Selenomethionine mitigates cognitive decline by targeting both tau hyperphosphorylation and autophagic clearance in an Alzheimer’s disease mouse model

Journal of Neuroscience

Volumn 37, Issue 9, 2017, Pages 2449-2462

  Zhang, Zhong Hao ^a   Wu, Qiu Yan ^a   Zheng, Rui ^a   Chen, Chen ^a   Chen, Yao ^a   Liu, Qiong ^a   Hoffmann, Peter R ^b   Ni, Jia Zuan ^a   Song, Guo Li ^a  

^a SHENZHEN UNIVERSITY   (China)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

Alzheimer s disease; Autophagy; Hyperphosphorylated tau; Selenomethionine; Tau; Tauopathy

Indexed keywords

BAFILOMYCIN; BETA ACTIN; CATHEPSIN D; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; SELENOMETHIONINE; TAU PROTEIN; AMYLOID PRECURSOR PROTEIN; BAFILOMYCIN A; ENZYME INHIBITOR; MACROLIDE; NERVE PROTEIN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGY; CELL FUNCTION; COGNITION; CONTROLLED STUDY; EXPERIMENTAL BEHAVIORAL TEST; GENETIC TRANSFECTION; HOMEOSTASIS; IMMUNOFLUORESCENCE; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TAUOPATHY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; AVOIDANCE BEHAVIOR; BRAIN; C57BL MOUSE; CELL CULTURE; COGNITION DISORDERS; COMPLICATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MAZE TEST; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY; PHYSIOLOGY; REACTION TIME; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AUTOPHAGY; AVOIDANCE LEARNING; BRAIN; CELLS, CULTURED; COGNITION DISORDERS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; MACROLIDES; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PRESENILIN-1; REACTION TIME; SELENOMETHIONINE; TAU PROTEINS;

EID: 85014442901     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3229-16.2017     Document Type: Article

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