Polyphenols delivery by polymeric materials: Challenges in cancer treatment

Drug Delivery

Volumn 24, Issue 1, 2017, Pages 162-180

  Vittorio, Orazio ^a   Curcio, Manuela ^b   Cojoc, Monica ^c   Goya, Gerardo F ^d   Hampel, Silke ^e   Iemma, Francesca ^b   Dubrovska, Anna ^c,f   Cirillo, Giuseppe ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF CALABRIA   (Italy)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^d UNIVERSITY OF ZARAGOZA   (Spain)

^e IFW DRESDEN   (Germany)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cancer therapy; Nanocarrier; Polymeric materials; Polyphenols

Indexed keywords

CARBON NANOHYBRID; CARBON NANOSTRUCTURE; MAGNETIC NANOPARTICLE; NANOCARRIER; NANOPARTICLE; POLYMER; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG; DRUG CARRIER; POLYPHENOL;

ANTINEOPLASTIC ACTIVITY; CANCER CELL; CANCER STEM CELL; CANCER THERAPY; CONJUGATE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; EPIGENETICS; HUMAN; MALIGNANT NEOPLASM; NANOTECHNOLOGY; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; REVIEW; TARGET CELL DESTRUCTION; ANIMAL; CHEMISTRY; NEOPLASMS; PROCEDURES;

ANIMALS; DRUG CARRIERS; HUMANS; NANOPARTICLES; NANOTECHNOLOGY; NEOPLASMS; POLYMERS; POLYPHENOLS;

EID: 85014874287     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717544.2016.1236846     Document Type: Review

References (257)

1. Abbad S, Waddad AY, Lv H, Zhou J. (2015). Preparation, in vitro and in vivo evaluation of Polymeric nanoparticles based on hyaluronic acidPoly(butyl cyanoacrylate) and D-alpha-tocopheryl Polyethylene glycol 1000 succinate for tumor-targeted delivery of Morin hydrate. Int J Nanomed 10:305-20.
2. Abdolahad M, Janmaleki M, Mohajerzadeh S, et al. (2013). Polyphenols attached graphene nanosheets for high efficiency NIR mediated photodestruction of cancer cells. Mater Sci Eng C 33:1498-505.
3. Abouzeid AH, Patel NR, Rachman IM, et al. (2013). Anti-cancer activity of anti-GLUT1 antibody-targeted polymeric micelles co-loaded with curcumin and doxorubicin. J Drug Target 21:994-1000.
4. Abouzeid AH, Patel NR, Sarisozen C, Torchilin VP. (2014). Transferrintargeted polymeric micelles co-loaded with curcumin and paclitaxel: efficient killing of paclitaxel-resistant cancer cells. Pharm Res 31: 1938-45.
5. Allen TM. (2002). Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2:750-63.
6. Altunbas A, Lee SJ, Rajasekaran SA, et al. (2011). Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles. Biomaterials 32:5906-14.
7. Ambrosi A, Chua CK, Khezri B, et al. (2012). Chemically reduced graphene contains inherent metallic impurities present in parent natural and synthetic graphite. Proc Natl Acad Sci U S A 109: 12899-904.
8. Asín L, Goya GF, Tres A, Ibarra MR. (2013). Induced cell toxicity originates dendritic cell death following magnetic hyperthermia treatment. Cell Death Disease 4:e596. doi: 10.1038/cddis.2013.121.
9. Atsumi T, Tonosaki K, Fujisawa S. (2006). Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin. Arch Oral Biol 51:913-21.
10. Baccelli I, Trumpp A. (2012). The evolving concept of cancer and metastasis stem cells. J Cell Biol 198:281-93.
11. Bagri A, Mattevi C, Acik M, et al. (2010). Structural evolution during the reduction of chemically derived graphene oxide. Nat Chem 2: 581-7.
12. Balasubramanian S, Ravindran Girija A, Nagaoka Y, et al. (2014). Curcumin and 5-Fluorouracil-loaded, folate-and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. Int J Nanomed 9: 437-59.
13. Bao S, Wu Q, Mclendon RE, et al. (2006). Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-60.
14. Bhattacharya K, Mukherjee SP, Gallud A, et al. (2016). Biological interactions of carbon-based nanomaterials: from coronation to degradation. Nanomed: Nanotechnol Biol Med 12:333-51.
15. Bianco A, Kostarelos K, Partidos CD, Prato M. (2005). Biomedical applications of functionalized carbon nanotubes. Chem Commun 5:571-7.
16. Bisht S, Feldmann G, Soni S, et al. (2007). Polymeric nanoparticle-encapsulated curcumin (‘‘nanocurcumin’’): a novel strategy for human cancer therapy. J Nanobiotechnol 5:3. doi: 10.1186/1477-3155-5-3.
17. Bisht S, Mizuma M, Feldmann G, et al. (2010). Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther 9:2255-64.
18. Brady DC, Crowe MS, Turski ML, et al. (2014). Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature 509:492-6.
19. Bravo L. (1998). Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56:317-33.
20. Brinkhuis RP, Rutjes FPJT, Van Hest JCM. (2011). Polymeric vesicles in biomedical applications. Polym Chem 2:1449-62.
21. Brozˇ P, Benito SM, Saw C, et al. (2005). Cell targeting by a generic receptor-targeted polymer nanocontainer platform. J Control Release 102:475-88.
22. Cao C, Sun L, Mo W, et al. (2015). Quercetin mediates b-catenin in pancreatic cancer stem-like cells. Pancreas 44:1334-19.
23. Carlson LJ, Cote B, Alani AW, Rao DA. (2014). Polymeric micellar codelivery of resveratrol and curcumin to mitigate in vitro doxorubicin-induced cardiotoxicity. J Pharm Sci 103:2315-22.
