-
1
-
-
65549095878
-
Origins. On the origin of the immune system
-
Travis, J. Origins. On the origin of the immune system. Science 2009, 324, 580–582.
-
(2009)
Science
, vol.324
, pp. 580-582
-
-
Travis, J.1
-
2
-
-
84886055095
-
Pattern recognition theory and the launch of modern innate immunity
-
Medzhitov, R. Pattern recognition theory and the launch of modern innate immunity. J. Immunol. 2013, 191, 4473–4474.
-
(2013)
J. Immunol
, vol.191
, pp. 4473-4474
-
-
Medzhitov, R.1
-
3
-
-
0037066427
-
The danger model: A renewed sense of self
-
Matzinger, P. The danger model: A renewed sense of self. Science 2002, 296, 301–305.
-
(2002)
Science
, vol.296
, pp. 301-305
-
-
Matzinger, P.1
-
4
-
-
84893352557
-
Recognition of tumors by the innate immune system and natural killer cells
-
Marcus, A.; Gowen, B.G.; Thompson, T.W.; Iannello, A.; Ardolino, M.; Deng, W.; Wang, L.; Shifrin, N.; Raulet, D.H. Recognition of tumors by the innate immune system and natural killer cells. Adv. Immunol. 2014, 122, 91–128.
-
(2014)
Adv. Immunol
, vol.122
, pp. 91-128
-
-
Marcus, A.1
Gowen, B.G.2
Thompson, T.W.3
Iannello, A.4
Ardolino, M.5
Deng, W.6
Wang, L.7
Shifrin, N.8
Raulet, D.H.9
-
5
-
-
42549113527
-
Therapeutics targeting tumor immune escape: Towards the development of new generation anticancer vaccines
-
Mocellin, S.; Nitti, D. Therapeutics targeting tumor immune escape: Towards the development of new generation anticancer vaccines. Med. Res. Rev. 2008, 28, 413–444.
-
(2008)
Med. Res. Rev.
, vol.28
, pp. 413-444
-
-
Mocellin, S.1
Nitti, D.2
-
6
-
-
84927585373
-
Innate immune recognition of cancer
-
Woo, S.R.; Corrales, L.; Gajewski, T.F. Innate immune recognition of cancer. Annu. Rev. Immunol. 2015, 33, 445–474.
-
(2015)
Annu. Rev. Immunol
, vol.33
, pp. 445-474
-
-
Woo, S.R.1
Corrales, L.2
Gajewski, T.F.3
-
8
-
-
84960192170
-
Stimulator of interferon genes (STING): A “new chapter” in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity
-
Poltorak, A.; Kurmyshkina, O.; Volkova, T. Stimulator of interferon genes (STING): A “new chapter” in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine Growth Factor Rev. 2016, 29, 83–91.
-
(2016)
Cytokine Growth Factor Rev
, vol.29
, pp. 83-91
-
-
Poltorak, A.1
Kurmyshkina, O.2
Volkova, T.3
-
9
-
-
78650370346
-
Anticancer function of polyinosinic-polycytidylic acid
-
Cheng, Y.S.; Xu, F. Anticancer function of polyinosinic-polycytidylic acid. Cancer Biol. Ther. 2010, 10, 1219–1223.
-
(2010)
Cancer Biol. Ther
, vol.10
, pp. 1219-1223
-
-
Cheng, Y.S.1
Xu, F.2
-
10
-
-
84889885063
-
Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence
-
Kottke, T.; Boisgerault, N.; Diaz, R.M.; Donnelly, O.; Rommelfanger-Konkol, D.; Pulido, J.; Thompson, J.; Mukhopadhyay, D.; Kaspar, R.; Coffey, M.; et al. Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence. Nat. Med. 2013, 19, 1625–1631.
-
(2013)
Nat. Med
, vol.19
, pp. 1625-1631
-
-
Kottke, T.1
Boisgerault, N.2
Diaz, R.M.3
Donnelly, O.4
Rommelfanger-Konkol, D.5
Pulido, J.6
Thompson, J.7
Mukhopadhyay, D.8
Kaspar, R.9
Coffey, M.10
-
11
-
-
34548731406
-
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system
-
Berraondo, P.; Nouze, C.; Preville, X.; Ladant, D.; Leclerc, C. Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system. Cancer Res. 2007, 67, 8847–8855.
-
(2007)
Cancer Res
, vol.67
, pp. 8847-8855
-
-
Berraondo, P.1
Nouze, C.2
Preville, X.3
Ladant, D.4
Leclerc, C.5
-
12
-
-
84992315668
-
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
-
Moynihan, K.D.; Opel, C.F.; Szeto, G.L.; Tzeng, A.; Zhu, E.F.; Engreitz, J.M.; Williams, R.T.; Rakhra, K.; Zhang, M.H.; Rothschilds, A.M.; et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat. Med. 2016, 22, 1402–1410.
-
(2016)
Nat. Med
, vol.22
, pp. 1402-1410
-
-
Moynihan, K.D.1
Opel, C.F.2
Szeto, G.L.3
Tzeng, A.4
Zhu, E.F.5
Engreitz, J.M.6
Williams, R.T.7
Rakhra, K.8
Zhang, M.H.9
Rothschilds, A.M.10
-
13
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S.; Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4, 499–511.
-
(2004)
Nat. Rev. Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
14
-
-
84905658804
-
Toll-like receptors and prostate cancer
-
Zhao, S.; Zhang, Y.; Zhang, Q.; Wang, F.; Zhang, D. Toll-like receptors and prostate cancer. Front. Immunol. 2014, 5, 352.
-
(2014)
Front. Immunol.
, vol.5
, pp. 352
-
-
Zhao, S.1
Zhang, Y.2
Zhang, Q.3
Wang, F.4
Zhang, D.5
-
15
-
-
1542377424
-
A Toll-like receptor that prevents infection by uropathogenic bacteria
-
Zhang, D.; Zhang, G.; Hayden, M.S.; Greenblatt, M.B.; Bussey, C.; Flavell, R.A.; Ghosh, S. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004, 303, 1522–1526.
-
(2004)
Science
, vol.303
, pp. 1522-1526
-
-
Zhang, D.1
Zhang, G.2
Hayden, M.S.3
Greenblatt, M.B.4
Bussey, C.5
Flavell, R.A.6
Ghosh, S.7
-
16
-
-
84954511155
-
MAP1S protein regulates the phagocytosis of bacteria and Toll-like receptor (TLR) Signaling
-
Shi, M.; Zhang, Y.; Liu, L.; Zhang, T.; Han, F.; Cleveland, J.; Wang, F.; McKeehan, W.L.; Li, Y.; Zhang, D. MAP1S protein regulates the phagocytosis of bacteria and Toll-like receptor (TLR) Signaling. J. Biol. Chem. 2016, 291, 1243–1250.
-
(2016)
J. Biol. Chem
, vol.291
, pp. 1243-1250
-
-
Shi, M.1
Zhang, Y.2
Liu, L.3
Zhang, T.4
Han, F.5
Cleveland, J.6
Wang, F.7
McKeehan, W.L.8
Li, Y.9
Zhang, D.10
-
17
-
-
58149269348
-
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
-
Kim, S.; Takahashi, H.; Lin, W.W.; Descargues, P.; Grivennikov, S.; Kim, Y.; Luo, J.L.; Karin, M. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 2009, 457, 102–106.
-
(2009)
Nature
, vol.457
, pp. 102-106
-
-
Kim, S.1
Takahashi, H.2
Lin, W.W.3
Descargues, P.4
Grivennikov, S.5
Kim, Y.6
Luo, J.L.7
Karin, M.8
-
18
-
-
0037065909
-
Inflammatory response after open heart surgery: Release of heat-shock protein 70 and signaling through Toll-like receptor-4
-
Dybdahl, B.; Wahba, A.; Lien, E.; Flo, T.H.; Waage, A.; Qureshi, N.; Sellevold, O.F.; Espevik, T.; Sundan, A. Inflammatory response after open heart surgery: Release of heat-shock protein 70 and signaling through Toll-like receptor-4. Circulation 2002, 105, 685–690.
-
(2002)
Circulation
, vol.105
, pp. 685-690
-
-
Dybdahl, B.1
Wahba, A.2
Lien, E.3
Flo, T.H.4
Waage, A.5
Qureshi, N.6
Sellevold, O.F.7
Espevik, T.8
Sundan, A.9
-
19
-
-
36749051886
-
History of bacillus Calmette-Guerin and bladder cancer: An immunotherapy success story
-
Herr, H.W.; Morales, A. History of bacillus Calmette-Guerin and bladder cancer: An immunotherapy success story. J. Urol. 2008, 179, 53–56.
-
(2008)
J. Urol
, vol.179
, pp. 53-56
-
-
Herr, H.W.1
Morales, A.2
-
20
-
-
84961392683
-
Impact of 2-, 4- and 9-valent HPV vaccines on morbidity and mortality from cervical cancer
-
Luckett, R.; Feldman, S. Impact of 2-, 4- and 9-valent HPV vaccines on morbidity and mortality from cervical cancer. Hum. Vaccin. Immunother. 2016, 12, 1332–1342.
