-
1
-
-
84864285795
-
Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
-
Inzucchi SE, Bergenstal RM, Buse JB et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012; 55: 1577-1596.
-
(2012)
Diabetologia
, vol.55
, pp. 1577-1596
-
-
Inzucchi, S.E.1
Bergenstal, R.M.2
Buse, J.B.3
-
2
-
-
84864283226
-
SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
-
Ferrannini E, Solini A. SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 2012; 8: 495-502.
-
(2012)
Nat Rev Endocrinol
, vol.8
, pp. 495-502
-
-
Ferrannini, E.1
Solini, A.2
-
3
-
-
25844468887
-
-
Procedure no. EMEA/H/C/002322. European Medicines Agency, London. Accessed 8 February 2014
-
European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP) Assessment Report: Forxiga (Dapagliflozin). Procedure no. EMEA/H/C/002322. European Medicines Agency, London, 2012. Available from URL: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002322/WC500136024.pdf. Accessed 8 February 2014.
-
(2012)
Committee for Medicinal Products for Human Use (CHMP) Assessment Report: Forxiga (Dapagliflozin)
-
-
-
4
-
-
84893252284
-
-
Rockville: U.S. Food and Drug Administration. Accessed 8 February 2014
-
U.S. Food and Drug Administration. FDA Approves Invokana to Treat Type 2 Diabetes [news release]. Rockville: U.S. Food and Drug Administration, 2013. Available from URL: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm345848.htm. Accessed 8 February 2014.
-
(2013)
FDA Approves Invokana to Treat Type 2 Diabetes [news release]
-
-
-
5
-
-
84894201808
-
-
Assessment Report: Invokana (Canagliflozin). Procedure no. EMEA/H/C/002649. European Medicines Agency, London. Accessed 8 February 2014
-
European Medicines Agency. Committe for Medicinal Products for Human Use (CHMP). Assessment Report: Invokana (Canagliflozin). Procedure no. EMEA/H/C/002649. European Medicines Agency, London, 2013. Available from URL: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002649/WC500156457.pdf. Accessed 8 February 2014.
-
(2013)
Committe for Medicinal Products for Human Use (CHMP)
-
-
-
6
-
-
84937201108
-
-
Rockville, MD: U.S. Food and Drug Administration. Accessed 8 February 2014
-
U.S. Food and Drug Administration. FDA Approves Forxiga to Treat Type 2 Diabetes [news release]. Rockville, MD: U.S. Food and Drug Administration, 2014. Available from URL: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm380829.htm. Accessed 8 February 2014.
-
(2014)
FDA Approves Forxiga to Treat Type 2 Diabetes [news release]
-
-
-
7
-
-
83655184724
-
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
-
Grempler R, Thomas L, Eckhardt M et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab 2012; 14: 83-90.
-
(2012)
Diabetes Obes Metab
, vol.14
, pp. 83-90
-
-
Grempler, R.1
Thomas, L.2
Eckhardt, M.3
-
8
-
-
25844468887
-
-
Summary of Opinion (initial authorization): Empagliflozin (Jardiance). Procedure no. EMEA/CHMP/157961. European Medicines Agency, London. Accessed 22 March 2014
-
European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP). Summary of Opinion (initial authorization): Empagliflozin (Jardiance). Procedure no. EMEA/CHMP/157961. European Medicines Agency, London, 2014. Available from URL: http://www. ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_- _Initial_authorisation/human/002677/WC500163556.pdf. Accessed 22 March 2014.
-
(2014)
Committee for Medicinal Products for Human Use (CHMP)
-
-
-
9
-
-
84882251091
-
Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis
-
Vasilakou D, Karagiannis T, Athanasiadou E et al. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med 2013; 159: 262-274.
-
(2013)
Ann Intern Med
, vol.159
, pp. 262-274
-
-
Vasilakou, D.1
Karagiannis, T.2
Athanasiadou, E.3
-
10
-
-
84890285675
-
Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials
-
Berhan A, Barker A. Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials. BMC Endocr Disord 2013; 13: 58.
-
(2013)
BMC Endocr Disord
, vol.13
, pp. 58
-
-
Berhan, A.1
Barker, A.2
-
11
-
-
84869745717
-
Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes
-
Clar C, Gill JA, Court R, Waugh N. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open 2012; 2: e001007.
