Polyphenol Conjugates and Human Health: A Perspective Review

Critical Reviews in Food Science and Nutrition

Volumn 56, Issue 2, 2016, Pages 326-337

  Cirillo, Giuseppe ^a   Curcio, Manuela ^a   Vittorio, Orazio ^b   Iemma, Francesca ^a   Restuccia, Donatella ^a   Spizzirri, Umile Gianfranco ^a   Puoci, Francesco ^a   Picci, Nevio ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

bio conjugates; biological properties; nanomaterials; polymers; Polyphenols

Indexed keywords

ANTIOXIDANTS; FREE RADICALS; IONIZATION OF GASES; NANOSTRUCTURED MATERIALS; POLYMERS;

BIO-CONJUGATES; BIOLOGICAL PROPERTIES; BIOMEDICAL FIELDS; CARDIO-VASCULAR DISEASE; COSMETIC INDUSTRY; CUMULATIVE EVIDENCE; INNOVATIVE MATERIALS; POLYPHENOLS;

DISEASES;

ANTIOXIDANT; POLYPHENOL;

CHEMISTRY; FOOD ANALYSIS; HUMAN; PLANT;

ANTIOXIDANTS; FOOD ANALYSIS; HUMANS; PLANTS; POLYPHENOLS;

EID: 84951751688     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2012.752342     Document Type: Article

References (111)