-
(2016)
Hum. Vaccin. Immunother
, vol.12
, pp. 1332-1342
-
-
Luckett, R.1
Feldman, S.2
-
21
-
-
84976350804
-
Application potential of Toll-like receptors in cancer immunotherapy: Systematic review
-
Shi, M.; Chen, X.; Ye, K.; Yao, Y.; Li, Y. Application potential of Toll-like receptors in cancer immunotherapy: Systematic review. Medicine (Baltimore) 2016, 95, e3951.
-
(2016)
Medicine (Baltimore)
, vol.95
-
-
Shi, M.1
Chen, X.2
Ye, K.3
Yao, Y.4
Li, Y.5
-
22
-
-
84918592462
-
SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines
-
Srivastava, A.K.; Dinc, G.; Sharma, R.K.; Yolcu, E.S.; Zhao, H.; Shirwan, H. SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines. Cancer Res. 2014, 74, 6441–6451.
-
(2014)
Cancer Res
, vol.74
, pp. 6441-6451
-
-
Srivastava, A.K.1
Dinc, G.2
Sharma, R.K.3
Yolcu, E.S.4
Zhao, H.5
Shirwan, H.6
-
23
-
-
84871217036
-
Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer
-
Adams, S.; Kozhaya, L.; Martiniuk, F.; Meng, T.C.; Chiriboga, L.; Liebes, L.; Hochman, T.; Shuman, N.; Axelrod, D.; Speyer, J.; et al. Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer. Clin. Cancer Res. 2012, 18, 6748–6757.
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 6748-6757
-
-
Adams, S.1
Kozhaya, L.2
Martiniuk, F.3
Meng, T.C.4
Chiriboga, L.5
Liebes, L.6
Hochman, T.7
Shuman, N.8
Axelrod, D.9
Speyer, J.10
-
24
-
-
84877867769
-
Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist
-
Burdelya, L.G.; Brackett, C.M.; Kojouharov, B.; Gitlin, I.I.; Leonova, K.I.; Gleiberman, A.S.; Aygun-Sunar, S.; Veith, J.; Johnson, C.; Haderski, G.J.; et al. Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist. Proc. Natl. Acad. Sci. USA 2013, 110, E1857–E1866.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E1857-E1866
-
-
Burdelya, L.G.1
Brackett, C.M.2
Kojouharov, B.3
Gitlin, I.I.4
Leonova, K.I.5
Gleiberman, A.S.6
Aygun-Sunar, S.7
Veith, J.8
Johnson, C.9
Haderski, G.J.10
-
25
-
-
84866754613
-
Prolonged subcutaneous administration of 852A, a novel systemic Toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies
-
Weigel, B.J.; Cooley, S.; DeFor, T.; Weisdorf, D.J.; Panoskaltsis-Mortari, A.; Chen, W.; Blazar, B.R.; Miller, J.S. Prolonged subcutaneous administration of 852A, a novel systemic Toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies. Am. J. Hematol. 2012, 87, 953–956.
-
(2012)
Am. J. Hematol
, vol.87
, pp. 953-956
-
-
Weigel, B.J.1
Cooley, S.2
Defor, T.3
Weisdorf, D.J.4
Panoskaltsis-Mortari, A.5
Chen, W.6
Blazar, B.R.7
Miller, J.S.8
-
26
-
-
77954646180
-
Intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma: A phase II study
-
Carpentier, A.; Metellus, P.; Ursu, R.; Zohar, S.; Lafitte, F.; Barrie, M.; Meng, Y.; Richard, M.; Parizot, C.; Laigle-Donadey, F.; et al. Intracerebral administration of CpG oligonucleotide for patients with recurrent glioblastoma: A phase II study. Neuro Oncol. 2010, 12, 401–408.
-
(2010)
Neuro Oncol
, vol.12
, pp. 401-408
-
-
Carpentier, A.1
Metellus, P.2
Ursu, R.3
Zohar, S.4
Lafitte, F.5
Barrie, M.6
Meng, Y.7
Richard, M.8
Parizot, C.9
Laigle-Donadey, F.10
-
27
-
-
84921289568
-
Poly(I:C) as cancer vaccine adjuvant: Knocking on the door of medical breakthroughs
-
Ammi, R.; De Waele, J.; Willemen, Y.; Van Brussel, I.; Schrijvers, D.M.; Lion, E.; Smits, E.L. Poly(I:C) as cancer vaccine adjuvant: Knocking on the door of medical breakthroughs. Pharmacol. Ther. 2015, 146, 120–131.
-
(2015)
Pharmacol. Ther
, vol.146
, pp. 120-131
-
-
Ammi, R.1
De Waele, J.2
Willemen, Y.3
Van Brussel, I.4
Schrijvers, D.M.5
Lion, E.6
Smits, E.L.7
-
28
-
-
55549114663
-
′ -Triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma
-
′ -Triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma. Nat. Med. 2008, 14, 1256–1263.
-
(2008)
Nat. Med
, vol.14
, pp. 1256-1263
-
-
Poeck, H.1
Besch, R.2
Maihoefer, C.3
Renn, M.4
Tormo, D.5
Morskaya, S.S.6
Kirschnek, S.7
Gaffal, E.8
Landsberg, J.9
Hellmuth, J.10
-
29
-
-
84875464528
-
Therapeutic efficacy of bifunctional siRNA combining TGF-beta1 silencing with RIG-I activation in pancreatic cancer
-
Ellermeier, J.; Wei, J.; Duewell, P.; Hoves, S.; Stieg, M.R.; Adunka, T.; Noerenberg, D.; Anders, H.J.; Mayr, D.; Poeck, H.; et al. Therapeutic efficacy of bifunctional siRNA combining TGF-beta1 silencing with RIG-I activation in pancreatic cancer. Cancer Res. 2013, 73, 1709–1720.
-
(2013)
Cancer Res
, vol.73
, pp. 1709-1720
-
-
Ellermeier, J.1
Wei, J.2
Duewell, P.3
Hoves, S.4
Stieg, M.R.5
Adunka, T.6
Noerenberg, D.7
Anders, H.J.8
Mayr, D.9
Poeck, H.10
-
30
-
-
84869233969
-
TRAIL and Noxa are selectively upregulated in prostate cancer cells downstream of the RIG-I/MAVS signaling pathway by nonreplicating Sendai virus particles
-
Matsushima-Miyagi, T.; Hatano, K.; Nomura, M.; Li-Wen, L.; Nishikawa, T.; Saga, K.; Shimbo, T.; Kaneda, Y. TRAIL and Noxa are selectively upregulated in prostate cancer cells downstream of the RIG-I/MAVS signaling pathway by nonreplicating Sendai virus particles. Clin. Cancer Res. 2012, 18, 6271–6283.
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 6271-6283
-
-
Matsushima-Miyagi, T.1
Hatano, K.2
Nomura, M.3
Li-Wen, L.4
Nishikawa, T.5
Saga, K.6
Shimbo, T.7
Kaneda, Y.8
-
31
-
-
79960022868
-
Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma
-
Matsuda, M.; Nimura, K.; Shimbo, T.; Hamasaki, T.; Yamamoto, T.; Matsumura, A.; Kaneda, Y. Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma. J. Neurooncol. 2011, 103, 19–31.
-
(2011)
J. Neurooncol
, vol.103
, pp. 19-31
-
-
Matsuda, M.1
Nimura, K.2
Shimbo, T.3
Hamasaki, T.4
Yamamoto, T.5
Matsumura, A.6
Kaneda, Y.7
-
32
-
-
80053152683
-
Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells
-
Kubler, K.; tho Pesch, C.; Gehrke, N.; Riemann, S.; Dassler, J.; Coch, C.; Landsberg, J.; Wimmenauer, V.; Polcher, M.; Rudlowski, C.; et al. Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells. Eur. J. Immunol. 2011, 41, 3028–3039.
-
(2011)
Eur. J. Immunol
, vol.41
, pp. 3028-3039
-
-
Kubler, K.1
Tho Pesch, C.2
Gehrke, N.3
Riemann, S.4
Dassler, J.5
Coch, C.6
Landsberg, J.7
Wimmenauer, V.8
Polcher, M.9
Rudlowski, C.10
-
33
-
-
84909633729
-
Pancreatic cancer-specific cell death induced in vivo by cytoplasmic-delivered polyinosine-polycytidylic acid
-
Bhoopathi, P.; Quinn, B.A.; Gui, Q.; Shen, X.N.; Grossman, S.R.; Das, S.K.; Sarkar, D.; Fisher, P.B.; Emdad, L. Pancreatic cancer-specific cell death induced in vivo by cytoplasmic-delivered polyinosine-polycytidylic acid. Cancer Res. 2014, 74, 6224–6235.
-
(2014)
Cancer Res
, vol.74
, pp. 6224-6235
-
-
Bhoopathi, P.1
Quinn, B.A.2
Gui, Q.3
Shen, X.N.4
Grossman, S.R.5
Das, S.K.6
Sarkar, D.7
Fisher, P.B.8
Emdad, L.9
-
34
-
-
84954405682
-
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response
-
Li, T.; Cheng, H.; Yuan, H.; Xu, Q.; Shu, C.; Zhang, Y.; Xu, P.; Tan, J.; Rui, Y.; Li, P.; et al. Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response. Sci. Rep. 2016, 6, 19049.