24. Castro Nava A, Cojoc M, Peitzsch C, et al. (2016). Development of novel radiochemotherapy approaches targeting prostate tumor progenitor cells using nanohybrids. Int J Cancer 137:2492-503.
25. Chang PY, Peng SF, Lee CY, et al. (2013a). Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Int J Oncol 43:1141-50.
26. Chang WW, Hu FW, Yu CC, et al. (2013b). Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck 35:413-19.
27. Chaudhuri P, Soni S, Sengupta S. (2010). Single-walled carbon nanotube-conjugated chemotherapy exhibits increased therapeutic index in melanoma. Nanotechnology 21:025102. doi: 10.1088/0957-4484/21/2/025102.
28. Choi KC, Myung GJ, Lee YH, et al. (2009). Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res 69:583-92.
29. Choudhury SR, Balasubramanian S, Chew YC, et al. (2011). (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis 32:1525-32.
30. Chung SS, Vadgama JV. (2015). Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFkB signaling. Anticancer Res 35:39-46.
31. Cirillo G, Curcio M, Vittorio O, et al. (2016). Polyphenol conjugates and human health: a perspective review. Crit Rev Food Sci Nutr 56: 326-37.
32. Cirillo G, Hampel S, Klingeler R, et al. (2011). Antioxidant multiwalled carbon nanotubes by free radical grafting of gallic acid: new materials for biomedical applications. J Pharm Pharmacol 63: 179-88.
33. Cirillo G, Kraemer K, Fuessel S, et al. (2010). Biological activity of a gallic acid-gelatin conjugate. Biomacromolecules 11:3309-15.
34. Cirillo G, Vittorio O, Hampel S, et al. (2013a). Quercetin nanocomposite as novel anticancer therapeutic: improved efficiency and reduced toxicity. Eur J Pharm Sci 49:359-65.
35. Cirillo G, Vittorio O, Hampel S, et al. (2013b). Incorporation of carbon nanotubes into a gelatin-catechin conjugate: innovative approach for the preparation of anticancer materials. Int J Pharm 446:176-82.
36. Cojoc M, Peitzsch C, Kurth I, et al. (2015). Aldehyde dehydrogenase is regulated by b-Catenin/TCF and promotes radioresistance in prostate cancer progenitor cells. Cancer Res 75:1482-94.
37. Cote B, Carlson LJ, Rao DA, Alani AWG. (2015). Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. J Control Release 213: 128-33.
38. Curcio M, Blanco-Fernandez B, Diaz-Gomez L, et al. (2015a). Hydrophobically modified keratin vesicles for GSH-responsive intracellular drug release. Bioconjug Chem 26:1900-7.
39. Curcio M, Cirillo G, Vittorio O, et al. (2015b). Hydrolyzed gelatin-based polymersomes as delivery devices of anticancer drugs. Eur Polym J 67:304-13.
40. Dai J, Mumper RJ. (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15: 7313-52.
41. Danhier F, Ansorena E, Silva JM, et al. (2012). PLGA-based nanoparticles: an overview of biomedical applications. J Control Release 161:505-22.
42. Das RK, Kasoju N, Bora U. (2010). Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. Nanomed: Nanotechnol Biol Med 6:e153-60.
43. David KI, Jaidev LR, Sethuraman S, Krishnan UM. (2015). Dual drug loaded chitosan nanoparticles-sugar-coated arsenal against pancreatic cancer. Colloids Surf B: Biointerfaces 135:689-98.
44. Deb G, Thakur VS, Limaye AM, Gupta S. (2015). Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells. Mol Carcinog 54:485-99.
45. Deepa G, Thulasidasan AKT, Anto RJ, et al. (2012). Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy. Int J Nanomed 7:4077-88.
46. Del Rio D, Rodriguez-Mateos A, Spencer JPE, et al. (2013). Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18:1818-92.
47. Dey S, Ambattu LA, Hari PR, et al. (2015). Glutathione-bearing fluorescent polymer-curcumin conjugate enables simultaneous drug delivery and label-free cellular imaging. Polymer (United Kingdom) 75:25-33.
48. Diehn M, Cho RW, Lobo NA, et al. (2009). Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458:780-3.
49. Discher BM, Hammer DA, Bates FS, Discher DE. (2000). Polymer vesicles in various media. Curr Opin Colloid Interface Sci 5:125-31.
50. Dong H, Tang M, Li Y, et al. (2015). Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery. Nanomedicine 10:1941-58.
51. Duan J, Mansour HM, Zhang Y, et al. (2012). Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm 426: 193-201.
52. Duan J, Zhang Y, Han S, et al. (2010). Synthesis and in vitro/in vivo anticancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm 400:211-20.
53. Eetezadi S, Ekdawi SN, Allen C. (2015). The challenges facing block copolymer micelles for cancer therapy: in vivo barriers and clinical translation. Adv Drug Deliv Rev 91:7-22.
54. Elbling L, Weiss RM, Teufelhofer O, et al. (2005). Green tea extract and ()-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J 19:807-9.
55. Erfani-Moghadam V, Nomani A, Zamani M, et al. (2014). A novel diblock copolymer of (monomethoxy poly [ethylene glycol]-oleate) with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells. Int J Nanomed 9: 5541-54.
56. Estanqueiro M, Amaral MH, Conceição J, Sousa Lobo JM. (2015). Nanotechnological carriers for cancer chemotherapy: the state of the art. Colloids Surf B: Biointerfaces 126:631-48.
57. Fan P, Fan S, Wang H, et al. (2013). Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway. Stem Cell Res Therapy 4:146. doi: 10.1186/scrt357.
