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Volumn 27, Issue 6, 2017, Pages 417-429

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN;

EID: 85013409487     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2017.01.006     Document Type: Review
Times cited : (241)

References (97)
  • 1
    • 84864710223 scopus 로고    scopus 로고
    • Selective insulin and leptin resistance in metabolic disorders
    • Könner, A.C., Brüning, J.C., Selective insulin and leptin resistance in metabolic disorders. Cell Metab. 16 (2012), 144–152.
    • (2012) Cell Metab. , vol.16 , pp. 144-152
    • Könner, A.C.1    Brüning, J.C.2
  • 2
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi, H., et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116 (2006), 3015–3025.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3015-3025
    • Shi, H.1
  • 3
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee, J.Y., et al. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 276 (2001), 16683–16689.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16683-16689
    • Lee, J.Y.1
  • 4
    • 58249096193 scopus 로고    scopus 로고
    • Fatty acid-induced NF-κB activation and insulin resistance in skeletal muscle are chain length dependent
    • Hommelberg, P.P.H., et al. Fatty acid-induced NF-κB activation and insulin resistance in skeletal muscle are chain length dependent. Am. J. Physiol. Endocrinol. Metab. 296 (2009), E114–E120.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , pp. E114-E120
    • Hommelberg, P.P.H.1
  • 5
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • Oh, D.Y., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142 (2010), 687–698.
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1
  • 6
    • 73949110679 scopus 로고    scopus 로고
    • Saturated fatty acids do not directly stimulate Toll-like receptor signaling
    • Erridge, C., Samani, N.J., Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler. Thromb. Vasc. Biol. 29 (2009), 1944–1949.
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 1944-1949
    • Erridge, C.1    Samani, N.J.2
  • 7
    • 84864657351 scopus 로고    scopus 로고
    • Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    • Pal, D., et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. 18 (2012), 1279–1285.
    • (2012) Nat. Med. , vol.18 , pp. 1279-1285
    • Pal, D.1
  • 8
    • 70350482557 scopus 로고    scopus 로고
    • Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner
    • Wong, S.W., et al. Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J. Biol. Chem. 284 (2009), 27384–27392.
    • (2009) J. Biol. Chem. , vol.284 , pp. 27384-27392
    • Wong, S.W.1
  • 9
    • 78650472774 scopus 로고    scopus 로고
    • Toll-like receptors: linking inflammation to metabolism
    • Könner, C.A., Brüning, J.C., Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol. Metab. 22 (2011), 16–23.
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 16-23
    • Könner, C.A.1    Brüning, J.C.2
  • 10
    • 84874247282 scopus 로고    scopus 로고
    • Implication of inflammatory signaling pathways in obesity-induced insulin resistance
    • Tanti, J.-F., et al. Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front. Endocrinol. (Lausanne), 3, 2012, 181.
    • (2012) Front. Endocrinol. (Lausanne) , vol.3 , pp. 181
    • Tanti, J.-F.1
  • 11
    • 70349859675 scopus 로고    scopus 로고
    • Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
    • Bierhaus, A., Nawroth, P.P., Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications. Diabetologia 52 (2009), 2251–2263.
    • (2009) Diabetologia , vol.52 , pp. 2251-2263
    • Bierhaus, A.1    Nawroth, P.P.2
  • 12
    • 20044363264 scopus 로고    scopus 로고
    • The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species
    • Lin, Y., et al. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J. Biol. Chem. 280 (2005), 4617–4626.
    • (2005) J. Biol. Chem. , vol.280 , pp. 4617-4626
    • Lin, Y.1
  • 13
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil, G.S., Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140 (2010), 900–917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 14
    • 84855605795 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress, obesity and diabetes
    • Cnop, M., et al. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol. Med. 18 (2016), 59–68.
