Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 21, 2011, Pages

  Hu, Joyce K ^a,b   Kagari, Takashi ^a,c   Clingan, Jonathan M ^a,b   Matloubian, Mehrdad ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Microenvironment; T cell differentiation; Trafficking

Indexed keywords

CHEMOKINE RECEPTOR CXCR3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; EFFECTOR CELL; LYMPHOCYTIC CHORIOMENINGITIS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; IMMUNOLOGIC MEMORY; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; RECEPTORS, CXCR3; T-LYMPHOCYTES;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS;

EID: 79957708430     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101881108     Document Type: Article

References (50)

1. Williams MA, Bevan MJ (2007) Effector and memory CTL differentiation. Annu Rev Immunol 25:171-192. (Pubitemid 46697906)
2. Gerlach C, et al. (2010) One naive T cell, multiple fates in CD8+ T cell differentiation. J Exp Med 207:1235-1246.
3. Joshi NS, et al. (2007) Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27:281-295. (Pubitemid 47284924)
4. Sarkar S, et al. (2008) Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med 205:625-640. (Pubitemid 351439309)
5. Bromley SK, Peterson DA, Gunn MD, Dustin ML (2000) Cutting edge: Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. J Immunol 165:15-19. (Pubitemid 30429484)
6. Matloubian M, et al. (2004) Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427:355-360. (Pubitemid 38133663)
7. Potsch C, Vöhringer D, Pircher H (1999) Distinct migration patterns of naive and effector CD8 T cells in the spleen: Correlation with CCR7 receptor expression and chemokine reactivity. Eur J Immunol 29:3562-3570. (Pubitemid 29527803)
8. Sallusto F, et al. (1999) Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol 29:2037-2045. (Pubitemid 29265560)
9. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 187:875-883. (Pubitemid 28141661)
10. Campanella GS, et al. (2008) Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci USA 105:4814-4819. (Pubitemid 351753829)
11. Hancock WW, et al. (2000) Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 192:1515-1520.
12. Nakanishi Y, Lu B, Gerard C, Iwasaki A (2009) CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature 462:510-513.
13. Thapa M, Carr DJ (2009) CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration. J Virol 83:9486-9501.
14. Wuest TR, Carr DJ (2008) Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. J Immunol 181:7985-7993.
15. Zhang B, Chan YK, Lu B, Diamond MS, Klein RS (2008) CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. J Immunol 180:2641-2649.
16. Farber JM (1990) A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc Natl Acad Sci USA 87:5238-5242.
17. Luster AD, Ravetch JV (1987) Genomic characterization of a gamma-interferon-inducible gene (IP-10) and identification of an interferon-inducible hypersensitive site. Mol Cell Biol 7:3723-3731. (Pubitemid 18076108)
18. Ohmori Y, Hamilton TA (1990) A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem Biophys Res Commun 168:1261-1267. (Pubitemid 20176015)
19. Vanguri P, Farber JM (1990) Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine. J Biol Chem 265:15049-15057.
20. Jung YW, Rutishauser RL, Joshi NS, Haberman AM, Kaech SM (2010) Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J Immunol 185:5315-5325.
21. Christensen JE, de Lemos C, Moos T, Christensen JP, Thomsen AR (2006) CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J Immunol 176:4235-4243. (Pubitemid 44264402)
22. Hsieh MF, et al. (2006) Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. J Immunol 177:1855-1863.
23. Kohlmeier JE, et al. (2009) CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection. J Immunol 183:4378-4384.
24. Stiles LN, Liu MT, Kane JA, Lane TE (2009) CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination. Autoimmunity 42:484-491.
25. Araki K, et al. (2009) mTOR regulates memory CD8 T-cell differentiation. Nature 460:108-112.
26. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708-712.
27. Wherry EJ, et al. (2003) Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 4:225-234. (Pubitemid 36322131)
28. Seiler P, et al. (1997) Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection. Eur J Immunol 27:2626-2633. (Pubitemid 27453853)
29. Ahmed R, Gray D (1996) Immunological memory and protective immunity: Understanding their relation. Science 272:54-60. (Pubitemid 26110754)
30. Kaech SM, Wherry EJ (2007) Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity 27:393-405. (Pubitemid 47418674)
31. Unsoeld H, Voehringer D, Krautwald S, Pircher H (2004) Constitutive expression of CCR7 directs effector CD8 T cells into the splenic white pulp and impairs functional activity. J Immunol 173:3013-3019. (Pubitemid 39142006)
32. Kwan J, Killeen N (2004) CCR7 directs the migration of thymocytes into the thymic medulla. J Immunol 172:3999-4007. (Pubitemid 38375211)
33. Badovinac VP, Porter BB, Harty JT (2002) Programmed contraction of CD8(+) T cells after infection. Nat Immunol 3:619-626. (Pubitemid 34752470)
34. Kaech SM, Ahmed R (2001) Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol 2:415-422. (Pubitemid 33706139)
35. Mercado R, et al. (2000) Early programming of T cell populations responding to bacterial infection. J Immunol 165:6833-6839. (Pubitemid 32001151)
36. Zehn D, Lee SY, Bevan MJ (2009) Complete but curtailed T-cell response to very low-affinity antigen. Nature 458:211-214.
37. Dauner JG, Williams IR, Jacob J (2008) Differential microenvironment localization of effector and memory CD8 T cells. J Immunol 180:291-299.
38. Khanna KM, McNamara JT, Lefrançois L (2007) In situ imaging of the endogenous CD8 T cell response to infection. Science 318:116-120.
39. Rutishauser RL, et al. (2009) Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity 31:296-308.
40. Wherry EJ, McElhaugh MJ, Eisenlohr LC (2002) Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope. J Immunol 168:4455-4461. (Pubitemid 34441347)
41. Hand TW, Morre M, Kaech SM (2007) Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc Natl Acad Sci USA 104:11730-11735. (Pubitemid 47175081)
42. Pearce EL, et al. (2009) Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460:103-107.
43. Prlic M, Bevan MJ (2009) Immunology: A metabolic switch to memory. Nature 460:41-42.
44. Jones RG, Thompson CB (2007) Revving the engine: Signal transduction fuels T cell activation. Immunity 27:173-178. (Pubitemid 47284920)
45. Sinclair LV, et al. (2008) Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 9:513-521. (Pubitemid 351560520)
46. Haring JS, Badovinac VP, Harty JT (2006) Inflaming the CD8+ T cell response. Immunity 25:19-29.
47. Badovinac VP, Tvinnereim AR, Harty JT (2000) Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290:1354-1358.
48. Whitmire JK, Tan JT, Whitton JL (2005) Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection. J Exp Med 201:1053-1059. (Pubitemid 40524673)
49. Castellino F, et al. (2006) Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440:890-895.
50. Matloubian M, David A, Engel S, Ryan JE, Cyster JG (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol 1:298-304.