58. Fang MZ, Wang Y, Ai N, et al. (2003). Tea polyphenol ()-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 63: 7563-70.
59. Feng L, Liu Z. (2011). Graphene in biomedicine: opportunities and challenges. Nanomedicine (Lond) 6:317-24.
60. Fernandes E, Ferreira JA, Andreia P, et al. (2015). New trends in guided nanotherapies for digestive cancers: a systematic review. J Control Release 209:288-307.
61. Fresco P, Borges F, Diniz C, Marques MPM. (2006). New insights on the anticancer properties of dietary polyphenols. Med Res Rev 26: 747-66.
62. Furfaro AL, Piras S, Domenicotti C, et al. (2016). Role of Nrf2, HO-1 and GSH in neuroblastoma cell resistance to Bortezomib. PLoS One 11:e0152465. doi: 10.1371/journal.pone.0152465.
63. Galati G, O’brien PJ. (2004). Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37:287-303.
64. Gao Y, Tollefsbol TO. (2015). Impact of epigenetic dietary components on cancer through histone modifications. Curr Med Chem 22: 2051-64.
65. Gharpure KM, Wu SY, Li C, et al. (2015). Nanotechnology: future of oncotherapy. Clin Cancer Res 21:3121-30.
66. Gong C, Deng S, Wu Q, et al. (2013). Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials 34:1413-32.
67. Guo D, Wu C, Li J, et al. (2009). Synergistic effect of functionalized nickel nanoparticles and quercetin on inhibition of the SMMC-7721 cells proliferation. Nanoscale Res Lett 4:1395-402.
68. Gou Q, Liu L, Wang C, et al. (2015). Polymeric nanoassemblies entrapping curcumin overcome multidrug resistance in ovarian cancer. Colloids Surf B: Biointerfaces 126:26-34.
69. Guo L, Peng Y, Li Y, et al. (2015). Cell death pathway induced by resveratrol-bovine serum albumin nanoparticles in a human ovarian cell line. Oncol Lett 9:1359-63.
70. Guo W, Li A, Jia Z, et al. (2013). Transferrin modified PEG-PLA-resveratrol conjugates: in vitro and in vivo studies for glioma. Eur J Pharmacol 718:41-7.
71. Gupte A, Mumper RJ. (2009). Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev 35: 32-46.
72. Gurunathan S, Han JW, Kim ES, et al. (2015). Reduction of graphene oxide by resveratrol: a novel and simple biological method for the synthesis of an effective anticancer nanotherapeutic molecule. Int J Nanomed 10:2951-69.
73. Hail Jr N, Cortes M, Drake EN, Spallholz JE. (2008). Cancer chemoprevention: a radical perspective. Free Radic Biol Med 45: 97-110.
74. Hanahan D, Weinberg RA. (2011). Hallmarks of cancer: the next generation. Cell 144:646-74.
75. Haratifar S, Meckling KA, Corredig M. (2014a). Antiproliferative activity of tea catechins associated with casein micelles, using HT29 colon cancer cells. J Dairy Sci 97:672-8.
76. Haratifar S, Meckling KA, Corredig M. (2014b). Bioefficacy of tea catechins encapsulated in casein micelles tested on a normal mouse cell line (4D/WT) and its cancerous counterpart (D/v-src) before and after in vitro digestion. Food Funct 5:1160-6.
77. Hernández R, Sacristán J, Asín L, et al. (2010). Magnetic hydrogels derived from polysaccharides with improved specific power absorption: potential devices for remotely triggered drug delivery. J Phys Chem B 114:12002-7.
78. Hou Z, Sang S, You H, et al. (2005). Mechanism of action of (-)epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. Cancer Res 65:8049-56.
79. Howes RM. (2006). The free radical fantasy: a panoply of paradoxes. Ann N Y Acad Sci 1067:22-6.
80. Hu B, Wang Y, Xie M, et al. (2015). Polymer nanoparticles composed with gallic acid grafted chitosan and bioactive peptides combined antioxidant, anticancer activities and improved delivery property for labile polyphenols. J Funct Foods 15:593-603.
81. Hu B, Xie M, Zhang C, Zeng X. (2014). Genipin-structured peptide - polysaccharide nanoparticles with significantly improved resistance to harsh gastrointestinal environments and their potential for oral delivery of polyphenols. J Agric Food Chem 62:12443-52.
82. Hu CMJ, Aryal S, Zhang L. (2010). Nanoparticle-assisted combination therapies for effective cancer treatment. Ther Deliv 1:323-34.
83. Huang W, Wan C, Luo Q, Huang Z. (2014). Genistein-inhibited cancer stem cell-like properties and reduced chemoresistance of gastric cancer. Int J Mol Sci 15:3432-43.
84. Huang YT, Lin YW, Chiu HM, Chiang BH. (2016). Curcumin induces apoptosis of colorectal cancer stem cells by coupling with CD44 marker. J Agric Food Chem 64:2247-53.
85. Jain AK, Thanki K, Jain S. (2013). Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Mol Pharm 10: 3459-74.
86. Jayakumar R, Menon D, Manzoor K, et al. (2010). Biomedical applications of chitin and chitosan based nanomaterials - a short review. Carbohydr Polym 82:227-32.
87. Jemal A, Siegel R, Xu J, Ward E. (2010). Cancer statistics, 2010. CA Cancer J Clin 60:277-300.
88. Johnstone TC, Suntharalingam K, Lippard SJ. (2016). The next generation of platinum drugs: targeted Pt(II) agents, nanoparticle delivery, and Pt(IV) prodrugs. Chem Rev 116:3436-86.
