Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery

Nano Research

Volumn 2, Issue 2, 2009, Pages 85-120

  Liu, Zhuang ^a   Tabakman, Scott ^a   Welsher, Kevin ^a   Dai, Hongjie ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Biomedical applications; Biomedical imaging; Biosensor; Carbon nanotubes; Drug delivery; Surface functionalization

Indexed keywords

EID: 65249178345     PISSN: 19980124     EISSN: 19980000     Source Type: Journal    
DOI: 10.1007/s12274-009-9009-8     Document Type: Article

References (158)

1. G. M. Whitesides 2003 The "right" size in nanobiotechnology Nat. Biotech. 21 1161 1165
2. C. R. Lowe 2000 Nanobiotechnology: The fabrication and applications of chemical and biological nanostructures Curr. Opin. Chem. Biol. 10 428 434 (Pubitemid 30496796)
3. L. Wang W. Zhao W. Tan 2008 Bioconjugated silica nanoparticles: Development and applications Nano Res. 1 99 115
4. S. Iijima 1991 Helical microtubules of graphitic carbon Nature 354 56 58
5. H. Dai 2002 Carbon nanotubes: Synthesis, integration, and properties Acc. Chem. Res. 35 1035 1044
6. Dresselhaus, M.; Dai, H. (eds.) MRS 2004 Carbon Nanotube Special Issue, Vol. 29, 2004.
7. D. Golberg P. M. F. J. Costa M. Mitome Y. Bando 2008 Nanotubes in a gradient electric field as revealed by STM TEM technique Nano Res. 1 166 175
8. W. Zhou C. Rutherglen P. Burke 2008 Wafer scale synthesis of dense aligned arrays of single-walled carbon nanotubes Nano Res. 1 158 165
9. H. Ago K. Petritsch M. S. P. Shaffer A. H. Windle R. H. Friend 1999 Composites of carbon nanotubes and conjugated polymers for photovoltaic devices Adv. Mater. 11 1281 1285 (Pubitemid 30503310)
10. A. Javey J. Guo Q. Wang M. Lundstrom H. J. Dai 2003 Ballistic carbon nanotube field-effect transistors Nature 424 654 657 (Pubitemid 36987985)
11. Q. Cao J. A. Rogers 2008 Random networks and aligned arrays of single-walled carbon nanotubes for electronic device applications Nano Res. 1 259 272
12. S. S. Fan M. G. Chapline N. R. Franklin T. W. Tombler A. M. Cassell H. J. Dai 1999 Self-oriented regular arrays of carbon nanotubes and their field emission properties Science 283 512 514 (Pubitemid 29061185)
13. A. C. Dillon K. M. Jones T. A. Bekkedahl C. H. Kiang D. S. Bethune M. J. Heben 1997 Storage of hydrogen in single-walled carbon nanotubes Nature 386 377 379 (Pubitemid 27154473)
14. R. J. Chen S. Bangsaruntip K. A. Drouvalakis N. W. S. Kam M. Shim Y. M. Li W. Kim P. J. Utz H. J. Dai 2003 Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors Proc. Nat. Acad. Sci. USA 100 4984 4989 (Pubitemid 36542645)
15. N. W. S. Kam T. C. Jessop P. A. Wender H. J. Dai 2004 Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells J. Am. Chem. Soc. 126 6850 6851 (Pubitemid 38855367)
16. Bianco, A.; Kostarelos, K.; Partidos, C. D.; Prato, M. Biomedical applications of functionalised carbon nanotubes. Chem. Commun. 2005, 571-577.