    • (2016) Trends Mol. Med. , vol.18 , pp. 59-68
    • Cnop, M.1
  • 15
    • 84878777666 scopus 로고    scopus 로고
    • Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
    • Eizirik, D.L., et al. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 56 (2013), 234–241.
    • (2013) Diabetologia , vol.56 , pp. 234-241
    • Eizirik, D.L.1
  • 16
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Özcan, U., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 309 (2005), 457–461.
    • (2005) Science , vol.309 , pp. 457-461
    • Özcan, U.1
  • 17
    • 79952003715 scopus 로고    scopus 로고
    • FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways
    • Jiao, P., et al. FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. Obesity (Silver Spring) 19 (2011), 483–491.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 483-491
    • Jiao, P.1
  • 18
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang, X., et al. Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity. Cell 135 (2008), 61–73.
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1
  • 19
    • 84859033154 scopus 로고    scopus 로고
    • High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects
    • Harte, A.L., et al. High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects. Diabetes Care 35 (2012), 375–382.
    • (2012) Diabetes Care , vol.35 , pp. 375-382
    • Harte, A.L.1
  • 20
    • 79951702804 scopus 로고    scopus 로고
    • Endotoxemia is associated with an increased risk of incident diabetes
    • Pussinen, P.J., et al. Endotoxemia is associated with an increased risk of incident diabetes. Diabetes Care 34 (2011), 392–397.
    • (2011) Diabetes Care , vol.34 , pp. 392-397
    • Pussinen, P.J.1
  • 21
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani, P.D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56 (2007), 1761–1772.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1
  • 22
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani, P.D., et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57 (2008), 1470–1481.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1
  • 23
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard, J.I., Chawla, A., Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 339 (2013), 172–177.
    • (2013) Science , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 24
    • 84866122780 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
    • Copps, K.D., White, M.F., Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55 (2012), 2565–2582.
    • (2012) Diabetologia , vol.55 , pp. 2565-2582
    • Copps, K.D.1    White, M.F.2
  • 25
    • 84857914467 scopus 로고    scopus 로고
    • Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans
    • Hasegawa, Y., et al. Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans. Circulation 125 (2012), 1122–1133.
    • (2012) Circulation , vol.125 , pp. 1122-1133
    • Hasegawa, Y.1
  • 26
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • Boura-Halfon, S., Zick, Y., Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 296 (2009), E581–E591.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , pp. E581-E591
    • Boura-Halfon, S.1    Zick, Y.2
  • 27
    • 70449724835 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
    • Tanti, J.-F., Jager, J., Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr. Opin. Pharmacol. 9 (2009), 753–762.
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 753-762
    • Tanti, J.-F.1    Jager, J.2
  • 28
    • 58149094542 scopus 로고    scopus 로고
    • S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2
    • Zhang, J., et al. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2. J. Biol. Chem. 283 (2008), 35375–35382.
    • (2008) J. Biol. Chem. , vol.283 , pp. 35375-35382
    • Zhang, J.1
  • 29
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes, O.N., et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl Acad. Sci. U. S. A. 98 (2001), 4640–4645.
    • (2001) Proc. Natl Acad. Sci. U. S. A. , vol.98 , pp. 4640-4645
    • Ozes, O.N.1
  • 30
    • 59149099937 scopus 로고    scopus 로고
    • IKKβ suppression of TSC1 function links the mTOR pathway with insulin resistance
    • Lee, D.-F., et al. IKKβ suppression of TSC1 function links the mTOR pathway with insulin resistance. Int. J. Mol. Med. 22 (2008), 633–638.
    • (2008) Int. J. Mol. Med. , vol.22 , pp. 633-638
    • Lee, D.-F.1
  • 32
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson, S.E., et al. Inflammation and insulin resistance. J. Clin. Invest. 116 (2006), 1793–1801.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1
  • 33
    • 47249148827 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo
    • Zabolotny, J.M., et al. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J. Biol. Chem. 283 (2008), 14230–14241.
