Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

Structure

Volumn 8, Issue 12, 2000, Pages 1329-1339

  Kwong, P D ^a   Wyatt, R ^a   Majeed, S ^a   Robinson, J ^a   Sweet, R W ^a   Sodroski, J ^a   Hendrickson, W A ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

17b; Antibody; CD4, complex; X ray

Indexed keywords

GLYCOPROTEIN GP 120; VIRUS GLYCOPROTEIN;

ANTIGEN BINDING; ARTICLE; CRYSTAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; COMPUTER SIMULATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, HIV;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034482696     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00547-5     Document Type: Article

References (74)

1. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS)
2. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
3. Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene
4. Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients
5. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III
6. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
7. HIV-1 entry co-factor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
8. Identification of a major co-receptor for primary isolates of HIV-1
9. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
10. HIV-1 entry into CD4+ cells is mediatd by the chemokine receptor CC-CKR-5
11. Cc CKR5: A Rantes, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
12. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
13. Core structure of gp41 from the HIV envelope glycoprotein
14. Atomic structure of the ectodomain from HIV-1 gp41
15. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
16. Energetics of the HIV gp120-CD4 binding reaction
17. The antigenic structure of the human immunodeficiency virus gp120 envelope glycoprotein
18. The HIV-1 envelope glycoproteins: Fusogens, antigens and immunogens
19. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR
20. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
21. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor
22. Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
23. A conserved human immunodeficiency virus gp120 glycoprotein structure involved in chemokine receptor binding
24. Tyrosine sulfation of the amino ternimus of CCR5 facilitates HIV-1 entry
25. Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera
26. Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates
27. Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization
28. Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1
29. The V1/V2 region of human immunodeficiency virus type 1 modulates the sensitivity to neutralization by soluble CD4 and cellular tropism
30. Determinants of HIV-1 envelope glycoprotein activation by sCD4 and monoclonal antibodies
31. Rapid selection for an N-linked oligosaccharide by monoclonal antibodies directed against the V3 loop of human immunodeficiency virus type 1
32. V2 loop glycosylation of the human immunodeficiecy virus type 1 SF162 envelope facilitates interaction of this protein with CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4 binding site antibodies
33. Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex
34. The neutralizing antibody response to HIV-1: Viral evasion and escape from humoral immunity
35. Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: Identification of replication-competent and -defective viral genomes
36. Why protein crystals favour some space-groups over others
37. Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1)
38. Use of cryoprotectants in combination with immiscible oils for flash cooling macromolecular crystals
39. Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus (HIV)
40. Profile of a quasispecies: The selected mutational landscape of HIV and Influenza
41. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
42. Crystal structure of an HIV-binding recombinant fragment of human CD4
43. Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices
44. Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding
45. Dimeric association and segmental variability in the structure of human CD4
46. Selection for neutralization resistance of the simian/human immunodeficiency virus SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation
47. Determinants of neutralization resistance in the envelope glycoproteins of a simian-human immunodeficiency virus passaged in vivo
48. Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity
49. Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein 120 retention from sCD4-sensitive isolates
50. Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1
51. Critical role of enhanced CD4 affinity in laboratory adaptation of human immunodeficiency virus type 1
52. CD4, CXCR-4 and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1
53. The level of CD4 expression limits infection of primary Rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses
54. Envelope proteins from clinical isolates of human immunodeficiency virus type 1 that are refractory to neutralization by soluble CD4 possess high affinity for the CD4 receptor
55. Regulation of oxygen affinity of hemoglobin: Influence of structure of the globin on the heme iron
56. Intrapatient variability of HIV type 1 group O ANT70 during a 10-year follow-up
57. Human immunodeficiency virus type 1 envelope gene structure and diversity in vivo after cocultivation in vitro
58. Molecular characterization of biologically diverse envelope variants of human immunodeficiency virus type 1 derived from an individual
59. Biologically diverse molecular variants within a single HIV-1 isolate
60. Interaction of poliovirus receptor with poliovirus
61. Three-dimensional structure of poliovirus receptor bound to poliovirus
62. Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor
63. Structure of a human common cold virus and functional relationship to other picornaviruses
64. Three-dimensional structure of poliovirus at 2.9 Å resolution
65. Distribution of drug resistance mutations in type 3 poliovirus identifies three reginos involved in uncoating functions
66. Processing of X-ray diffraction data collected in oscillation mode
67. Crystallography & NMR system: A new software suite for macromolecular structure determination
68. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
69. A gentle vapor diffusion technique for cross-linking of protein crystals for cryocrystallography
70. AMoRe: An automated package for molecular replacement
71. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
72. Molscript: A program to produce both detailed and schematic plots of protein structures
73. Improved methods for building protein models in electron density maps and the location of errors in these models