17. P. Cherukuri S. M. Bachilo S. H. Litovsky R. B. Weisman 2004 Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells J. Am. Chem. Soc. 126 15638 15639 (Pubitemid 39602412)
18. Z. Liu X. Sun N. Nakayama H. Dai 2007 Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery ACS Nano 1 50 56
19. S. J. Tans M. H. Devoret H. J. Dai A. Thess R. E. Smalley L. J. Geerligs C. Dekker 1997 Individual single-wall carbon nanotubes as quantum wires Nature 386 474 477 (Pubitemid 27164068)
20. N. W. S. Kam M. O'Connell J. A. Wisdom H. Dai 2005 Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction Proc. Natl. Acad. Sci. USA 102 11600 11605 (Pubitemid 41170772)
21. P. Chakravarty R. Marches N. S. Zimmerman A. D. E. Swafford P. Bajaj I. H. Musselman P. Pantano R. K. Draper E. S. Vitetta 2008 Thermal ablation of tumor cells with anti body-functionalized single-walled carbon nanotubes Proc. Natl. Acad. Sci. U S A 105 8697 8702
22. A. d. l. Zerda C. Zavaleta S. Keren S. Vaithilingam S. Bodapati Z. Liu J. Levi T. -J. Ma O. Oralkan Z. Cheng 2008 Photoacoustic molecular imaging in living mice utilizing targeted carbon nanotubes Nat. Nanotech. 3 557 562
23. M. J. O'Connell S. M. Bachilo C. B. Huffman V. C. Moore M. S. Strano E. H. Haroz K. L. Rialon P. J. Boul W. H. Noon C. Kittrell 2002 Band gap fluorescence from individual single-walled carbon nanotubes Science 297 593 596
24. K. Welsher Z. Liu D. D. Liu H. Dai 2008 Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules Nano Lett. 8 586 590
25. A. M. Rao E. Richter S. Bandow B. Chase P. C. Eklund K. A. Williams S. Fang K. R. Subbaswamy M. Menon A. Thess 1997 Diameter-selective Raman scattering from vibrational modes in carbon nanotubes Science 275 187 191 (Pubitemid 127696277)
26. D. A. Heller S. Baik T. E. Eurell M. S. Strano 2005 Single-walled carbon nanotube spectroscopy in live cells: Towards long-term labels and optical sensors Adv. Mater. 17 2793 2799
27. D. Pantarotto R. Singh D. McCarthy M. Erhardt J. P. Briand M. Prato K. Kostarelos A. Bianco 2004 Functionalized carbon nanotubes for plasmid DNA gene delivery Angew. Chem. Int. Ed. 43 5242 5246 (Pubitemid 39382552)
28. Y. Liu D. C. Wu W. D. Zhang X. Jiang C. B. He T. S. Chung S. H. Goh K. W. Leong 2005 Polyethyleniminegrafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA Angew. Chem. Int. Ed. 44 4782 4785 (Pubitemid 41059186)
29. R. Singh D. Pantarotto D. McCarthy O. Chaloin J. Hoebeke C. D. Partidos J. P. Briand M. Prato A. Bianco K. Kostarelos 2005 Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: Toward the construction of nanotube-based gene delivery vectors J. Am. Chem. Soc. 127 4388 4396 (Pubitemid 40463064)
30. L. Z. Gao L. Nie T. H. Wang Y. J. Qin Z. X. Guo D. L. Yang X. Y. Yan 2006 Carbon nanotube delivery of the GFP gene into mammalian cells ChemBioChem 7 239 242 (Pubitemid 43220934)
31. X. W. Tang S. Bansaruntip N. Nakayama E. Yenilmez Y. L. Chang Q. Wang 2006 Carbon nanotube DNA sensor and sensing mechanism Nano Lett. 6 1632 1636 (Pubitemid 44327523)
32. Chen, Z.; Tabakman, S. M.; Goodwin, A. P.; Kattah, M. G.; Daranciang, D.; Wang, X.; Zhang, G.; Li, X.; Liu, Z.; Utz, P. J., et al. Protein microarrays with carbon nanotubes as multi-color Raman labels. Nat. Biotech. 2008, in press, DOI: 10.1038/nbt.150.
33. N. W. S. Kam H. Dai 2005 Carbon nanotubes as intracellular protein transporters: Generality and biological functionality J. Am. Chem. Soc. 127 6021 6026 (Pubitemid 40577658)
34. N. W. S. Kam Z. A. Liu H. J. Dai 2006 Carbon nanotubes as intracellular transporters for proteins and DNA: An investigation of the uptake mechanism and pathway Angew. Chem. Int. Ed. 45 577 581 (Pubitemid 43121447)
35. N. W. S. Kam Z. Liu H. Dai 2005 Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing J. Am. Chem. Soc. 127 12492 12493 (Pubitemid 41292159)
36. Pantarotto, D.; Briand, J. P.; Prato, M.; Bianco, A. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem. Commun. 2004, 16-17.