1. K.Abe,, S.Yuki, and K.Kogure, (1988). Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19:480–485.
2. R.Aneja,, P.W.Hake,, T.J.Burroughs,, A.G.Denenberg,, H.R.Wong, and B.Zingarelli, (2004). Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. Mol. Med. 10:55–62.
3. C.Ankolekar,, D.Johnson,, M.da Silva Pinto,, K.Johnson,, R.Labbe, and K.Shetty, (2011). Inhibitory potential of tea polyphenolics and influence of extraction time against Helicobacter pylori and lack of inhibition of beneficial lactic acid bacteria. J. Med. Food 14:1321–1329.
4. A.Azzi,, K.J.A.Davies, and F.Kelly, (2004). Free radical biology–terminology and critical thinking. FEBS Lett. 558:3–6.
5. C.F.Babbs, (1990). Free radicals and the etiology of colon cancer. Free Rad. Biol. Med. 8:191–200.
6. J.H.Bae,, K.C.Mun,, W.K.Park,, S.R.Lee,, S.I.Suh,, W.K.Baek,, M.B.Yim,, T.K.Kwon, and D.K.Song, (2002). EGCG attenuates AMPA-induced intracellular calcium increase in hippocampal neurons. Biochem. Biophys. Res. Commun. 290:1506–1512.
7. S.R.Bhatt,, M.F.Lokhandwala, and A.A.Banday, (2011). Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur. J. Pharmacol. 667:258–264.
8. L.Bravo, (1998). Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutrit. Rev. 56:317–333.
9. F.F.Bruno,, A.Trotta,, S.Fossey,, S.Nagarajan,, R.Nagarajan,, L.A.Samuelson, and J.Kumar, (2010). Enzymatic synthesis and characterization of polyQuercetin. J. Macromol. Sci. A 47:1191–1196.
10. Y.Cai,, Q.Luo,, M.Sun, and H.Corke, (2004). Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 74:2157–2184.
11. R.A.Casero, and P.M.Woster, (2009). Recent advances in the development of polyamine analogues as antitumor agents. J. Med. Chem. 52:4551–4573.
12. R.Cassano,, S.Trombino,, R.Muzzalupo,, L.Tavano, and N.Picci, (2009). A novel dextran hydrogel linking trans-ferulic acid for the stabilization and transdermal delivery of vitamin E. Eur. J. Pharm. Biopharm. 72:232–238.
13. L.Cavallaro,, B.Egan,, C.O’ Morain, and F.Di Mario, (2006). Treatment of Helicobacter pylori infection. Helicobacter 11:36–39.
14. T.Cecchi,, P.Cecchi, and P.Passamonti, (2011). The first quantitative rating system of the antioxidant capacity of beauty creams via the Briggs–Rauscher reaction: A crucial step towards evidence-based cosmetics. Analyst 136:613–618.
15. S.Y.Chae,, M.Jang, and J.Nah, (2004). Influence of molecular weight on oral absorption of water soluble chitosans. J. Control Rel. 102:383–394.
16. F.Chen,, Z.Shi,, K.G.Neoh, and E.T.Kang, (2009). Antioxidant and antibacterial activities of eugenol and carvacrol-grafted chitosan nanoparticles. Biotech. Bioeng. 104:30–39.
17. Y.T.Choi,, C.H.Jung,, S.R.Lee,, J.H.Bae,, W.K.Baek,, M.H.Suh,, J.Park,, C.W.Park, and S.I.Suh, (2001). (-)-Epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons. Life Sci. 70:603–614.
18. E.I.Chung,, M.Kurisawa,, Y.Tachibana,, H.Uyama, and S.Kobayashi, (2003b). Enzymatic synthesis and antioxidant property of poly(allylamine)–catechin conjugate. Chem. Lett. 32:620–621.
19. J.E.Chung,, M.Kurisawa,, H.Uyama, and S.Kobayashi, (2003a). Enzymatic synthesis and antioxidant property of gelatin-catechin conjugates. Biotech. Lett. 25:1993–1997.
20. E.L.Ciani,, L.Groneng,, M.Voltattorni,, V.Rolseth,, A.Contestabile, and R.E.Pausen, (1996). Inhibition of free radical production of free radical scavenging protects cultured neurons against apoptosis induced by beta-amyloid peptide. Mol. Pharmacol. 47:890–897.