89. Kakarala M, Brenner DE, Korkaya H, et al. (2010). Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat 122:777-85.
90. Karthikeyan S, Hoti SL, Prasad NR. (2015). Resveratrol loaded gelatin nanoparticles synergistically inhibits cell cycle progression and constitutive NF-kappaB activation, and induces apoptosis in non-small cell lung cancer cells. Biomed Pharmacotherapy 70: 274-82.
91. Kaur S, Greaves P, Cooke DN, et al. (2007). Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts. J Agric Food Chem 55:3378-85.
92. Kawanishi S, Oikawa S, Murata M. (2005). Evaluation for safety of antioxidant chemopreventive agents. Antioxid Redox Signal 7: 1728-39.
93. Khan MA, Hussain A, Sundaram MK, et al. (2015). (-)Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells. Oncol Rep 33: 1976-84.
94. Khan N, Afaq F, Saleem M, et al. (2006). Targeting multiple signaling pathways by green tea polyphenol ()-epigallocatechin-3-gallate. Cancer Res 66:2500-5.
95. Khan N, Bharali DJ, Adhami VM, et al. (2014). Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model. Carcinogenesis 35:415-23.
96. Khan N, Mukhtar H. (2015). Dietary agents for prevention and treatment of lung cancer. Cancer Lett 359:155-64.
97. Kiew SF, Kiew LV, Lee HB, et al. (2016). Assessing biocompatibility of graphene oxide-based nanocarriers: a review. J Control Release 226: 217-28.
98. Kim BYS, Rutka JT, Chan WCW. (2010). Current concepts: nanomedicine. N Engl J Med 363:2434-43.
99. Kim SH, Adhikari BB, Cruz S, et al. (2015a). Targeted intracellular delivery of resveratrol to glioblastoma cells using apolipoprotein E-containing reconstituted HDL as a nanovehicle. PLoS One 10:e0135130. doi: 10.1371/journal.pone.0135130.
100. Kim SJ, Lee JM, Kumer RA, et al. (2015b). Environmentally friendly synthesis of P-doped reduced graphene oxide with high dispersion stability by using red table wine. Chem - Asian J 10: 1192-7.
101. Kim SO, Kim MR. (2013). (-)Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC-1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity. Int J Oncol 42:349-58.
102. Kim TH, Jiang HH, Youn YS, et al. (2011). Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. Int J Pharm 403:285-91.
103. Kim YJ, Park MR, Kim MS, Kwon OH. (2012). Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells. Mater Chem Phys 133:674-80.
104. Kobuchi H, Roy S, Sen CK, et al. (1999). Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Am J Physiol - Cell Physiol 277:C403-11.
105. Kong ANT, Yu R, Chen C, et al. (2000). Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch Pharmacal Res 23:1-16.
106. Kresty LA, Frankel WL, Hammond CD, et al. (2006). Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett’s esophagus patients. Nutr Cancer 54: 148-56.
107. Kumar M, Grzelakowski M, Zilles J, et al. (2007). Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z. Proc Natl Acad Sci U S A 104: 20719-24.
108. Kumar S, Lather V, Pandita D. (2016). A facile green approach to prepare core-shell hybrid PLGA nanoparticles for resveratrol delivery. Int J Biol Macromol 84:380-4.
109. Kumari P, Ghosh B, Biswas S. (2016). Nanocarriers for cancer-targeted drug delivery. J Drug Target 24:179-91.
110. Lam CW, James JT, Mccluskey R, et al. (2006). A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks. Crit Rev Toxicol 36:189-217.
111. Lambert JD, Elias RJ. (2010). The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys 501:65-72.
112. Lee HA, Park S, Kim Y. (2013a). Effect of b-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells. Oncol Rep 30:1869-77.
113. Lee SH, Nam HJ, Kang HJ, et al. (2013b). Epigallocatechin-3-gallate attenuates head and neck cancer stem cell traits through suppression of Notch pathway. Eur J Cancer 49:3210-18.
114. Lee WJ, Shim JY, Zhu BT. (2005). Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol 68:1018-30.
115. León-González AJ, Auger C, Schini-Kerth VB. (2015). Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy. Biochem Pharmacol 98:371-80.
116. Li J, Wang Y, Yang C, et al. (2009). Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1. Mol Pharmacol 76:81-90.
117. Li L, Xiang D, Shigdar S, et al. (2014). Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. Int J Nanomed 9:1083-96.
118. Li SH, Fu J, Watkins DN, et al. (2013). Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway. Mol Cell Biochem 373:217-27.
119. Li Y, Zhang T, Korkaya H, et al. (2010). Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res 16:2580-90.
120. Li YJ, Wu SL, Lu SM, et al. (2015). (-)Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial-mesenchymal transition via NF-kB p65 inactivation. Tumor Biol 36:2747-61.
121. Liang J, Li F, Fang Y, et al. (2011). Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles. Colloids Surf B: Biointerfaces 82:297-301.
122. Liang J, Li F, Fang Y, et al. (2014). Cytotoxicity and apoptotic effects of tea polyphenol-loaded chitosan nanoparticles on human hepatoma HepG2 cells. Mater Sci Eng C 36:7-13.
123. Liang K, Ng S, Lee F, et al. (2016). Targeted intracellular protein delivery based on hyaluronic acid-green tea catechin nanogels. Acta Biomater 33:142-52.
124. Ligeret H, Barthelemy S, Zini R, et al. (2004). Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore. Free Radic Biol Med 36:919-29.
125. Lim JY, Kim YS, Kim KM, et al. (2014). β-Carotene inhibits neuroblastoma tumorigenesis by regulating cell differentiation and cancer cell stemness. Biochem Biophys Res Commun 450:1475-80.
