Inactivation of NF-ΚB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K

Journal of Biological Chemistry

Volumn 284, Issue 27, 2009, Pages 18368-18376

  Gao, Zhanguo ^a   Yin, Jun ^a   Zhang, Jin ^a   He, Qing ^a   McGuinness, Owen P ^b   Ye, Jianping ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; BLOOD GLUCOSE; BODY FATS; DRUG TARGETS; FOOD INTAKE; GLUCOSE PRODUCTION; GLUCOSE UPTAKE; HEPATOCYTES; INDUCED PROTEINS; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCK OUTS; METABOLIC PHENOTYPE; PRIMARY CULTURE; PROTEASOME INHIBITORS; SKELETAL MUSCLE; TRANSLATIONAL INHIBITION; TUMOR NECROSIS FACTORS; WILD TYPES;

DEGRADATION; GLUCOSE; LIVER; MUSCLE;

INSULIN;

GLUCOSE; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; S6 KINASE; TUMOR NECROSIS FACTOR ALPHA; CARRIER PROTEIN; FRAP1 PROTEIN, MOUSE; I KAPPA B KINASE; IKBKB PROTEIN, MOUSE; PHOSPHOTRANSFERASE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CONTROLLED STUDY; DRUG TARGETING; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME REGULATION; FIBROBLAST CULTURE; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORT; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; LIVER CELL; LIVER LEVEL; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; SKELETAL MUSCLE; WILD TYPE; ANIMAL; BODY WEIGHT; CELL CULTURE; CYTOLOGY; FAT INTAKE; FEMALE; FIBROBLAST; GENETICS; HYPERINSULINISM; LIVER; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; OBESITY; PHYSIOLOGY; PROTEIN PROCESSING;

MUS;

ANIMALS; BODY WEIGHT; CARRIER PROTEINS; CELLS, CULTURED; DIETARY FATS; FEMALE; FIBROBLASTS; GLUCOSE CLAMP TECHNIQUE; HEPATOCYTES; HYPERINSULINISM; I-KAPPA B KINASE; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; NF-KAPPA B P50 SUBUNIT; OBESITY; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67650566364     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.007260     Document Type: Article

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