메뉴 건너뛰기




Volumn 85, Issue , 2014, Pages 133-159

Mutant p53 and the response to chemotherapy and radiation

Author keywords

Chemoresistance; Chemotherapy; DNA damage; Genomics; p53; Prognostic factor; Radiation; Radioresistance

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 84920459884     PISSN: 03060225     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-017-9211-0_8     Document Type: Article
Times cited : (47)

References (104)
  • 1
    • 0030865104 scopus 로고    scopus 로고
    • Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents
    • O'Connor PM, Jackman J, Bae I, Myers TG, Fan S, Mutoh M, Scudiero DA, Monks A, Sausville EA et al (1997) Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 57: 4285-4300.
    • (1997) Cancer Res , vol.57 , pp. 4285-4300
    • O’Connor, P.M.1    Jackman, J.2    Bae, I.3    Myers, T.G.4    Fan, S.5    Mutoh, M.6    Scudiero, D.A.7    Monks, A.8    Sausville, E.A.9
  • 2
    • 0037047157 scopus 로고    scopus 로고
    • Apoptotic threshold is lowered by p53 transactivation of caspase-6
    • MacLachlan TK, El-Deiry WS (2002) Apoptotic threshold is lowered by p53 transactivation of caspase-6. Proc Natl Acad Sci U S A 99: 9492-9497.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9492-9497
    • McLachlan, T.K.1    El-Deiry, W.S.2
  • 6
    • 70349443284 scopus 로고    scopus 로고
    • When mutants gain new powers: News from the mutant p53 field
    • Brosh R, Rotter V (2009) When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 9: 701-713.
    • (2009) Nat Rev Cancer , vol.9 , pp. 701-713
    • Brosh, R.1    Rotter, V.2
  • 9
    • 0033552948 scopus 로고    scopus 로고
    • Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
    • Blandino G, Levine AJ, Oren M (1999) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 18: 477-485.
    • (1999) Oncogene , vol.18 , pp. 477-485
    • Blandino, G.1    Levine, A.J.2    Oren, M.3
  • 10
    • 0033368192 scopus 로고    scopus 로고
    • De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line
    • Asada N, Tsuchiya H, Tomita K (1999) De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. Anticancer Res 19: 5131-5137.
    • (1999) Anticancer Res , vol.19 , pp. 5131-5137
    • Asada, N.1    Tsuchiya, H.2    Tomita, K.3
  • 11
    • 0032749714 scopus 로고    scopus 로고
    • Modulation of cisplatinum cytotoxicity by p53: Effect of p53-mediated apoptosis and DNA repair
    • Fan J, Bertino JR (1999) Modulation of cisplatinum cytotoxicity by p53: effect of p53-mediated apoptosis and DNA repair. Mol Pharmacol 56: 966-972.
    • (1999) Mol Pharmacol , vol.56 , pp. 966-972
    • Fan, J.1    Bertino, J.R.2
  • 12
    • 0033572965 scopus 로고    scopus 로고
    • Accumulation of mutant p53(V143A) modulates the growth, clonogenicity, and radiochemosensitivity of malignant glioma cells independent of endogenous p53 status
    • Bartussek C, Naumann U, Weller M (1999) Accumulation of mutant p53(V143A) modulates the growth, clonogenicity, and radiochemosensitivity of malignant glioma cells independent of endogenous p53 status. Exp Cell Res 253: 432-439.
    • (1999) Exp Cell Res , vol.253 , pp. 432-439
    • Bartussek, C.1    Naumann, U.2    Weller, M.3
  • 13
    • 0034978219 scopus 로고    scopus 로고
    • Various forms of mutant p53 confer sensitivity to cisplatin and doxorubicin in bladder cancer cells
    • Chang FL, Lai MD (2001) Various forms of mutant p53 confer sensitivity to cisplatin and doxorubicin in bladder cancer cells. J Urol 166: 304-310.
