Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

Nature Structural and Molecular Biology

Volumn 24, Issue 4, 2017, Pages 370-378

  Liu, Qingbo ^a   Acharya, Priyamvada ^a,b   Dolan, Michael A ^a   Zhang, Peng ^a   Guzzo, Christina ^a   Lu, Jacky ^a   Kwon, Alice ^a   Gururani, Deepali ^a   Miao, Huiyi ^a   Bylund, Tatsiana ^a   Chuang, Gwo Yu ^a   Druz, Aliaksandr ^a   Zhou, Tongqing ^a   Rice, William J ^b   Wigge, Christoph ^b   Carragher, Bridget ^b   Potter, Clinton S ^b   Kwong, Peter D ^a   Lusso, Paolo ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; PROTEIN BINDING;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; CONFORMATIONAL TRANSITION; CRYOELECTRON MICROSCOPY; ELECTRON MICROSCOPY; ENVELOPE GENE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SOMATIC HYPERMUTATION; STOICHIOMETRY; SURFACE AREA; SURFACE PROPERTY; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; HEK293 CELL LINE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KINETICS; METABOLISM; MUTAGENESIS; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; SURFACE PLASMON RESONANCE; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; BINDING SITES; CRYOELECTRON MICROSCOPY; HEK293 CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; KINETICS; MUTAGENESIS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; SURFACE PLASMON RESONANCE;

EID: 85013157801     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3382     Document Type: Article

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