IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity

Diabetes

Volumn 63, Issue 10, 2014, Pages 3334-3345

  Weissmann, Laís ^a   Quaresma, Paula G F ^a   Santos, Andressa C ^a   De Matos, Alexandre H B ^a   Pascoal, Vínicius D'Ávila Bittencourt ^a   Zanotto, Tamires M ^a   Castro, Gisele ^a   Guadagnini, Dioze ^a   Silva, Joelcimar Martins Da ^b   Velloso, Licio A ^a   Bittencourt, Jackson C ^b   Lopes Cendes, Iscia ^a   Saad, Mario J A ^a   Prada, Patricia O ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; JANUS KINASE 2; LEPTIN; MESSENGER RNA; PROTEIN KINASE B; PYRUVIC ACID; SMALL INTERFERING RNA; STAT3 PROTEIN; I KAPPA B KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; ENERGY BALANCE; ENERGY EXPENDITURE; ENZYME PHOSPHORYLATION; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPOPHAGIA; HYPOTHALAMUS; INSULIN RESISTANCE; LIPID DIET; LIVER; MALE; METABOLIC PARAMETERS; MOUSE; NERVE CELL; NONHUMAN; OBESITY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THERMOGENESIS; UPREGULATION; ANIMAL; DRUG ANTAGONISM; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; BODY WEIGHT; DIET, HIGH-FAT; HYPOTHALAMUS; I-KAPPA B KINASE; INSULIN; INSULIN RESISTANCE; LEPTIN; LIVER; MALE; MICE; MICE, OBESE; NEURONS; OBESITY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84907546285     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1817     Document Type: Article

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