메뉴 건너뛰기




Volumn 38, Issue 4, 2017, Pages 287-297

Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 12; INTERLEUKIN 15 RECEPTOR ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR T BET; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

EID: 85014490223     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2017.02.003     Document Type: Review
Times cited : (118)

References (108)
  • 2
    • 34250212629 scopus 로고    scopus 로고
    • The transcriptional regulation of B cell lineage commitment
    • 2 Nutt, S.L., Kee, B.L., The transcriptional regulation of B cell lineage commitment. Immunity 26 (2007), 715–725.
    • (2007) Immunity , vol.26 , pp. 715-725
    • Nutt, S.L.1    Kee, B.L.2
  • 3
    • 33847690322 scopus 로고    scopus 로고
    • Terminal differentiation of lymphocytes depends on Blimp-1
    • 3 Kallies, A., Nutt, S.L., Terminal differentiation of lymphocytes depends on Blimp-1. Curr. Opin. Immunol. 19 (2007), 156–162.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 156-162
    • Kallies, A.1    Nutt, S.L.2
  • 4
    • 84886790466 scopus 로고    scopus 로고
    • T-bet: a bridge between innate and adaptive immunity
    • 4 Lazarevic, V., et al. T-bet: a bridge between innate and adaptive immunity. Nat. Rev. Immunol. 13 (2013), 777–789.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 777-789
    • Lazarevic, V.1
  • 5
    • 84969754451 scopus 로고    scopus 로고
    • + T cells against microbes
    • + T cells against microbes. Annu. Rev. Immunol. 34 (2016), 317–334.
    • (2016) Annu. Rev. Immunol. , vol.34 , pp. 317-334
    • Sallusto, F.1
  • 6
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • 6 Szabo, S.J., et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000), 655–669.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1
  • 7
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • 7 Zheng, W., Flavell, R.A., The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997), 587–596.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 8
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • 8 Johnston, R.J., et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325 (2009), 1006–1010.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1
  • 9
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • 9 Yu, D., et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31 (2009), 457–468.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1
  • 10
    • 69249101229 scopus 로고    scopus 로고
    • Bcl6 mediates the development of T follicular helper cells
    • 10 Nurieva, R.I., et al. Bcl6 mediates the development of T follicular helper cells. Science 325 (2009), 1001–1005.
    • (2009) Science , vol.325 , pp. 1001-1005
    • Nurieva, R.I.1
  • 11
    • 84255178198 scopus 로고    scopus 로고
    • Early Th1 cell differentiation is marked by a Tfh cell-like transition
    • 11 Nakayamada, S., et al. Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 35 (2011), 919–931.
    • (2011) Immunity , vol.35 , pp. 919-931
    • Nakayamada, S.1
  • 12
    • 80755172184 scopus 로고    scopus 로고
    • Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells
    • 12 Pepper, M., et al. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35 (2011), 583–595.
    • (2011) Immunity , vol.35 , pp. 583-595
    • Pepper, M.1
  • 13
    • 80755163540 scopus 로고    scopus 로고
    • + cell properties during viral infection
    • + cell properties during viral infection. Immunity 35 (2011), 633–646.
    • (2011) Immunity , vol.35 , pp. 633-646
    • Marshall, H.D.1
  • 14
    • 79956201473 scopus 로고    scopus 로고
    • The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
    • 14 Oestreich, K.J., et al. The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J. Exp. Med. 208 (2011), 1001–1013.
    • (2011) J. Exp. Med. , vol.208 , pp. 1001-1013
    • Oestreich, K.J.1
  • 15
    • 84952978140 scopus 로고    scopus 로고
    • Severe malaria infections impair germinal center responses by inhibiting T follicular helper cell differentiation
    • 15 Ryg-Cornejo, V., et al. Severe malaria infections impair germinal center responses by inhibiting T follicular helper cell differentiation. Cell Rep. 14 (2016), 68–81.
    • (2016) Cell Rep. , vol.14 , pp. 68-81
    • Ryg-Cornejo, V.1
  • 16
    • 78751690647 scopus 로고    scopus 로고
    • + T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • + T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 34 (2011), 108–121.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1
  • 17
    • 84885743368 scopus 로고    scopus 로고
    • + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
    • + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity 39 (2013), 758–769.