    • (2008) J. Biol. Chem. , vol.283 , pp. 14230-14241
    • Zabolotny, J.M.1
  • 34
    • 79955487247 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    • Holland, W.L., et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Invest. 121 (2011), 1858–1870.
    • (2011) J. Clin. Invest. , vol.121 , pp. 1858-1870
    • Holland, W.L.1
  • 35
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: common threads and missing links
    • Samuel, V.T., Shulman, G.I., Mechanisms for insulin resistance: common threads and missing links. Cell 148 (2012), 852–871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 36
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar, B., et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17 (2011), 179–188.
    • (2011) Nat. Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 37
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkKβ
    • Yuan, M., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkKβ. Science 293 (2001), 1673–1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1
  • 38
    • 69449097633 scopus 로고    scopus 로고
    • The protein kinase IKKε regulates energy balance in obese mice
    • Chiang, S.-H., et al. The protein kinase IKKε regulates energy balance in obese mice. Cell 138 (2009), 961–975.
    • (2009) Cell , vol.138 , pp. 961-975
    • Chiang, S.-H.1
  • 39
    • 77951181327 scopus 로고    scopus 로고
    • Uncoupling of inflammation and insulin resistance by NF-κB in transgenic mice through elevated energy expenditure
    • Tang, T., et al. Uncoupling of inflammation and insulin resistance by NF-κB in transgenic mice through elevated energy expenditure. J. Biol. Chem. 285 (2010), 4637–4644.
    • (2010) J. Biol. Chem. , vol.285 , pp. 4637-4644
    • Tang, T.1
  • 40
    • 67650566364 scopus 로고    scopus 로고
    • Inactivation of NF-κB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K
    • Gao, Z., et al. Inactivation of NF-κB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K. J. Biol. Chem. 284 (2009), 18368–18376.
    • (2009) J. Biol. Chem. , vol.284 , pp. 18368-18376
    • Gao, Z.1
  • 41
    • 84941653528 scopus 로고    scopus 로고
    • Deletion of nuclear factor-κB p50 upregulates fatty acid utilization and contributes to an anti-obesity and high-endurance phenotype in mice
    • Minegishi, Y., et al. Deletion of nuclear factor-κB p50 upregulates fatty acid utilization and contributes to an anti-obesity and high-endurance phenotype in mice. Am. J. Physiol. Endocrinol. Metab. 309 (2015), E523–E533.
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.309 , pp. E523-E533
    • Minegishi, Y.1
  • 42
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • Rosen, E.D., Spiegelman, B.M., What we talk about when we talk about fat. Cell 156 (2014), 20–44.
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 43
    • 84879482207 scopus 로고    scopus 로고
    • Chemokine systems link obesity to insulin resistance
    • Ota, T., Chemokine systems link obesity to insulin resistance. Diabetes Metab. J. 37 (2013), 165–172.
    • (2013) Diabetes Metab. J. , vol.37 , pp. 165-172
    • Ota, T.1
  • 44
    • 84881029152 scopus 로고    scopus 로고
    • Chronic adipose tissue inflammation: all immune cells on the stage
    • Cildir, G., et al. Chronic adipose tissue inflammation: all immune cells on the stage. Trends Mol. Med. 19 (2013), 487–500.
    • (2013) Trends Mol. Med. , vol.19 , pp. 487-500
    • Cildir, G.1
  • 45
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti, S., et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46 (2005), 2347–2355.
    • (2005) J. Lipid Res. , vol.46 , pp. 2347-2355
    • Cinti, S.1
  • 46
    • 84455191537 scopus 로고    scopus 로고
    • Constitutive activation of IKKβ in adipose tissue prevents diet-induced obesity in mice
    • Jiao, P., et al. Constitutive activation of IKKβ in adipose tissue prevents diet-induced obesity in mice. Endocrinology 153 (2012), 154–165.
