The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells

Blood

Volumn 119, Issue 18, 2012, Pages 4174-4181

  Nguyen, Hai Vu ^a   Mouly, Enguerran ^a   Chemin, Karine ^a   Luinaud, Romain ^a   Despres, Raymonde ^a   Fermand, Jean Paul ^a,b   Arnulf, Bertrand ^a,b   Bories, Jean Christophe ^a  

^a UNIVERSITÉ PARIS DIDEROT   (France)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G2A; STAT1 PROTEIN; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; COMPLEX FORMATION; CONTROLLED STUDY; ENHANCER REGION; GENE REARRANGEMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 84860710456     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-09-378182     Document Type: Article

References (34)

1. Manis JP, Tian M, Alt FW. Mechanism and control of class-switch recombination. Trends Immunol. 2002;23(1):31-39. (Pubitemid 34098959)
2. Chaudhuri J, Basu U, Zarrin A, et al. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol. 2007;94: 157-214. (Pubitemid 46856611)
3. Stavnezer J. Molecular processes that regulate class switching. Curr Top Microbiol Immunol. 2000;245(2):127-168.
4. Coutelier JP, van der Logt JT, Heessen FW, Warnier G, Van Snick J. IgG2a restriction of murine antibodies elicited by viral infections. J Exp Med. 1987;165(1):64-69. (Pubitemid 17223672)
5. Collins JT, Dunnick WA. Germline transcripts of the murine immunoglobulin gamma 2a gene: Structure and induction by IFN-gamma. Int Immunol. 1993;5(8):885-891. (Pubitemid 23241760)
6. Finkelman FD, Katona IM, Mosmann TR, Coffman RL. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J Immunol. 1988;140(4):1022-1027. (Pubitemid 18088561)
7. Snapper CM, Peschel C, Paul WE. IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide. J Immunol. 1988;140(7):2121-2127. (Pubitemid 18098464)
8. Yoshimoto T, Okada K, Morishima N, et al. Induction of IgG2a class switching in B cells by IL-27. J Immunol. 2004 173(4): 2479-2485 (Pubitemid 39063105)
9. Gerth AJ, Lin L, Peng SL. T-bet regulates T-independent IgG2a class switching. Int Immunol. 2003;15(8):937-944. (Pubitemid 36987291)
10. Peng SL. The T-box transcription factor T-bet in immunity and autoimmunity. Cell Mol Immunol. 2006;3(2):87-95.
11. Peng SL, Szabo SJ, Glimcher LH. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A. 2002; 99(8):5545-5550. (Pubitemid 34411585)
12. Leprince D, Gegonne A, Coll J, et al. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature. 1983;306(5941): 395-397. (Pubitemid 14242756)
13. Nye JA, Petersen JM, Gunther CV, Jonsen MD, Graves BJ. Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev. 1992; 6(6):975-990.
14. Dittmer J. The biology of the Ets1 proto-oncogene. Mol Cancer. 2003;2(1):29.
15. Russell L, Garrett-Sinha LA. Transcription factor Ets-1 in cytokine and chemokine gene regulation. Cytokine. 2010;51(3):217-226.
16. Grenningloh R, Kang BY, Ho IC. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med. 2005;201(4):615-626. (Pubitemid 40289551)
17. Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC. Ets-1 is a negative regulator of Th17 differentiation. J Exp Med. 2007;204(12):2825-2835. (Pubitemid 350179553)
18. Mouly E, Chemin K, Nguyen HV, et al. The Ets-1 transcription factor controls the development and function of natural regulatory T cells. J Exp Med. 2010;207(10):2113-2125.
19. Bories JC, Willerford DM, Grevin D, et al. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 1995;377(6550):635-638.
20. Eyquem S, Chemin K, Fasseu M, et al. The development of early and mature B cells is impaired in mice deficient for the Ets-1 transcription factor. Eur J Immunol. 2004;34(11):3187-3196. (Pubitemid 39549397)
21. John SA, Clements JL, Russell LM, Garrett- Sinha LA. Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. J Biol Chem. 2008;283(2): 951-962.
22. Eyquem S, Lagresle C, Fasseu M, Sigaux F, Bories JC. Disruption of the lineage restriction of TCR beta gene rearrangements. Eur J Immunol. 2002;32(11):3256-3266. (Pubitemid 35414883)
23. Eyquem S, Chemin K, Fasseu M, Bories JC. The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus. Proc Natl Acad Sci U S A. 2004;101(44):15712- 15717. (Pubitemid 39473553)
24. Nikolajczyk BS, Sanchez JA, Sen R. ETS proteindependent accessibility changes at the immunoglobulin mu heavy chain enhancer. Immunity. 1999;11(1):11-20. (Pubitemid 29359953)
25. Shi MJ, Park SR, Kim PH, Stavnezer J. Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1. Int Immunol. 2001;13(6):733-746. (Pubitemid 32514697)
26. Stütz AM, Woisetschlager M. Functional synergism of STAT6 with either NF-kappa B or PU. 1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 1999;163(8):4383-4391. (Pubitemid 29474506)
27. Peng SL, Li J, Lin L, Gerth A. The role of T-bet in B cells. Nat Immunol. 2003;4(11):1041; author reply 1041.
28. Placek K, Gasparian S, Coffre M, et al. Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells. J Immunol. 2009; 183(12):7743-7751.
29. Yang Y, Ochando JC, Bromberg JS, Ding Y. Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood. 2007;110(7):2494-2500. (Pubitemid 47523171)
30. Liu N, Ohnishi N, Ni L, Akira S, Bacon KB. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat Immunol. 2003;4(7):687-693. (Pubitemid 36874446)
31. Rameil P, Lecine P, Ghysdael J, Gouilleux F, Kahn-Perles B, Imbert J. IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells. Oncogene. 2000;19(17): 2086-2097. (Pubitemid 30251374)
32. Laurencikiene J, Deveikaite V, Severinson E. HS1,2 enhancer regulation of germline epsilon and gamma2b promoters in murine B lymphocytes: Evidence for specific promoter-enhancer interactions. J Immunol. 2001;167(6):3257-3265. (Pubitemid 32852566)
33. Perlot T, Alt FW. Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol. 2008;99:1-32.
34. Placek K, Coffre M, Maiella S, Bianchi E, Rogge L. Genetic and epigenetic networks controlling T helper 1 cell differentiation. Immunology. 2009; 127(2):155-162.