-
(2016)
Sci. Rep
, vol.6
-
-
Li, T.1
Cheng, H.2
Yuan, H.3
Xu, Q.4
Shu, C.5
Zhang, Y.6
Xu, P.7
Tan, J.8
Rui, Y.9
-
35
-
-
84940172128
-
Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma
-
Nakamura, T.; Miyabe, H.; Hyodo, M.; Sato, Y.; Hayakawa, Y.; Harashima, H. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J. Control. Release 2015, 216, 149–157.
-
(2015)
J. Control. Release
, vol.216
, pp. 149-157
-
-
Nakamura, T.1
Miyabe, H.2
Hyodo, M.3
Sato, Y.4
Hayakawa, Y.5
Harashima, H.6
-
36
-
-
84928199174
-
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
-
283ra252
-
Fu, J.; Kanne, D.B.; Leong, M.; Glickman, L.H.; McWhirter, S.M.; Lemmens, E.; Mechette, K.; Leong, J.J.; Lauer, P.; Liu, W.; et al. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. Sci. Transl. Med. 2015, 7, 283ra252.
-
(2015)
Sci. Transl. Med
, vol.7
-
-
Fu, J.1
Kanne, D.B.2
Leong, M.3
Glickman, L.H.4
McWhirter, S.M.5
Lemmens, E.6
Mechette, K.7
Leong, J.J.8
Lauer, P.9
Liu, W.10
-
37
-
-
84865145772
-
The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells
-
Shatz, M.; Menendez, D.; Resnick, M.A. The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells. Cancer Res. 2012, 72, 3948–3957.
-
(2012)
Cancer Res
, vol.72
, pp. 3948-3957
-
-
Shatz, M.1
Menendez, D.2
Resnick, M.A.3
-
38
-
-
84875189381
-
Molecular pathways: Toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity
-
Ridnour, L.A.; Cheng, R.Y.; Switzer, C.H.; Heinecke, J.L.; Ambs, S.; Glynn, S.; Young, H.A.; Trinchieri, G.; Wink, D.A. Molecular pathways: Toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity. Clin. Cancer Res. 2013, 19, 1340–1346.
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 1340-1346
-
-
Ridnour, L.A.1
Cheng, R.Y.2
Switzer, C.H.3
Heinecke, J.L.4
Ambs, S.5
Glynn, S.6
Young, H.A.7
Trinchieri, G.8
Wink, D.A.9
-
39
-
-
84899883271
-
MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression
-
Shi, M.; Yao, Y.; Han, F.; Li, Y. MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression. PLoS ONE 2014, 9, e86839.
-
(2014)
Plos ONE
, vol.9
-
-
Shi, M.1
Yao, Y.2
Han, F.3
Li, Y.4
-
40
-
-
84855174166
-
Toll-like receptor transcriptome in the HPV-positive cervical cancer microenvironment
-
DeCarlo, C.A.; Rosa, B.; Jackson, R.; Niccoli, S.; Escott, N.G.; Zehbe, I. Toll-like receptor transcriptome in the HPV-positive cervical cancer microenvironment. Clin. Dev. Immunol. 2012, 2012, 785825.
-
(2012)
Clin. Dev. Immunol.
, vol.2012
, pp. 785825
-
-
Decarlo, C.A.1
Rosa, B.2
Jackson, R.3
Niccoli, S.4
Escott, N.G.5
Zehbe, I.6
-
41
-
-
79953320415
-
Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth
-
Cai, Z.; Sanchez, A.; Shi, Z.; Zhang, T.; Liu, M.; Zhang, D. Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth. Cancer Res. 2011, 71, 2466–2475.
-
(2011)
Cancer Res
, vol.71
, pp. 2466-2475
-
-
Cai, Z.1
Sanchez, A.2
Shi, Z.3
Zhang, T.4
Liu, M.5
Zhang, D.6
-
42
-
-
0036921999
-
Roles of Toll-like receptors in natural interferon-producing cells as sensors in immune surveillance
-
Ito, T.; Amakawa, R.; Fukuhara, S. Roles of Toll-like receptors in natural interferon-producing cells as sensors in immune surveillance. Hum. Immunol. 2002, 63, 1120–1125.
-
(2002)
Hum. Immunol
, vol.63
, pp. 1120-1125
-
-
Ito, T.1
Amakawa, R.2
Fukuhara, S.3
-
43
-
-
84856939962
-
TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: Mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity
-
Kalb, M.L.; Glaser, A.; Stary, G.; Koszik, F.; Stingl, G. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: Mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. J. Immunol. 2012, 188, 1583–1591.
-
(2012)
J. Immunol
, vol.188
, pp. 1583-1591
-
-
Kalb, M.L.1
Glaser, A.2
Stary, G.3
Koszik, F.4
Stingl, G.5
-
44
-
-
80052556774
-
HMGB1 and microparticles as mediators of the immune response to cell death
-
Pisetsky, D.S.; Gauley, J.; Ullal, A.J. HMGB1 and microparticles as mediators of the immune response to cell death. Antioxid. Redox Sign. 2011, 15, 2209–2219.
-
(2011)
Antioxid. Redox Sign
, vol.15
, pp. 2209-2219
-
-
Pisetsky, D.S.1
Gauley, J.2
Ullal, A.J.3
-
45
-
-
20444432334
-
Toll-like receptors on tumor cells facilitate evasion of immune surveillance
-
Huang, B.; Zhao, J.; Li, H.; He, K.L.; Chen, Y.; Chen, S.H.; Mayer, L.; Unkeless, J.C.; Xiong, H. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res. 2005, 65, 5009–5014.
-
(2005)
Cancer Res
, vol.65
, pp. 5009-5014
-
-
Huang, B.1
Zhao, J.2
Li, H.3
He, K.L.4
Chen, Y.5
Chen, S.H.6
Mayer, L.7
Unkeless, J.C.8
Xiong, H.9
-
46
-
-
37849032618
-
Cancers take their Toll—The function and regulation of Toll-like receptors in cancer cells
-
Chen, R.; Alvero, A.B.; Silasi, D.A.; Steffensen, K.D.; Mor, G. Cancers take their Toll—The function and regulation of Toll-like receptors in cancer cells. Oncogene 2008, 27, 225–233.
-
(2008)
Oncogene
, vol.27
, pp. 225-233
-
-
Chen, R.1
Alvero, A.B.2
Silasi, D.A.3
Steffensen, K.D.4
Mor, G.5
-
47
-
-
0037180757
-
Inflammation and cancer
-
Coussens, L.M.; Werb, Z. Inflammation and cancer. Nature 2002, 420, 860–867.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
48
-
-
58149231380
-
Cancer: Inflaming metastasis
-
Mantovani, A. Cancer: Inflaming metastasis. Nature 2009, 457, 36–37.
-
(2009)
Nature
, vol.457
, pp. 36-37
-
-
Mantovani, A.1
-
49
-
-
84931562356
-
Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9
-
Liu, Y.; Yan, W.; Tohme, S.; Chen, M.; Fu, Y.; Tian, D.; Lotze, M.; Tang, D.; Tsung, A. Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9. J. Hepatol. 2015, 63, 114–121.
-
(2015)
J. Hepatol
, vol.63
, pp. 114-121
-
-
Liu, Y.1
Yan, W.2
Tohme, S.3
Chen, M.4
Fu, Y.5
Tian, D.6
Lotze, M.7
Tang, D.8
Tsung, A.9
-
50
-
-
84992126289
-
The role of Toll-Like Receptors in hematopoietic malignancies
-
Monlish, D.A.; Bhatt, S.T.; Schuettpelz, L.G. The role of Toll-Like Receptors in hematopoietic malignancies. Front. Immunol. 2016, 7, 390.
-
(2016)
Front. Immunol.
, vol.7
, pp. 390
-
-
Monlish, D.A.1
Bhatt, S.T.2
Schuettpelz, L.G.3
-
51
-
-
84867605321
-
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation
-
Tye, H.; Kennedy, C.L.; Najdovska, M.; McLeod, L.; McCormack, W.; Hughes, N.; Dev, A.; Sievert, W.; Ooi, C.H.; Ishikawa, T.O.; et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 2012, 22, 466–478.
-
(2012)
Cancer Cell
, vol.22
, pp. 466-478
-
-
Tye, H.1
Kennedy, C.L.2
Najdovska, M.3
McLeod, L.4
McCormack, W.5
Hughes, N.6
Dev, A.7
Sievert, W.8
Ooi, C.H.9
Ishikawa, T.O.10
-
52
-
-
84940380708
-
Enhancing cancer immunotherapy via activation of innate immunity
-
Goldberg, J.L.; Sondel, P.M. Enhancing cancer immunotherapy via activation of innate immunity. Semin. Oncol. 2015, 42, 562–572.
