Correlation of fitness landscapes from three orthologous TIM barrels originates from sequence and structure constraints

Nature Communications

Volumn 8, Issue , 2017, Pages

  Chan, Yvonne H ^a   Venev, Sergey V ^a   Zeldovich, Konstantin B ^a   Matthews, C Robert ^a  

^a Biochemistry and Molecular Pharmacology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; FUNGAL ENZYME; INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE; PROTEIN BINDING; RECOMBINANT PROTEIN;

CELLS AND CELL COMPONENTS; CORRELATION; DIVERGENCE; ENVIRONMENTAL STRESS; EVOLUTION; FITNESS; GENETIC ANALYSIS; MUTATION; NUMERICAL MODEL; PHYLOGENETICS; PROKARYOTE; PROTEIN;

ADAPTATION; ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EPISTASIS; FUNGAL STRAIN; NONHUMAN; PHYLOGENY; POINT MUTATION; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; TEMPERATURE STRESS; THERMOPHILIC BACTERIUM; THERMOTOGA MARITIMA; THERMUS THERMOPHILUS; ALPHA HELIX; BETA SHEET; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENE EXPRESSION; GENE VECTOR; GENETICS; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOLECULAR MODEL; MUTATION; PROTEIN DOMAIN; STRUCTURAL HOMOLOGY; SULFOLOBUS SOLFATARICUS; THERMODYNAMICS;

PROKARYOTA;

AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; EVOLUTION, MOLECULAR; GENE EXPRESSION; GENETIC VECTORS; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY; SULFOLOBUS SOLFATARICUS; THERMODYNAMICS; THERMOTOGA MARITIMA; THERMUS THERMOPHILUS;

EID: 85014702390     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14614     Document Type: Article

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