37. Z. Liu K. Chen C. Davis S. Sherlock Q. Cao X. Chen H. Dai 2008 Drug delivery with carbon nanotubes for in vivo cancer treatment Cancer Res. 68 6652 6660
38. D. X. Cui F. R. Tian C. S. Ozkan M. Wang H. J. Gao 2005 Effect of single wall carbon nanotubes on human HEK293 cells Toxicol. Lett. 155 73 85 (Pubitemid 39600739)
39. C. W. Lam J. T. James R. McCluskey R. L. Hunter 2004 Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation Toxicol. Lett. 77 126 134 (Pubitemid 38128652)
40. D. B. Warheit B. R. Laurence K. L. Reed D. H. Roach G. A. M. Reynolds T. R. Webb 2004 Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats Toxicol. Lett. 77 117 125 (Pubitemid 38128651)
41. L. H. Ding J. Stilwell T. T. Zhang O. Elboudwarej H. J. Jiang J. P. Selegue P. A. Cooke J. W. Gray F. Q. F. Chen 2005 Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nanoonions on human skin fibroblast Nano Lett. 5 2448 2464 (Pubitemid 43090840)
42. M. Bottini S. Bruckner K. Nika N. Bottini S. Bellucci A. Magrini A. Bergamaschi T. Mustelin 2006 Multi-walled carbon nanotubes induce T lymphocyte apoptosis Toxicol. Lett. 160 121 126 (Pubitemid 41578955)
43. C. A. Poland R. Duffin I. Kinloch A. Maynard W. A. H. Wallace A. Seaton V. Stone S. Brown W. MacNee K. Donaldson 2008 Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study Nat. Nanotech. 3 423 428
44. Z. Liu W. B. Cai L. N. He N. Nakayama K. Chen X. M. Sun X. Y. Chen H. J. Dai 2007 In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice Nat. Nanotech. 2 47 52 (Pubitemid 46210038)
45. Z. Liu C. Davis W. Cai L. He X. Chen H. Dai 2008 Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy Proc. Natl. Acad. Sci. USA 105 1410 1415
46. R. Singh D. Pantarotto L. Lacerda G. Pastorin C. Klumpp M. Prato A. Bianco K. Kostarelos 2006 Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers Proc. Nat. Acad. Sci. USA 103 3357 3362 (Pubitemid 43346474)
47. L. Lacerda A. Soundararajan R. Singh G. Pastorin K. T. Al-Jamal J. Turton P. Frederik M. A. Herrero S. L. A. Bao D. Emfietzoglou 2008 Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion Adv. Mater. 20 225 230
48. S. T. Yang W. Guo Y. Lin X. Y. Deng H. F. Wang H. F. Sun Y. F. Liu X. Wang W. Wang M. Chen 2007 Biodistribution of pristine single-walled carbon nanotubes in vivo J. Phys. Chem. C 111 17761 17764 (Pubitemid 350279908)
49. Deng, X. Y.; Yang, S. T.; Nie, H. Y.; Wang, H. F.; Liu, Y. F. A generally adoptable radiotracing method for tracking carbon nanotubes in animals. Nanotechnology 2008, 19, 075101.
50. P. Cherukuri C. J. Gannon T. K. Leeuw H. K. Schmidt R. E. Smalley S. A. Curley R. B. Weisman 2006 Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence Proc. Natl. Acad. Sci. USA 103 18882 18886 (Pubitemid 350002796)
51. Z. Liu M. Winters M. Holodniy H. J. Dai 2007 siRNA delivery into human T cells and primary cells with carbonnanotube transporters Angew. Chem. Int. Ed. 46 2023 2027 (Pubitemid 46973660)
52. W. Wu S. Wieckowski G. Pastorin M. Benincasa C. Klumpp J. P. Briand R. Gennaro M. Prato A. Bianco 2005 Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes Angew. Chem. Int. Ed. 44 6358 6362 (Pubitemid 41454662)
53. H. Dumortier S. Lacotte G. Pastorin R. Marega W. Wu D. Bonifazi J. P. Briand M. Prato S. Muller A. Bianco 2006 Functionalized carbon nanotubes are noncytotoxic and preserve the functionality of primary immune cells Nano Lett. 6 1522 1528 (Pubitemid 44195341)
54. X. Chen G. S. Lee A. Zettl C. R. Bertozzi 2004 Biomimetic engineering of carbon nanotubes by using cell surface mucin mimics Angew. Chem. Int. Ed. 43 6111 6116 (Pubitemid 39611874)
55. X. Chen U. C. Tam J. L. Czlapinski G. S. Lee D. Rabuka A. Zettl C. R. Bertozzi 2006 Interfacing carbon nanotubes with living cells J. Am. Chem. Soc. 128 6292 6293 (Pubitemid 43727247)
56. S. F. Chin R. H. Baughman A. B. Dalton G. R. Dieckmann R. K. Draper C. Mikoryak I. H. Musselman V. Z. Poenitzsch H. Xie P. Pantano 2007 Amphiphilic helical peptide enhances the uptake of single-walled carbon nanotubes by living cells Exper. Biol. Med. 232 1236 1244 (Pubitemid 47503065)
57. Yehia, H. N.; Draper, R. K.; Mikoryak, C.; Walker, E. K.; Bajaj, P.; Musselman, I. H.; Daigrepont, M. C.; Dieckmann, G. R.; Pantano, P. Single-walled carbon nanotube interactions with HeLa cells. J. Nanobiotech. 2007, 5, 8.