21. G.Cirillo,, S.Hampel,, R.Klingeler,, F.Puoci,, F.Iemma,, M.Curcio,, O.I.Parisi,, U.G.Spizzirri,, N.Picci,, A.Leonhardt,, M.Ritschel, and B.Büchner, (2011). Antioxidant multi-walled carbon nanotubes by free radical grafting of gallic acid: New materials for biomedical applications. J. Pharm. Pharmacol. 63:179–188.
22. G.Cirillo,, K.Kraemer,, S.Fuessel,, F.Puoci,, M.Curcio,, U.G.Spizzirri,, I.Altimari, and F.Iemma, (2010). Biological activity of a gallic acid-gelatin conjugate. Biomacromolecules 11:3309–3315.
23. G.Cirillo,, F.Puoci,, F.Iemma,, M.Curcio,, O.I.Parisi,, U.G.Spizzirri,, I.Altimari, and N.Picci, (2012). Starch-quercetin conjugate by radical grafting: Synthesis and biological characterization. Pharm. Dev. Technol. 17:466–476.
24. M.Curcio,, F.Puoci,, F.Iemma,, O.I.Parisi,, G.Cirillo,, U.G.Spizzirri, and N.Picci, (2009). Covalent insertion of antioxidant molecules on chitosan by a free radical grafting procedure. J. Agric. Food Chem. 57:5933–5938.
25. L.Z.Ellis,, W.Liu,, Y.Luo,, M.Okamoto,, D.Qu,, J.H.Dunn, and M.Fujita, (2011). Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion. Biochem. Biophys. Res. Comm. 414:551–556.
26. H.Esen, and S.H.Kusefoglu, (2003). Photolytic and free-radical polymerization of cinnamate esters of epoxidized plant oil triglycerides. J. Appl. Polym. Sci. 89:3882–3888.
27. M.A.Findeis,, G.M.Musso,, C.C.Arico-Muendel,, H.W.Benjamin,, A.M.Hundal,, J.J.Lee,, J.Chin,, M.Kelley,, J.Wakefield,, N.J.Hayward, and S.M.Molineaux, (1999). Modified-peptide inhibitors of amyloid beta-peptide polymerization. Biochemistry 38:6791–6800.
28. /+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract. Canc. Prev. Res. 4:907–915.
29. B.Frei, and J.V.Higdon, (2003). Antioxidant activity of tea polyphenols in vivo: Evidence from animal studies. J. Nutr. 133:3275S–3284S.
30. H.Fujiki,, M.Suganuma,, M.Kurusu,, S.Okabe,, Y.Imayoshi,, S.Taniguchi, and T.Yoshida, (2003). New TNF-α releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. Mutat. Res. 523–524:119–125.
31. P.Gogoi,, S.Hazarika,, N.N.Dutta, and P.G.Rao, (2010). Kinetics and mechanism on laccase catalyzed synthesis of poly(allylamine)–catechin conjugate. Chem. Eng. J. 163:86–92.
32. P.Gresele,, C.Cerletti,, G.Guglielmini,, P.Pignatelli,, G.de Gaetano, and F.Violi, (2011). Effects of resveratrol and other wine polyphenols on vascular function: An update. J. Nutr. Biochem. 22:201–211.
33. B.Halliwell, (2011). Free radicals and antioxidants–quo vadis? Trends Pharmacol. Sci. 32:125–130.
34. B.Halliwell, and J.M.Gutteridge, (1994). Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence? Lancet 344:721–724.
35. M.A.Harish Nayaka,, U.V.Sathisha, and S.M.Dharmesh, (2010). Cytoprotective and antioxidant activity of free, conjugated and insoluble-bound phenolic acids from swallow root (Decalepis hamiltonii). Food Chem. 119:1307–1312.
36. K.C.Hsu,, G.H.Lu, and C.L.Jao, (2009). Antioxidative properties of peptides prepared from tuna cooking juice hydrolysates with orientase (Bacillus subtilis). Food Res. Int. 42:647–652.
37. J.Huang,, G.Zhan,, B.Zheng,, D.Sun,, F.Lu,, Y.Lin,, H.Chen,, Z.Zheng,, Y.Zheng, and Q.Li, (2011). Biogenic silver nanoparticles by cacumen platycladi extract: Synthesis, formation mechanism, and antibacterial activity. Ind. Eng. Chem. Res. 50:9095–9106.
38. J.H.Huang,, C.C.Huang,, J.Y.Fang,, C.Yang,, C.M.Chan,, N.L.Wu,, S.W.Kang, and C.F.Hung, (2010). Protective effects of myricetin against ultraviolet-B-induced damage in human keratinocytes. Toxicol. in Vitro 24:21–28.
