Molecular architecture of native HIV-1 gp120 trimers

Nature

Volumn 455, Issue 7209, 2008, Pages 109-113

  Liu, Jun ^a   Bartesaghi, Alberto ^a   Borgnia, Mario J ^a   Sapiro, Guillermo ^b   Subramaniam, Sriram ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; MEMBRANE PROTEIN; NEUTRALIZING ANTIBODY;

ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS; IMAGE CLASSIFICATION; INFECTIOUS DISEASE; PROTEIN; TOMOGRAPHY; VIRUS;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; TOMOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 51349162563     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07159     Document Type: Article

References (30)

1. Dalgleish, A. G. et al. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312, 763-767 (1984).
2. Kwong, P. D. et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393, 648-659 (1998).
3. Zhou, T. et al. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature 445, 732-737 (2007).
4. Burton, D. R. et al. HIV vaccine design and the neutralizing antibody problem. Nature Immunol. 5, 233-236 (2004).
5. Huang, C. C. et al. Structure of a V3-containing HIV-1 gp120 core. Science 310, 1025-1028 (2005).
6. Kwong, P. D. et al. Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus. J. Virol. 74, 1961-1972 (2000).
7. Chen, B. et al. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature 433, 834-841 (2005).
8. Subramaniam, S. Bridging the imaging gap: Visualizing subcellular architecture with electron tomography. Curr. Opin. Microbiol. 8, 316-322 (2005).
9. Sattentau, Q. J. & Moore, J. P. Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding. J. Exp. Med. 174, 407-415 (1991).
10. Kwong, P. D. et al. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature 420, 678-682 (2002).
11. Chan, D. C. & Kim, P. S. HIV entry and its inhibition. Cell 93, 681-684 (1998).
12. Zanetti, G. et al. Cryo-electron tomographic structure of an immunodeficiency virus envelope complex in situ. PLoS Pathog. 2, e83 (2006).
13. Zhu, P. et al. Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature 441, 847-852 (2006).
14. Myszka, D. G. et al. Energetics of the HIV gp120-CD4 binding reaction. Proc. Natl Acad. Sci. USA 97, 9026-9031 (2000).
15. Wyatt, R. et al. The antigenic structure of the HIV gp120 envelope glycoprotein. Nature 393, 705-711 (1998).
16. Cao, J. et al. Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein. J. Virol. 71, 9808-9812 (1997).
17. Johnson, W. E. et al. A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelope. J. Virol. 76, 2075-2086 (2002).
18. Saunders, C. J. et al. The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner. J. Virol. 79, 9069-9080 (2005).
19. Gorny, M. K. et al. Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles. J. Virol. 79, 5232-5237 (2005).
20. Bennett, A. E. et al. Cryo electron tomographic analysis of an HIV neutralizing protein and its complex with native viral gp120. J. Biol. Chem. 282, 27754-27759 (2007).
21. Healey, D. et al. Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding. J. Exp. Med. 172, 1233-1242 (1990).
22. Ashish et al. Conformational rearrangement within the soluble domains of the CD4 receptor is ligand-specific. J. Biol. Chem. 283, 2761-2772 (2008).
23. Montefiori, D. et al. Antibody-based HIV-1 vaccines: Recent developments and future directions. PLoS Med. 4, e348 (2007).
24. Zwick, M. B. & Burton, D. R. HIV-1 neutralization: Mechanisms and relevance to vaccine design. Curr. HIV Res. 5, 608-624 (2007).
25. Sougrat, R. et al. Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry. PLoS Pathog. 3, e63 (2007).
26. Bartesaghi, A. et al. Classification and 3D averaging with missing wedge correction in biological electron tomography. J. Struct. Biol. 162, 436-450 (2008).
27. Goddard, T. D., Huang, C. C. & Ferrin, T. E. Visualizing density maps with UCSF Chimera. J. Struct. Biol. 157, 281-287 (2007).
28. Rossio, J. L. et al. Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. J. Virol. 72, 7992-8001 (1998).
29. Kremer, J. R., Mastronarde, D. N. & McIntosh, J. R. Computer visualization of three-dimensional image data using IMOD. J. Struct. Biol. 116, 71-76 (1996).
30. Winkler, H. 3D reconstruction and processing of volumetric data in cryo-electron tomography. J. Struct. Biol. 157, 126-137 (2007).