Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes

Diabetology and Metabolic Syndrome

Volumn 8, Issue 1, 2016, Pages

  Jojima, Teruo ^a   Tomotsune, Takanori ^a   Iijima, Toshie ^a   Akimoto, Kazumi ^a   Suzuki, Kunihiro ^a   Aso, Yoshimasa ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Dipeptidyl peptidase 4; Fibrosis; Inflammation; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis; Sodium glucose co transporter 2

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; EMPAGLIFLOZIN; FATTY ACID; INTERLEUKIN 6; LINAGLIPTIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; C57BL 6 MOUSE; COLLAGEN METABOLISM; COMBINATION DRUG THERAPY; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DRUG MECHANISM; DRUG POTENTIATION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENE; GENE EXPRESSION REGULATION; HEPATITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTERLEUKIN 6 GENE; LIVER FIBROSIS; MALE; MONOCYTE CHEMOATTRACTANT PROTEIN 1 GENE; MONOTHERAPY; MOUSE; MOUSE MODEL; MYOFIBROBLAST; NEWBORN; NONALCOHOLIC FATTY LIVER; NONALCOHOLIC FATTY LIVER DISEASE ACTIVITY SCORE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TUMOR NECROSIS FACTOR ALPHA GENE;

EID: 84979220732     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/s13098-016-0169-x     Document Type: Article

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