39. F.Iemma,, F.Puoci,, M.Curcio,, O.I.Parisi,, G.Cirillo,, U.G.Spizzirri, and N.Picci, (2010). Ferulic acid as a comonomer in the synthesis of a novel polymeric chain with biological properties. J. Appl. Polym. Sci. 115:784–789.
40. N.Ihara,, M.Kurisawa,, J.E.Chung,, H.Uyama, and S.Kobayashi, (2005). Enzymatic synthesis of a catechin conjugate of polyhedral oligomeric silsesquioxane and evaluation of its antioxidant activity. Appl. Microbiol. Biotechnol. 66:430–433.
41. N.Ihara,, S.Schmitz,, M.Kurisawa,, J.E.Chung,, H.Uyama, and S.Kobayashi, (2004). Amplification of inhibitory activity of catechin against disease-related enzymes by conjugation on poly(ϵ-lysine). Biomacromolecules 5:1633–1636.
42. G.Jin, and H.Yoshioka, (2005). Synthesis of lipophilic poly-lauronyl(+)-catechins and radical-scavenging activity. Biosci. Biotechnol. Biochem. 69:440–447.
43. M.Kakran,, N.G.Sahoo, and L.Li, (2011). Dissolution enhancement of quercetin through nanofabrication, complexation, and solid dispersion. Coll. Surf. B Bioint. 88:121–130.
44. S.Kim, and A.Cavaco-Paulo, (2012). Laccase-catalysed protein–flavonoid conjugates for flax fibre modification. Appl. Microbiol. Biotechnol. 93:585–600.
45. S.K.Kim,, Y.T.Kim,, H.G.Byun,, K.S.Nam,, D.S.Joo, and F.Shahidi, (2001). Isolation and characterization of antioxidative peptides from gelatin hydrolysate of Alaska Pollack skin. J. Agric. Food Chem. 49:1984–1989.
46. R.Kleemann,, L.Verschuren,, M.Morrison,, S.Zadelaar,, M.J.van Erk,, P.Y.Wielinga, and T.Kooistra, (2011). Antiinflammatory, antiproliferative and antiatherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis 218:44–52.
47. R.Konwarh,, J.Prasad Saikia,, N.Karak, and B.Kumar Konwar, (2010). ‘Poly(ethylene glycol)magnetic nanoparticles curcumin’ trio: Directed morphogenesis and synergistic free radical scavenging. Coll. Surf. B Bioint. 81:578–586.
48. M.Kurisawa,, J.E.Chung,, H.Uyama, and S.Kobayashi, (2003a). Laccase-catalyzed synthesis and antioxidant property of poly(catechin). Macromol. Biosci. 3:758–764.
49. M.Kurisawa,, J.E.Chung,, H.Uyama, and S.Kobayashi, (2003b). Enzymatic synthesis and antioxidant properties of poly(rutin). Biomacromolecules 4:1394–1399.
50. M.Kurisawa,, J.E.Chung,, H.Uyama, and S.Kobayashi, (2004). Oxidative coupling of epigallocatechin gallate amplifies antioxidant activity and inhibits xanthine oxidase activity. Chem. Commun. 10:294–295.
51. S.Y.Kwak,, S.Lee,, J.K.Yang, and Y.S.Lee, (2012). Antioxidative activities of caffeoyl-proline dipeptides. Food Chem. 130:847–852.
52. S.Y.Kwak,, H.S.Seo, and Y.S.Lee, (2009). Synergistic antioxidative activities of hydroxycinnamoyl-peptides. J. Pept. Sci. 15:634–641.
53. H.Lee,, J.H.Bae, and S.R.Lee, (2004). Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. J. Neurosci. Res. 77:892–900.
54. S.R.Lee,, S.I.Suh, and S.P.Kim, (2000). Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci. Lett. 287:191–194.
55. H.Li,, N.Xia, and U.Förstermann, (2012). Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide 26:102–110.
56. Y.Li,, S.Danmark,, U.Edlund,, A.Finne-Wistrand,, X.He,, M.Norgard,, E.Blomén,, K.Hultenby,, G.Andersson, and U.Lindgren, (2011a). Resveratrol-conjugated poly-e-caprolactone facilitates in vitro mineralization and in vivo bone regeneration. Acta Biomat. 7:751–758.