    • (2012) Endocrinology , vol.153 , pp. 154-165
    • Jiao, P.1
  • 47
    • 0036212593 scopus 로고    scopus 로고
    • Exclusive action of transmembrane TNFα in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance
    • Haiyan, X.U., et al. Exclusive action of transmembrane TNFα in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology 143 (2002), 1502–1511.
    • (2002) Endocrinology , vol.143 , pp. 1502-1511
    • Haiyan, X.U.1
  • 48
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • Blüher, M., et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell 3 (2002), 25–38.
    • (2002) Dev. Cell , vol.3 , pp. 25-38
    • Blüher, M.1
  • 49
    • 84874399589 scopus 로고    scopus 로고
    • Lessons on conditional gene targeting in mouse adipose tissue
    • Lee, K.Y., et al. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes 62 (2013), 864–874.
    • (2013) Diabetes , vol.62 , pp. 864-874
    • Lee, K.Y.1
  • 50
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • Li, S., et al. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl Acad. Sci. U. S. A. 107 (2010), 3441–3446.
    • (2010) Proc. Natl Acad. Sci. U. S. A. , vol.107 , pp. 3441-3446
    • Li, S.1
  • 51
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • Cohen, J.C., et al. Human fatty liver disease: old questions and new insights. Science 332 (2011), 1519–1523.
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1
  • 52
    • 84964734732 scopus 로고    scopus 로고
    • The role of macrophages in obesity-driven chronic liver disease
    • Devisscher, L., et al. The role of macrophages in obesity-driven chronic liver disease. J. Leukoc. Biol. 99 (2016), 693–698.
    • (2016) J. Leukoc. Biol. , vol.99 , pp. 693-698
    • Devisscher, L.1
  • 53
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • Cai, D., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat. Med. 11 (2005), 183–190.
    • (2005) Nat. Med. , vol.11 , pp. 183-190
    • Cai, D.1
  • 54
    • 84865536932 scopus 로고    scopus 로고
    • Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation
    • Sunami, Y., et al. Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology 56 (2012), 1117–1128.
    • (2012) Hepatology , vol.56 , pp. 1117-1128
    • Sunami, Y.1
  • 55
    • 84937857809 scopus 로고    scopus 로고
    • Moderate activation of IKK2–NF-κB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis
    • Lu, H., et al. Moderate activation of IKK2–NF-κB in unstressed adult mouse liver induces cytoprotective genes and lipogenesis without apparent signs of inflammation or fibrosis. BMC Gastroenterol., 15, 2015, 94.
    • (2015) BMC Gastroenterol. , vol.15 , pp. 94
    • Lu, H.1
  • 56
    • 20044387026 scopus 로고    scopus 로고
    • IKK-β links inflammation to obesity-induced insulin resistance
    • Arkan, M.C., et al. IKK-β links inflammation to obesity-induced insulin resistance. Nat. Med. 11 (2005), 191–198.
    • (2005) Nat. Med. , vol.11 , pp. 191-198
    • Arkan, M.C.1
  • 57
    • 84976297627 scopus 로고    scopus 로고
    • Inactivation of NF-κB p65 (RelA) in liver improves insulin sensitivity and inhibits cAMP/PKA pathway
    • Ke, B., et al. Inactivation of NF-κB p65 (RelA) in liver improves insulin sensitivity and inhibits cAMP/PKA pathway. Diabetes 64 (2015), 3355–3362.
    • (2015) Diabetes , vol.64 , pp. 3355-3362
    • Ke, B.1
  • 58
    • 84924529835 scopus 로고    scopus 로고
    • Cholesterol-induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice
    • Gruben, N., et al. Cholesterol-induced hepatic inflammation does not underlie the predisposition to insulin resistance in dyslipidemic female LDL receptor knockout mice. J. Diabetes Res., 2015, 2015, 956854.
