Silencing I2PP2A rescues tau pathologies and memory deficits through rescuing PP2A and inhibiting GSK-3ß signaling in human tau transgenic mice

Frontiers in Aging Neuroscience

Volumn 6, Issue JUN, 2014, Pages

  Zhang, Yao ^a   Ma, Rong Hong ^b   Li, Xia Chun ^a,b   Zhang, Jia Yu ^a,b   Shi, Hai Rong ^a,b   Wei, Wei ^a,b,c   Luo, Dan Ju ^a,b   Wang, Qun ^a,b   Wang, Jian Zhi ^a,b   Liu, Gong Ping ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c JINAN UNIVERSITY   (China)

Author keywords

Alzheimer disease; Glycogen synthase kinase 3 ; Inhibitor 2 of protein phosphatase 2A; Memory; Tau hyperphosphorylation

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; INHIBITOR 2 OF PHOSPHOPROTEIN PHOSPHATASE 2A; LENTIVIRUS VECTOR; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE B; SERINE; SMALL INTERFERING RNA; TAU PROTEIN; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITE; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HEK293 CELL LINE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM MEMORY; MOUSE; NERVE CELL PLASTICITY; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN PHOSPHORYLATION; SHORT TERM MEMORY; SIGNAL TRANSDUCTION; TAUOPATHY; TRANSGENIC MOUSE;

EID: 84904576539     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00123     Document Type: Article

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