-
(2012)
BMJ Open
, vol.2
-
-
Clar, C.1
Gill, J.A.2
Court, R.3
Waugh, N.4
-
12
-
-
84860183617
-
A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials
-
Musso G, Gambino R, Cassader M, Pagano G. A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Ann Med 2012; 44: 375-393.
-
(2012)
Ann Med
, vol.44
, pp. 375-393
-
-
Musso, G.1
Gambino, R.2
Cassader, M.3
Pagano, G.4
-
13
-
-
84898791935
-
Efficacy and safety of sodium glucose co-transport-2 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials
-
Monami M, Nardini C, Mannucci E. Efficacy and safety of sodium glucose co-transport-2 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 2014; 16: 457-466.
-
(2014)
Diabetes Obes Metab
, vol.16
, pp. 457-466
-
-
Monami, M.1
Nardini, C.2
Mannucci, E.3
-
14
-
-
69149107165
-
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
-
Moher D, Liberati A, TetzlaffJ, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151: 264-269.
-
(2009)
Ann Intern Med
, vol.151
, pp. 264-269
-
-
Moher, D.1
Liberati, A.2
Tetzlaff, J.3
Altman, D.G.4
-
15
-
-
84859001212
-
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
-
Higgins JP, Altman DG, Gotzsche PC et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; 343: d5928.
-
(2011)
BMJ
, vol.343
-
-
Higgins, J.P.1
Altman, D.G.2
Gotzsche, P.C.3
-
16
-
-
0030922816
-
Bias in meta-analysis detected by a simple, graphical test
-
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634.
-
(1997)
BMJ
, vol.315
, pp. 629-634
-
-
Egger, M.1
Davey Smith, G.2
Schneider, M.3
Minder, C.4
-
18
-
-
84959801619
-
Statistical aspects of the analysis of data from retrospective studies of disease
-
Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719-748.
-
(1959)
J Natl Cancer Inst
, vol.22
, pp. 719-748
-
-
Mantel, N.1
Haenszel, W.2
-
19
-
-
0037098199
-
Quantifying heterogeneity in a meta-analysis
-
Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539-1558.
-
(2002)
Stat Med
, vol.21
, pp. 1539-1558
-
-
Higgins, J.P.1
Thompson, S.G.2
-
20
-
-
84899961819
-
Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebocontrolled trial
-
Barnett AH, Mithal A, Manassie J et al. Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebocontrolled trial. Lancet Diabetes Endocrinol 2014; 2: 369-384.
-
(2014)
Lancet Diabetes Endocrinol
, vol.2
, pp. 369-384
-
-
Barnett, A.H.1
Mithal, A.2
Manassie, J.3
-
21
-
-
84879795546
-
A phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
-
Ferrannini E, Seman L, Seewaldt-Becker E, Hantel S, Pinnetti S, Woerle HJ. A phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes. Diabetes Obes Metab 2013; 15: 721-728.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 721-728
-
-
Ferrannini, E.1
Seman, L.2
Seewaldt-Becker, E.3
Hantel, S.4
Pinnetti, S.5
Woerle, H.J.6
-
22
-
-
84891851923
-
Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
-
Ferrannini E, Berk A, Hantel S et al. Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care 2013; 36: 4015-4021.
-
(2013)
Diabetes Care
, vol.36
, pp. 4015-4021
-
-
Ferrannini, E.1
Berk, A.2
Hantel, S.3
-
23
-
-
84885952950
-
Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
-
Häring HU, Merker L, Seewaldt-Becker E et al. Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care 2013; 36: 3396-3404.
-
(2013)
Diabetes Care
, vol.36
, pp. 3396-3404
-
-
Häring, H.U.1
Merker, L.2
Seewaldt-Becker, E.3
-
24
-
-
84884205144
-
Empagliflozin as add-on to metformin for 24 weeks improves glycemic control in patients with type 2 diabetes (T2DM)
-
Häring HU, Merker L, Seewaldt-Becker E et al. Empagliflozin as add-on to metformin for 24 weeks improves glycemic control in patients with type 2 diabetes (T2DM). Diabetes 2013; 62: A282.