    • (2015) J. Diabetes Res. , vol.2015 , pp. 956854
    • Gruben, N.1
  • 59
    • 84892872444 scopus 로고    scopus 로고
    • Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice
    • Funke, A., et al. Cholesterol-induced hepatic inflammation does not contribute to the development of insulin resistance in male LDL receptor knockout mice. Atherosclerosis 232 (2014), 390–396.
    • (2014) Atherosclerosis , vol.232 , pp. 390-396
    • Funke, A.1
  • 60
    • 84873310784 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model
    • Aparicio-Vergara, M., Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model. Hepatology 57 (2013), 566–576.
    • (2013) Hepatology , vol.57 , pp. 566-576
    • Aparicio-Vergara, M.1
  • 61
    • 39549101229 scopus 로고    scopus 로고
    • Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis
    • Wunderlich, F.T., et al. Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proc. Natl Acad. Sci. U. S. A. 105 (2008), 1297–1302.
    • (2008) Proc. Natl Acad. Sci. U. S. A. , vol.105 , pp. 1297-1302
    • Wunderlich, F.T.1
  • 62
    • 33846839443 scopus 로고    scopus 로고
    • Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    • Luedde, T., et al. Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 11 (2007), 119–132.
    • (2007) Cancer Cell , vol.11 , pp. 119-132
    • Luedde, T.1
  • 63
    • 84946544180 scopus 로고    scopus 로고
    • NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity-mediated hepatocyte apoptosis
    • Kondylis, V., et al. NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity-mediated hepatocyte apoptosis. Cancer Cell 28 (2015), 582–598.
    • (2015) Cancer Cell , vol.28 , pp. 582-598
    • Kondylis, V.1
  • 64
    • 47749136267 scopus 로고    scopus 로고
    • IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
    • Luedde, T., et al. IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. Proc. Natl Acad. Sci. U. S. A. 105 (2008), 9733–9738.
    • (2008) Proc. Natl Acad. Sci. U. S. A. , vol.105 , pp. 9733-9738
    • Luedde, T.1
  • 65
    • 84981489530 scopus 로고    scopus 로고
    • IκB kinase α/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1
    • Koppe, C., et al. IκB kinase α/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1. Hepatology 64 (2016), 1217–1231.
    • (2016) Hepatology , vol.64 , pp. 1217-1231
    • Koppe, C.1
  • 66
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park, E.J., et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140 (2010), 197–208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1
  • 67
    • 84862000588 scopus 로고    scopus 로고
    • NF-κB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action
    • Sheng, L., et al. NF-κB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat. Med. 18 (2012), 943–949.
    • (2012) Nat. Med. , vol.18 , pp. 943-949
    • Sheng, L.1
  • 68
    • 84901237824 scopus 로고    scopus 로고
    • Myokines in insulin resistance and type 2 diabetes
    • Eckardt, K., et al. Myokines in insulin resistance and type 2 diabetes. Diabetologia 57 (2014), 1087–1099.
    • (2014) Diabetologia , vol.57 , pp. 1087-1099
    • Eckardt, K.1
  • 69
    • 11144356766 scopus 로고    scopus 로고
    • Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
    • Röhl, M., et al. Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance. J. Clin. Invest. 113 (2004), 474–481.
    • (2004) J. Clin. Invest. , vol.113 , pp. 474-481
    • Röhl, M.1
  • 70
    • 5444262078 scopus 로고    scopus 로고
    • IKKβ/NF-κB activation causes severe muscle wasting in mice
    • Cai, D., et al. IKKβ/NF-κB activation causes severe muscle wasting in mice. Cell 119 (2004), 285–298.
    • (2004) Cell , vol.119 , pp. 285-298
    • Cai, D.1
  • 71
    • 84929952571 scopus 로고    scopus 로고
    • Hypothalamic innate immune reaction in obesity
    • Kälin, S., et al. Hypothalamic innate immune reaction in obesity. Nat. Rev. Endocrinol. 11 (2015), 339–351.