    • (2013) Immunity , vol.39 , pp. 758-769
    • Locci, M.1
  • 18
    • 84958259928 scopus 로고    scopus 로고
    • Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection
    • 18 Cubas, R., et al. Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection. J. Immunol. 195 (2015), 5625–5636.
    • (2015) J. Immunol. , vol.195 , pp. 5625-5636
    • Cubas, R.1
  • 19
    • 84878454838 scopus 로고    scopus 로고
    • Inadequate T follicular cell help impairs B cell immunity during HIV infection
    • 19 Cubas, R.A., et al. Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nat. Med. 19 (2013), 494–499.
    • (2013) Nat. Med. , vol.19 , pp. 494-499
    • Cubas, R.A.1
  • 20
    • 84983776546 scopus 로고    scopus 로고
    • Induction of Th1-biased T follicular helper (Tfh) cells in lymphoid tissues during chronic simian immunodeficiency virus infection defines functionally distinct germinal center Tfh cells
    • 20 Velu, V., et al. Induction of Th1-biased T follicular helper (Tfh) cells in lymphoid tissues during chronic simian immunodeficiency virus infection defines functionally distinct germinal center Tfh cells. J. Immunol. 197 (2016), 1832–1842.
    • (2016) J. Immunol. , vol.197 , pp. 1832-1842
    • Velu, V.1
  • 21
    • 84992702535 scopus 로고    scopus 로고
    • Protective neutralizing influenza antibody response in the absence of T follicular helper cells
    • 21 Miyauchi, K., et al. Protective neutralizing influenza antibody response in the absence of T follicular helper cells. Nat. Immunol. 17 (2016), 1447–1458.
    • (2016) Nat. Immunol. , vol.17 , pp. 1447-1458
    • Miyauchi, K.1
  • 22
    • 74049131014 scopus 로고    scopus 로고
    • Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells
    • 22 Pepper, M., et al. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat. Immunol. 11 (2010), 83–89.
    • (2010) Nat. Immunol. , vol.11 , pp. 83-89
    • Pepper, M.1
  • 23
    • 84866532132 scopus 로고    scopus 로고
    • Induction and molecular signature of pathogenic TH17 cells
    • 23 Lee, Y., et al. Induction and molecular signature of pathogenic TH17 cells. Nat. Immunol. 13 (2012), 991–999.
    • (2012) Nat. Immunol. , vol.13 , pp. 991-999
    • Lee, Y.1
  • 24
    • 84949196321 scopus 로고    scopus 로고
    • CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity
    • 24 Wang, C., et al. CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity. Cell 163 (2015), 1413–1427.
    • (2015) Cell , vol.163 , pp. 1413-1427
    • Wang, C.1
  • 25
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL-17-producing T cells in inflammatory responses
    • 25 Hirota, K., et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat. Immunol. 12 (2011), 255–263.
    • (2011) Nat. Immunol. , vol.12 , pp. 255-263
    • Hirota, K.1
  • 26
    • 67650433931 scopus 로고    scopus 로고
    • T-bet is essential for encephalitogenicity of both Th1 and Th17 cells
    • 26 Yang, Y., et al. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 206 (2009), 1549–1564.
    • (2009) J. Exp. Med. , vol.206 , pp. 1549-1564
    • Yang, Y.1
  • 27
    • 84896402211 scopus 로고    scopus 로고
    • The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-gamma-producing T helper 17 cells
    • 27 Wang, Y., et al. The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-gamma-producing T helper 17 cells. Immunity 40 (2014), 355–366.
    • (2014) Immunity , vol.40 , pp. 355-366
    • Wang, Y.1
  • 28
    • 84969921427 scopus 로고    scopus 로고
    • + T cell responses in the intestine
    • + T cell responses in the intestine. Nat. Commun., 7, 2016, 11627.
    • (2016) Nat. Commun. , vol.7 , pp. 11627
    • Krausgruber, T.1
  • 29
    • 34548027000 scopus 로고    scopus 로고
    • + T cell fates via the graded expression of T-bet transcription factor
    • + T cell fates via the graded expression of T-bet transcription factor. Immunity 27 (2007), 281–295.