58. M. L. Schipper N. Nakayama-Ratchford C. R. Davis N. W. S. Kam P. Chu Z. Liu X. Sun H. Dai S. S. Gambhir 2008 A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice Nat. Nanotech. 3 216 221
59. S. Niyogi M. A. Hamon H. Hu B. Zhao P. Bhowmik R. Sen M. E. Itkis R. C. Haddon 2002 Chemistry of single-walled carbon nanotubes Acc. Chem. Res. 35 1105 1113
60. I. D. Rosca F. Watari M. Uo T. Akaska 2005 Oxidation of multiwalled carbon nanotubes by nitric acid Carbon 43 3124 3131
61. L. Zeng L. B. Alemany C. L. Edwards A. R. Barron 2008 Demonstration of covalent sidewall functionalization of single wall carbon nanotubes by NMR spectroscopy: Side chain length dependence on the observation of the sidewall sp3 carbons Nano Res. 1 72 88
62. B. Zhao H. Hu A. P. Yu D. Perea R. C. Haddon 2005 Synthesis and characterization of water soluble single-walled carbon nanotube graft copolymers J. Am. Chem. Soc. 127 8197 8203 (Pubitemid 40799677)
63. K. M. Lee L. C. Li L. M. Dai 2005 Asymmetric end-functionalization of multi-walled carbon nanotubes J. Am. Chem. Soc. 127 4122 4123 (Pubitemid 40463009)
64. M. J. Moghaddam S. Taylor M. Gao S. M. Huang L. M. Dai M. J. McCall 2004 Highly efficient binding of DNA on the sidewalls and tips of carbon nanotubes using photochemistry Nano Lett. 4 89 93 (Pubitemid 38167870)
65. K. S. Coleman S. R. Bailey S. Fogden M. L. H. Green 2003 Functionalization of single-walled carbon nanotubes via the Bingel reaction J. Am. Chem. Soc. 125 8722 8723 (Pubitemid 36886199)
66. T. Umeyama N. Tezuka M. Fujita Y. Matano N. Takeda K. Murakoshi K. Yoshida S. Isoda H. Imahori 2007 Retention of intrinsic electronic properties of soluble single-walled carbon nanotubes after a significant degree of sidewall functionalization by the Bingel reaction J. Phys. Chem. C 111 9734 9741 (Pubitemid 47155158)
67. V. Georgakilas K. Kordatos M. Prato D. M. Guldi M. Holzinger A. Hirsch 2002 Organic functionalization of carbon nanotubes J. Am. Chem. Soc. 124 760 761 (Pubitemid 34112779)
68. N. Tagmatarchis M. Prato 2004 Functionalization of carbon nanotubes via 1,3-dipolar cycloadditions J. Mater. Chem. 14 437 439
69. Pastorin, G.; Wu, W.; Wieckowski, S.; Briand, J. P.; Kostarelos, K.; Prato, M.; Bianco, A. Double functionalisation of carbon nanotubes for multimodal drug delivery. Chem. Commun. 2006, 1182-1184.
70. R. J. Chen Y. G. Zhang D. W. Wang H. J. Dai 2001 Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization J. Am. Chem. Soc. 123 3838 3839 (Pubitemid 32879553)
71. J. Chen H. Y. Liu W. A. Weimer M. D. Halls D. H. Waldeck G. C. Walker 2002 Noncovalent engineering of carbon nanotube surfaces by rigid, functional conjugated polymers J. Am. Chem. Soc. 124 9034 9035
72. P. Wu X. Chen N. Hu U. C. Tam O. Blixt A. Zettl C. R. Bertozzi 2008 Biocompatible carbon nanotubes generated by functionalization with glycodendrimers Angew. Chem. Int. Ed. 47 5022 5025
73. M. Zheng A. Jagota E. D. Semke B. A. Diner R. S. Mclean S. R. Lustig R. E. Richardson N. G. Tassi 2003 DNA-assisted dispersion and separation of carbon nanotubes Nat. Mater. 2 338 342
74. X. Tu M. Zheng 2008 A DNA-based approach to the carbon nanotube sorting problem Nano Res. 1 185 194
75. H. K. Moon C. I. Chang D. -K. Lee H. C. Choi 2008 Effect of nucleases on the cellular internalization of fluorescent labeled DNA-functionalized single-walled carbon nanotubes Nano Res. 1 351 360
76. N. Nakayama-Ratchford S. Bangsaruntip X. M. Sun K. Welsher H. J. Dai 2007 Noncovalent functionalization of carbon nanotubes by fluorescein-polyethylene glycol: Supramolecular conjugates with pH-dependent absorbance and fluorescence J. Am. Chem. Soc. 129 2448 2449 (Pubitemid 46364046)