57. Y.Li,, X.Li,, Y.S.Wong,, T.Chen,, H.Zhang,, C.Liu, and W.Zheng, (2011b). The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials 32:9068–9076.
58. C.Lu, and M.P.Mattson, (2001). Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons. Exp. Neurol. 70:180–185.
59. N.R.Maddux,, S.B.Joshi,, D.B.Volkin,, J.P.Ralston, and C.R.Middaugh, (2011). Multidimensional methods for the formulation of biopharmaceuticals and vaccines. Food Hydrocol. 25:1813–1827.
60. M.Maeda,, H.Murakami,, H.Ohta, and M.Tajima, (1992). Stimulation of IgM 15 production in human-human hybridoma HB4C5 cells by chitosan. Biosci. Biotechnol. Biochem. 56:427–431.
61. S.Maqsood, and S.Benjakul, (2010). Comparative studies of four different phenolic compounds on in vitro antioxidative activity and the preventive effect on lipid oxidation of fish oil emulsion and fish mince. Food Chem. 119:123–132.
62. E.Mendis,, N.Rajapakse, and S.K.Kim, (2005). Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish gelatin hydrolysate. J. Agric. Food Chem. 53:581–587.
63. N.Mita,, S.Tawaki,, H.Uyama, and S.Kobayashi, (2003). Laccase-catalyzed oxidative polymerization of phenols. Macromol. Biosci. 3:253–257.
64. F.L.Muller,, M.S.Lustgarten,, Y.Jang,, A.Richardson, and H.Van Remmen, (2007). Trends in oxidative aging theories. Free Rad. Biol. Med. 43:477–503.
65. R.M.Murphy, (2002). Peptide aggregation in neurodegenerative disease. Annu. Rev. Biomed. Eng. 4:155–174.
66. C.W.Nelson,, E.P.Wei,, J.T.Povlishock,, H.A.Kontos, and M.A.Moskowitz, (1992). Oxygen radicals in cerebral ischemia. Am. J. Physiol. 263:1356–1362.
67. M.Ouberai,, P.Dumy,, S.Chierici, and J.Garcia, (2009). Synthesis and biological evaluation of clicked curcumin and clicked KLVFFA conjugates as inhibitors of β-amyloid fibril formation. Bioconjugate Chem. 20:2123–2132.
68. S.Padhye,, D.Chavan,, S.Pandey,, J.Deshpande,, K.V.Swamy, and F.H.Sarkar, (2010). Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry. Mini-Rev. Med. Chem. 10:372–387.
69. O.I.Parisi,, F.Puoci,, F.Iemma,, G.De Luca,, M.Curcio,, G.Cirillo,, U.G.Spizzirri, and N.Picci, (2010). Antioxidant and spectroscopic studies of crosslinked polymers synthesized by grafting polymerization of ferulic acid. Polym. Adv. Technol. 21:774–779.
70. E.Y.Park,, H.Murakami, and Y.Matsumura, (2005). Effects of the addition of amino acids and peptides on lipid oxidation in a powdery model system. J. Agric. Food Chem. 53:8334–8341.
71. W.Pasanphan,, G.R.Buettner, and S.Chirachanchai, (2010). Chitosan gallate as a novel potential polysaccharide antioxidant: An EPR study. Carbohyd. Res. 345:132–140.
72. I.Pawlaczyk,, L.Czerchawski,, W.Kuliczkowski,, B.Karolko,, W.Pilecki,, W.Witkiewicz, and R.Gancarz, (2011). Anticoagulant and anti-platelet activity of polyphenolic-polysaccharide preparation isolated from the medicinal plant Erigeron canadensis L. Thromb. Res. 127:328–340.
73. I.Pawlaczyk,, L.Czerchawski,, W.Pilecki,, E.Lamer-Zarawska, and R.Gancarz, (2009). Polyphenolic-polysaccharide compounds from selected medicinal plants of Asteraceae and Rosaceae families: Chemical characterization and blood anticoagulant activity. Carbohyd. Res. 77:568–575.
74. F.Perez-Vizcaino,, J.Duarte, and R.Andriantsitohaina, (2006). Endothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols. Free Rad. Res. 40:1054–1065.
75. B.Poaty,, S.Dumarҫay,, P.Gérardin, and D.Perrin, (2012). Modification of grape seed and wood tannins to lipophilic antioxidant derivatives. Ind. Crops Prod. 31:509–515.