    • (2007) Immunity , vol.27 , pp. 281-295
    • Joshi, N.S.1
  • 30
    • 47749141467 scopus 로고    scopus 로고
    • + T cells lacking T-bet and eomesodermin
    • + T cells lacking T-bet and eomesodermin. Science 321 (2008), 408–411.
    • (2008) Science , vol.321 , pp. 408-411
    • Intlekofer, A.M.1
  • 31
    • 30044440799 scopus 로고    scopus 로고
    • + T cell fate coupled by T-bet and eomesodermin
    • + T cell fate coupled by T-bet and eomesodermin. Nat. Immunol. 6 (2005), 1236–1244.
    • (2005) Nat. Immunol. , vol.6 , pp. 1236-1244
    • Intlekofer, A.M.1
  • 32
    • 0242410712 scopus 로고    scopus 로고
    • + T cell function by the transcription factor Eomesodermin
    • + T cell function by the transcription factor Eomesodermin. Science 302 (2003), 1041–1043.
    • (2003) Science , vol.302 , pp. 1041-1043
    • Pearce, E.L.1
  • 33
    • 79959375167 scopus 로고    scopus 로고
    • + T cell responses during chronic infection
    • + T cell responses during chronic infection. Nat. Immunol. 12 (2011), 663–671.
    • (2011) Nat. Immunol. , vol.12 , pp. 663-671
    • Kao, C.1
  • 34
    • 84870230232 scopus 로고    scopus 로고
    • + T cells cooperate to contain chronic viral infection
    • + T cells cooperate to contain chronic viral infection. Science 338 (2012), 1220–1225.
    • (2012) Science , vol.338 , pp. 1220-1225
    • Paley, M.A.1
  • 35
    • 84971523245 scopus 로고    scopus 로고
    • The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection
    • 35 Dominguez, C.X., et al. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J. Exp. Med. 212 (2015), 2041–2056.
    • (2015) J. Exp. Med. , vol.212 , pp. 2041-2056
    • Dominguez, C.X.1
  • 36
    • 84960194165 scopus 로고    scopus 로고
    • + T cell differentiation controlled by transcription factors Blimp-1 and T-bet
    • + T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nat. Immunol. 17 (2016), 422–432.
    • (2016) Nat. Immunol. , vol.17 , pp. 422-432
    • Xin, A.1
  • 37
    • 84908127758 scopus 로고    scopus 로고
    • + T cells during influenza viral infection
    • + T cells during influenza viral infection. Immunity 41 (2014), 633–645.
    • (2014) Immunity , vol.41 , pp. 633-645
    • Laidlaw, B.J.1
  • 38
    • 84963543332 scopus 로고    scopus 로고
    • T-box transcription factors combine with the cytokines TGF-beta and IL-15 to control tissue-resident memory T cell fate
    • 38 Mackay, L.K., et al. T-box transcription factors combine with the cytokines TGF-beta and IL-15 to control tissue-resident memory T cell fate. Immunity 43 (2015), 1101–1111.
    • (2015) Immunity , vol.43 , pp. 1101-1111
    • Mackay, L.K.1
  • 39
    • 84964887792 scopus 로고    scopus 로고
    • Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
    • 39 Mackay, L.K., et al. Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science 352 (2016), 459–463.
    • (2016) Science , vol.352 , pp. 459-463
    • Mackay, L.K.1
  • 40
    • 84976272630 scopus 로고    scopus 로고
    • NK cells and type 1 innate lymphoid cells: partners in host defense
    • 40 Spits, H., et al. NK cells and type 1 innate lymphoid cells: partners in host defense. Nat. Immunol. 17 (2016), 758–764.
    • (2016) Nat. Immunol. , vol.17 , pp. 758-764
    • Spits, H.1
  • 41
    • 84896847858 scopus 로고    scopus 로고
    • T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow
    • 41 Daussy, C., et al. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J. Exp. Med. 211 (2014), 563–577.
    • (2014) J. Exp. Med. , vol.211 , pp. 563-577
    • Daussy, C.1
  • 42
    • 84898640432 scopus 로고    scopus 로고
    • Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages
    • 42 Klose, C.S., et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 157 (2014), 340–356.
