Resveratrol loaded gelatin nanoparticles synergistically inhibits cell cycle progression and constitutive NF-kappaB activation, and induces apoptosis in non-small cell lung cancer cells

Biomedicine and Pharmacotherapy

Volumn 70, Issue C, 2015, Pages 274-282

  Karthikeyan, Subburayan ^a,b   Hoti, Sugeerappa Laxmanappa ^a   Prasad, Nagarajan Rajendra ^b  

^a Nehru Nagar   (India)

^b ANNAMALAI UNIVERSITY   (India)

Author keywords

Apoptosis; Coacervation; DAPI; Gelatin nanoparticles; Nuclear fragmentation; Resveratrol

Indexed keywords

CASPASE 3; CELL NUCLEUS DNA; CISPLATIN; ENZYME; ENZYME CAT; GELATIN; GENOMIC DNA; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID HYDROPEROXIDE; NANOCARRIER; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; RESVERATROL; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; NANOPARTICLE; STILBENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL DEATH; COACERVATION; CONTROLLED STUDY; DNA DETERMINATION; DNA FRAGMENTATION; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; FLOW CYTOMETRY; LUNG CANCER CELL LINE; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINE; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; DRUG EFFECTS; DRUG POTENTIATION; HUMAN; LUNG NEOPLASMS; METABOLISM; MOUSE; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CATTLE; CELL CYCLE; CELL LINE, TUMOR; DRUG SYNERGISM; GELATIN; HUMANS; LUNG NEOPLASMS; MICE; NANOPARTICLES; NF-KAPPA B; STILBENES;

EID: 84927563943     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2015.02.006     Document Type: Article

References (55)