76. F.Puoci,, F.Iemma,, M.Curcio,, O.I.Parisi,, G.Cirillo,, U.G.Spizzirri, and N.Picci, (2008). Synthesis of methacrylic-ferulic acid copolymer with antioxidant properties by single-step free radical polymerization. J. Agric. Food Chem. 56:10646–10650.
77. F.Puoci,, C.Morelli,, G.Cirillo,, M.Curcio,, O.I.Parisi,, P.Maris,, D.Sisci, and N.Picci, (2012). Anticancer activity of a quercetin-based polymer towards HeLa cancer cells. Anticancer Res. 32:2843–2847.
78. B.Qin,, M.M.Polansky,, D.Harry, and R.A.Anderson, (2010). Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. Mol. Nutr. Food Res. 54:S14–S23.
79. B.Relja,, E.Tottel,, L.Breig,, D.Henrich,, H.Schneider,, I.Marzi, and M.Lehnert, (2011). Effects of green tea catechins on the pro-inflammatory response after haemorrhage/resuscitation in rats. Br. J. Nutr. 105:1791–1797.
80. S.Rimbaud,, M.Ruiz,, J.Piquereau,, P.Mateo,, D.Fortin,, V.Veksler,, A.Garnier, and R.Ventura-Clapier, (2011). Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. Plos One 6:e26391.
81. C.Romero,, E.Medina,, J.Vargas,, M.Brenes, and A.De Castro, (2007). In vitro activity of olive oil polyphenols against Helicobacter pylori. J. Agric. Food Chem. 55:680–686.
82. A.Rosa,, M.P.Melis,, M.Deiana,, A.Atzeri,, G.Appendino,, G.Corona,, A.Incani,, D.Loru, and M.A.Dessì, (2008). Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. Chem. Phys. Lip. 155:16–23.
83. K.Saito,, D.H.Jin,, T.Ogawa,, K.Muramoto,, E.Hatakeyama,, T.Yasuhara, and K.Nokihara, (2003). Antioxidative properties of tripeptide libraries prepared by the combinatorial chemistry. J. Agric. Food Chem. 51:3668–3674.
84. S.Sakanaka,, Y.Tachibana,, N.Ishihara, and L.R.Juneja, (2004). Antioxidant activity of egg-yolk protein hydrolysates in a linoleic acid oxidation system. Food Chem. 86:99–103.
85. S.Saleem,, H.Zhuang,, S.Biswal,, Y.Christen, and S.Doré, (2008). Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury. Stroke 39:3389–3396.
86. J.Saluk-Juszczak,, B.Olas,, I.Pawlaczyk,, R.Gancarz, and B.Wachowicz, (2007). Effects of the extract from Conyza canadensis on human blood platelet aggregation. Gen. Physiol. Biophys. 26:150–152.
87. H.S.Seo,, S.Y.Kwak, and Y.S.Lee, (2010). Antioxidative activities of histidine containing caffeic acid-dipeptides. Bioorg. Med. Chem. Lett. 20:4266–4272.
88. A.Serpen,, E.Capuano,, V.Fogliano, and V.Gökmen, (2007). New procedure to measure the antioxidant activity of insoluble food components. J. Agric. Food Chem. 55:7676–7681.
89. Z.A.Shah,, R.C.Li,, A.S.Ahmad,, T.W.Kensler,, M.Yamamoto,, S.Biswal, and S.Doré, (2010). The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. J. Cereb. Blood Flow. Met. 30:1951–1961.
90. Z.A.Shah,, S.E.Nada, and S.Doré, (2011). Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (Egb 761) neuroprotection. Neuroscience 180:248–255.
91. C.L.Shen,, J.K.Yeh,, C.Samathanam,, J.J.Cao,, B.J.Stoecker,, R.Y.Dagda,, M.C.Chyu,, D.M.Dunn, and J.S.Wang, (2011). Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation. Osteoporos. Int. 22:327–337.
92. D.H.Shin,, Y.C.Bae,, J.S.Kim-Han,, J.H.Lee,, I.J.Choi,, K.H.Son,, S.S.Kang,, W.K.Kim, and B.H.Han, (2006). Polyphenol amentoflavone affords neuroprotection against neonatal hypoxic-ischemic brain damage via multiple mechanisms. J. Neurochem. 96:561–572.