    • (2014) Cell , vol.157 , pp. 340-356
    • Klose, C.S.1
  • 43
    • 84862777436 scopus 로고    scopus 로고
    • The transcription factors T-bet and eomes control key checkpoints of natural killer cell maturation
    • 43 Gordon, S.M., et al. The transcription factors T-bet and eomes control key checkpoints of natural killer cell maturation. Immunity 36 (2012), 55–67.
    • (2012) Immunity , vol.36 , pp. 55-67
    • Gordon, S.M.1
  • 44
    • 84977471548 scopus 로고    scopus 로고
    • T-bet and eomesodermin in NK cell development, maturation, and function
    • 44 Simonetta, F., et al. T-bet and eomesodermin in NK cell development, maturation, and function. Front. Immunol., 7, 2016, 241.
    • (2016) Front. Immunol. , vol.7 , pp. 241
    • Simonetta, F.1
  • 45
    • 84875445419 scopus 로고    scopus 로고
    • The transcription factor T-bet is essential for the development of NKp46 innate lymphocytes via the Notch pathway
    • 45 Rankin, L.C., et al. The transcription factor T-bet is essential for the development of NKp46 innate lymphocytes via the Notch pathway. Nat. Immunol. 14 (2013), 389–395.
    • (2013) Nat. Immunol. , vol.14 , pp. 389-395
    • Rankin, L.C.1
  • 46
    • 84997701962 scopus 로고    scopus 로고
    • Adipose-resident group 1 innate lymphoid cells promote obesity-associated insulin resistance
    • 46 O'sullivan, T.E., et al. Adipose-resident group 1 innate lymphoid cells promote obesity-associated insulin resistance. Immunity 45 (2016), 428–441.
    • (2016) Immunity , vol.45 , pp. 428-441
    • O'sullivan, T.E.1
  • 47
    • 79951470129 scopus 로고    scopus 로고
    • A role for Blimp1 in the transcriptional network controlling natural killer cell maturation
    • 47 Kallies, A., et al. A role for Blimp1 in the transcriptional network controlling natural killer cell maturation. Blood 117 (2011), 1869–1879.
    • (2011) Blood , vol.117 , pp. 1869-1879
    • Kallies, A.1
  • 48
    • 1842785209 scopus 로고    scopus 로고
    • T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells
    • 48 Townsend, M.J., et al. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20 (2004), 477–494.
    • (2004) Immunity , vol.20 , pp. 477-494
    • Townsend, M.J.1
  • 49
    • 84907365390 scopus 로고    scopus 로고
    • + intraepithelial lymphocyte development
    • + intraepithelial lymphocyte development. Immunity 41 (2014), 230–243.
    • (2014) Immunity , vol.41 , pp. 230-243
    • Klose, C.S.1
  • 50
    • 84886673181 scopus 로고    scopus 로고
    • Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells
    • 50 Lee, Y.J., et al. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat. Immunol. 14 (2013), 1146–1154.
    • (2013) Nat. Immunol. , vol.14 , pp. 1146-1154
    • Lee, Y.J.1
  • 51
    • 84867856710 scopus 로고    scopus 로고
    • + innate lymphoid cells
    • + innate lymphoid cells. Immunity 37 (2012), 674–684.
    • (2012) Immunity , vol.37 , pp. 674-684
    • Powell, N.1
  • 52
    • 84883801440 scopus 로고    scopus 로고
    • Diversity among memory B cells: origin, consequences, and utility
    • 52 Tarlinton, D., Good-Jacobson, K., Diversity among memory B cells: origin, consequences, and utility. Science 341 (2013), 1205–1211.
    • (2013) Science , vol.341 , pp. 1205-1211
    • Tarlinton, D.1    Good-Jacobson, K.2
  • 53
    • 0037117557 scopus 로고    scopus 로고
    • T-bet regulates IgG class switching and pathogenic autoantibody production
    • 53 Peng, S.L., et al. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 5545–5550.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 5545-5550
    • Peng, S.L.1
  • 54
    • 84861235461 scopus 로고    scopus 로고
    • Divergent transcriptional programming of class-specific B cell memory by T-bet and RORalpha
    • 54 Wang, N.S., et al. Divergent transcriptional programming of class-specific B cell memory by T-bet and RORalpha. Nat. Immunol. 13 (2012), 604–611.
