Inactivation of NF-κB p65 (RelA) in liver improves insulin sensitivity and inhibits cAMP/PKA pathway

Diabetes

Volumn 64, Issue 10, 2015, Pages 3355-3362

  Ke, Bilun ^a,b   Zhao, Zhiyun ^b   Ye, Xin ^b   Gao, Zhanguo ^c   Manganiello, Vincent ^d   Wu, Bin ^a   Ye, Jianping ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c XINXIANG MEDICAL UNIVERSITY   (China)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3B; I KAPPA B KINASE ALPHA; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PROTEIN KINASE B; PYRUVIC ACID; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; FAT INTAKE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; PDE3B PROTEIN, HUMAN; PHOSPHODIESTERASE III;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BODY COMPOSITION; BODY WEIGHT; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME PHOSPHORYLATION; FOOD INTAKE; GENE DELETION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLUCONEOGENESIS; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; ENERGY METABOLISM; FAT INTAKE; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; INFLAMMATION; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIVER; METABOLISM; PHYSIOLOGY;

ANIMALS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DIETARY FATS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; PROMOTER REGIONS, GENETIC; TRANSCRIPTION FACTOR RELA;

EID: 84976297627     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0242     Document Type: Article

References (27)

1. Yuan M, Konstantopoulos N, Lee J, et al. Reversal of obesity- and dietinduced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001;293:1673-1677
2. Röhl M, Pasparakis M, Baudler S, et al. Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest 2004;113:474-481
3. Arkan MC, Hevener AL, Greten FR, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005;11:191-198
4. Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005;11:183-190
5. Cai D, Frantz JD, Tawa NE Jr, et al. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 2004;119:285-298
6. Jiao P, Feng B, Ma J, et al. Constitutive activation of IKKβ in adipose tissue prevents diet-induced obesity in mice. Endocrinology 2012;153:154-165
7. Zhang J, Gao Z, Yin J, Quon MJ, Ye J. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(α) signaling through IKK2. J Biol Chem 2008;283:35375-35382
8. Gao Z, Hwang D, Bataille F, et al. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 2002;277:48115-48121
9. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995;376:167-170
10. Gao Z, Zhang J, Henagan TM, et al. P65 inactivation in adipocytes and macrophages attenuates adipose inflammatory response in lean but not in obese mice. Am J Physiol Endocrinol Metab 2015;308:E496-E505
11. Gao Z, Yin J, Zhang J, He Q, McGuinness OP, Ye J. Inactivation of NF-kappaB p50 Leads to insulin sensitization in liver through post-translational inhibition of p70S6K. J Biol Chem 2009;284:18368-18376
12. Tang T, Zhang J, Yin J, et al. Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem 2010;285:4637-4644
13. Hofmann SM, Zhou L, Perez-Tilve D, et al. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest 2007;117:3271-3282
14. Liu H, Tang JR, Choi YH, et al. Importance of cAMP-response elementbinding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes. J Biol Chem 2006;281:21096-21113
15. Gao Z, He Q, Peng B, Chiao PJ, Ye J. Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function. J Biol Chem 2006;281:4540-4547
16. Young SH, Ye J, Frazer DG, Shi X, Castranova V. Molecular mechanism of tumor necrosis factor-alpha production in 1→3-beta-glucan (zymosan)-activated macrophages. J Biol Chem 2001;276:20781-20787
17. Ye J, Zhang X, Dong Z. Characterization of the human granulocytemacrophage colony-stimulating factor gene promoter: an AP1 complex and an Sp1-related complex transactivate the promoter activity that is suppressed by a YY1 complex. Mol Cell Biol 1996;16:157-167
18. Degerman E, Ahmad F, Chung YW, et al. From PDE3B to the regulation of energy homeostasis. Curr Opin Pharmacol 2011;11:676-682
19. Ye J, McGuinness OP. Inflammation during obesity is not all bad: evidence from animal and human studies. Am J Physiol Endocrinol Metab 2013;304:E466-E477
20. Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 2007;76:481-511
21. Guirguis E, Hockman S, Chung YW, et al. A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice. Endocrinology 2013;154:3152-3167
22. Choi YH, Park S, Hockman S, et al. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J Clin Invest 2006;116:3240-3251
23. Wada T, Onogi Y, Kimura Y, et al. Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions. Eur J Pharmacol 2013;707:120-129
24. Rahn Landström T, Mei J, Karlsson M, Manganiello V, Degerman E. Downregulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP. Biochem J 2000;346:337-343
25. Razani B, Reichardt AD, Cheng G. Non-canonical NF-κB signaling activation and regulation: principles and perspectives. Immunol Rev 2011;244:44-54
26. Sheng L, Zhou Y, Chen Z, et al. NF-κB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med 2012;18:943-949
27. Mowers J, Uhm M, Reilly SM, et al. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKϵ and TBK1. eLife 2013;2:e01119