93. J.C.Shiu,, M.H.Ho,, S.H.Yu,, A.C.Chao,, Y.R.Su,, W.J.Chen,, Z.C.Chiang, and W.P.Yang, (2010). Preparation and characterization of caffeic acid grafted chitosan/CPTMS hybrid scaffolds. Carbohyd. Polym. 79:724–730.
94. H.Sies, (1997). Oxidative stress: Oxidants and antioxidants. Exp. Physiol. 82:291–295.
95. E.Simoni,, C.Bergamini,, R.Fato,, A.Tarozzi,, S.Bains,, R.Motterlini,, A.Cavalli,, M.L.Bolognesi,, A.Minarini,, P.Hrelia,, G.Lenaz,, M.Rosini, and C.Melchiorre, (2010). Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents. J. Med. Chem. 53:7264–7268.
96. A.Simonyi,, Q.Wang,, R.L.Miller,, M.Yusof,, P.B.Shelat,, A.Y.Sun, and G.Y.Sun, (2005). Polyphenols in cerebral ischemia novel targets for neuroprotection. Mol. Neurobiol. 31:135–147.
97. F.Sousa,, G.M.Guebitz, and V.Kokol, (2009). Antimicrobial and antioxidant properties of chitosan enzymatically functionalized with flavonoids. Progress Biochem. 44:749–756.
98. U.G.Spizzirri,, I.Altimari,, F.Puoci,, O.I.Parisi,, F.Iemma, and N.Picci, (2011). Innovative antioxidant thermo-responsive hydrogels by radical grafting of catechin on inulin chain. Carbohyd. Polym. 84:517–523.
99. U.G.Spizzirri,, F.Iemma,, F.Puoci,, G.Cirillo,, M.Curcio,, O.I.Parisi, and N.Picci, (2009). Synthesis of antioxidant polymers by grafting of gallic acid and catechin on gelatin. Biomacromolecules 10:1923–1930.
100. U.G.Spizzirri,, O.I.Parisi,, F.Iemma,, G.Cirillo,, F.Puoci,, M.Curcio, and N.Picci, (2010). Antioxidant–polysaccharide conjugates for food application by eco-friendly grafting procedure. Carbohyd. Polym. 79:333–340.
101. J.W.Stephens,, P.M.Khanolkar, and S.C.Bain, (2009). The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease. Atherosclerosis 202:321–329.
102. M.Suganuma,, Y.Ohkura,, S.Okabe, and H.Fujiki, (2001). Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice. J. Cancer Res. Clin. Oncol. 127:69–72.
103. S.Trombino,, R.Cassano,, E.Bloise,, R.Muzzalupo,, S.Leta,, F.Puoci, and N.Picci, (2008). Design and synthesis of cellulose derivatives with antioxidant activity. Macromol. Biosci. 8:86–95.
104. R.Tsao, (2010). Chemistry and biochemistry of dietary polyphenols. Nutrients 2:1231–1246.
105. H.Uyama (2007). Artificial polymeric flavonoids: Synthesis and applications. Macromol. Biosci. 7:410–422.
106. C.Valenta,, E.Schwarz, and A.Bernkop-Schnurch, (1998). Lysozyme-caffeic acid conjugates: Possible novel preservatives for dermal formulations. Int. J. Pharm. 174:125–132.
107. D.Venkat Ratnam,, D.D.Ankola,, V.Bhardwaj,, D.K.Sahana, and M.N.V.Ravi Kumar, (2006). Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. J. Control. Rel. 113:189–207.
108. P.Vitaglione,, F.Morisco,, G.Mazzone,, D.C.Amoruso,, M.T.Ribecco,, A.Romano,, V.Fogliano,, N.Caporaso, and G.D’Argenio, (2010). Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 52:1652–1661.
109. O.Vittorio,, G.Cirillo,, F.Iemma,, G.Di Turi,, E.Jacchetti,, M.Curcio,, S.Barbuti,, N.Funel,, O.I.Parisi,, F.Puoci, and N.Picci, (2012). Dextran-catechin conjugate: A potential treatment against the pancreatic ductal adenocarcinoma. Pharm. Res. 29:2601–2614.
110. P.P.Wattamwar,, S.S.Hardas,, D.A.Butterfield,, K.W.Anderson, and T.D.Dziubla, (2011). Tuning of the pro-oxidant and antioxidant activity of trolox through the controlled release from biodegradable poly(trolox ester) polymers. J. Biomed. Mat. Res. A 99A:184–191.
111. W.Xie,, P.Xu,, W.Wang, and Q.Liu, (2002). Preparation and antibacterial activity of a water-soluble chitosan derivative. Carbohydr. Polym. 50:35–40.