77. D. M. Guldi H. Taieb G. M. A. Rahman N. Tagmatarchis M. Prato 2005 Novel photoactive single-walled carbon nanotube-porphyrin polymer wraps: Efficient and long-lived intracomplex charge separation Adv. Mater. 17 871 875
78. C. Richard F. Balavoine P. Schultz T. W. Ebbesen C. Mioskowski 2003 Supramolecular self-assembly of lipid derivatives on carbon nanotubes Science 300 775 778 (Pubitemid 36532107)
79. H. Wang W. Zhou D. L. Ho K. I. Winey J. E. Fischer C. J. Glinka E. K. Hobbie 2004 Dispersing single-walled carbon nanotubes with surfactants: A small angle neutron scattering study Nano Lett. 4 1789 1793 (Pubitemid 39297464)
80. S. S. Wong E. Joselevich A. T. Woolley C. L. Cheung C. M. Lieber 1998 Covalently functionalized nanotubes as nanometre-sized probes in chemistry and biology Nature 394 52 55 (Pubitemid 28321797)
81. Y. Lin S. Taylor H. P. Li K. A. S. Fernando L. W. Qu W. Wang L. R. Gu B. Zhou Y. P. Sun 2004 Advances toward bioapplications of carbon nanotubes J. Mater. Chem. 14 527 541
82. F. Balavoine P. Schultz C. Richard V. Mallouh T. W. Ebbesen C. Mioskowski 1999 Helical crystallization of proteins on carbon nanotubes: A first step towards the development of new biosensors Angew. Chem. Int. Ed. 38 1912 1915 (Pubitemid 29339658)
83. M. Shim N. Kam R. Chen Y. Li H. Dai 2002 Functionalization of carbon nanotubes for biocompatibility and biom-olecular recognition Nano Lett. 2 285 288 (Pubitemid 135706308)
84. B. R. Azamian J. J. Davis K. S. Coleman C. B. Bagshaw M. L. H. Green 2002 Bioelectrochemical single-walled carbon nanotubes J. Am. Chem. Soc. 124 12664 12665 (Pubitemid 35215982)
85. B. F. Erlanger B. X. Chen M. Zhu L. Brus 2001 Binding of an anti-fullerene IgG monoclonal antibody to single wall carbon nanotubes Nano Lett. 1 465 467 (Pubitemid 33673967)
86. S. Q. Wang E. S. Humphreys S. Y. Chung D. F. Delduco S. R. Lustig H. Wang K. N. Parker N. W. Rizzo S. Subramoney Y. M. Chiang 2003 Peptides with selective affinity for carbon nanotubes Nat. Mater. 2 196 200
87. R. J. Chen H. C. Choi S. Bangsaruntip E. Yenilmez X. W. Tang Q. Wang Y. L. Chang H. J. Dai 2004 An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices J. Am. Chem. Soc. 126 1563 1568 (Pubitemid 38200826)
88. D. Chandler 2005 Interfaces and the driving force of hydrophobic assembly Nature 437 640 647 (Pubitemid 41486526)
89. S. S. Karajanagi A. A. Vertegel R. S. Kane J. S. Dordick 2004 Structure and function of enzymes adsorbed onto single-walled carbon nanotubes Langmuir 20 11594 11599
90. J. Kong N. R. Franklin C. W. Zhou M. G. Chapline S. Peng K. J. Cho H. J. Dai 2000 Nanotube molecular wires as chemical sensors Science 287 622 625 (Pubitemid 30070903)
91. H. R. Byon H. C. Choi 2006 Network single-walled carbon nanotube-field effect transistors (SWNT FETs) with increased Schottky contact area for highly sensitive biosensor applications J. Am. Chem. Soc. 128 2188 2189 (Pubitemid 43296872)
92. S. N. Kim J. F. Rusling F. Papadimitrakopoulos 2007 Carbon nanotubes for electronic and electrochemical detection of biomolecules Adv. Mater. 19 3214 3228 (Pubitemid 350044460)
93. J. Wang 2005 Carbon-nanotube-based electrochemical biosensors: A review Electroanalysis 17 7 14
94. T. K. Leeuw R. M. Reith R. A. Simonette M. E. Harden P. Cherukuri D. A. Tsyboulski K. M. Beckingham R. B. Weisman 2007 Single-walled carbon nanotubes in the intact organism: Near-IR imaging and biocompatibility studies in Drosophila Nano Lett. 7 2650 2654 (Pubitemid 47522416)
95. H. Jin D. A. Heller M. S. Strano 2008 Single-particle tracking of endocytosis and exocytosis of single-walled carbon nanotubes in NIH-3T3 cells Nano Lett. 8 1577 1585
96. P. W. Barone R. S. Parker M. S. Strano 2005 In vivo fluorescence detection of glucose using a single-walled carbon nanotube optical sensor: Design, fluorophore properties, advantages, and disadvantages Anal. Chem. 77 7556 7562 (Pubitemid 41746222)