-
(2015)
Semin. Oncol
, vol.42
, pp. 562-572
-
-
Goldberg, J.L.1
Sondel, P.M.2
-
53
-
-
84872801225
-
Trial Watch: Experimental Toll-like receptor agonists for cancer therapy
-
Galluzzi, L.; Vacchelli, E.; Eggermont, A.; Fridman, W.H.; Galon, J.; Sautes-Fridman, C.; Tartour, E.; Zitvogel, L.; Kroemer, G. Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology 2012, 1, 699–716.
-
(2012)
Oncoimmunology
, vol.1
, pp. 699-716
-
-
Galluzzi, L.1
Vacchelli, E.2
Eggermont, A.3
Fridman, W.H.4
Galon, J.5
Sautes-Fridman, C.6
Tartour, E.7
Zitvogel, L.8
Kroemer, G.9
-
54
-
-
84863862334
-
Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner
-
Koizumi, S.; Masuko, K.; Wakita, D.; Tanaka, S.; Mitamura, R.; Kato, Y.; Tabata, H.; Nakahara, M.; Kitamura, H.; Nishimura, T. Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner. Cell. Immunol. 2012, 276, 153–161.
-
(2012)
Cell. Immunol
, vol.276
, pp. 153-161
-
-
Koizumi, S.1
Masuko, K.2
Wakita, D.3
Tanaka, S.4
Mitamura, R.5
Kato, Y.6
Tabata, H.7
Nakahara, M.8
Kitamura, H.9
Nishimura, T.10
-
55
-
-
84871230007
-
Synergy of topical Toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer
-
Dewan, M.Z.; Vanpouille-Box, C.; Kawashima, N.; DiNapoli, S.; Babb, J.S.; Formenti, S.C.; Adams, S.; Demaria, S. Synergy of topical Toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer. Clin. Cancer Res. 2012, 18, 6668–6678.
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 6668-6678
-
-
Dewan, M.Z.1
Vanpouille-Box, C.2
Kawashima, N.3
Dinapoli, S.4
Babb, J.S.5
Formenti, S.C.6
Adams, S.7
Demaria, S.8
-
56
-
-
40149085707
-
Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (Poly A:U) for locally advanced gastric cancer after curative surgery: Final results of 15-year follow-up
-
Jeung, H.C.; Moon, Y.W.; Rha, S.Y.; Yoo, N.C.; Roh, J.K.; Noh, S.H.; Min, J.S.; Kim, B.S.; Chung, H.C. Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (poly A:U) for locally advanced gastric cancer after curative surgery: Final results of 15-year follow-up. Ann. Oncol. 2008, 19, 520–526.
-
(2008)
Ann. Oncol.
, vol.19
, pp. 520-526
-
-
Jeung, H.C.1
Moon, Y.W.2
Rha, S.Y.3
Yoo, N.C.4
Roh, J.K.5
Noh, S.H.6
Min, J.S.7
Kim, B.S.8
Chung, H.C.9
-
57
-
-
84871922810
-
Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice
-
Van De Voort, T.J.; Felder, M.A.; Yang, R.K.; Sondel, P.M.; Rakhmilevich, A.L. Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice. J. Immunother. 2013, 36, 29–40.
-
(2013)
J. Immunother
, vol.36
, pp. 29-40
-
-
Van De Voort, T.J.1
Felder, M.A.2
Yang, R.K.3
Sondel, P.M.4
Rakhmilevich, A.L.5
-
58
-
-
84941790061
-
TLR activation and ionizing radiation induce strong immune responses against multiple tumor entities
-
Scholch, S.; Rauber, C.; Weitz, J.; Koch, M.; Huber, P.E. TLR activation and ionizing radiation induce strong immune responses against multiple tumor entities. Oncoimmunology 2015, 4, e1042201.
-
(2015)
Oncoimmunology
, vol.4
-
-
Scholch, S.1
Rauber, C.2
Weitz, J.3
Koch, M.4
Huber, P.E.5
-
59
-
-
84887494213
-
Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion
-
Tel, J.; Sittig, S.P.; Blom, R.A.; Cruz, L.J.; Schreibelt, G.; Figdor, C.G.; de Vries, I.J. Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion. J. Immunol. 2013, 191, 5005–5012.
-
(2013)
J. Immunol
, vol.191
, pp. 5005-5012
-
-
Tel, J.1
Sittig, S.P.2
Blom, R.A.3
Cruz, L.J.4
Schreibelt, G.5
Figdor, C.G.6
De Vries, I.J.7
-
60
-
-
0142092614
-
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
-
Le Bon, A.; Etchart, N.; Rossmann, C.; Ashton, M.; Hou, S.; Gewert, D.; Borrow, P.; Tough, D.F. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat. Immunol. 2003, 4, 1009–1015.
-
(2003)
Nat. Immunol
, vol.4
, pp. 1009-1015
-
-
Le Bon, A.1
Etchart, N.2
Rossmann, C.3
Ashton, M.4
Hou, S.5
Gewert, D.6
Borrow, P.7
Tough, D.F.8
-
61
-
-
84921047960
-
Viral RNA detection by RIG-I-like receptors
-
Yoneyama, M.; Onomoto, K.; Jogi, M.; Akaboshi, T.; Fujita, T. Viral RNA detection by RIG-I-like receptors. Curr. Opin. Immunol. 2015, 32, 48–53.
-
(2015)
Curr. Opin. Immunol
, vol.32
, pp. 48-53
-
-
Yoneyama, M.1
Onomoto, K.2
Jogi, M.3
Akaboshi, T.4
Fujita, T.5
-
62
-
-
84884157315
-
Master sensors of pathogenic RNA—RIG-I like receptors
-
Schlee, M. Master sensors of pathogenic RNA—RIG-I like receptors. Immunobiology 2013, 218, 1322–1335.
-
(2013)
Immunobiology
, vol.218
, pp. 1322-1335
-
-
Schlee, M.1
-
63
-
-
84869845792
-
A structure-based model of RIG-I activation
-
Kolakofsky, D.; Kowalinski, E.; Cusack, S. A structure-based model of RIG-I activation. RNA 2012, 18, 2118–2127.
-
(2012)
RNA
, vol.18
, pp. 2118-2127
-
-
Kolakofsky, D.1
Kowalinski, E.2
Cusack, S.3
-
64
-
-
84899957213
-
Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I
-
Peisley, A.; Wu, B.; Xu, H.; Chen, Z.J.; Hur, S. Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature 2014, 509, 110–114.
-
(2014)
Nature
, vol.509
, pp. 110-114
-
-
Peisley, A.1
Wu, B.2
Xu, H.3
Chen, Z.J.4
Hur, S.5
-
65
-
-
84862994793
-
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response
-
Jiang, X.; Kinch, L.N.; Brautigam, C.A.; Chen, X.; Du, F.; Grishin, N.V.; Chen, Z.J. Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity 2012, 36, 959–973.
-
(2012)
Immunity
, vol.36
, pp. 959-973
-
-
Jiang, X.1
Kinch, L.N.2
Brautigam, C.A.3
Chen, X.4
Du, F.5
Grishin, N.V.6
Chen, Z.J.7
-
66
-
-
84893811728
-
The laboratory of genetics and physiology 2: Emerging insights into the controversial functions of this RIG-I-like receptor
-
Zhu, Z.; Zhang, X.; Wang, G.; Zheng, H. The laboratory of genetics and physiology 2: Emerging insights into the controversial functions of this RIG-I-like receptor. BioMed Res. Int. 2014, 2014, 960190.
-
(2014)
Biomed Res. Int.
, vol.2014
, pp. 960190
-
-
Zhu, Z.1
Zhang, X.2
Wang, G.3
Zheng, H.4
-
67
-
-
84971015088
-
Activation of the MDA-5-IPS-1 viral sensing pathway induces cancer cell death and type I IFN-dependent antitumor immunity
-
Yu, X.; Wang, H.; Li, X.; Guo, C.; Yuan, F.; Fisher, P.B.; Wang, X.Y. Activation of the MDA-5-IPS-1 viral sensing pathway induces cancer cell death and type I IFN-dependent antitumor immunity. Cancer Res. 2016, 76, 2166–2176.
-
(2016)
Cancer Res
, vol.76
, pp. 2166-2176
-
-
Yu, X.1
Wang, H.2
Li, X.3
Guo, C.4
Yuan, F.5
Fisher, P.B.6
Wang, X.Y.7
-
68
-
-
0033970831
-
Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway
-
Balachandran, S.; Roberts, P.C.; Kipperman, T.; Bhalla, K.N.; Compans, R.W.; Archer, D.R.; Barber, G.N. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway. J. Virol. 2000, 74, 1513–1523.
-
(2000)
J. Virol
, vol.74
, pp. 1513-1523
-
-
Balachandran, S.1
Roberts, P.C.2
Kipperman, T.3
Bhalla, K.N.4
Compans, R.W.5
Archer, D.R.6
Barber, G.N.7
-
69
-
-
0344731406
-
Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB
-
Gil, J.; Alcami, J.; Esteban, M. Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. Mol. Cell. Biol. 1999, 19, 4653–4663.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 4653-4663
-
-
Gil, J.1
Alcami, J.2
Esteban, M.3
-
70
-
-
0030924144
-
A study of the interferon antiviral mechanism: Apoptosis activation by the 2–5A system
-
Castelli, J.C.; Hassel, B.A.; Wood, K.A.; Li, X.L.; Amemiya, K.; Dalakas, M.C.; Torrence, P.F.; Youle, R.J. A study of the interferon antiviral mechanism: Apoptosis activation by the 2–5A system. J. Exp. Med. 1997, 186, 967–972.