    • (2001) J Urol , vol.166 , pp. 304-310
    • Chang, F.L.1    Lai, M.D.2
  • 19
    • 84857989986 scopus 로고    scopus 로고
    • Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53
    • Martinez-Rivera M, Siddik ZH (2012) Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53. Biochem Pharmacol 83: 1049-1062.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1049-1062
    • Martinez-Rivera, M.1    Siddik, Z.H.2
  • 20
    • 0038021147 scopus 로고    scopus 로고
    • Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF rastransformants-expressing gain of function MTp53
    • Bristow RG, Peacock J, Jang A, Kim J, Hill RP, Benchimol S (2003) Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF rastransformants-expressing gain of function MTp53. Oncogene 22: 2960-2966.
    • (2003) Oncogene , vol.22 , pp. 2960-2966
    • Bristow, R.G.1    Peacock, J.2    Jang, A.3    Kim, J.4    Hill, R.P.5    Benchimol, S.6
  • 22
    • 34247899190 scopus 로고    scopus 로고
    • Cancer-derived p53 mutants suppress p53-target gene expression-potential mechanism for gain of function of mutant p53
    • Vikhanskaya F, Lee MK, Mazzoletti M, Broggini M, Sabapathy K (2007) Cancer-derived p53 mutants suppress p53-target gene expression-potential mechanism for gain of function of mutant p53. Nucleic Acids Res 35: 2093-2104.
    • (2007) Nucleic Acids Res , vol.35 , pp. 2093-2104
    • Vikhanskaya, F.1    Lee, M.K.2    Mazzoletti, M.3    Broggini, M.4    Sabapathy, K.5
  • 23
    • 34147172345 scopus 로고    scopus 로고
    • p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3
    • Wong RP, Tsang WP, Chau PY, Co NN, Tsang TY, Kwok TT (2007) p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3. Mol Cancer Ther 6: 1054-1061.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1054-1061
    • Wong, R.P.1    Tsang, W.P.2    Chau, P.Y.3    Co, N.N.4    Tsang, T.Y.5    Kwok, T.T.6
  • 24
    • 30544452870 scopus 로고    scopus 로고
    • Mutant p53 gain of function: Reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
    • Bossi G, Lapi E, Strano S, Rinaldo C, Blandino G, Sacchi A (2006) Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression. Oncogene 25: 304-309.
    • (2006) Oncogene , vol.25 , pp. 304-309
    • Bossi, G.1    Lapi, E.2    Strano, S.3    Rinaldo, C.4    Blandino, G.5    Sacchi, A.6
  • 25
    • 0030232710 scopus 로고    scopus 로고
    • The p53 gene as a modifier of intrinsic radiosensitivity: Implications for radiotherapy
    • Bristow RG, Benchimol S, Hill RP (1996) The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy. Radiother Oncol 40: 197-223.
    • (1996) Radiother Oncol , vol.40 , pp. 197-223
    • Bristow, R.G.1    Benchimol, S.2    Hill, R.P.3
  • 26
    • 0345256634 scopus 로고    scopus 로고
    • The role of p53 in chemosensitivity and radiosensitivity
    • El-Deiry WS (2003) The role of p53 in chemosensitivity and radiosensitivity. Oncogene 22: 7486-7495.
    • (2003) Oncogene , vol.22 , pp. 7486-7495
    • El-Deiry, W.S.1
  • 27
    • 0034093941 scopus 로고    scopus 로고
    • p53: Biology and role for cellular radiosensitivity
    • Dahm-Daphi J (2000) p53: biology and role for cellular radiosensitivity. Strahlenther Onkol 176: 278-285.
    • (2000) Strahlenther Onkol , vol.176 , pp. 278-285
    • Dahm-Daphi, J.1
  • 28
    • 0027285380 scopus 로고
    • p53 mutations increase resistance to ionizing radiation
    • Lee JM, Bernstein A (1993) p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci U S A 90: 5742-5746.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5742-5746
    • Lee, J.M.1    Bernstein, A.2
  • 29
    • 0032499298 scopus 로고    scopus 로고
    • Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation
    • Bristow RG, Hu Q, Jang A, Chung S, Peacock J, Benchimol S, Hill R (1998) Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation. Oncogene 16: 1789-1802.