97. E. S. Jeng A. E. Moll A. C. Roy J. B. Gastala M. S. Strano 2006 Detection of DNA hybridization using the near-infrared band-gap fluorescence of single-walled carbon nanotubes Nano Lett. 6 371 375
98. P. W. Barone S. Baik D. A. Heller M. S. Strano 2004 Near-infrared optical sensors based on single-walled carbon nanotubes Nat. Mater. 4 86 92
99. B. C. Satishkumar L. O. Brown Y. Gao C. C. Wang H. L. Wang S. K. Doorn 2007 Reversible fluorescence quenching in carbon nanotubes for biomolecular sensing Nat. Nanotech. 2 560 564 (Pubitemid 47367543)
100. R. H. Yang J. Y. Jin Y. Chen N. Shao H. Z. Kang Z. Xiao Z. W. Tang Y. R. Wu Z. Zhu W. H. Tan 2008 Carbon nanotube-quenched fluorescent oligonucleotides: Probes that fluoresce upon hybridization J. Am. Chem. Soc. 130 8351 8358
101. J. Crochet M. Clemens T. Hertel 2007 Quantum yield heterogeneities of aqueous single-wall carbon nanotube suspensions J. Am. Chem. Soc. 129 8058 8059 (Pubitemid 47035105)
102. G. Y. Zhang P. F. Qi X. R. Wang Y. R. Lu X. L. Li R. Tu S. Bangsaruntip D. Mann L. Zhang H. J. Dai 2006 Selective etching of metallic carbon nanotubes by gasphase reaction Science 314 974 977
103. G. MacBeath S. L. Schreiber 2000 Printing proteins as microarrays for high-throughput function determination Science 289 1760 1763
104. R. C. Bailey G. A. Kwong C. G. Radu O. N. Witte J. R. Heath 2007 DNA-encoded antibody libraries: A unified platform for multiplexed cell sorting and detection of genes and proteins J. Am. Chem. Soc. 129 1959 1967 (Pubitemid 46318268)
105. W. H. Robinson C. DiGennaro W. Hueber B. B. Haab M. Kamachi E. J. Dean S. Fournel D. Fong M. C. Genovese H. E. de Vegvar 2002 Autoantigen microarrays for multiplex characterization of autoantibody responses Nat. Med. 8 295 301 (Pubitemid 34250109)
106. S. Nie S. R. Emory 1997 Probing single molecules and single nanoparticles by surface-enhanced Raman scattering Science 275 1102 1106 (Pubitemid 27097304)
107. D. L. Jeanmaire R. P. Vanduyne 1977 Surface Raman Spectroelectrochemistry.1. Heterocyclic, aromatic, and aliphatic amines adsorbed on anodized silver electrode J. Electroanal. Chem. 84 1 20
108. V. Espina E. C. Woodhouse J. Wulfkuhle H. D. Asmussen E. F. Petricoin L. A. Liotta 2004 Protein microarray detection strategies: Focus on direct detection technologies J. Immunol. Methods 290 121 133 (Pubitemid 38917135)
109. A. Prakash P. Mallick J. Whiteaker H. Zhang A. Paulovich M. Flory H. Lee R. Aebersold B. Schwikowski 2006 Signal maps for mass spectrometry-based comparative proteomics Mol. Cell. Proteomics 5 423 432
110. A. A. Shvedova E. R. Kisin R. Mercer A. R. Murray V. J. Johnson A. I. Potapovich Y. Y. Tyurina O. Gorelik S. Arepalli D. Schwegler-Berry 2005 Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice Am. J. Phys. Lung Cell. Mol. Physiol. 289 L698 L708 (Pubitemid 41504399)
111. J. Muller F. Huaux N. Moreau P. Misson J. F. Heilier M. Delos M. Arras A. Fonseca J. B. Nagy D. Lison 2005 Respiratory toxicity of multi-wall carbon nanotubes Toxicol. Appl. Pharmacol. 207 221 231 (Pubitemid 41207915)
112. C. M. Sayes F. Liang J. L. Hudson J. Mendez W. H. Guo J. M. Beach V. C. Moore C. D. Doyle J. L. West W. E. Billups 2006 Functionalization density dependence of single-walled carbon nanotubes cytotoxicity In vitro Toxicol. Lett. 161 135 142 (Pubitemid 41790286)
113. Dong, L.; Joseph, K. L.; Witkowski, C. M.; Craig, M. M. Cytotoxicity of single-walled carbon nanotubes suspended in various surfactants. Nanotechnology 2008, 19, 255702.
114. Plata, D. L.; Gschwend, P. M.; Reddy, C. M. Industrially synthesized single-walled carbon nanotubes: Compositional data for users, environmental risk assessments, and source apportionment. Nanotechnology 2008, 19, 185706.
