An experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologs

Molecular Biology and Evolution

Volumn 31, Issue 10, 2014, Pages 2753-2769

  Bloom, Jesse D ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

deep mutational scanning; lactamase; phylogenetics; protein evolution; substitution model

Indexed keywords

AMINO ACID; BETA LACTAMASE SHV; BETA LACTAMASE TEM 1; PENICILLINASE; BETA LACTAMASE; BETA-LACTAMASE TEM-1;

AMINO ACID ANALYSIS; ARTICLE; EVOLUTIONARY HOMOLOGY; EXPERIMENTAL STUDY; HUMAN; INTERMETHOD COMPARISON; MUTATION RATE; PHYLOGENETIC TREE; PHYLOGENY; ALGORITHM; CHEMICAL STRUCTURE; DNA MUTATIONAL ANALYSIS; GENETICS; REPRODUCTIVE FITNESS; SEQUENCE HOMOLOGY;

ALGORITHMS; BETA-LACTAMASES; DNA MUTATIONAL ANALYSIS; GENETIC FITNESS; MODELS, MOLECULAR; MUTATION RATE; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 84923357744     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu220     Document Type: Article

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