    • (1998) Oncogene , vol.16 , pp. 1789-1802
    • Bristow, R.G.1    Hu, Q.2    Jang, A.3    Chung, S.4    Peacock, J.5    Benchimol, S.6    Hill, R.7
  • 34
    • 44849106090 scopus 로고    scopus 로고
    • Induction of genetic instability by gain-of-function p53 cancer mutants
    • Xu Y (2008) Induction of genetic instability by gain-of-function p53 cancer mutants. Oncogene 27: 3501-3507.
    • (2008) Oncogene , vol.27 , pp. 3501-3507
    • Xu, Y.1
  • 35
    • 84874735362 scopus 로고    scopus 로고
    • The tumor suppressor, p53, contributes to radiosensitivity of lung cancer cells by regulating autophagy and apoptosis
    • Cheng G, Kong D, Hou X, Liang B, He M, Liang N, Ma S, Liu X (2013) The tumor suppressor, p53, contributes to radiosensitivity of lung cancer cells by regulating autophagy and apoptosis. Cancer Biother Radiopharm 28: 153-159.
    • (2013) Cancer Biother Radiopharm , vol.28 , pp. 153-159
    • Cheng, G.1    Kong, D.2    Hou, X.3    Liang, B.4    He, M.5    Liang, N.6    Ma, S.7    Liu, X.8
  • 36
    • 22744458985 scopus 로고    scopus 로고
    • Transcriptional activities of mutant p53: When mutations are more than a loss
    • Kim E, Deppert W (2004) Transcriptional activities of mutant p53: when mutations are more than a loss. J Cell Biochem 93: 878-886.
    • (2004) J Cell Biochem , vol.93 , pp. 878-886
    • Kim, E.1    Deppert, W.2
  • 38
    • 84856117319 scopus 로고    scopus 로고
    • p53 mutants induce transcription of NF-kappaB2 in H1299 cells through CBP and STAT binding on the NF-kappaB2 promoter and gain of function activity
    • Vaughan CA, Singh S, Windle B, Sankala HM, Graves PR, Andrew Yeudall W, Deb SP, Deb S (2012) p53 mutants induce transcription of NF-kappaB2 in H1299 cells through CBP and STAT binding on the NF-kappaB2 promoter and gain of function activity. Arch Biochem Biophys 518: 79-88.
    • (2012) Arch Biochem Biophys , vol.518 , pp. 79-88
    • Vaughan, C.A.1    Singh, S.2    Windle, B.3    Sankala, H.M.4    Graves, P.R.5    Andrew Yeudall, W.6    Deb, S.P.7    Deb, S.8
  • 41
    • 79959840762 scopus 로고    scopus 로고
    • Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance
    • Sankala H, Vaughan C, Wang J, Deb S, Graves PR (2011) Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance. Arch Biochem Biophys 512: 52-60.
    • (2011) Arch Biochem Biophys , vol.512 , pp. 52-60
    • Sankala, H.1    Vaughan, C.2    Wang, J.3    Deb, S.4    Graves, P.R.5
  • 42
    • 0029619819 scopus 로고
    • The MDR1 downstream promoter contains sequence-specific binding sites for wild-type p53
    • Strauss BE, Shivakumar C, Deb SP, Deb S, Haas M (1995) The MDR1 downstream promoter contains sequence-specific binding sites for wild-type p53. Biochem Biophys Res Commun 217: 825-831.
    • (1995) Biochem Biophys Res Commun , vol.217 , pp. 825-831
    • Strauss, B.E.1    Shivakumar, C.2    Deb, S.P.3    Deb, S.4    Haas, M.5
  • 44
    • 84875509079 scopus 로고    scopus 로고
    • Gain-of-function activity of mutant p53 in lung cancer through up-regulation of receptor protein tyrosine kinase Axl
    • Vaughan CA, Singh S, Windle B, Yeudall WA, Frum R, Grossman SR, Deb SP, Deb S (2012) Gain-of-function activity of mutant p53 in lung cancer through up-regulation of receptor protein tyrosine kinase Axl. Genes Cancer 3: 491-502.