-
(1997)
J. Exp. Med
, vol.186
, pp. 967-972
-
-
Castelli, J.C.1
Hassel, B.A.2
Wood, K.A.3
Li, X.L.4
Amemiya, K.5
Dalakas, M.C.6
Torrence, P.F.7
Youle, R.J.8
-
71
-
-
0031882216
-
′ -oligoadenylate-dependent RNase L
-
′ -oligoadenylate-dependent RNase L. J. Virol. 1998, 72, 1146–1152.
-
(1998)
J. Virol
, vol.72
, pp. 1146-1152
-
-
Maitra, R.K.1
Silverman, R.H.2
-
72
-
-
0037790592
-
Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
-
Chawla-Sarkar, M.; Lindner, D.J.; Liu, Y.F.; Williams, B.R.; Sen, G.C.; Silverman, R.H.; Borden, E.C. Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003, 8, 237–249.
-
(2003)
Apoptosis
, vol.8
, pp. 237-249
-
-
Chawla-Sarkar, M.1
Lindner, D.J.2
Liu, Y.F.3
Williams, B.R.4
Sen, G.C.5
Silverman, R.H.6
Borden, E.C.7
-
73
-
-
77649202152
-
The interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases
-
Yu, C.Y.; Chiang, R.L.; Chang, T.H.; Liao, C.L.; Lin, Y.L. The interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases. J. Virol. 2010, 84, 2421–2431.
-
(2010)
J. Virol
, vol.84
, pp. 2421-2431
-
-
Yu, C.Y.1
Chiang, R.L.2
Chang, T.H.3
Liao, C.L.4
Lin, Y.L.5
-
74
-
-
84881292306
-
MAVS regulates apoptotic cell death by decreasing K48-linked ubiquitination of voltage-dependent anion channel 1
-
Guan, K.; Zheng, Z.; Song, T.; He, X.; Xu, C.; Zhang, Y.; Ma, S.; Wang, Y.; Xu, Q.; Cao, Y.; et al. MAVS regulates apoptotic cell death by decreasing K48-linked ubiquitination of voltage-dependent anion channel 1. Mol. Cell. Biol. 2013, 33, 3137–3149.
-
(2013)
Mol. Cell. Biol
, vol.33
, pp. 3137-3149
-
-
Guan, K.1
Zheng, Z.2
Song, T.3
He, X.4
Xu, C.5
Zhang, Y.6
Ma, S.7
Wang, Y.8
Xu, Q.9
Cao, Y.10
-
75
-
-
84893354769
-
A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis
-
El Maadidi, S.; Faletti, L.; Berg, B.; Wenzl, C.; Wieland, K.; Chen, Z.J.; Maurer, U.; Borner, C. A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. J. Immunol. 2014, 192, 1171–1183.
-
(2014)
J. Immunol
, vol.192
, pp. 1171-1183
-
-
El Maadidi, S.1
Faletti, L.2
Berg, B.3
Wenzl, C.4
Wieland, K.5
Chen, Z.J.6
Maurer, U.7
Borner, C.8
-
76
-
-
68849096790
-
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells
-
Besch, R.; Poeck, H.; Hohenauer, T.; Senft, D.; Hacker, G.; Berking, C.; Hornung, V.; Endres, S.; Ruzicka, T.; Rothenfusser, S.; et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J. Clin. Investig. 2009, 119, 2399–2411.
-
(2009)
J. Clin. Investig
, vol.119
, pp. 2399-2411
-
-
Besch, R.1
Poeck, H.2
Hohenauer, T.3
Senft, D.4
Hacker, G.5
Berking, C.6
Hornung, V.7
Endres, S.8
Ruzicka, T.9
Rothenfusser, S.10
-
77
-
-
79959838502
-
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa
-
Eitz Ferrer, P.; Potthoff, S.; Kirschnek, S.; Gasteiger, G.; Kastenmuller, W.; Ludwig, H.; Paschen, S.A.; Villunger, A.; Sutter, G.; Drexler, I.; et al. Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa. PLoS Pathog. 2011, 7, e1002083.
-
(2011)
Plos Pathog
, vol.7
-
-
Eitz Ferrer, P.1
Potthoff, S.2
Kirschnek, S.3
Gasteiger, G.4
Kastenmuller, W.5
Ludwig, H.6
Paschen, S.A.7
Villunger, A.8
Sutter, G.9
Drexler, I.10
-
78
-
-
84875981860
-
MAVS-mediated apoptosis and its inhibition by viral proteins
-
Lei, Y.; Moore, C.B.; Liesman, R.M.; O’Connor, B.P.; Bergstralh, D.T.; Chen, Z.J.; Pickles, R.J.; Ting, J.P. MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS ONE 2009, 4, e5466.
-
(2009)
Plos ONE
, vol.4
-
-
Lei, Y.1
Moore, C.B.2
Liesman, R.M.3
O’Connor, B.P.4
Bergstralh, D.T.5
Chen, Z.J.6
Pickles, R.J.7
Ting, J.P.8
-
79
-
-
77952578865
-
Viral apoptosis is induced by IRF-3-mediated activation of Bax
-
Chattopadhyay, S.; Marques, J.T.; Yamashita, M.; Peters, K.L.; Smith, K.; Desai, A.; Williams, B.R.; Sen, G.C. Viral apoptosis is induced by IRF-3-mediated activation of Bax. EMBO J. 2010, 29, 1762–1773.
-
(2010)
EMBO J
, vol.29
, pp. 1762-1773
-
-
Chattopadhyay, S.1
Marques, J.T.2
Yamashita, M.3
Peters, K.L.4
Smith, K.5
Desai, A.6
Williams, B.R.7
Sen, G.C.8
-
80
-
-
84967106620
-
Ubiquitination of the transcription factor IRF-3 Activates RIPA, the apoptotic pathway that protects mice from viral pathogenesis
-
Chattopadhyay, S.; Kuzmanovic, T.; Zhang, Y.; Wetzel, J.L.; Sen, G.C. Ubiquitination of the transcription factor IRF-3 Activates RIPA, the apoptotic pathway that protects mice from viral pathogenesis. Immunity 2016, 44, 1151–1161.
-
(2016)
Immunity
, vol.44
, pp. 1151-1161
-
-
Chattopadhyay, S.1
Kuzmanovic, T.2
Zhang, Y.3
Wetzel, J.L.4
Sen, G.C.5
-
81
-
-
21644466490
-
Identification of TRAIL as an interferon regulatory factor 3 transcriptional target
-
Kirshner, J.R.; Karpova, A.Y.; Kops, M.; Howley, P.M. Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J. Virol. 2005, 79, 9320–9324.
-
(2005)
J. Virol
, vol.79
, pp. 9320-9324
-
-
Kirshner, J.R.1
Karpova, A.Y.2
Kops, M.3
Howley, P.M.4
-
82
-
-
84857081504
-
Apoptosis induced by mammalian reovirus is beta interferon (IFN) independent and enhanced by IFN regulatory factor 3- and NF-kappaB-dependent expression of Noxa
-
Knowlton, J.J.; Dermody, T.S.; Holm, G.H. Apoptosis induced by mammalian reovirus is beta interferon (IFN) independent and enhanced by IFN regulatory factor 3- and NF-kappaB-dependent expression of Noxa. J. Virol. 2012, 86, 1650–1660.
-
(2012)
J. Virol
, vol.86
, pp. 1650-1660
-
-
Knowlton, J.J.1
Dermody, T.S.2
Holm, G.H.3
-
83
-
-
84966891722
-
Satoh, T.; et al. Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs
-
Ranoa, D.R.; Parekh, A.D.; Pitroda, S.P.; Huang, X.; Darga, T.; Wong, A.C.; Huang, L.; Andrade, J.; Staley, J.P.; Satoh, T.; et al. Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs. Oncotarget 2016, 7, 26496–26515.
-
(2016)
Oncotarget
, vol.7
, pp. 26496-26515
-
-
Ranoa, D.R.1
Parekh, A.D.2
Pitroda, S.P.3
Huang, X.4
Darga, T.5
Wong, A.C.6
Huang, L.7
Andrade, J.8
Staley, J.P.9
-
84
-
-
84920459884
-
Mutant p53 and the response to chemotherapy and radiation
-
Tchelebi, L.; Ashamalla, H.; Graves, P.R. Mutant p53 and the response to chemotherapy and radiation. Subcell. Biochem. 2014, 85, 133–159.
-
(2014)
Subcell. Biochem
, vol.85
, pp. 133-159
-
-
Tchelebi, L.1
Ashamalla, H.2
Graves, P.R.3
-
85
-
-
84882348691
-
Nucleic acid driven sterile inflammation
-
Ablasser, A.; Hertrich, C.; Wassermann, R.; Hornung, V. Nucleic acid driven sterile inflammation. Clin. Immunol. 2013, 147, 207–215.