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 339-351
    • Kälin, S.1
  • 72
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • De Souza, C.T., et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146 (2005), 4192–4199.
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1
  • 73
    • 84889025109 scopus 로고    scopus 로고
    • Neuroinflammatory basis of metabolic syndrome
    • Purkayastha, S., Cai, D., Neuroinflammatory basis of metabolic syndrome. Mol. Metab. 2 (2013), 356–363.
    • (2013) Mol. Metab. , vol.2 , pp. 356-363
    • Purkayastha, S.1    Cai, D.2
  • 74
    • 84873198464 scopus 로고    scopus 로고
    • CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age
    • Vogt, M.C., Brüning, J.C., CNS insulin signaling in the control of energy homeostasis and glucose metabolism – from embryo to old age. Trends Endocrinol. Metab. 24 (2013), 76–84.
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 76-84
    • Vogt, M.C.1    Brüning, J.C.2
  • 75
    • 84940107968 scopus 로고    scopus 로고
    • Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance
    • Benzler, J., et al. Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance. Diabetes 64 (2015), 2015–2027.
    • (2015) Diabetes , vol.64 , pp. 2015-2027
    • Benzler, J.1
  • 76
    • 84912111827 scopus 로고    scopus 로고
    • Distinct roles for JNK and IKK activation in agouti-related peptide neurons in the development of obesity and insulin resistance
    • Tsaousidou, E., et al. Distinct roles for JNK and IKK activation in agouti-related peptide neurons in the development of obesity and insulin resistance. Cell Rep. 9 (2014), 1495–1506.
    • (2014) Cell Rep. , vol.9 , pp. 1495-1506
    • Tsaousidou, E.1
  • 77
    • 84907546285 scopus 로고    scopus 로고
    • IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity
    • Weissmann, L., et al. IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity. Diabetes 63 (2014), 3334–3345.
    • (2014) Diabetes , vol.63 , pp. 3334-3345
    • Weissmann, L.1
  • 78
    • 84875179301 scopus 로고    scopus 로고
    • An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions
    • Reilly, S.M., et al. An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions. Nat. Med. 19 (2013), 313–321.
    • (2013) Nat. Med. , vol.19 , pp. 313-321
    • Reilly, S.M.1
  • 79
    • 84879460607 scopus 로고    scopus 로고
    • Islet inflammation: a unifying target for diabetes treatment?
    • Imai, Y., et al. Islet inflammation: a unifying target for diabetes treatment?. Trends Endocrinol. Metab. 24 (2013), 351–360.
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 351-360
    • Imai, Y.1
  • 80
    • 34548431826 scopus 로고    scopus 로고
    • Increased number of islet-associated macrophages in type 2 diabetes
    • Ehses, J.A., et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56 (2007), 2356–2370.
    • (2007) Diabetes , vol.56 , pp. 2356-2370
    • Ehses, J.A.1
  • 81
    • 0034711250 scopus 로고    scopus 로고
    • Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor
    • Giannoukakis, N., et al. Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor. J. Biol. Chem. 275 (2000), 36509–36513.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36509-36513
    • Giannoukakis, N.1
  • 82
    • 33645518035 scopus 로고    scopus 로고
    • Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents
    • Eldor, R., et al. Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents. Proc. Natl Acad. Sci. U. S. A. 103 (2006), 5072–5077.
    • (2006) Proc. Natl Acad. Sci. U. S. A. , vol.103 , pp. 5072-5077
    • Eldor, R.1
  • 83
    • 0035966006 scopus 로고    scopus 로고
    • A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells
    • Cardozo, A.K., et al. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J. Biol. Chem. 276 (2001), 48879–48886.
    • (2001) J. Biol. Chem. , vol.276 , pp. 48879-48886
    • Cardozo, A.K.1
  • 84
    • 44749083828 scopus 로고    scopus 로고
    • Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells
    • Ortis, F., et al. Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells. Diabetologia 51 (2008), 1213–1225.