    • (2012) Genes Cancer , vol.3 , pp. 491-502
    • Vaughan, C.A.1    Singh, S.2    Windle, B.3    Yeudall, W.A.4    Frum, R.5    Grossman, S.R.6    Deb, S.P.7    Deb, S.8
  • 46
    • 0033549844 scopus 로고    scopus 로고
    • Cloning and characterization of the human BAG-1 gene promoter: Upregulation by tumor-derived p53 mutants
    • Yang X, Pater A, Tang SC (1999) Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants. Oncogene 18: 4546-4553.
    • (1999) Oncogene , vol.18 , pp. 4546-4553
    • Yang, X.1    Pater, A.2    Tang, S.C.3
  • 48
    • 30944461587 scopus 로고    scopus 로고
    • Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53
    • Zalcenstein A, Weisz L, Stambolsky P, Bar J, Rotter V, Oren M (2006) Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53. Oncogene 25: 359-369.
    • (2006) Oncogene , vol.25 , pp. 359-369
    • Zalcenstein, A.1    Weisz, L.2    Stambolsky, P.3    Bar, J.4    Rotter, V.5    Oren, M.6
  • 49
    • 84871869428 scopus 로고    scopus 로고
    • Identification of novel mutant p53 interacting proteins by proteomic analysis
    • Deb S, Graves PR (2013) Identification of novel mutant p53 interacting proteins by proteomic analysis. Methods Mol Biol 962: 85-94.
    • (2013) Methods Mol Biol , vol.962 , pp. 85-94
    • Deb, S.1    Graves, P.R.2
  • 50
    • 84871892027 scopus 로고    scopus 로고
    • Measurement of chemosensitivity and growth rate in p53 expressing cells
    • Ramamoorthy M, Vaughan C, Deb S, Deb SP (2012) Measurement of chemosensitivity and growth rate in p53 expressing cells. Methods Mol Biol 962: 127-133.
    • (2012) Methods Mol Biol , vol.962 , pp. 127-133
    • Ramamoorthy, M.1    Vaughan, C.2    Deb, S.3    Deb, S.P.4
  • 51
    • 15244362062 scopus 로고    scopus 로고
    • P53 abnormalities and outcomes in colorectal cancer: A systematic review
    • Munro AJ, Lain S, Lane DP (2005) P53 abnormalities and outcomes in colorectal cancer: a systematic review. Br J Cancer 92: 434-444.
    • (2005) Br J Cancer , vol.92 , pp. 434-444
    • Munro, A.J.1    Lain, S.2    Lane, D.P.3
  • 52
    • 0142087616 scopus 로고    scopus 로고
    • Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: A Gynecologic Oncology Group Study
    • Havrilesky L, Darcy kM, Hamdan H, Priore RL, Leon J, Bell J, Berchuck A (2003) Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol 21: 3814-3825.
    • (2003) J Clin Oncol , vol.21 , pp. 3814-3825
    • Havrilesky, L.1    Darcy k, M.2    Hamdan, H.3    Priore, R.L.4    Leon, J.5    Bell, J.6    Berchuck, A.7
  • 56
    • 0033041769 scopus 로고    scopus 로고
    • Carboplatin and paclitaxel, alone and in combination: Dose escalation, measurement of renal function, and role of the p53 tumor suppressor gene
    • Calvert AH, Ghokul S, Al-Azraqi A, Wright J, Lind M, Bailey N, Highley M, Siddiqui N, Lunec J et al (1999) Carboplatin and paclitaxel, alone and in combination: dose escalation, measurement of renal function, and role of the p53 tumor suppressor gene. Semin Oncol 26: 90-94.
    • (1999) Semin Oncol , vol.26 , pp. 90-94
    • Calvert, A.H.1    Ghokul, S.2    Al-Azraqi, A.3    Wright, J.4    Lind, M.5    Bailey, N.6    Highley, M.7    Siddiqui, N.8    Lunec, J.9
  • 61
    • 0035160889 scopus 로고    scopus 로고
    • The effects of p53 status and human papillomavirus infection on the clinical outcome of patients with stage IIIB cervical carcinoma treated with radiation therapy alone
    • Ishikawa H, Mitsuhashi N, Sakurai H, Maebayashi K, Niibe H (2001) The effects of p53 status and human papillomavirus infection on the clinical outcome of patients with stage IIIB cervical carcinoma treated with radiation therapy alone. Cancer 91: 80-89.