    • (2012) Nat. Immunol. , vol.13 , pp. 604-611
    • Wang, N.S.1
  • 55
    • 0041522519 scopus 로고    scopus 로고
    • T-bet regulates T-independent IgG2a class switching
    • 55 Gerth, A.J., et al. T-bet regulates T-independent IgG2a class switching. Int. Immunol. 15 (2003), 937–944.
    • (2003) Int. Immunol. , vol.15 , pp. 937-944
    • Gerth, A.J.1
  • 56
    • 84969245659 scopus 로고    scopus 로고
    • B cell IFN-gamma receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
    • 56 Jackson, S.W., et al. B cell IFN-gamma receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J. Exp. Med. 213 (2016), 733–750.
    • (2016) J. Exp. Med. , vol.213 , pp. 733-750
    • Jackson, S.W.1
  • 57
    • 0038639600 scopus 로고    scopus 로고
    • CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
    • 57 Liu, N., et al. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 4 (2003), 687–693.
    • (2003) Nat. Immunol. , vol.4 , pp. 687-693
    • Liu, N.1
  • 58
    • 76249112770 scopus 로고    scopus 로고
    • IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching
    • 58 Kashiwada, M., et al. IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 821–826.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 821-826
    • Kashiwada, M.1
  • 59
    • 66049120992 scopus 로고    scopus 로고
    • Ikaros controls isotype selection during immunoglobulin class switch recombination
    • 59 Sellars, M., et al. Ikaros controls isotype selection during immunoglobulin class switch recombination. J. Exp. Med. 206 (2009), 1073–1087.
    • (2009) J. Exp. Med. , vol.206 , pp. 1073-1087
    • Sellars, M.1
  • 60
    • 84983784437 scopus 로고    scopus 로고
    • Cutting edge: B cell-intrinsic T-bet expression is required to control chronic viral infection
    • 60 Barnett, B.E., et al. Cutting edge: B cell-intrinsic T-bet expression is required to control chronic viral infection. J. Immunol. 197 (2016), 1017–1022.
    • (2016) J. Immunol. , vol.197 , pp. 1017-1022
    • Barnett, B.E.1
  • 61
    • 31544463262 scopus 로고    scopus 로고
    • Long-lived plasma cells in immunity and immunopathology
    • 61 Moser, K., et al. Long-lived plasma cells in immunity and immunopathology. Immunol. Lett. 103 (2006), 83–85.
    • (2006) Immunol. Lett. , vol.103 , pp. 83-85
    • Moser, K.1
  • 62
    • 84882759383 scopus 로고    scopus 로고
    • T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
    • 62 Rubtsova, K., et al. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), E3216–E3224.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. E3216-E3224
    • Rubtsova, K.1
  • 63
    • 80051569441 scopus 로고    scopus 로고
    • A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
    • 63 Hao, Y., et al. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood 118 (2011), 1294–1304.
    • (2011) Blood , vol.118 , pp. 1294-1304
    • Hao, Y.1
  • 64
    • 80051568169 scopus 로고    scopus 로고
    • + B-cell population is important for the development of autoimmunity
    • + B-cell population is important for the development of autoimmunity. Blood 118 (2011), 1305–1315.
    • (2011) Blood , vol.118 , pp. 1305-1315
    • Rubtsov, A.V.1
  • 65
    • 84969132610 scopus 로고    scopus 로고
    • IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity
    • 65 Domeier, P.P., et al. IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med. 213 (2016), 715–732.
    • (2016) J. Exp. Med. , vol.213 , pp. 715-732
    • Domeier, P.P.1
  • 66
    • 18944370055 scopus 로고    scopus 로고
    • Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor
    • 66 Harris, D.P., et al. Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J. Immunol. 174 (2005), 6781–6790.
    • (2005) J. Immunol. , vol.174 , pp. 6781-6790
    • Harris, D.P.1
  • 67
    • 28244458933 scopus 로고    scopus 로고
    • Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells
    • 67 Harris, D.P., et al. Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J. Immunol. 175 (2005), 7103–7107.
