Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts

International Journal of Pharmaceutics

Volumn 464, Issue 1-2, 2014, Pages 168-177

  Mikhail, Andrew S ^a,b   Eetezadi, Sina ^a   Ekdawi, Sandra N ^a   Stewart, James ^b   Allen, Christine ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Innovation Centre   (Canada)

Author keywords

Block copolymer micelle; Cancer; Nanomedicine; Nanoparticle; Spheroid; Tumor penetration

Indexed keywords

BLOCK COPOLYMER MICELLE; COPOLYMER; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MICELLE; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; SPHEROID CELL; TUMOR SPHEROID; TUMOR XENOGRAFT; UTERINE CERVIX CANCER;

BLOCK COPOLYMER MICELLE; CANCER; NANOMEDICINE; NANOPARTICLE; SPHEROID; TUMOR PENETRATION;

ANIMALS; FEMALE; HELA CELLS; HT29 CELLS; HUMANS; MICE; MICE, NUDE; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; POLYMERS; SPHEROIDS, CELLULAR; TIME FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84896697586     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.01.010     Document Type: Article

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