1. Jemal A., Thun M.J., Ries L.A., Howe H.L., Weir H.K., Center M.M., et al. Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Inst 2008, 100:1672-1694.
2. Han D.K.M., Haudenschild C.C., Hong M.K., Tinkle B.T., Leon M.B., Liau G. Evidence for apoptosis in human atherogenesis and in a rat vascular injury modal. Am J Pathol 1995, 147:267-277.
3. Cohen G.M. Caspase: the executioners of apoptosis. Biochem J 1997, 326:1-16.
4. Akgul C., Moulding D.A., Edwards S.W. Molecular control of neutrophil apoptosis. FEBS Lett 2001, 487:318-322.
5. Zhi Y.H., Panayotis P., James H.W., Nichola K., Vincent J.K., Eric A.H. A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line. J Biol Chem 2001, 276:38748-38754.
6. Lozano G., Elledge S.J. p53 sends nucleotides to repair DNA. Nature 2000, 404:24-25.
7. Ciciarello M., Mangiacasale R., Casenghi M., Limongi M.Z., D'Angelo M., Soddu S., et al. p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the and p53-mediated G1 arrest following transient inhibition of the mitotic spindle. J Biol Chem 2001, 276:19205-19213.
8. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998, 282:1497-1501.
9. Kundu J.K., Surh Y.J. Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets. Mutat Res 2004, 555:65-80.
10. Filomeni G., Graziani I., Rotilio G., Ciriolo M.R. Trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways. Genes Nutr 2007, 2:295-305.
11. Signorelli P., Ghidoni R. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem 2005, 16:449-466.
12. Lu Z., Cheng B., Hu Y.L., Zhan Y.H., Zou G.L. Complexation of resveratrol with cyclodextrins: solubility and antioxidant activity. Food Chem 2009, 113:17-20.
13. Juan M.E., Buenafuente J., Casals I., Planas J.M. Plasmatic levels of trans-resveratrol in rats. Food Res Int 2002, 35:195-199.
14. Gabr Y., Assem N., Michael A., Fahmy L. Evaluation studies on oxypolygelatin and degraded gelatin as plasma volume expander. Arzneimittelforschung 1996, 46:763-766.
15. Young S., Wong M., Tabata Y., Mikos A.G. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 2005, 109:256-274.
16. Brigger I., Dubernet C., Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 2002, 54:631-651.
17. Reddy L.H. Drug delivery to tumours: recent strategies. J Pharm Pharmacol 2005, 57:1231.
18. Karthikeyan S., Prasad N.R., Ganamani A., Balamurugan E. Anticancer activity of resveratrol-loaded gelatin nanoparticles on NCI-H460 non-small cell lung cancer cells. Biomed Prevent Nut 2013, 3:64-73.
19. Karthikeyan S., Prasad N.R. Anticancer activity of resveratrol-loaded gelatin nanoparticles on Ehrlich's Ascites Carcinoma in Swiss albino mice. J Res Nanobiotechnol 2013, 1:31-38.
20. Niehaus W.G., Samuelsson B. Formation of malondialdehyde from phospholipids arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968, 61:26-130.
21. Jiang Z.Y., Hunt J.V., Wolff S.P. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein. Anal Biochem 1992, 202:384-389.
22. Kakkar Z.Y.P., Das B., Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase (SOD). Indian J Biochem Biophys 1984, 21:130-132.
23. Sinha K.A. Colorimetric assay of catalase. Anal Biochem 1972, 47:389-394.
24. Rotruck J.T., Pope A., Ganther H.E. Selenium; biochemical roles as components of glutathione peroxidase. Science 1973, 179:588-590.
25. Ellman G.L. Tissue sulfydryl groups. Arch Biochem Biophys 1959, 82:70-77.
26. Tsai S.C., Lu C.C., Lee C.Y., Lin Y.C., Chung J.G., Kuo S.C., et al. AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells. Int J Oncol 2012, 41:1683-1692.
27. DeVita V.T. Dose-response is alive and well. J Clin Oncol 1986, 4:1157-1159.
28. Min L.W. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev 2009, 35:57-68.
29. Palumbo M., Russo A., Cardile V., Renis M., Paolino D., Puglisi G., et al. Improved antioxidant effect of idebenone-loaded polyethyl-2-cyanoacrylate nanocapsules tested on human fibroblasts. Pharm Res 2002, 19:71-78.
30. Schaffazick S.R., Pohlmann A.R., de Cordova C.A., Creczynski-Pasa T.B., Guterres S.S. Protective properties of melatonin-loaded nanoparticles against lipid peroxidation. Int J Pharm 2005, 289:209-213.
31. Lu Z., Chen R., Fu R., Xiong J., Hu Y. Cytotoxicity and inhibition of lipid peroxidation activity of resveratrol/cyclodextrin inclusion complexes. J Incl Phenom Macrocycl Chem 2012, 73:313-320.
32. Karthikeyan S., Kanimozhi G., Prasad N.R., Mahalakshmi R. Radiosensitizing effect of ferulic acid on mechanism in human cervical carcinoma cells in vitro. Toxicol In Vitro 2011, 25:1366-1375.
33. Rice-Evans C., Burdon R. Free radical-lipid interactions and their pathological consequences. Prog Lipid Res 1993, 32:71-110.
34. Prasad N.R., Karthikeyan A., Karthikeyan S., Reddy B.V. Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line. Mol Cell Biochem 2011, 349:11-19.
35. Jose Merlin J.P., Rajendra Prasad N., Shibli S.M.A., Sebeela M. Ferulic acid loaded poly-d,l-lactide-co-glycolide nanoparticles: systematic study of particle size, drug encapsulation efficiency and anticancer effect in non-small cell lung carcinoma cell line in vitro. Biomed Prevent Nut 2012, 2:69-76.
36. Kerr J.F., Winterford C.M., Harmon B.V. Apoptosis: its significance in cancer and cancer therapy. Cancer 1994, 73:2013-2026.
37. Higuchi Y. Glutathione depletion-induced chromosomal DNA\fragmentation associated with apoptosis and necrosis. J Cell Mol Med 2004, l8:45-64.
38. Wang L., Zhang H., Chen B., Xia G., Wang S., Cheng J., et al. Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine 2012, 7:789-798.
39. Rajendran P., Delage B., Dashwood W.M., Yu T.W., Wuth B., Williams D.E., et al. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer 2011, 10:68.
40. Holme A.L., Pervaiz S. Resveratrol in cell fate decisions. J Bioenerg Biomembr 2007, 39:59-63.
41. Raynal S., Nocentini S., Croisy A., Lawrence D.A., Jullien P. Transforming growth factor-beta1 enhances the lethal effects of DNA-damaging agents in a human lung-cancer cell line. Int J Cancer 1997, 72:356-361.
42. Fulda S., Debatin K.M. Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 2004, 23:6702-6711.
43. Kuo P.L., Chiang L.C., Lin C. Resveratrol-induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Life Sci 2002, 72:23-34.
44. El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M. WAF1, a potential mediator of p53 tumor suppression. Cell 1993, 75:817-825.
45. Ling Y.H., Liebes L., Zou Y., Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 2003, 278:33714-33723.
46. Doi S., Soda H., Oka M., Tsurutani J., Kitazaki T., Nakamura Y., et al. The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells. Mol Cancer Ther 2004, 3:1397-1402.
47. Wang I.K., Lin-Shiau S.Y., Lin J.K. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer 1999, 35:1517-1525.
48. Li T.M., Chen G.W., Su C.C., Lin J.G., Yeh C.C., Cheng K.C., et al. Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells. Anticancer Res 2005, 25:971-979.
49. Hayward R.L., Macpherson J.S., Cummings J., Monia B.P., Smyth J.F., Jodrell D.I. Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: genetic evidence for specificity of the antisense effect. Mol Cancer Ther 2004, 3:169-178.
50. Sinicrope F.A., Penington R.C. Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2. Mol Cancer Ther 2005, 4:1475-1483.
51. Chen Z., Jin K., Gao L., Lou G., Jin Y., Yu Y., et al. Antitumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol 2010, 643:170-179.
52. Zhou H.B., Yan Y., Sun Y.N., Zhu J.R. Resveratrol induces apoptosis in human esophageal carcinoma cells. World J Gastroenterol 2003, 9:408-411.
53. Kim Y.A., Choi B.T., Lee Y.T., Park D.I., Rhee S.H., Park K.Y., et al. Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol Rep 2004, 11:441-446.
54. Bharti A.C., Aggarwal B.B. Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol 2002, 64:883-888.
55. Asou H., Koshizuka K., Kyo T., Takata N., Kamada N., Koeffier H.P. Resveratrol, a natural product derived from grapes, is a new inducer of differentiation in human myeloid leukemias. Int J Hematol 2002, 75:528-533.