126. Lim KJ, Bisht S, Bar EE, et al. (2011). A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ther 11:464-73.
127. Lima Jr E, Torres TE, Rossi LM, et al. (2013). Size dependence of the magnetic relaxation and specific power absorption in iron oxide nanoparticles. J Nanopart Res 15:1654. doi: 10.1007/s11051-013-1654-x.
128. Lin CH, Chao LK, Hung PH, Chen YJ. (2014). EGCG inhibits the growth and tumorigenicity of nasopharyngeal tumor-initiating cells through attenuation of STAT3 activation. Int J Clin Exp Pathol 7: 2372-81.
129. Lin Y, Taylor S, Li H, et al. (2004). Advances toward bioapplications of carbon nanotubes. J Mater Chem 14:527-41.
130. Lin YH, Chen ZR, Lai CH, et al. (2015). Active targeted nanoparticles for oral administration of gastric cancer therapy. Biomacromolecules 16:3021-32.
131. Liu CM, Peng CY, Liao YW, et al. (2015). Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction. J Formosan Med Assoc. [Epub ahead of print]. doi: 10.1016/j.jfma.2016.01.004.
132. Liu L, Sun L, Wu Q, et al. (2013). Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis. Int J Pharm 443:175-82.
133. Liu Z, Tabakman S, Welsher K, Dai H. (2009). Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Res 2:85-120.
134. Lu Y, Park K. (2013). Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs. Int J Pharm 453: 198-214.
135. Luo J, Solimini NL, Elledge SJ. (2009). Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136:823-37.
136. Luo Y, Prestwich GD. (2002). Cancer-targeted polymeric drugs. Curr Cancer Drug Targets 2:209-26.
137. Lv L, Guo Y, Shen Y, et al. (2015). Intracellularly degradable, self-assembled amphiphilic block copolycurcumin nanoparticles for efficient in vivo cancer chemotherapy. Adv Healthcare Mater 4: 1496-501.
138. Lv L, Qiu K, Yu X, et al. (2016). Amphiphilic copolymeric micelles for doxorubicin and curcumin co-delivery to reverse multidrug resistance in breast cancer. J Biomed Nanotechnol 12: 973-85.
139. Lv L, Shen Y, Li M, et al. (2013). Novel 4-arm poly(ethylene glycol)-block-poly(anhydride-esters) amphiphilic copolymer micelles loading curcumin: preparation, characterization, and in vitro evaluation. BioMed Res Int 2013:507103. doi: 10.1155/2013/507103.
140. Madhusudana Rao K, Krishna Rao KS, Ramanjaneyulu G, Ha CS. (2015). Curcumin encapsulated pH sensitive gelatin based interpenetrating polymeric network nanogels for anti cancer drug delivery. Int J Pharm 478:788-95.
141. Makharza S, Cirillo G, Bachmatiuk A, et al. (2013). Graphene oxide-based drug delivery vehicles: functionalization, characterization, and cytotoxicity evaluation. J Nanopart Res 15:2099. doi:10.1007/s11051-013-2099-y.
142. Mangalathillam S, Rejinold NS, Nair A, et al. (2012). Curcumin loaded chitin nanogels for skin cancer treatment via the transdermal route. Nanoscale 4:239-50.
143. Manju S, Sreenivasan K. (2011). Enhanced drug loading on magnetic nanoparticles by layer-by-layer assembly using drug conjugates: blood compatibility evaluation and targeted drug delivery in cancer cells. Langmuir 27:14489-96.
144. Meeran SM, Patel SN, Li Y, et al. (2012). Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS One 7:e37748. doi: 10.1371/journal.pone.0037748.
145. Mikhail AS, Eetezadi S, Ekdawi SN, et al. (2014). Image-based analysis of the size-and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts. Int J Pharm 464: 168-77.
146. Minko T, Kopečková P, Pozharov V, Kopeček J. (1998). HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line. J Control Release 54:223-33.
147. Mirakabad FST, Akbarzadeh A, Milani M, et al. (2016). A comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line. Artif Cells Nanomed Biotechnol 44:423-30.
148. Mishra B, Priyadarsini KI, Bhide MK, et al. (2004). Reactions of superoxide radicals with curcumin: probable mechanisms by optical spectroscopy and EPR. Free Radic Res 38:355-62.
149. Mukerjee A, Vishwanatha JK. (2009). Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 29:3867-75.
150. Nair KL, Thulasidasan AKT, Deepa G, et al. (2012). Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier. Int J Pharm 425:44-52.
151. Nichenametla SN, Taruscio TG, Barney DL, Exon JH. (2006). A review of the effects and mechanisms of polyphenolics in cancer. Crit Rev Food Sci Nutr 46:161-83.
152. Numsen Jr H. (2008). Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis. Free Radic Biol Med 44: 1382-93.
153. Nyanhongo GS, Nugroho Prasetyo E, Herrero Acero E, Guebitz GM. (2012). Engineering strategies for successful development of functional polymers using oxidative enzymes. Chem Eng Technol 35: 1359-72.
154. Oliver S, Vittorio O, Cirillo G, Boyer C. (2016). Enhancing the therapeutic effects of polyphenols with macromolecules. Polym Chem 7:1529-44.
155. Onaca O, Enea R, Hughes DW, Meier W. (2009). Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Macromol Biosci 9:129-39.
156. Ortega AL, Mena S, Estrela JM. (2011). Glutathione in cancer cell death. Cancers 3:1285-310.
157. Pacardo DB, Ligler FS, Gu Z. (2015). Programmable nanomedicine: synergistic and sequential drug delivery systems. Nanoscale 7: 3381-91.