-
(2013)
Diabetes
, vol.62
-
-
Häring, H.U.1
Merker, L.2
Seewaldt-Becker, E.3
-
25
-
-
84903761368
-
Empagliflozin monotherapy for 12 weeks improves glycemic control in Japanese patients with type 2 diabetes (T2DM)
-
Kadowaki T, Haneda M, Inagaki N et al. Empagliflozin monotherapy for 12 weeks improves glycemic control in Japanese patients with type 2 diabetes (T2DM). Diabetes 2013; 62: A297-298.
-
(2013)
Diabetes
, vol.62
, pp. A297-298
-
-
Kadowaki, T.1
Haneda, M.2
Inagaki, N.3
-
26
-
-
84892477577
-
Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial
-
Kovacs CS, Seshiah V, Swallow R et al. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab 2013; 16: 147-158.
-
(2013)
Diabetes Obes Metab
, vol.16
, pp. 147-158
-
-
Kovacs, C.S.1
Seshiah, V.2
Swallow, R.3
-
27
-
-
84885954870
-
Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial
-
Roden M, Weng J, Eilbracht J et al. Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol 2013; 1: 208-219.
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, pp. 208-219
-
-
Roden, M.1
Weng, J.2
Eilbracht, J.3
-
28
-
-
84887191925
-
Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
-
Rosenstock J, Seman LJ, Jelaska A et al. Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab 2013; 15: 1154-1160.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 1154-1160
-
-
Rosenstock, J.1
Seman, L.J.2
Jelaska, A.3
-
29
-
-
84903792530
-
Empagliflozin as add on to basal insulin for 78 weeks improves glycemic control with weight loss in insulin-treated type 2 diabetes (T2DM)
-
Rosenstock J, Jelaska A, Wang F et al. Empagliflozin as add on to basal insulin for 78 weeks improves glycemic control with weight loss in insulin-treated type 2 diabetes (T2DM). Can J Diabetes 2013; 37: S32.
-
(2013)
Can J Diabetes
, vol.37
-
-
Rosenstock, J.1
Jelaska, A.2
Wang, F.3
-
30
-
-
84892658063
-
Empagliflozin improves blood pressure in patients with type 2 diabetes (T2DM) and hypertension
-
Tikkanen I, Narko K, Zeller C et al. Empagliflozin improves blood pressure in patients with type 2 diabetes (T2DM) and hypertension. Diabetologia 2013; 56: S377.
-
(2013)
Diabetologia
, vol.56
-
-
Tikkanen, I.1
Narko, K.2
Zeller, C.3
-
31
-
-
84882243403
-
Handling of rescue and missing data affects synthesis and interpretation of evidence: the sodium-glucose cotransporter 2 inhibitor example
-
Stack CB, Localio AR, Griswold ME, Goodman SN, Mulrow CD. Handling of rescue and missing data affects synthesis and interpretation of evidence: the sodium-glucose cotransporter 2 inhibitor example. Ann Intern Med 2013; 159: 285-288.
-
(2013)
Ann Intern Med
, vol.159
, pp. 285-288
-
-
Stack, C.B.1
Localio, A.R.2
Griswold, M.E.3
Goodman, S.N.4
Mulrow, C.D.5
-
32
-
-
84858020943
-
Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
-
Bolinder J, Ljunggren O, Kullberg J et al. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab 2012; 97: 1020-1031.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 1020-1031
-
-
Bolinder, J.1
Ljunggren, O.2
Kullberg, J.3
-
33
-
-
84888073572
-
Canagliflozin, a sodium glucose cotransporter 2 inhibitor, reduces body weight mainly through loss of fat mass in subjects with type 2 diabetes
-
Toubro S, Cefalu WT, Xie J et al. Canagliflozin, a sodium glucose cotransporter 2 inhibitor, reduces body weight mainly through loss of fat mass in subjects with type 2 diabetes. Diabetologia 2012; 55: S313-314.
-
(2012)
Diabetologia
, vol.55
, pp. S313-314
-
-
Toubro, S.1
Cefalu, W.T.2
Xie, J.3
-
34
-
-
84893872877
-
Metabolic response to sodiumglucose cotransporter 2 inhibition in type 2 diabetic patients
-
Ferrannini E, Muscelli E, Frascerra S et al. Metabolic response to sodiumglucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest 2014; 124: 499-508.
-
(2014)
J Clin Invest
, vol.124
, pp. 499-508
-
-
Ferrannini, E.1
Muscelli, E.2
Frascerra, S.3
-
35
-
-
84893827104
-
Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
-
Merovci A, Solis-Herrera C, Daniele G et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest 2014; 124: 509-514.