    • (2008) Diabetologia , vol.51 , pp. 1213-1225
    • Ortis, F.1
  • 85
    • 0035488777 scopus 로고    scopus 로고
    • Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents beta-cell apoptosis
    • Heimberg, H., et al. Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents beta-cell apoptosis. Diabetes 50 (2001), 2219–2224.
    • (2001) Diabetes , vol.50 , pp. 2219-2224
    • Heimberg, H.1
  • 86
    • 0035746917 scopus 로고    scopus 로고
    • Expression of a dominant negative inhibitor of NF-κB protects MIN6 beta-cells from cytokine-induced apoptosis
    • Baker, M.S., et al. Expression of a dominant negative inhibitor of NF-κB protects MIN6 beta-cells from cytokine-induced apoptosis. J. Surg. Res. 97 (2001), 117–122.
    • (2001) J. Surg. Res. , vol.97 , pp. 117-122
    • Baker, M.S.1
  • 87
    • 84964697787 scopus 로고    scopus 로고
    • Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
    • Malle, E.K., et al. Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity. J. Exp. Med. 212 (2015), 1239–1254.
    • (2015) J. Exp. Med. , vol.212 , pp. 1239-1254
    • Malle, E.K.1
  • 88
    • 84874646329 scopus 로고    scopus 로고
    • The endothelium in diabetes: its role in insulin access and diabetic complications
    • Kolka, C.M., Bergman, R.N., The endothelium in diabetes: its role in insulin access and diabetic complications. Rev. Endocr. Metab. Disord. 14 (2013), 13–19.
    • (2013) Rev. Endocr. Metab. Disord. , vol.14 , pp. 13-19
    • Kolka, C.M.1    Bergman, R.N.2
  • 89
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance
    • Odegaard, J.I., et al. Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance. Cell Metab. 7 (2008), 496–507.
    • (2008) Cell Metab. , vol.7 , pp. 496-507
    • Odegaard, J.I.1
  • 90
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn, O., Olefsky, J.M., The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 18 (2012), 363–374.
    • (2012) Nat. Med. , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 91
    • 84918563183 scopus 로고    scopus 로고
    • Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?
    • Kraakman, M.J., et al. Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?. Front. Immunol., 5, 2014, 470.
    • (2014) Front. Immunol. , vol.5 , pp. 470
    • Kraakman, M.J.1
  • 92
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F.R., et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004), 285–296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 93
    • 84940417328 scopus 로고    scopus 로고
    • Activated Kupffer cells inhibit insulin sensitivity in obese mice
    • Tencerova, M., et al. Activated Kupffer cells inhibit insulin sensitivity in obese mice. FASEB J. 29 (2015), 2959–2969.
    • (2015) FASEB J. , vol.29 , pp. 2959-2969
    • Tencerova, M.1
  • 94
    • 84878782369 scopus 로고    scopus 로고
    • Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity
    • Donath, M.Y., et al. Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity. Cell Metab. 17 (2013), 860–872.
    • (2013) Cell Metab. , vol.17 , pp. 860-872
    • Donath, M.Y.1
  • 95
    • 84856641109 scopus 로고    scopus 로고
    • NF-κB, the first quarter-century: remarkable progress and outstanding questions
    • Hayden, M.S., Ghosh, S., NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 26 (2012), 203–234.
    • (2012) Genes Dev. , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 96
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-κB signaling pathway
    • Sun, S.-C., Non-canonical NF-κB signaling pathway. Cell Res. 21 (2011), 71–85.
    • (2011) Cell Res. , vol.21 , pp. 71-85
    • Sun, S.-C.1
  • 97
    • 84976285443 scopus 로고    scopus 로고
    • The unfolded protein response in immunity and inflammation
    • Grootjans, J., et al. The unfolded protein response in immunity and inflammation. Nat. Rev. Immunol. 16 (2016), 469–484.
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 469-484
    • Grootjans, J.1


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