    • (2005) J. Immunol. , vol.175 , pp. 7103-7107
    • Harris, D.P.1
  • 68
    • 0034568991 scopus 로고    scopus 로고
    • Reciprocal regulation of polarized cytokine production by effector B and T cells
    • 68 Harris, D.P., et al. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat. Immunol. 1 (2000), 475–482.
    • (2000) Nat. Immunol. , vol.1 , pp. 475-482
    • Harris, D.P.1
  • 69
    • 84983760966 scopus 로고    scopus 로고
    • Cutting edge: IL-4, IL-21, and IFN-γ interact to govern T-bet and CD11c expression in TLR-activated B cells
    • 69 Naradikian, M.S., et al. Cutting edge: IL-4, IL-21, and IFN-γ interact to govern T-bet and CD11c expression in TLR-activated B cells. J. Immunol. 197 (2016), 1023–1028.
    • (2016) J. Immunol. , vol.197 , pp. 1023-1028
    • Naradikian, M.S.1
  • 70
    • 79952091851 scopus 로고    scopus 로고
    • CXCR3 in T cell function
    • 70 Groom, J.R., Luster, A.D., CXCR3 in T cell function. Exp. Cell Res. 317 (2011), 620–631.
    • (2011) Exp. Cell Res. , vol.317 , pp. 620-631
    • Groom, J.R.1    Luster, A.D.2
  • 71
    • 33947190910 scopus 로고    scopus 로고
    • Temporal dissection of T-bet functions
    • 71 Matsuda, J.L., et al. Temporal dissection of T-bet functions. J. Immunol. 178 (2007), 3457–3465.
    • (2007) J. Immunol. , vol.178 , pp. 3457-3465
    • Matsuda, J.L.1
  • 72
    • 0032536869 scopus 로고    scopus 로고
    • Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
    • 72 Sallusto, F., et al. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187 (1998), 875–883.
    • (1998) J. Exp. Med. , vol.187 , pp. 875-883
    • Sallusto, F.1
  • 73
    • 84870491540 scopus 로고    scopus 로고
    • CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines
    • 73 Serre, K., et al. CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines. Blood 120 (2012), 4552–4559.
    • (2012) Blood , vol.120 , pp. 4552-4559
    • Serre, K.1
  • 74
    • 84857125483 scopus 로고    scopus 로고
    • Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection
    • 74 Onodera, T., et al. Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 2485–2490.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 2485-2490
    • Onodera, T.1
  • 75
    • 84870864876 scopus 로고    scopus 로고
    • + T helper 1 cell differentiation
    • + T helper 1 cell differentiation. Immunity 37 (2012), 1091–1103.
    • (2012) Immunity , vol.37 , pp. 1091-1103
    • Groom, J.R.1
  • 76
    • 78649853665 scopus 로고    scopus 로고
    • T-bet and eomesodermin are required for T cell-mediated antitumor immune responses
    • 76 Zhu, Y., et al. T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J. Immunol. 185 (2010), 3174–3183.
    • (2010) J. Immunol. , vol.185 , pp. 3174-3183
    • Zhu, Y.1
  • 77
    • 78649263390 scopus 로고    scopus 로고
    • Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression
    • 77 Miller, S.A., et al. Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol. Cell 40 (2010), 594–605.
    • (2010) Mol. Cell , vol.40 , pp. 594-605
    • Miller, S.A.1
  • 78
    • 80054722812 scopus 로고    scopus 로고
    • Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells
    • 78 Joshi, N.S., et al. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. J. Immunol. 187 (2011), 4068–4076.
    • (2011) J. Immunol. , vol.187 , pp. 4068-4076
    • Joshi, N.S.1
  • 79
    • 84887515800 scopus 로고    scopus 로고
    • + T cells are critical for protection against influenza A virus
    • + T cells are critical for protection against influenza A virus. Immunity 39 (2013), 939–948.
    • (2013) Immunity , vol.39 , pp. 939-948
    • Slutter, B.1
  • 80
    • 68249134207 scopus 로고    scopus 로고
    • KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors
    • 80 Weinreich, M.A., et al. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity 31 (2009), 122–130.