158. Park EJ, Pezzuto JM. (2012). Flavonoids in cancer prevention. Anti-Cancer Agents Med Chem 12:836-51.
159. Peitzsch C, Cojoc M, Hein L, et al. (2016). An epigenetic reprograming strategy to resensitize radioresistant prostate cancer cells. Cancer Res 76:2637-51.
160. Peng C, Hu W, Zhou Y, et al. (2010). Intracellular imaging with a graphene-based fluorescent probe. Small 6:1686-92.
161. Peng SF, Lee CY, Hour MJ, et al. (2014). Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. Int J Oncol 44: 238-46.
162. Pillai JJ, Thulasidasan AKT, Anto RJ, et al. (2014). Folic acid conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel for site specific delivery of hydrophobic drugs to cancer cells. J Nanobiotechnol 12:25. doi: 10.1186/1477-3155-12-25.
163. Podaralla S, Averineni R, Alqahtani M, Perumal O. (2012). Synthesis of novel biodegradable methoxy poly(ethylene glycol)-zein micelles for effective delivery of curcumin. Mol Pharm 9:2778-86.
164. Polster J, Dithmar H, Feucht W. (2003). Are histones the targets for flavan-3-ols (catechins) in nuclei? Biol Chem 384:997-1006.
165. Popat A, Karmakar S, Jambhrunkar S, et al. (2014). Curcumincyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids Surf B: Biointerfaces 117: 520-7.
166. Prajakta D, Ratnesh J, Chandan K, et al. (2009). Curcumin loaded pH-sensitive nanoparticles for the treatment of colon cancer. J Biomed Nanotechnol 5:445-55.
167. Procházková D, Boušová I, Wilhelmová N. (2011). Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82:513-23.
168. Punfa W, Yodkeeree S, Pitchakarn P, et al. (2012). Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells. Acta Pharmacol Sin 33:823-31.
169. Puoci F, Morelli C, Cirillo G, et al. (2012). Anticancer activity of a quercetin-based polymer towards HeLa cancer cells. Anticancer Res 32:2843-7.
170. Pérez-Herrero E, Fernández-Medarde A. (2015). Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy. Eur J Pharm Biopharm 93:52-79.
171. Rao CNR, Sood AK, Subrahmanyam KS, Govindaraj A. (2009). Graphene: the new two-dimensional nanomaterial. Angew Chem Int Ed 48:7752-77.
172. Ravichandran S, Nagarajan S, Ku BC, et al. (2012). Halogen-free ultra-high flame retardant polymers through enzyme catalysis. Green Chem 14:819-24.
173. Ray L, Kumar P, Gupta KC. (2013). The activity against Ehrlich’s ascites tumors of doxorubicin contained in self assembled, cell receptor targeted nanoparticle with simultaneous oral delivery of the green tea polyphenol epigallocatechin-3-gallate. Biomaterials 34: 3064-76.
174. Riggio C, Calatayud MP, Giannaccini M, et al. (2014). The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field. Nanomed: Nanotechnol Biol Med 10:1549-58.
175. Říhová B, Strohalm J, Prausová J, et al. (2003). Cytostatic and immunomobilizing activities of polymer-bound drugs: experimental and first clinical data. J Control Release 91:1-16.
176. Ringsdorf H. (1975). Structure and properties of pharmacologically active polymers. J Polym Sci Polym Symp 51:135-53.
177. Rodova M, Fu J, Watkins DN, et al. (2012). Sonic Hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PLoS One 7:e46083. doi: 10.1371/journal.pone.0046083.
178. Safavy A, Raisch KP, Mantena S, et al. (2007). Design and development of water-soluble curcumin conjugates as potential anticancer agents. J Med Chem 50:6284-8.
179. Sahu A, Bora U, Kasoju N, Goswami P. (2008a). Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomater 4:1752-61.
180. Sahu A, Kasoju N, Bora U. (2008b). Fluorescence study of the curcumincasein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules 9:2905-12.
181. Sahu A, Kasoju N, Goswami P, Bora U. (2011). Encapsulation of curcumin in Pluronic block copolymer micelles for drug delivery applications. J Biomater Appl 25:619-39.
182. Sanna V, Pintus G, Roggio AM, et al. (2011). Targeted biocompatible nanoparticles for the delivery of ()-epigallocatechin 3-gallate to prostate cancer cells. J Med Chem 54:1321-32.
183. Sanna V, Siddiqui IA, Sechi M, Mukhtar H. (2013). Resveratrol-loaded nanoparticles based on poly(epsiloncaprolactone) and poly(d,l-lactic-co-glycolic acid)-poly(ethylene glycol) blend for prostate cancer treatment. Mol Pharm 10:3871-81.
184. Sanoj Rejinold N, Muthunarayanan M, Chennazhi KP, et al. (2011). Curcumin loaded fibrinogen nanoparticles for cancer drug delivery. J Biomed Nanotechnol 7:521-34.
185. Sarisozen C, Abouzeid AH, Torchilin VP. (2014). The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors. Eur J Pharm Biopharm 88:539-50.
186. Saxena V, Hussain MD. (2013). Polymeric mixed micelles for delivery of curcumin to multidrug resistant ovarian cancer. J Biomed Nanotechnol 9:1146-54.
187. Schroeter H, Spencer JPE, Rice-Evans C, Williams RJ. (2001). Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3. Biochem J 358:547-57.
188. Scott DW, Loo G. (2004). Curcumin-induced GADD153 gene upregulation in human colon cancer cells. Carcinogenesis 25:2155-64.
189. Shao S, Li L, Yang G, et al. (2011). Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers. Int J Pharm 421:310-20.
190. Shen G, Xu C, Hu R, et al. (2005). Comparison of ()-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J Mice and C57BL/6J/Nrf2 (-) mice. Pharm Res 22:1805-20.