    • (2001) Cancer , vol.91 , pp. 80-89
    • Ishikawa, H.1    Mitsuhashi, N.2    Sakurai, H.3    Maebayashi, K.4    Niibe, H.5
  • 63
    • 84863102966 scopus 로고    scopus 로고
    • Value of TP53 status for predicting response to neoadjuvant chemotherapy in breast cancer: A meta-analysis
    • Chen MB, Zhu YQ, Xu JY, Wang LQ, Liu CY, Ji ZY, Lu PH (2012) Value of TP53 status for predicting response to neoadjuvant chemotherapy in breast cancer: a meta-analysis. PLoS One 7: e39655.
    • (2012) PLoS One , vol.7
    • Chen, M.B.1    Zhu, Y.Q.2    Xu, J.Y.3    Wang, L.Q.4    Liu, C.Y.5    Ji, Z.Y.6    Lu, P.H.7
  • 65
    • 79957645965 scopus 로고    scopus 로고
    • Gene expression signature of TP53 but not its mutation status predicts response to sequential paclitaxel and 5-FU/epirubicin/cyclophosphamide in human breast cancer
    • Oshima K, Naoi Y, Kishi K, Nakamura Y, Iwamoto T, Shimazu K, Nakayama T, Kim SJ, Baba Y et al (2011) Gene expression signature of TP53 but not its mutation status predicts response to sequential paclitaxel and 5-FU/epirubicin/cyclophosphamide in human breast cancer. Cancer Lett 307: 149-157.
    • (2011) Cancer Lett , vol.307 , pp. 149-157
    • Oshima, K.1    Naoi, Y.2    Kishi, K.3    Nakamura, Y.4    Iwamoto, T.5    Shimazu, K.6    Nakayama, T.7    Kim, S.J.8    Baba, Y.9
  • 67
    • 0028875410 scopus 로고
    • Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy
    • Bergh J, Norberg T, Sjogren S, Lindgren A, Holmberg L (1995) Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat Med 1: 1029-1034.
    • (1995) Nat Med , vol.1 , pp. 1029-1034
    • Bergh, J.1    Norberg, T.2    Sjogren, S.3    Lindgren, A.4    Holmberg, L.5
  • 70
    • 0028859453 scopus 로고
    • p53 status predicts survival in breast cancer patients treated with or without postoperative radiotherapy: A novel hypothesis based on clinical findings
    • Jansson T, Inganas M, Sjogren S, Norberg T, Lindgren A, Holmberg L, Bergh J (1995) p53 status predicts survival in breast cancer patients treated with or without postoperative radiotherapy: a novel hypothesis based on clinical findings. J Clin Oncol 13: 2745-2751.
    • (1995) J Clin Oncol , vol.13 , pp. 2745-2751
    • Jansson, T.1    Inganas, M.2    Sjogren, S.3    Norberg, T.4    Lindgren, A.5    Holmberg, L.6    Bergh, J.7
  • 72
  • 73
    • 0342973089 scopus 로고    scopus 로고
    • TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck
    • Alsner J, Sorensen SB, Overgaard J (2001) TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck. Radiother Oncol 59: 179-185.
    • (2001) Radiother Oncol , vol.59 , pp. 179-185
    • Alsner, J.1    Sorensen, S.B.2    Overgaard, J.3
  • 74
    • 0032763639 scopus 로고    scopus 로고
    • Cumulative prognostic value of p53 mutations and bcl-2 protein expression in head-and-neck cancer treated by radiotherapy
    • Gallo O, Chiarelli I, Boddi V, Bocciolini C, Bruschini L, Porfirio B (1999) Cumulative prognostic value of p53 mutations and bcl-2 protein expression in head-and-neck cancer treated by radiotherapy. Int J Cancer 84: 573-579.
    • (1999) Int J Cancer , vol.84 , pp. 573-579
    • Gallo, O.1    Chiarelli, I.2    Boddi, V.3    Bocciolini, C.4    Bruschini, L.5    Porfirio, B.6
  • 76
    • 0036843814 scopus 로고    scopus 로고
    • A lack of association between p53 mutations and recurrent nasopharyngeal carcinomas refractory to radiotherapy
    • Chang KP, Hao SP, Lin SY, Tsao KC, Kuo TT, Tsai MH, Tseng CK, Tsang NM (2002) A lack of association between p53 mutations and recurrent nasopharyngeal carcinomas refractory to radiotherapy. Laryngoscope 112: 2015-2019.