-
(2013)
Clin. Immunol
, vol.147
, pp. 207-215
-
-
Ablasser, A.1
Hertrich, C.2
Wassermann, R.3
Hornung, V.4
-
86
-
-
34547143110
-
Honda, K.; et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka, A.; Wang, Z.; Choi, M.K.; Yanai, H.; Negishi, H.; Ban, T.; Lu, Y.; Miyagishi, M.; Kodama, T.; Honda, K.; et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007, 448, 501–505.
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
Negishi, H.5
Ban, T.6
Lu, Y.7
Miyagishi, M.8
Kodama, T.9
-
87
-
-
68049092912
-
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
-
Chiu, Y.H.; Macmillan, J.B.; Chen, Z.J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009, 138, 576–591.
-
(2009)
Cell
, vol.138
, pp. 576-591
-
-
Chiu, Y.H.1
Macmillan, J.B.2
Chen, Z.J.3
-
88
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung, V.; Ablasser, A.; Charrel-Dennis, M.; Bauernfeind, F.; Horvath, G.; Caffrey, D.R.; Latz, E.; Fitzgerald, K.A. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009, 458, 514–518.
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
Horvath, G.5
Caffrey, D.R.6
Latz, E.7
Fitzgerald, K.A.8
-
89
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Burckstummer, T.; Baumann, C.; Bluml, S.; Dixit, E.; Durnberger, G.; Jahn, H.; Planyavsky, M.; Bilban, M.; Colinge, J.; Bennett, K.L.; et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 2009, 10, 266–272.
-
(2009)
Nat. Immunol
, vol.10
, pp. 266-272
-
-
Burckstummer, T.1
Baumann, C.2
Bluml, S.3
Dixit, E.4
Durnberger, G.5
Jahn, H.6
Planyavsky, M.7
Bilban, M.8
Colinge, J.9
Bennett, K.L.10
-
90
-
-
77958140656
-
IFI16 is an innate immune sensor for intracellular DNA
-
Unterholzner, L.; Keating, S.E.; Baran, M.; Horan, K.A.; Jensen, S.B.; Sharma, S.; Sirois, C.M.; Jin, T.; Latz, E.; Xiao, T.S.; et al. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 2010, 11, 997–1004.
-
(2010)
Nat. Immunol
, vol.11
, pp. 997-1004
-
-
Unterholzner, L.1
Keating, S.E.2
Baran, M.3
Horan, K.A.4
Jensen, S.B.5
Sharma, S.6
Sirois, C.M.7
Jin, T.8
Latz, E.9
Xiao, T.S.10
-
91
-
-
77957009390
-
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
-
Kim, T.; Pazhoor, S.; Bao, M.; Zhang, Z.; Hanabuchi, S.; Facchinetti, V.; Bover, L.; Plumas, J.; Chaperot, L.; Qin, J.; et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc. Natl. Acad. Sci. USA 2010, 107, 15181–15186.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15181-15186
-
-
Kim, T.1
Pazhoor, S.2
Bao, M.3
Zhang, Z.4
Hanabuchi, S.5
Facchinetti, V.6
Bover, L.7
Plumas, J.8
Chaperot, L.9
Qin, J.10
-
92
-
-
77952566304
-
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
-
Yang, P.; An, H.; Liu, X.; Wen, M.; Zheng, Y.; Rui, Y.; Cao, X. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat. Immunol. 2010, 11, 487–494.
-
(2010)
Nat. Immunol
, vol.11
, pp. 487-494
-
-
Yang, P.1
An, H.2
Liu, X.3
Wen, M.4
Zheng, Y.5
Rui, Y.6
Cao, X.7
-
93
-
-
80052969639
-
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
-
Zhang, Z.; Yuan, B.; Bao, M.; Lu, N.; Kim, T.; Liu, Y.J. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 2011, 12, 959–965.
-
(2011)
Nat. Immunol
, vol.12
, pp. 959-965
-
-
Zhang, Z.1
Yuan, B.2
Bao, M.3
Lu, N.4
Kim, T.5
Liu, Y.J.6
-
94
-
-
79955004696
-
Baseler, M.W.; et al. Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN
-
Zhang, X.; Brann, T.W.; Zhou, M.; Yang, J.; Oguariri, R.M.; Lidie, K.B.; Imamichi, H.; Huang, D.W.; Lempicki, R.A.; Baseler, M.W.; et al. Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN. J. Immunol. 2011, 186, 4541–4545.
-
(2011)
J. Immunol
, vol.186
, pp. 4541-4545
-
-
Zhang, X.1
Brann, T.W.2
Zhou, M.3
Yang, J.4
Oguariri, R.M.5
Lidie, K.B.6
Imamichi, H.7
Huang, D.W.8
Lempicki, R.A.9
-
95
-
-
84875224757
-
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
-
Ferguson, B.J.; Mansur, D.S.; Peters, N.E.; Ren, H.; Smith, G.L. DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. eLife 2012, 1, e00047.
-
(2012)
Elife
, vol.1
-
-
Ferguson, B.J.1
Mansur, D.S.2
Peters, N.E.3
Ren, H.4
Smith, G.L.5
-
96
-
-
84874278336
-
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
-
Kondo, T.; Kobayashi, J.; Saitoh, T.; Maruyama, K.; Ishii, K.J.; Barber, G.N.; Komatsu, K.; Akira, S.; Kawai, T. DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc. Natl. Acad. Sci. USA 2013, 110, 2969–2974.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 2969-2974
-
-
Kondo, T.1
Kobayashi, J.2
Saitoh, T.3
Maruyama, K.4
Ishii, K.J.5
Barber, G.N.6
Komatsu, K.7
Akira, S.8
Kawai, T.9
-
97
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
-
Sun, L.; Wu, J.; Du, F.; Chen, X.; Chen, Z.J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013, 339, 786–791.
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
98
-
-
53349168904
-
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
-
Zhong, B.; Yang, Y.; Li, S.; Wang, Y.Y.; Li, Y.; Diao, F.; Lei, C.; He, X.; Zhang, L.; Tien, P.; et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 2008, 29, 538–550.
-
(2008)
Immunity
, vol.29
, pp. 538-550
-
-
Zhong, B.1
Yang, Y.2
Li, S.3
Wang, Y.Y.4
Li, Y.5
Diao, F.6
Lei, C.7
He, X.8
Zhang, L.9
Tien, P.10
-
99
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa, H.; Barber, G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008, 455, 674–678.
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
100
-
-
80054966913
-
STING is a direct innate immune sensor of cyclic di-GMP
-
Burdette, D.L.; Monroe, K.M.; Sotelo-Troha, K.; Iwig, J.S.; Eckert, B.; Hyodo, M.; Hayakawa, Y.; Vance, R.E. STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011, 478, 515–518.
-
(2011)
Nature
, vol.478
, pp. 515-518
-
-
Burdette, D.L.1
Monroe, K.M.2
Sotelo-Troha, K.3
Iwig, J.S.4
Eckert, B.5
Hyodo, M.6
Hayakawa, Y.7
Vance, R.E.8
-
101
-
-
80052662208
-
MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP
-
Jin, L.; Hill, K.K.; Filak, H.; Mogan, J.; Knowles, H.; Zhang, B.; Perraud, A.L.; Cambier, J.C.; Lenz, L.L. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J. Immunol. 2011, 187, 2595–2601.
-
(2011)
J. Immunol
, vol.187
, pp. 2595-2601
-
-
Jin, L.1
Hill, K.K.2
Filak, H.3
Mogan, J.4
Knowles, H.5
Zhang, B.6
Perraud, A.L.7
Cambier, J.C.8
Lenz, L.L.9
-
102
-
-
84879385334
-
′ -linked cyclic dinucleotide second messenger that activates STING
-
′ -linked cyclic dinucleotide second messenger that activates STING. Nature 2013, 498, 380–384.
-
(2013)
Nature
, vol.498
, pp. 380-384
-
-
Ablasser, A.1
Goldeck, M.2
Cavlar, T.3
Deimling, T.4
Witte, G.5
Rohl, I.6
Hopfner, K.P.7
Ludwig, J.8
Hornung, V.9
-
103
-
-
84880508067
-
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
-
Zhang, X.; Shi, H.; Wu, J.; Sun, L.; Chen, C.; Chen, Z.J. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 2013, 51, 226–235.
-
(2013)
Mol. Cell
, vol.51
, pp. 226-235
-
-
Zhang, X.1
Shi, H.2
Wu, J.3
Sun, L.4
Chen, C.5
Chen, Z.J.6
-
104
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
-
Ishikawa, H.; Ma, Z.; Barber, G.N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009, 461, 788–792.
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
105
-
-
84899077215
-
Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-kappaB activation through TBK1
-
Abe, T.; Barber, G.N. Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-kappaB activation through TBK1. J. Virol. 2014, 88, 5328–5341.
