incl Mol Pathol: 1992; 61 359 366