Accurate measurement of the effects of all amino-acid mutations on influenza hemagglutinin

Viruses

Volumn 8, Issue 6, 2016, Pages

  Doud, Michael B ^a,b   Bloom, Jesse D ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Deep mutational scanning; Evolution; Hemagglutinin; Influenza; Mutational tolerance

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; H1N1 VIRUS HEMAGGLUTININ; MUTANT PROTEIN;

AGAR GEL ELECTROPHORESIS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE FREQUENCY; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; INFLUENZA A VIRUS (H1N1); MEASUREMENT ACCURACY; NONHUMAN; PHYLOGENY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; VIRUS GENE; VIRUS MUTANT; VIRUS REPLICATION; ANIMAL; CELL LINE; DNA MUTATIONAL ANALYSIS; DOG; GENETICS; HUMAN; INFLUENZA A VIRUS; METABOLISM; MICROBIAL VIABILITY; PHYSIOLOGY; VIRULENCE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; DNA MUTATIONAL ANALYSIS; DOGS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS; MICROBIAL VIABILITY; MUTANT PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 84973131100     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v8060155     Document Type: Article

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