-
(2014)
J. Virol
, vol.88
, pp. 5328-5341
-
-
Abe, T.1
Barber, G.N.2
-
106
-
-
84970963467
-
Agonist-mediated activation of STING induces apoptosis in malignant B cells
-
Tang, C.H.; Zundell, J.A.; Ranatunga, S.; Lin, C.; Nefedova, Y.; Del Valle, J.R.; Hu, C.C. Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res. 2016, 76, 2137–2152.
-
(2016)
Cancer Res
, vol.76
, pp. 2137-2152
-
-
Tang, C.H.1
Zundell, J.A.2
Ranatunga, S.3
Lin, C.4
Nefedova, Y.5
Del Valle, J.R.6
Hu, C.C.7
-
107
-
-
84886027402
-
Host restriction factor SAMHD1 limits human T cell leukemia virus type I infection of monocytes via STING-mediated apoptosis
-
Sze, A.; Belgnaoui, S.M.; Olagnier, D.; Lin, R.; Hiscott, J.; van Grevenynghe, J. Host restriction factor SAMHD1 limits human T cell leukemia virus type I infection of monocytes via STING-mediated apoptosis. Cell Host Microbe 2013, 14, 422–434.
-
(2013)
Cell Host Microbe
, vol.14
, pp. 422-434
-
-
Sze, A.1
Belgnaoui, S.M.2
Olagnier, D.3
Lin, R.4
Hiscott, J.5
Van Grevenynghe, J.6
-
108
-
-
84885332714
-
STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
-
Petrasek, J.; Iracheta-Vellve, A.; Csak, T.; Satishchandran, A.; Kodys, K.; Kurt-Jones, E.A.; Fitzgerald, K.A.; Szabo, G. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc. Natl. Acad. Sci. USA 2013, 110, 16544–16549.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 16544-16549
-
-
Petrasek, J.1
Iracheta-Vellve, A.2
Csak, T.3
Satishchandran, A.4
Kodys, K.5
Kurt-Jones, E.A.6
Fitzgerald, K.A.7
Szabo, G.8
-
109
-
-
84919884654
-
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production
-
White, M.J.; McArthur, K.; Metcalf, D.; Lane, R.M.; Cambier, J.C.; Herold, M.J.; van Delft, M.F.; Bedoui, S.; Lessene, G.; Ritchie, M.E.; et al. Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production. Cell 2014, 159, 1549–1562.
-
(2014)
Cell
, vol.159
, pp. 1549-1562
-
-
White, M.J.1
McArthur, K.2
Metcalf, D.3
Lane, R.M.4
Cambier, J.C.5
Herold, M.J.6
Van Delft, M.F.7
Bedoui, S.8
Lessene, G.9
Ritchie, M.E.10
-
110
-
-
84912120595
-
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
-
Woo, S.R.; Fuertes, M.B.; Corrales, L.; Spranger, S.; Furdyna, M.J.; Leung, M.Y.; Duggan, R.; Wang, Y.; Barber, G.N.; Fitzgerald, K.A.; et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 2014, 41, 830–842.
-
(2014)
Immunity
, vol.41
, pp. 830-842
-
-
Woo, S.R.1
Fuertes, M.B.2
Corrales, L.3
Spranger, S.4
Furdyna, M.J.5
Leung, M.Y.6
Duggan, R.7
Wang, Y.8
Barber, G.N.9
Fitzgerald, K.A.10
-
111
-
-
84912128872
-
Weichselbaum RR7. STING-Dependent Cytosolic DNA Sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
-
Deng, L.; Liang, H.; Xu, M.; Yang, X.; Burnette, B.; Arina, A.; Li, X.D.; Mauceri, H.; Beckett, M.; Darga, T.; et al. Weichselbaum RR7. STING-Dependent Cytosolic DNA Sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014, 41, 843–852.
-
(2014)
Immunity
, vol.41
, pp. 843-852
-
-
Deng, L.1
Liang, H.2
Xu, M.3
Yang, X.4
Burnette, B.5
Arina, A.6
Li, X.D.7
Mauceri, H.8
Beckett, M.9
Darga, T.10
-
112
-
-
84943630992
-
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors
-
Liu, X.; Pu, Y.; Cron, K.; Deng, L.; Kline, J.; Frazier, W.A.; Xu, H.; Peng, H.; Fu, Y.X.; Xu, M.M. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat. Med. 2015, 21, 1209–1215.
-
(2015)
Nat. Med
, vol.21
, pp. 1209-1215
-
-
Liu, X.1
Pu, Y.2
Cron, K.3
Deng, L.4
Kline, J.5
Frazier, W.A.6
Xu, H.7
Peng, H.8
Fu, Y.X.9
Xu, M.M.10
-
113
-
-
0028063124
-
Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation. J
-
Perera, P.Y.; Barber, S.A.; Ching, L.M.; Vogel, S.N. Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation. J. Immunol. 1994, 153, 4684–4693.
-
(1994)
Immunol
, vol.153
, pp. 4684-4693
-
-
Perera, P.Y.1
Barber, S.A.2
Ching, L.M.3
Vogel, S.N.4
-
114
-
-
84877795529
-
Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid
-
Conlon, J.; Burdette, D.L.; Sharma, S.; Bhat, N.; Thompson, M.; Jiang, Z.; Rathinam, V.A.; Monks, B.; Jin, T.; Xiao, T.S.; et al. Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid. J. Immunol. 2013, 190, 5216–5225.
-
(2013)
J. Immunol
, vol.190
, pp. 5216-5225
-
-
Conlon, J.1
Burdette, D.L.2
Sharma, S.3
Bhat, N.4
Thompson, M.5
Jiang, Z.6
Rathinam, V.A.7
Monks, B.8
Jin, T.9
Xiao, T.S.10
-
116
-
-
84882815198
-
′)p] and targeting by antiviral DMXAA
-
′)p] and targeting by antiviral DMXAA. Cell 2013, 154, 748–762.
-
(2013)
Cell
, vol.154
, pp. 748-762
-
-
Gao, P.1
Ascano, M.2
Zillinger, T.3
Wang, W.4
Dai, P.5
Serganov, A.A.6
Gaffney, B.L.7
Shuman, S.8
Jones, R.A.9
Deng, L.10
-
117
-
-
79952321425
-
Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines
-
Peng, S.; Monie, A.; Pang, X.; Hung, C.F.; Wu, T.C. Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines. J. Biomed. Sci. 2011, 18, 21.
-
(2011)
J. Biomed. Sci
, vol.18
, pp. 21
-
-
Peng, S.1
Monie, A.2
Pang, X.3
Hung, C.F.4
Wu, T.C.5
-
118
-
-
84929705879
-
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
-
Corrales, L.; Glickman, L.H.; McWhirter, S.M.; Kanne, D.B.; Sivick, K.E.; Katibah, G.E.; Woo, S.R.; Lemmens, E.; Banda, T.; Leong, J.J.; et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015, 11, 1018–1030.
-
(2015)
Cell Rep
, vol.11
, pp. 1018-1030
-
-
Corrales, L.1
Glickman, L.H.2
McWhirter, S.M.3
Kanne, D.B.4
Sivick, K.E.5
Katibah, G.E.6
Woo, S.R.7
Lemmens, E.8
Banda, T.9
Leong, J.J.10
-
119
-
-
84950141423
-
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
-
Demaria, O.; De Gassart, A.; Coso, S.; Gestermann, N.; Di Domizio, J.; Flatz, L.; Gaide, O.; Michielin, O.; Hwu, P.; Petrova, T.V.; et al. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc. Natl. Acad. Sci. USA 2015, 112, 15408–15413.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 15408-15413
-
-
Demaria, O.1
De Gassart, A.2
Coso, S.3
Gestermann, N.4
Di Domizio, J.5
Flatz, L.6
Gaide, O.7
Michielin, O.8
Hwu, P.9
Petrova, T.V.10
-
120
-
-
84964698449
-
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment
-
Ohkuri, T.; Ghosh, A.; Kosaka, A.; Zhu, J.; Ikeura, M.; David, M.; Watkins, S.C.; Sarkar, S.N.; Okada, H. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol. Res. 2014, 2, 1199–1208.
-
(2014)
Cancer Immunol. Res
, vol.2
, pp. 1199-1208
-
-
Ohkuri, T.1
Ghosh, A.2
Kosaka, A.3
Zhu, J.4
Ikeura, M.5
David, M.6
Watkins, S.C.7
Sarkar, S.N.8
Okada, H.9
-
121
-
-
84937978529
-
STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice
-
Wang, Z.; Celis, E. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol. Immunother. 2015, 64, 1057–1066.
-
(2015)
Cancer Immunol. Immunother
, vol.64
, pp. 1057-1066
-
-
Wang, Z.1
Celis, E.2
-
122
-
-
84885169498
-
Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses
-
Huang, L.; Li, L.; Lemos, H.; Chandler, P.R.; Pacholczyk, G.; Baban, B.; Barber, G.N.; Hayakawa, Y.; McGaha, T.L.; Ravishankar, B.; et al. Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J. Immunol. 2013, 191, 3509–3513.