-
(2014)
J Clin Invest
, vol.124
, pp. 509-514
-
-
Merovci, A.1
Solis-Herrera, C.2
Daniele, G.3
-
36
-
-
84898854471
-
Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis
-
Baker WL, Smyth LR, Riche DM, Bourret EM, Chamberlin KW, White WB. Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis. J Am Soc Hypertens 2014; 8: 262-275.
-
(2014)
J Am Soc Hypertens
, vol.8
, pp. 262-275
-
-
Baker, W.L.1
Smyth, L.R.2
Riche, D.M.3
Bourret, E.M.4
Chamberlin, K.W.5
White, W.B.6
-
37
-
-
84880850027
-
Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
-
Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 2013; 15: 853-862.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 853-862
-
-
Lambers Heerspink, H.J.1
de Zeeuw, D.2
Wie, L.3
Leslie, B.4
List, J.5
-
38
-
-
84897394040
-
Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
-
Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int 2013; 85: 962-971.
-
(2013)
Kidney Int
, vol.85
, pp. 962-971
-
-
Kohan, D.E.1
Fioretto, P.2
Tang, W.3
List, J.F.4
-
39
-
-
84876311251
-
Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
-
Yale JF, Bakris G, Cariou B et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab 2013; 15: 463-473.
-
(2013)
Diabetes Obes Metab
, vol.15
, pp. 463-473
-
-
Yale, J.F.1
Bakris, G.2
Cariou, B.3
-
40
-
-
84912551157
-
Empagliflozin in patients with type 2 diabetes mellitus and stage 3A, 3B and 4 chronic kidney disease (CKD)
-
Mithal A, Bernett AH, Manassie J et al. Empagliflozin in patients with type 2 diabetes mellitus and stage 3A, 3B and 4 chronic kidney disease (CKD). Diebetologia 2013; 56: S382.
-
(2013)
Diebetologia
, vol.56
-
-
Mithal, A.1
Bernett, A.H.2
Manassie, J.3
-
41
-
-
80755180389
-
-
Accessed 22 March 2014
-
National Institute for Health and Care Excellence. Guide to the Methods of Technology Appraisal 2013. Available from URL: http://publications.nice.org.uk/pmg9. Accessed 22 March 2014.
-
(2013)
Guide to the Methods of Technology Appraisal
-
-
-
42
-
-
51749114627
-
Four decades of uncertainty: landmark trials in glycaemic control and cardiovascular outcome in type 2 diabetes
-
Matthews DR, Tsapas A. Four decades of uncertainty: landmark trials in glycaemic control and cardiovascular outcome in type 2 diabetes. Diab Vasc Dis Res 2008; 5: 216-218.
-
(2008)
Diab Vasc Dis Res
, vol.5
, pp. 216-218
-
-
Matthews, D.R.1
Tsapas, A.2
-
43
-
-
84883452474
-
Rationale, design and baseline characteristics of a 4-year (208-week) phase III trial of empagliflozin, an SGLT2 inhibitor, versus glimepiride as add-on to metformin in patients with type 2 diabetes mellitus with insufficient glycemic control
-
Ridderstrale M, Svaerd R, Zeller C, Kim G, Woerle HJ, Broedl UC. Rationale, design and baseline characteristics of a 4-year (208-week) phase III trial of empagliflozin, an SGLT2 inhibitor, versus glimepiride as add-on to metformin in patients with type 2 diabetes mellitus with insufficient glycemic control. Cardiovasc Diabetol 2013; 12: 129.
-
(2013)
Cardiovasc Diabetol
, vol.12
, pp. 129
-
-
Ridderstrale, M.1
Svaerd, R.2
Zeller, C.3
Kim, G.4
Woerle, H.J.5
Broedl, U.C.6
-
44
-
-
84903781276
-
Design of the empagliflozin cardiovascular (CV) outcome event trial in type 2 diabetes (T2D)
-
Zinman B, Inzucchi SE, Lachin J et al. Design of the empagliflozin cardiovascular (CV) outcome event trial in type 2 diabetes (T2D). Can J Diabetes 2013; 37: S29-30.
-
(2013)
Can J Diabetes
, vol.37
, pp. S29-30
-
-
Zinman, B.1
Inzucchi, S.E.2
Lachin, J.3
|