    • (2009) Immunity , vol.31 , pp. 122-130
    • Weinreich, M.A.1
  • 81
    • 84870027825 scopus 로고    scopus 로고
    • STATs shape the active enhancer landscape of T cell populations
    • 81 Vahedi, G., et al. STATs shape the active enhancer landscape of T cell populations. Cell 151 (2012), 981–993.
    • (2012) Cell , vol.151 , pp. 981-993
    • Vahedi, G.1
  • 82
    • 79957708430 scopus 로고    scopus 로고
    • Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation
    • 82 Hu, J.K., et al. Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), E118–E127.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. E118-E127
    • Hu, J.K.1
  • 83
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • 83 Koch, M.A., et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10 (2009), 595–602.
    • (2009) Nat. Immunol. , vol.10 , pp. 595-602
    • Koch, M.A.1
  • 84
    • 84923035090 scopus 로고    scopus 로고
    • Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance
    • 84 Yu, F., et al. Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance. Nat. Immunol. 16 (2015), 197–206.
    • (2015) Nat. Immunol. , vol.16 , pp. 197-206
    • Yu, F.1
  • 85
    • 84866483591 scopus 로고    scopus 로고
    • reg cell populations required to limit infection-induced pathology
    • reg cell populations required to limit infection-induced pathology. Immunity 37 (2012), 511–523.
    • (2012) Immunity , vol.37 , pp. 511-523
    • Hall, A.O.1
  • 86
    • 85016352384 scopus 로고    scopus 로고
    • T-bet enhances regulatory T cell fitness and directs control of Th1 responses in crescentic GN
    • 86 Nosko, A., et al. T-bet enhances regulatory T cell fitness and directs control of Th1 responses in crescentic GN. J. Am. Soc. Nephrol. 28 (2017), 185–196.
    • (2017) J. Am. Soc. Nephrol. , vol.28 , pp. 185-196
    • Nosko, A.1
  • 87
    • 85003426944 scopus 로고    scopus 로고
    • Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice
    • 87 Tan, T.G., et al. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), E8141–E8150.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. E8141-E8150
    • Tan, T.G.1
  • 89
    • 33751584436 scopus 로고    scopus 로고
    • + T cell differentiation
    • + T cell differentiation. J. Immunol. 177 (2006), 7515–7519.
    • (2006) J. Immunol. , vol.177 , pp. 7515-7519
    • Takemoto, N.1
  • 90
    • 0035827347 scopus 로고    scopus 로고
    • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
    • 90 Mullen, A.C., et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292 (2001), 1907–1910.
    • (2001) Science , vol.292 , pp. 1907-1910
    • Mullen, A.C.1
  • 91
    • 74549216531 scopus 로고    scopus 로고
    • Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
    • 91 Pipkin, M.E., et al. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32 (2010), 79–90.
    • (2010) Immunity , vol.32 , pp. 79-90
    • Pipkin, M.E.1
  • 92
    • 84856062668 scopus 로고    scopus 로고
    • + T cells in vivo
    • + T cells in vivo. Eur. J. Immunol. 42 (2012), 320–329.
    • (2012) Eur. J. Immunol. , vol.42 , pp. 320-329
    • Wiesel, M.1
  • 93
    • 84944681622 scopus 로고    scopus 로고
    • The interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells
    • 93 Ray, J.P., et al. The interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells. Immunity 43 (2015), 690–702.
    • (2015) Immunity , vol.43 , pp. 690-702
    • Ray, J.P.1
  • 94
    • 84866499256 scopus 로고    scopus 로고
    • reg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor beta2
    • reg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor beta2. Immunity 37 (2012), 501–510.
    • (2012) Immunity , vol.37 , pp. 501-510
    • Koch, M.A.1
  • 95
    • 33646467806 scopus 로고    scopus 로고
    • Differential effects of IL-27 on human B cell subsets
    • 95 Larousserie, F., et al. Differential effects of IL-27 on human B cell subsets. J. Immunol. 176 (2006), 5890–5897.
    • (2006) J. Immunol. , vol.176 , pp. 5890-5897
    • Larousserie, F.1
  • 96
    • 4043122529 scopus 로고    scopus 로고
    • Induction of IgG2a class switching in B cells by IL-27
    • 96 Yoshimoto, T., et al. Induction of IgG2a class switching in B cells by IL-27. J. Immunol. 173 (2004), 2479–2485.