-
(2013)
J. Immunol
, vol.191
, pp. 3509-3513
-
-
Huang, L.1
Li, L.2
Lemos, H.3
Chandler, P.R.4
Pacholczyk, G.5
Baban, B.6
Barber, G.N.7
Hayakawa, Y.8
McGaha, T.L.9
Ravishankar, B.10
-
123
-
-
84965032473
-
STING promotes the growth of tumors characterized by low antigenicity via IDO activation
-
Lemos, H.; Mohamed, E.; Huang, L.; Ou, R.; Pacholczyk, G.; Arbab, A.S.; Munn, D.; Mellor, A.L. STING promotes the growth of tumors characterized by low antigenicity via IDO activation. Cancer Res. 2016, 76, 2076–2081.
-
(2016)
Cancer Res
, vol.76
, pp. 2076-2081
-
-
Lemos, H.1
Mohamed, E.2
Huang, L.3
Ou, R.4
Pacholczyk, G.5
Arbab, A.S.6
Munn, D.7
Mellor, A.L.8
-
124
-
-
84971237993
-
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
-
Chen, Q.; Boire, A.; Jin, X.; Valiente, M.; Er, E.E.; Lopez-Soto, A.; Jacob, L.S.; Patwa, R.; Shah, H.; Xu, K.; et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 2016, 533, 493–498.
-
(2016)
Nature
, vol.533
, pp. 493-498
-
-
Chen, Q.1
Boire, A.2
Jin, X.3
Valiente, M.4
Er, E.E.5
Lopez-Soto, A.6
Jacob, L.S.7
Patwa, R.8
Shah, H.9
Xu, K.10
-
125
-
-
77953337676
-
Inhibiting the inhibitors: Evaluating agents targeting cancer immunosuppression
-
Whiteside, T.L. Inhibiting the inhibitors: Evaluating agents targeting cancer immunosuppression. Expert Opin. Biol. Ther. 2010, 10, 1019–1035.
-
(2010)
Expert Opin. Biol. Ther
, vol.10
, pp. 1019-1035
-
-
Whiteside, T.L.1
-
126
-
-
84885528644
-
Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines
-
Butt, A.Q.; Mills, K.H. Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines. Oncogene 2014, 33, 4623–4631.
-
(2014)
Oncogene
, vol.33
, pp. 4623-4631
-
-
Butt, A.Q.1
Mills, K.H.2
-
127
-
-
84954348557
-
Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response
-
Levy, L.; Mishalian, I.; Bayuch, R.; Zolotarov, L.; Michaeli, J.; Fridlender, Z.G. Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response. Oncoimmunology 2015, 4, e998469.
-
(2015)
Oncoimmunology
, vol.4
-
-
Levy, L.1
Mishalian, I.2
Bayuch, R.3
Zolotarov, L.4
Michaeli, J.5
Fridlender, Z.G.6
-
128
-
-
84876415183
-
Using macrophage activation to augment immunotherapy of established tumours
-
Fridlender, Z.G.; Jassar, A.; Mishalian, I.; Wang, L.C.; Kapoor, V.; Cheng, G.; Sun, J.; Singhal, S.; Levy, L.; Albelda, S.M. Using macrophage activation to augment immunotherapy of established tumours. Br. J. Ccancer 2013, 108, 1288–1297.
-
(2013)
Br. J. Ccancer
, vol.108
, pp. 1288-1297
-
-
Fridlender, Z.G.1
Jassar, A.2
Mishalian, I.3
Wang, L.C.4
Kapoor, V.5
Cheng, G.6
Sun, J.7
Singhal, S.8
Levy, L.9
Albelda, S.M.10
-
129
-
-
34547794178
-
PD-1 and PD-1 ligands: From discovery to clinical application
-
Okazaki, T.; Honjo, T. PD-1 and PD-1 ligands: From discovery to clinical application. Int. Immunol. 2007, 19, 813–824.
-
(2007)
Int. Immunol
, vol.19
, pp. 813-824
-
-
Okazaki, T.1
Honjo, T.2
-
130
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman, G.J.; Long, A.J.; Iwai, Y.; Bourque, K.; Chernova, T.; Nishimura, H.; Fitz, L.J.; Malenkovich, N.; Okazaki, T.; Byrne, M.C.; et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000, 192, 1027–1034.
-
(2000)
J. Exp. Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
Bourque, K.4
Chernova, T.5
Nishimura, H.6
Fitz, L.J.7
Malenkovich, N.8
Okazaki, T.9
Byrne, M.C.10
-
131
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh, P.C.; Harview, C.L.; Yearley, J.H.; Shintaku, I.P.; Taylor, E.J.; Robert, L.; Chmielowski, B.; Spasic, M.; Henry, G.; Ciobanu, V.; et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014, 515, 568–571.
-
(2014)
Nature
, vol.515
, pp. 568-571
-
-
Tumeh, P.C.1
Harview, C.L.2
Yearley, J.H.3
Shintaku, I.P.4
Taylor, E.J.5
Robert, L.6
Chmielowski, B.7
Spasic, M.8
Henry, G.9
Ciobanu, V.10
-
132
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
-
Robert, C.; Ribas, A.; Wolchok, J.D.; Hodi, F.S.; Hamid, O.; Kefford, R.; Weber, J.S.; Joshua, A.M.; Hwu, W.J.; Gangadhar, T.C.; et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial. Lancet 2014, 384, 1109–1117.
-
(2014)
Lancet
, vol.384
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
Weber, J.S.7
Joshua, A.M.8
Hwu, W.J.9
Gangadhar, T.C.10
-
133
-
-
84954474607
-
IFNgamma producing CD8+ T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas
-
Buferne, M.; Chasson, L.; Grange, M.; Mas, A.; Arnoux, F.; Bertuzzi, M.; Naquet, P.; Leserman, L.; Schmitt-Verhulst, A.M.; Auphan-Anezin, N. IFNgamma producing CD8+ T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas. Oncoimmunology 2015, 4, e974959.
-
(2015)
Oncoimmunology
, vol.4
-
-
Buferne, M.1
Chasson, L.2
Grange, M.3
Mas, A.4
Arnoux, F.5
Bertuzzi, M.6
Naquet, P.7
Leserman, L.8
Schmitt-Verhulst, A.M.9
Auphan-Anezin, N.10
-
134
-
-
84907979458
-
The IL-2 cytokine family in cancer immunotherapy
-
Sim, G.C.; Radvanyi, L. The IL-2 cytokine family in cancer immunotherapy. Cytokine Growth Factor Rev. 2014, 25, 377–390.
-
(2014)
Cytokine Growth Factor Rev
, vol.25
, pp. 377-390
-
-
Sim, G.C.1
Radvanyi, L.2
-
135
-
-
84902191817
-
IL-2: The first effective immunotherapy for human cancer
-
Rosenberg, S.A. IL-2: The first effective immunotherapy for human cancer. J. Immunol. 2014, 192, 5451–5458.
-
(2014)
J. Immunol
, vol.192
, pp. 5451-5458
-
-
Rosenberg, S.A.1
-
136
-
-
84920577302
-
Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
-
Conlon, K.C.; Lugli, E.; Welles, H.C.; Rosenberg, S.A.; Fojo, A.T.; Morris, J.C.; Fleisher, T.A.; Dubois, S.P.; Perera, L.P.; Stewart, D.M.; et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J. Clin. Oncol. 2015, 33, 74–82.
-
(2015)
J. Clin. Oncol
, vol.33
, pp. 74-82
-
-
Conlon, K.C.1
Lugli, E.2
Welles, H.C.3
Rosenberg, S.A.4
Fojo, A.T.5
Morris, J.C.6
Fleisher, T.A.7
Dubois, S.P.8
Perera, L.P.9
Stewart, D.M.10
-
137
-
-
26644452073
-
Macrophage polarization comes of age
-
Mantovani, A.; Sica, A.; Locati, M. Macrophage polarization comes of age. Immunity 2005, 23, 344–346.
-
(2005)
Immunity
, vol.23
, pp. 344-346
-
-
Mantovani, A.1
Sica, A.2
Locati, M.3
-
138
-
-
77952937103
-
The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time
-
Ma, J.; Liu, L.; Che, G.; Yu, N.; Dai, F.; You, Z. The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 2010, 10, 112.
-
(2010)
BMC Cancer
, vol.10
, pp. 112
-
-
Ma, J.1
Liu, L.2
Che, G.3
Yu, N.4
Dai, F.5
You, Z.6
-
139
-
-
84877816431
-
Enhancement of the anti-melanoma response of Hu14.18K322A by alphaCD40 + CpG
-
Alderson, K.L.; Luangrath, M.; Elsenheimer, M.M.; Gillies, S.D.; Navid, F.; Rakhmilevich, A.L.; Sondel, P.M. Enhancement of the anti-melanoma response of Hu14.18K322A by alphaCD40 + CpG. Cancer Immunol. Immunother. 2013, 62, 665–675.
-
(2013)
Cancer Immunol. Immunother
, vol.62
, pp. 665-675
-
-
Alderson, K.L.1
Luangrath, M.2
Elsenheimer, M.M.3
Gillies, S.D.4
Navid, F.5
Rakhmilevich, A.L.6
Sondel, P.M.7
|