Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats

Neurochemical Research

Volumn 39, Issue 11, 2014, Pages 2068-2077

  Su, Jingyuan ^a   Zhang, Tingting ^a   Wang, Kanwen ^a   Zhu, Tingzhun ^a   Li, Xiaoming ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

3 Methyladenine (3 MA); Autophagy; Cerebral ischemia; Neuroprotection; Remote ischemia perconditioning (RIPer)

Indexed keywords

3 METHYLADENINE; BECLIN 1; CATHEPSIN B; PEROXIDASE; PROTEIN BAD; PROTEIN BCL 2; RAPAMYCIN; 3-METHYLADENINE; ADENINE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN SIZE; BRAIN WATER; CARDIOVASCULAR FUNCTION; CHEMOLUMINESCENCE; CONTROLLED STUDY; FEMORAL ARTERY; IMMUNOHISTOCHEMISTRY; NEUROPROTECTION; NICK END LABELING; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; RAT; REMOTE ISCHEMIC PERCONDITIONING; REPERFUSION INJURY; SKIN COLOR; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL MODEL; CEREBRAL INFARCTION; DRUG EFFECTS; ISCHEMIC POSTCONDITIONING; ISCHEMIC PRECONDITIONING; MALE; PROCEDURES; SPRAGUE DAWLEY RAT;

ADENINE; ANIMALS; AUTOPHAGY; BRAIN ISCHEMIA; CEREBRAL INFARCTION; ISCHEMIC POSTCONDITIONING; ISCHEMIC PRECONDITIONING; MALE; MODELS, ANIMAL; NEUROPROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIROLIMUS;

EID: 84910122496     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-014-1396-x     Document Type: Article

References (29)

1. Kitagawa K, Matsumoto M, Tagaya M, Hata R, Ueda H, Niinobe M, Handa N, Fukunaga R, Kimura K, Mikoshiba K (1990) ‘Ischemic tolerance’ phenomenon found in the brain. Brain Res 528:21–24
2. Zhao H, Sapolsky RM, Steinberg GK (2006) Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J Cereb Blood Flow Metab 26:1114–1121
3. Wang J-Y, Shen J, Gao Q, Ye Z-G, Yang S-Y, Liang H-W, Bruce IC, Luo B-Y, Xia Q (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. Stroke 39:983–990
4. Moskowitz MA, Waeber C (2011) Remote ischemic preconditioning making the brain more tolerant, safely and inexpensively. Circulation 123:709–711
5. Hess DC, Hoda MN, Bhatia K (2013) Remote limb preconditioning and postconditioning will it translate into a promising treatment for acute stroke? Stroke 44:1191–1197
6. Ren C, Yan Z, Wei D, Gao X, Chen X, Zhao H (2009) Limb remote ischemic postconditioning protects against focal ischemia in rats. Brain Res 1288:88–94
7. Hahn CD, Manlhiot C, Schmidt MR, Nielsen TT, Redington AN (2011) Remote ischemic per-conditioning a novel therapy for acute stroke? Stroke 42:2960–2962
8. Purcell H, Pepper J (2007) An arm and a leg to protect the heart? Lancet 370:542–543
9. Ren C, Gao M, Dornbos D, Ding Y, Zeng X, Luo Y, Ji X (2011) Remote ischemic post-conditioning reduced brain damage in experimental ischemia/reperfusion injury. Neurol Res 33:514–519
10. Kondo Y, Kanzawa T, Sawaya R, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5:726–734
11. Tesco G (2012) Autophagy: a common road to perdition in acute brain injuries and Alzheimer’s disease. J Neurochem 120:475–476
12. Orvedahl A, Levine B (2008) Eating the enemy within: autophagy in infectious diseases. Cell Death Differ 16:57–69
13. Shi R, Weng J, Zhao L, Li XM, Gao TM, Kong J (2012) Excessive autophagy contributes to neuron death in cerebral ischemia. CNS Neurosci Ther 18:250–260
14. Xu M, Zhang H-l (2011) Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy. Acta Pharmacol Sin 32:1089–1099
15. Sheng R, Zhang L-S, Han R, Liu X-Q, Gao B, Qin Z-H (2010) Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy 6:482–494
16. Yan W, Zhang H, Bai X, Lu Y, Dong H, Xiong L (2011) Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. Brain Res 1402:109–121
17. Qi ZF, Luo YM, Liu XR, Wang RL, Zhao HP, Yan F, Song ZJ, Luo M, Ji XM (2012) AKT/GSK3β-dependent autophagy contributes to the neuroprotection of limb remote ischemic postconditioning in the transient cerebral ischemic rat model. CNS Neurosci Ther 18:965–973
18. Gao L, Jiang T, Guo J, Liu Y, Cui G, Gu L, Su L, Zhang Y (2012) Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PLoS One 7:e46092
19. Mizushima N (2004) Methods for monitoring autophagy. Int J Biochem Cell Biol 36:2491–2502
20. Wen Y-D, Sheng R, Zhang L-S, Han R, Zhang X, Zhang X-D, Han F, Fukunaga K, Qin Z-H (2008) Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 4:762–769
21. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84–91
22. Garcia JH, Wagner S, Liu K-F, Hu X-J (1995) Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats Statistical validation. Stroke 26:627–635
23. Rosenberg GA, Scremin O, Estrada E, Kyner WT (1992) Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats. Stroke 23:1767–1773
24. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, Johnson MH, Hill WD, Ergul A, Fagan SC (2012) Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke 43:2794–2799
25. Nitatori T, Sato N, Waguri S, Karasawa Y, Araki H, Shibanai K, Kominami E, Uchiyama Y (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15:1001–1011
26. Wang J-Y, Xia Q, Chu K-T, Pan J, Sun L-N, Zeng B, Zhu Y-J, Wang Q, Wang K, Luo B-Y (2011) Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy. J Neuropathol Exp Neurol 70:314–322
27. Carloni S, Girelli S, Scopa C, Buonocore G, Longini M, Balduini W (2010) Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia. Autophagy 6:366–377
28. Murgia MG, Jordan S, Kahan BD (1996) The side effect profile of sirolimus: a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients. Kidney Int 49:209–216
29. Li L, Luo W, Huang L, Zhang W, Gao Y, Jiang H, Zhang C, Long L, Chen S (2010) Remote perconditioning reduces myocardial injury in adult valve replacement: a randomized controlled trial. J Surg Res 164:e21–e26