BACE1 RNA interference improves spatial memory and attenuates Aβ burden in a streptozotocin-induced tau hyperphosphorylated rat model

Cell Biochemistry and Function

Volumn 32, Issue 7, 2014, Pages 590-596

  Yu, Chun Jiang ^a   Liu, Wei ^b   Chen, Hong Yuan ^a   Wang, Li ^a   Zhang, Zhi Ren ^a  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b Haidian Hospital   (China)

Author keywords

Alzheimer's disease; Amyloid beta; BACE1; RNA interference; Tau

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE PROTEIN, RAT; PEPTIDE FRAGMENT; SECRETASE; STREPTOZOCIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARNES MAZE TEST; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MORRIS WATER MAZE TEST; NEUROFIBRILLARY TANGLE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; RAT; RNA INTERFERENCE; SPATIAL MEMORY; WESTERN BLOTTING; ANIMAL; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; GENETICS; METABOLISM; PHOSPHORYLATION; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; MALE; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SPATIAL MEMORY; STREPTOZOCIN; TAU PROTEINS;

EID: 84914148137     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.3055     Document Type: Article

References (39)

1. Li R, Lindholm K, Yang LB, et al. Amyloid beta peptide load is correlated with increased b-secretase activity in sporadic Alzheimer's disease patients. Proc Natl Acad Sci U S A 2004; 101: 3632-3637.
2. Hong L, Koelsch G, Lin X, et al. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science 2000; 290: 150-153.
3. Tiscornia G, Singer O, Ikawa M, et al. A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A 2003; 100: 1844-1848.
4. Naldini L, Blömer U, Gallay P, et al. In vivo gene delivery and stable transduction of non-dividing cells by a lentiviral vector. Science 1996; 272: 263-267.
5. Ohno M, Sametsky EA, Younkin LH, et al. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron 2004; 41: 27-33.
6. Yoon SY, Choi JE, Yoon JH, et al. BACE inhibitor reduces APP-β-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration. Neurobiol Dis 2006; 22: 435-444.
7. Yoon SY, Choi JE, Hwang O, et al. Construction of a vector generating both siRNA and a fluorescent reporter: an siRNA study in cultured neurons. Mol Cells 2004; 18: 127-130.
8. de la Monte SM, Wands JR. Alzheimer's disease is type 3 diabetes-evidence reviewed. J Diabetes Sci Technol 2008; 2: 1101-1113.
9. Park SA. A common pathogenic mechanism linking type-2 diabetes and Alzheimer's disease: evidence from animal models. J Clin Neurol 2011; 7: 10-18.
10. Jolivalt CG, Hurford R, Lee CA, et al. Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice. Exp Neurol 2010; 223: 422-431.
11. Plaschke K, Kopitz J, Siegelin M, et al. Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbPP-overexpressing mice. J Alzheimers Dis 2010; 19: 691-704.
12. Wang X, Zheng W, Xie JW, et al. Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model. Mol Neurodegener 2010; 5: 46.
13. Ke YD, Delerue F, Gladbach A, Gotz J, Ittner LM. Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 2009; 4: e7917.
14. Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411(6836): 494-498.
15. Krichevsky AM, Kosik KS. RNAi functions in cultured mammalian neurons. Proc Natl Acad Sci U S A 2002; 99(18): 11926-11929.
16. Tuszynski MH. Gene therapy for neurological disease. Expert Opin Biol Ther 2003; 3: 815-828.
17. Marr RA, Rockenstein E, Mukherjee A, et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci 2003; 23: 1992-1996.
18. Pfeifer A, Kessler T, Silletti S, et al. Suppression of angiogenesis by lentiviral delivery of PEX, a non-catalytic fragment of matrix metallo-proteinase 2. Proc Natl Acad Sci U S A 2000; 97: 12227-12232.
19. Devi L, Alldred MJ, Ginsberg SD, et al. Sex- and brain region-specific acceleration of b-amyloidogenesis following behavioural stress in a mouse model of Alzheimer's disease. Mol Brain 2010; 3: 34.
20. Zhang WJ, Tan YF, Yue JT, et al. Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats. Acta Neurol Scand 2007; 117: 205-210.
21. Liu Y, Liu H, Yang J, et al. Increased amyloid beta-peptide (1-40) level in brain of streptozotocin-induced diabetic rats. Neuroscience 2008; 153: 796-802.
22. Castellani RJ, Gupta Y, Sheng B, et al. A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Lab Invest 2011; 91: 1777-1786.
23. Alldred MJ, Che S, Ginsberg SD, et al. Terminal continuation (TC) RNA amplification enables expression profiling using minute RNA input obtained from mouse brain. Int J Mol Sci 2008; 9: 2091-2104.
24. Sheng B, Wang X, Su B, et al. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J Neurochem 2012; 120(3): 419-429.
25. Sheng B, Song B, Zheng Z, et al. Abnormal cleavage of APP impairs its functions in cell adhesion and migration. Neurosci Lett 2010; 450: 327-331.
26. Holsinger RM, McLean CA, Beyreuther K, et al. Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann Neurol 2002; 51: 783-786.
27. Huse JT, Liu K, Pijak DS, et al. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain. J Biol Chem 2002; 277: 16278-16284.
28. Chang WP, Koelsch G, Wong S, et al. In vivo inhibition of A-beta production by memapsin 2 (beta-secretase) inhibitors. J Neurochem 2011; 89: 1409-1416.
29. Davidson BL, Paulson HL. Molecular medicine for the brain: silencing of disease genes with RNA interference. Lancet Neurol 2004; 3: 145-149.
30. Kao SC, Krichevsky AM, Kosik KS, et al. BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem 2004; 279: 1942-1949.
31. Stokin GB, Lillo C, Falzone TL, et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 2005; 307: 1282-1288.
32. Sheng JG, Price DL, Koliatsos VE. The β-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain. Exp Neurol 2003; 184: 1053-1057.
33. Kuwako K, Nishimura I, Uetsuki T, et al. Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein. Brain Res Mol Brain Res 2002; 107: 166-175.
34. Coulson DT, Beyer N, Quinn JG, et al. BACE1 mRNA expression in Alzheimer's disease post-mortem brain tissue. J Alzheimers Dis 2010; 22: 1111-1122.
35. Borghi R, Patriarca S, Traverso N, et al. The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease. Neurobiol Aging 2007; 28: 1009-1014.
36. Preece P, Virley DJ, Costandi M, et al. β-Secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease. Brain Res Mol Brain Res 2000; 116: 155-158.
37. Kim HS, Park CH, Cha SH, et al. Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. FASEB J 2000; 14: 1508-1517.
38. Song DK, Won MH, Jung JS, et al. Behavioural and neuropathological changes induced by central injection of carboxyl-terminal fragment of beta-amyloid precursor protein in mice. J Neurochem 1998; 71: 875-878.
39. Oster-Granite ML, McPhie DL, Greenan J, et al. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J Neurosci 1996; 121: 6732-6741.