191. Shen L, Ji HF. (2007). Theoretical study on physicochemical properties of curcumin. Spectrochim Acta A Mol Biomol Spectrosc 67:619-23.
192. Shirode AB, Bharali DJ, Nallanthighal S, et al. (2015). Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention. Int J Nanomed 10:475-84.
193. Shpaisman N, Sheihet L, Bushman J, et al. (2012). One-step synthesis of biodegradable curcumin-derived hydrogels as potential soft tissue fillers after breast cancer surgery. Biomacromolecules 13:2279-86.
194. Shutava TG, Balkundi SS, Vangala P, et al. (2009). Layer-by-layercoated gelatin nanoparticles as a vehicle for delivery of natural polyphenols. ACS Nano 3:1877-85.
195. Siddiqui IA, Adhami VM, Bharali DJ, et al. (2009). Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate. Cancer Res 69:1712-16.
196. Siddiqui IA, Adhami VM, Chamcheu CJ, Mukhtar H. (2012). Impact of nanotechnology in cancer: emphasis on nanochemoprevention. Int J Nanomed 7:591-605.
197. Siddiqui IA, Bharali DJ, Nihal M, et al. (2014). Excellent anti-proliferative and pro-apoptotic effects of ()-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo. Nanomed: Nanotechnol Biol Med 10:1619-26.
198. Singh M, Bhatnagar P, Mishra S, et al. (2015). PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma. Int J Nanomed 10:6789-809.
199. Singh M, Bhatnagar P, Srivastava AK, et al. (2011). Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles. J Biomed Nanotechnol 7: 202. doi: 10.1166/jbn.2011.1268.
200. Sirova M, Kabesova M, Kovar L, et al. (2013). HPMA copolymer-bound doxorubicin induces immunogenic tumor cell death. Curr Med Chem 20:4815-26.
201. Sobczak M, Debek C, Oledzka E, Kozłowski R. (2013). Polymeric systems of antimicrobial peptides-strategies and potential applications. Molecules 18:14122-37.
202. Song Z, Zhu W, Liu N, et al. (2014). Linolenic acid-modified PEG-PCL micelles for curcumin delivery. Int J Pharm 471:312-21.
203. Sparmann A, Van Lohuizen M. (2006). Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6:846-56.
204. Spencer JPE, Schroeter H, Crossthwaithe AJ, et al. (2001). Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. Free Radic Biol Med 31:1139-46.
205. Spizzirri UG, Cirillo G, Picci N, Iemma F. (2014). Recent development in the synthesis of eco-friendly polymeric antioxidants. Curr Org Chem 18:2912-27.
206. Spizzirri UG, Curcio M, Cirillo G, et al. (2015a). Recent advances in the synthesis and biomedical applications of nanocomposite hydrogels. Pharmaceutics 7:413-37.
207. Spizzirri UG, Hampel S, Cirillo G, et al. (2015b). Functional gelatin-carbon nanotubes nanohybrids with enhanced antibacterial activity. Int J Polym Mater Polym Biomater 64:439-47.
208. Stylianopoulos T, Jain RK. (2015). Design considerations for nanother-apeutics in oncology. Nanomed: Nanotechnol Biol Med 11:1893-907.
209. Su CC, Lin JG, Li TM, et al. (2006). Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res 26:4379-89.
210. Su J, Chen F, Cryns VL, Messersmith PB. (2011). Catechol polymers for pH-responsive, targeted drug delivery to cancer cells. J Am Chem Soc 133:11850-3.
211. Sun L, Zhang C, Li P. (2014a). Copolymeric micelles for delivery of EGCG and cyclopamine to pancreatic cancer cells. Nutr Cancer 66: 896-903.
212. Sun Y, Du L, Liu Y, et al. (2014b). Transdermal delivery of the in situ hydrogels of curcumin and its inclusion complexes of hydroxypropyl-b-cyclodextrin for melanoma treatment. Int J Pharm 469:31-9.
213. Tang SN, Singh C, Nall D, et al. (2010). The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal 5:14. doi: 10.1186/1750-2187-5-14.
214. Teong B, Lin CY, Chang SJ, et al. (2015). Enhanced anti-cancer activity by curcumin-loaded hydrogel nanoparticle derived aggregates on A549 lung adenocarcinoma cells. J Mater Sci: Mater Med 26:5357. doi: 10.1007/s10856-014-5357-3.
215. Thakur VS, Gupta K, Gupta S. (2012). Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases. Int J Oncol 41:353-61.
216. Toden S, Tran HM, Tovar-Camargo OA, et al. (2016). Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer. Oncotarget 7:16158-71.
217. Tong R, Cheng J. (2007). Anticancer polymeric nanomedicines. Polym Rev 47:345-81.
218. Torchilin VP. (2007). Micellar nanocarriers: pharmaceutical perspectives. Pharm Res 24:1-16.
219. Tsouris V, Joo MK, Kim SH, et al. (2014). Nano carriers that enable codelivery of chemotherapy and RNAi agents for treatment of drugresistant cancers. Biotechnol Adv 32:1037-50.
220. Van Berlo D, Wilhelmi V, Boots AW, et al. (2014). Apoptotic, inflammatory, and fibrogenic effects of two different types of multiwalled carbon nanotubes in mouse lung. Arch Toxicol 88:1725-37.
221. Verderio P, Bonetti P, Colombo M, et al. (2013). Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. Biomacromolecules 14:672-82.
222. Vittorio O, Brandl M, Cirillo G, et al. (2016a). Dextran-catechin: an anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth. Oncotarget 7:47479-93.