115. A. Casey E. Herzog M. Davoren F. M. Lyng H. J. Byrne G. Chambers 2007 Spectroscopic analysis confirms the interactions between single walled carbon nanotubes and various dyes commonly used to assess cytotoxicity Carbon 45 1425 1432 (Pubitemid 46829030)
116. J. M. Worle-Knirsch K. Pulskamp H. F. Krug 2006 Oops they did it again! Carbon nanotubes hoax scientists in viability assays Nano Lett. 6 1261 1268 (Pubitemid 44013492)
117. S. T. Yang X. Wang G. Jia Y. Gu T. Wang H. Nie C. Ge H. Wang Y. Liu 2008 Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice Toxicol. Lett. 181 182 189
118. S. T. Yang K. A. Fernando J. H. Liu J. Wang H. F. Sun Y. Liu M. Chen Y. Huang X. Wang H. Wang 2008 Covalently PEGylated carbon nanotubes with stealth character in vivo Small 4 940 944
119. C. Salvador-Morales E. Flahaut E. Sim J. Sloan M. L. H. Green R. B. Sim 2006 Complement activation and protein adsorption by carbon nanotubes Mol. Immunol. 43 193 201 (Pubitemid 41384125)
120. K. Kostarelos L. Lacerda G. Pastorin W. Wu S. Wieckowski J. Luangsivilay S. Godefroy D. Pantarotto J. P. Briand S. Muller 2007 Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type Nat. Nanotech. 2 1080 113 (Pubitemid 46230832)
121. R. P. Feazell N. Nakayama-Ratchford H. Dai S. J. Lippard 2007 Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design J. Am. Chem. Soc. 129 8438 8349 (Pubitemid 47066504)
122. Ali-Boucetta, H.; Al-Jamal, K. T.; McCarthy, D.; Prato, M.; Bianco, A.; Kostarelos, K. Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. Chem. Commun. 2008, 459-461.
123. T. Murakami J. Fan M. Yudasaka S. Iijima K. Shiba 2006 Solubilization of single-wall carbon nanohorns using a PEG-doxorubicin conjugate Mol. Pharmaceutics 3 407 414 (Pubitemid 44351923)
124. X. Sun Z. Liu K. Welsher J. T. Robinson A. Goodwin S. Zaric H. Dai 2008 Nano-graphene oxide for cellular imaging and drug delivery Nano Res. 1 203 212
125. Z. Liu J. T. Robinson X. M. Sun H. J. Dai 2008 PEGylated nanographene oxide for delivery of water-insoluble cancer drugs J. Am. Chem. Soc. 130 10876 10877
126. S. Dhar Z. Liu J. Thomale H. Dai S. J. Lippard 2008 Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device J. Am. Chem. Soc. 130 11467 11476
127. Z. Liu X. Li S. M. Tabakman K. Jiang S. Fan H. Dai 2008 Multiplexed multi-color Raman imaging of live cells with isotopically modified single walled carbon nanotubes J. Am. Chem. Soc. 130 13540 13541
128. P. Chakravarty R. Marches N. S. Zimmerman A. D. Swafford P. Bajaj I. H. Musselman P. Pantano R. K. Draper E. S. Vitetta 2008 Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes Proc. Natl. Acad. Sci. USA 105 8697 8702
129. M. R. McDevitt D. Chattopadhyay B. J. Kappel J. S. Jaggi S. R. Schiffman C. Antczak J. T. Njardarson R. Brentjens D. A. Scheinberg 2007 Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes J. Nucl. Med. 48 1180 1189 (Pubitemid 47052659)
130. H. Kataura Y. Maniwa T. Kodama K. Kikuchi K. Hirahara K. Suenaga S. Iijima S. Suzuki Y. Achiba W. Kratschmer 2001 High-yield fullerene encapsulation in single-wall carbon nanotubes Synth. Met. 121 1195 1196
131. Jeong, G. H.; Farajian, A. A.; Hatakeyama, R.; Hirata, T.; Yaguchi, T.; Tohji, K.; Mizuseki, H.; Kawazoe, Y. Cesium encapsulation in single-walled carbon nanotubes via plasma ion irradiation: Application to junction formation and ab initio investigation. Phys. Rev. B 2003, 68, 075410.
132. L. J. Li A. N. Khlobystov J. G. Wiltshire G. A. D. Briggs R. J. Nicholas 2005 Diameter-selective encapsulation of metallocenes in single-walled carbon nanotubes Nat. Mater. 4 481 485
133. T. Kaneko T. Okada R. Hatakeyama 2007 DNA encapsulation inside carbon nanotubes using micro electrolyte plasmas Contrib. Plasma Phys. 47 57 63
134. Hilder, T. A.; Hill, J. M. Modelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes. Nanotechnology 2007, 18, 275704.
