Cutting edge: B cell-intrinsic T-bet expression is required to control chronic viral infection

Journal of Immunology

Volumn 197, Issue 4, 2016, Pages 1017-1022

  Barnett, Burton E ^a   Staupe, Ryan P ^a   Odorizzi, Pamela M ^a   Palko, Olesya ^a   Tomov, Vesselin T ^a   Mahan, Alison E ^b   Gunn, Bronwyn ^b   Chen, Diana ^c   Paley, Michael A ^a   Alter, Galit ^b   Reiner, Steven L ^d   Lauer, Georg M ^c   Teijaro, John R ^e   Wherry, E John ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Koch Institute for Integrative Cancer Research   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Columbia University ^*  (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G2A; TRANSCRIPTION FACTOR T BET; IMMUNOGLOBULIN G; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELL LINEAGE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCTION; INFECTION CONTROL; LYMPHOCYTE PROLIFERATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; VIRUS INFECTION; ANIMAL; B LYMPHOCYTE SUBPOPULATION; CELL SEPARATION; CHRONIC DISEASE; DISEASE MODEL; DNA MICROARRAY; IMMUNOLOGY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CELL SEPARATION; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOGLOBULIN G; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; T-BOX DOMAIN PROTEINS;

EID: 84983784437     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500368     Document Type: Article

References (21)

1. Virgin, H. W., E. J. Wherry, and R. Ahmed. 2009. Redefining chronic viral infection. Cell 138: 30-50.
2. Walker, L. M., S. K. Phogat, P. Y. Chan-Hui, D. Wagner, P. Phung, J. L. Goss, T. Wrin, M. D. Simek, S. Fling, J. L. Mitcham, et al; Protocol G Principal Investigators. 2009. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 326: 285-289.
3. Oldstone, M. B. 2013. Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza. Proc. Natl. Acad. Sci. USA 110: 4180-4183.
4. Bergthaler, A., L. Flatz, A. Verschoor, A. N. Hegazy, M. Holdener, K. Fink, B. Eschli, D. Merkler, R. Sommerstein, E. Horvath, et al. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. [Published erratum appears in 2009 PLoS Biol. 7(8): doi:10.1371/annotation/42dca769-eca8-4e8fa6b5-236355b631ff. ] PLoS Biol. 7: E1000080.
5. Whitmire, J. K., M. S. Asano, S. M. Kaech, S. Sarkar, L. G. Hannum, M. J. Shlomchik, and R. Ahmed. 2009. Requirement of B cells for generating CD4+ T cell memory. J. Immunol. 182: 1868-1876.
6. Paley, M. A., D. C. Kroy, P. M. Odorizzi, J. B. Johnnidis, D. V. Dolfi, B. E. Barnett, E. K. Bikoff, E. J. Robertson, G. M. Lauer, S. L. Reiner, and E. J. Wherry. 2012. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 338: 1220-1225.
7. Zhu, J., D. Jankovic, A. J. Oler, G. Wei, S. Sharma, G. Hu, L. Guo, R. Yagi, H. Yamane, G. Punkosdy, et al. 2012. The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity 37: 660-673.
8. Aït-Azzouzene, D., D. H. Kono, R. Gonzalez-Quintial, L. J. McHeyzer-Williams, M. Lim, D. Wickramarachchi, T. Gerdes, A. L. Gavin, P. Skog, M. G. McHeyzer- Williams, et al. 2010. Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice. J. Immunol. 185: 1015-1027.
9. Baldridge, J. R., and M. J. Buchmeier. 1992. Mechanisms of antibody-mediated protection against lymphocytic choriomeningitis virus infection: mother-to-baby transfer of humoral protection. J. Virol. 66: 4252-4257.
10. Graham, B. S., and D. M. Ambrosino. 2015. History of passive antibody administration for prevention and treatment of infectious diseases. Curr. Opin. HIV AIDS 10: 129-134.
11. Peng, S. L., S. J. Szabo, and L. H. Glimcher. 2002. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. USA 99: 5545-5550.
12. Wang, N. S., L. J. McHeyzer-Williams, S. L. Okitsu, T. P. Burris, S. L. Reiner, and M. G. McHeyzer-Williams. 2012. Divergent transcriptional programming of classspecific B cell memory by T-bet and RORa. Nat. Immunol. 13: 604-611.
13. Yamada, D. H., H. Elsaesser, A. Lux, J. M. Timmerman, S. L. Morrison, J. C. de la Torre, F. Nimmerjahn, and D. G. Brooks. 2015. Suppression of Fcg-receptor-mediated antibody effector function during persistent viral infection. Immunity 42: 379-390.
14. Wieland, A., R. Shashidharamurthy, A. O. Kamphorst, J. H. Han, R. D. Aubert, B. P. Choudhury, S. R. Stowell, J. Lee, G. A. Punkosdy, M. J. Shlomchik, et al. 2015. Antibody effector functions mediated by Fcg-receptors are compromised during persistent viral infection. Immunity 42: 367-378.
15. Richter, K., and A. Oxenius. 2013. Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcgR or complement. Eur. J. Immunol. 43: 2349-2360.
16. Straub, T., O. Schweier, M. Bruns, F. Nimmerjahn, A. Waisman, and H. Pircher. 2013. Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcgR. Eur. J. Immunol. 43: 2338-2348.
17. Seiler, P., U. Kalinke, T. Rulicke, E. M. Bucher, C. Böse, R. M. Zinkernagel, and H. Hengartner. 1998. Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. J. Virol. 72: 2253-2258.
18. Ackerman, M. E., M. Crispin, X. Yu, K. Baruah, A. W. Boesch, D. J. Harvey, A. S. Dugast, E. L. Heizen, A. Ercan, I. Choi, et al. 2013. Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. J. Clin. Invest. 123: 2183-2192.
19. Lazarevic, V., L. H. Glimcher, and G. M. Lord. 2013. T-bet: A bridge between innate and adaptive immunity. Nat. Rev. Immunol. 13: 777-789.
20. Sydora, B. C., B. D. Jamieson, R. Ahmed, and M. Kronenberg. 1996. Intestinal intraepithelial lymphocytes respond to systemic lymphocytic choriomeningitis virus infection. Cell. Immunol. 167: 161-169.
21. Naradikian, M. S., A. Myles, D. P. Beiting, K. J. Roberts, L. Dawson, R. S. Herati, B. Bengsch, S. L. Linderman, E. Stelekati, R. Spolski, et al. 2016. Cutting edge: IL-4, IL-21, and IFN-g interact to govern T-bet and CD11c expression in TLRactivated B cells. J. Immunol. 197: 1023-1028.