223. Vittorio O, Brandl M, Cirillo G, et al. (2014a). Novel functional cisplatin carrier based on carbon nanotubes-quercetin nanohybrid induces synergistic anticancer activity against neuroblastoma in vitro. RSC Adv 4:31378-84.
224. Vittorio O, Cirillo G, Iemma F, et al. (2012). Dextran-catechin conjugate: a potential treatment against the pancreatic ductal adenocarcinoma. Pharm Res 29:2601-14.
225. Vittorio O, Cojoc M, Curcio M, et al. (2016b). Polyphenol conjugates by immobilized laccase: the green synthesis of dextran-catechin. Macromol Chem Phys 217:1488-92.
226. Vittorio O, Voliani V, Faraci P, et al. (2014b). Magnetic catechin-dextran conjugate as targeted therapeutic for pancreatic tumour cells. J Drug Target 22:408-15.
227. Vyas AR, Moura MB, Hahm ER, et al. (2016). Sulforaphane inhibits c-Myc-mediated prostate cancer stem-like traits. J Cell Biochem. 117:2482-95.
228. Wang AZ, Langer R, Farokhzad OC. (2012a). Nanoparticle delivery of cancer drugs. Annu Rev Med 63:185-98.
229. Wang BL, Shen YM, Zhang QW, et al. (2013). Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer. Int J Nanomed 8:3521-31.
230. Wang G, Wang JJ, To TSS, et al. (2015a). Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes. Int J Nanomed 10: 5005-23.
231. Wang H, Wang J, Deng X, et al. (2004). Biodistribution of carbon single-wall carbon nanotubes in mice. J Nanosci Nanotechnol 4: 1019-24.
232. Wang K, Zhang T, Liu L, et al. (2012b). Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells. Int J Nanomed 7:4487-97.
233. Wang KK, Sampliner RE. (2008). Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett’s esophagus. Am J Gastroenterol 103:788-97.
234. Wang S, Chen R, Morott J, et al. (2015b). MPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Expert Opin Drug Deliv 12:361-73.
235. Wang W, Zhang L, Le Y, et al. (2016). Synergistic effect of PEGylated resveratrol on delivery of anticancer drugs. Int J Pharm 498:134-41.
236. Wang X, Chen Y, Dahmani FZ, et al. (2014). Amphiphilic carboxymethyl chitosan-quercetin conjugate with P-gp inhibitory properties for oral delivery of paclitaxel. Biomaterials 35:7654-65.
237. Wang Y, Li Z, Wang J, et al. (2011). Graphene and graphene oxide: biofunctionalization and applications in biotechnology. Trends Biotechnol 29:205-12.
238. Wani KD, Kitture R, Ahmed A, et al. (2011). Synthesis, characterization and in vitro study of curcumin-functionalized citric acid-capped magnetic (CCF) nanoparticles as drug delivery agents in cancer. J Bionanosci 5:59-65.
239. Williams RJ, Spencer JPE, Rice-Evans C. (2004). Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36:838-49.
240. Wu DS, Shen JZ, Yu AF, et al. (2013). Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16 INK4a. Oncol Rep 30: 2969-75.
241. Wu L, Guo L, Liang Y, et al. (2015). Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Oncol Rep 34:3311-17.
242. Xiao L, Mertens M, Wortmann L, et al. (2015). Enhanced in vitro and in vivo cellular imaging with green tea coated water-soluble iron oxide nanocrystals. ACS Appl Mater Interfaces 7:6530-40.
243. Yallapu MM, Dobberpuhl MR, Maher DM, et al. (2012). Design of curcumin loaded cellulose nanoparticles for prostate cancer. Curr Drug Metab 13:120-8.
244. Yallapu MM, Ebeling MC, Khan S, et al. (2013). Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment. Mol Cancer Ther 12:1471-80.
245. Yallapu MM, Gupta BK, Jaggi M, Chauhan SC. (2010a). Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J Colloid Interface Sci 351:19-29.
246. Yallapu MM, Khan S, Maher DM, et al. (2014). Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials 35: 8635-48.
247. Yallapu MM, Maher DM, Sundram V, et al. (2010b). Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res 3:11. doi: 10.1186/1757-2215-3-11.
248. Yao LH, Jiang YM, Shi J, et al. (2004). Flavonoids in food and their health benefits. Plant Foods Hum Nutr 59:113-22.
249. Yoo CB, Jones PA. (2006). Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5:37-50.
250. Zahnow CA, Topper M, Stone M, et al. (2016). Inhibitors of DNA methylation, histone deacetylation, and histone demethylation: a perfect combination for cancer therapy. Adv Cancer Res 130:55-111.
251. Zhang L, Li L, Jiao M, et al. (2012a). Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway. Cancer Lett 323:48-57.
252. Zhang L, Qi Z, Huang Q, et al. (2014a). Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery. Colloids Surf B: Biointerfaces 123:15-22.
253. Zhang L, Zhao W, Ma Z, et al. (2012b). Enzymatic polymerization of phenol catalyzed by horseradish peroxidase in aqueous micelle system. Eur Polym J 48:580-5.
254. Zhang Y, Petibone D, Xu Y, et al. (2014b). Toxicity and efficacy of carbon nanotubes and graphene: the utility of carbon-based nanoparticles in nanomedicine. Drug Metab Rev 46:232-46.
255. Zhang Y, Yang C, Wang W, et al. (2016). Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer. Sci Rep 6:21225. doi: 10.1038/srep21225.
256. Zhou H, Sun X, Zhang L, et al. (2012). Fabrication of biopolymeric complex coacervation core micelles for efficient tea polyphenol delivery via a green process. Langmuir 28:14553-61.
257. Zhu W, Song Z, Wei P, et al. (2015). Y-shaped biotinconjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin. J Colloid Interface Sci 443: 1-7.