135. T. A. Hilder J. M. Hill 2008 Probability of encapsulation of paclitaxel and doxorubicin into carbon nanotubes Micro Nano Lett. 3 41 49
136. C. C. Mello D. Conte 2004 Revealing the world of RNA interference Nature 431 338 342 (Pubitemid 39265673)
137. E. Marshall 1999 Clinical trials Gene therapy death prompts review of adenovirus vector Science 286 2244 2245
138. S. Hacein-Bey-Abina C. von Kalle M. Schmidt F. Le Deist N. Wulffraat E. McIntyre I. Radford J. L. Villeval C. C. Fraser M. Cavazzana-Calvo 2003 A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency New Engl. J. Med. 348 255 256 (Pubitemid 36077924)
139. Z. H. Zhang X. Y. Yang Y. Zhang B. Zeng Z. J. Wang T. H. Zhu R. B. S. Roden Y. S. Chen R. C. Yang 2006 Delivery of telomerase reverse transcriptase small interfering RNA in complex with positively charged single-walled carbon nanotubes suppresses tumor growth Clin. Cancer Res. 12 4933 4939 (Pubitemid 44338581)
140. H. S. Choi W. Liu P. Misra E. Tanaka J. P. Zimmer B. I. Ipe M. G. Bawendi J. V. Frangioni 2007 Renal clearance of quantum dots Nat. Biotech. 25 1165 1170 (Pubitemid 47538116)
141. H. F. Wang J. Wang X. Y. Deng H. F. Sun Z. J. Shi Z. N. Gu Y. F. Liu Y. L. Zhao 2004 Biodistribution of carbon single-wall carbon nanotubes in mice J. Nanosci. Nanotech. 4 1019 1024
142. X. Deng G. Jia H. Wang H. Sun X. Wang S. Yang T. Wang Y. Liu 2007 Translocation and fate of multi-walled carbon nanotubes in vivo Carbon 45 1419 1424 (Pubitemid 46829028)
143. G. Pavlinkova G. W. Beresford B. J. M. Booth S. K. Batra D. Colcher 1999 Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of MAb CC49 in colon carcinoma xenografts J. Nucl. Med. 40 1536 1546 (Pubitemid 29428939)
144. S. S. Olmsted J. L. Padgett A. I. Yudin K. J. Whaley T. R. Moench R. A. Cone 2001 Diffusion of macromolecules and virus-like particles in human cervical mucus Biophys. J. 81 1930 1937 (Pubitemid 32917145)
145. A. Goel D. Colcher J. Baranowska-Kortylewicz S. Augustine B. J. M. Booth G. Pavlinkova S. K. Batra 2000 Genetically engineered tetravalent single-chain Fv of the pancarcinoma monoclonal antibody CC49: Improved biodistribution and potential for therapeutic application Cancer Res. 60 6964 6971 (Pubitemid 32059170)
146. J. E. Aubin 1979 Autofluorescence of viable cultured mammalian cells J. Histochem. Cytochem. 27 36 43
147. Wang, F.; Dukovic, G.; Brus, L. E.; Heinz, T. F. Time-resolved fluorescence of carbon nanotubes and its implication for radiative lifetimes. Phys. Rev. Lett. 2004, 92, 177401.
148. J. Lefebvre D. G. Austing J. Bond P. Finnie 2006 Photoluminescence imaging of suspended single-walled carbon nanotubes Nano Lett. 6 1603 1608 (Pubitemid 44327518)
149. Reich, S.; Dworzak, M.; Hoffmann, A.; Thomsen, C.; Strano, M. S. Excited-state carrier lifetime in single-walled carbon nanotubes. Phys. Rev. B 2005, 71, 033402.
150. L. Cognet D. A. Tsyboulski J. D. R. Rocha C. D. Doyle J. M. Tour R. B. Weisman 2007 Stepwise quenching of exciton fluorescence in carbon nanotubes by single-molecule reactions Science 316 1465 1468 (Pubitemid 46906610)
151. D. A. Heller R. M. Mayrhofer S. Baik Y. V. Grinkova M. L. Usrey M. S. Strano 2004 Concomitant length and diameter separation of single-walled carbon nanotubes J. Am. Chem. Soc. 126 14567 14573 (Pubitemid 39463638)
152. J. Crochet M. Clemens T. Hertel 2007 Quantum yield heterogeneities of aqueous single-wall carbon nanotube suspensions J. Am. Chem. Soc. 129 8058 8059 (Pubitemid 47035105)
153. S. Keren C. Zavaleta Z. Cheng A. de la Zerda O. Gheysens S. S. Gambhir 2008 Noninvasive molecular imaging of small living subjects using Raman spectroscopy Proc. Nat. Acad. Sci. USA 105 5844 5849
154. C. Zavaleta A. d. l. Zerda Z. Liu S. Keren Z. Cheng M. Schipper X. Chen H. Dai S. S. Gambhir 2008 Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes Nano Lett. 8 2800 2805
155. Xu, M. H.; Wang, L. H. V. Photoacoustic imaging in biomedicine. Rev. Sci. Instrum. 2006, 77, 041101.
156. X. Sun S. Zaric D. Daranciang K. Welsher Y. Lu X. Li H. Dai 2008 Optical properties of ultrashort semiconducting single-walled carbon nanotube capsules down to sub-10 nm J. Am. Chem. Soc. 130 6551 6555
157. X. L. Li X. M. Tu S. Zaric K. Welsher W. S. Seo W. Zhao H. J. Dai 2007 Selective synthesis combined with chemical separation of single-walled carbon nanotubes for chirality selection J. Am. Chem. Soc. 129 15770 15771
158. A. Jorio R. Saito J. H. Hafner C. M. Lieber M. Hunter T. McClure G. Dresselhaus M. S. Dresselhaus 2001 Structural (n, m) determination of isolated single-wall carbon nanotubes by resonant Raman scattering Phys. Rev. Lett. 86 1118 1121