    • (2004) J. Immunol. , vol.173 , pp. 2479-2485
    • Yoshimoto, T.1
  • 97
    • 28244472817 scopus 로고    scopus 로고
    • Stat1-dependent synergistic activation of T-bet for IgG2a production during early stage of B cell activation
    • 97 Xu, W., Zhang, J.J., Stat1-dependent synergistic activation of T-bet for IgG2a production during early stage of B cell activation. J. Immunol. 175 (2005), 7419–7424.
    • (2005) J. Immunol. , vol.175 , pp. 7419-7424
    • Xu, W.1    Zhang, J.J.2
  • 98
    • 84860710456 scopus 로고    scopus 로고
    • The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells
    • 98 Nguyen, H.V., et al. The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells. Blood 119 (2012), 4174–4181.
    • (2012) Blood , vol.119 , pp. 4174-4181
    • Nguyen, H.V.1
  • 99
    • 79956085895 scopus 로고    scopus 로고
    • Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
    • 99 Liao, W., et al. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat. Immunol. 12 (2011), 551–559.
    • (2011) Nat. Immunol. , vol.12 , pp. 551-559
    • Liao, W.1
  • 100
    • 84885156779 scopus 로고    scopus 로고
    • Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-beta1 signaling
    • 100 Grange, M., et al. Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-beta1 signaling. J. Immunol. 191 (2013), 3712–3724.
    • (2013) J. Immunol. , vol.191 , pp. 3712-3724
    • Grange, M.1
  • 101
    • 84896372779 scopus 로고    scopus 로고
    • Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells
    • 101 Ray, J.P., et al. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity 40 (2014), 367–377.
    • (2014) Immunity , vol.40 , pp. 367-377
    • Ray, J.P.1
  • 102
    • 0037013930 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    • 102 Gorelik, L., et al. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J. Exp. Med. 195 (2002), 1499–1505.
    • (2002) J. Exp. Med. , vol.195 , pp. 1499-1505
    • Gorelik, L.1
  • 103
    • 85002609650 scopus 로고    scopus 로고
    • + T cells sustain the immune response to chronic viral infections
    • + T cells sustain the immune response to chronic viral infections. Immunity 45 (2016), 415–427.
    • (2016) Immunity , vol.45 , pp. 415-427
    • Utzschneider, D.T.1
  • 104
    • 84988410229 scopus 로고    scopus 로고
    • + T cells curtail chronic viral infection
    • + T cells curtail chronic viral infection. Nature 537 (2016), 412–428.
    • (2016) Nature , vol.537 , pp. 412-428
    • He, R.1
  • 105
    • 84988266244 scopus 로고    scopus 로고
    • + T cells that provide the proliferative burst after PD-1 therapy
    • + T cells that provide the proliferative burst after PD-1 therapy. Nature 537 (2016), 417–421.
    • (2016) Nature , vol.537 , pp. 417-421
    • Im, S.J.1
  • 106
    • 84981285538 scopus 로고    scopus 로고
    • + follicular cytotoxic T cells control viral infection in B cell follicles
    • + follicular cytotoxic T cells control viral infection in B cell follicles. Nat. Immunol. 17 (2016), 1187–1196.
    • (2016) Nat. Immunol. , vol.17 , pp. 1187-1196
    • Leong, Y.A.1
  • 107
    • 84940450115 scopus 로고    scopus 로고
    • Synchronizing transcriptional control of T cell metabolism and function
    • 107 Man, K., Kallies, A., Synchronizing transcriptional control of T cell metabolism and function. Nat. Rev. Immunol. 15 (2015), 574–584.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 574-584
    • Man, K.1    Kallies, A.2
  • 108
    • 84911132031 scopus 로고    scopus 로고
    • Bcl-6 directly represses the gene program of the glycolysis pathway
    • 108 Oestreich, K.J., et al. Bcl-6 directly represses the gene program of the glycolysis pathway. Nat. Immunol. 15 (2014), 957–964.
    • (2014) Nat. Immunol. , vol.15 , pp. 957-964
    • Oestreich, K.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.