    • (2002) Laryngoscope , vol.112 , pp. 2015-2019
    • Chang, K.P.1    Hao, S.P.2    Lin, S.Y.3    Tsao, K.C.4    Kuo, T.T.5    Tsai, M.H.6    Tseng, C.K.7    Tsang, N.M.8
  • 77
    • 0032874396 scopus 로고    scopus 로고
    • Patterns of p53 gene mutations in head and neck cancer: Full-length gene sequencing and results of primary radiotherapy
    • Saunders ME, MacKenzie R, Shipman R, Fransen E, Gilbert R, Jordan RC (1999) Patterns of p53 gene mutations in head and neck cancer: full-length gene sequencing and results of primary radiotherapy. Clin Cancer Res 5: 2455-2463.
    • (1999) Clin Cancer Res , vol.5 , pp. 2455-2463
    • Saunders, M.E.1    McKenzie, R.2    Shipman, R.3    Fransen, E.4    Gilbert, R.5    Jordan, R.C.6
  • 80
    • 0029868812 scopus 로고    scopus 로고
    • p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma
    • Prendergast NJ, Atkins MR, Schatte EC, Paulson DF, Walther PJ (1996) p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma. J Urol 155: 1685-1692.
    • (1996) J Urol , vol.155 , pp. 1685-1692
    • Prendergast, N.J.1    Atkins, M.R.2    Schatte, E.C.3    Paulson, D.F.4    Walther, P.J.5
  • 81
    • 0033000960 scopus 로고    scopus 로고
    • p53 gene alterations in prostate cancer after radiation failure and their association with clinical outcome: A molecular and immunohistochemical analysis
    • Rakozy C, Grignon DJ, Li Y, Gheiler E, Gururajanna B, Pontes JE, Sakr W, Wood DP Jr, Sarkar FH (1999) p53 gene alterations in prostate cancer after radiation failure and their association with clinical outcome: a molecular and immunohistochemical analysis. Pathol Res Pract 195: 129-135.
    • (1999) Pathol Res Pract , vol.195 , pp. 129-135
    • Rakozy, C.1    Grignon, D.J.2    Li, Y.3    Gheiler, E.4    Gururajanna, B.5    Pontes, J.E.6    Sakr, W.7    Wood, D.P.8    Sarkar, F.H.9
  • 83
    • 0027942844 scopus 로고
    • p53 in hematologic malignancies
    • Imamura J, Miyoshi I, Koeffler HP (1994) p53 in hematologic malignancies. Blood 84: 2412-2421.
    • (1994) Blood , vol.84 , pp. 2412-2421
    • Imamura, J.1    Miyoshi, I.2    Koeffler, H.P.3
  • 84
    • 0028172868 scopus 로고
    • p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P, Fenaux P (1994) p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84: 3148-3157.
    • (1994) Blood , vol.84 , pp. 3148-3157
    • Wattel, E.1    Preudhomme, C.2    Hecquet, B.3    Vanrumbeke, M.4    Quesnel, B.5    Dervite, I.6    Morel, P.7    Fenaux, P.8
  • 85
    • 79957949229 scopus 로고    scopus 로고
    • Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: Results from the LRF CLL4 trial
    • Gonzalez D, Martinez P, Wade R, Hockley S, Oscier D, Matutes E, Dearden CE, Richards SM, Catovsky D, Morgan GJ (2012) Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial. J Clin Oncol 29: 2223-2229.
    • (2012) J Clin Oncol , vol.29 , pp. 2223-2229
    • Gonzalez, D.1    Martinez, P.2    Wade, R.3    Hockley, S.4    Oscier, D.5    Matutes, E.6    Dearden, C.E.7    Richards, S.M.8    Catovsky, D.9    Morgan, G.J.10
  • 86
  • 90
    • 0034663195 scopus 로고    scopus 로고
    • p53 mutations do not predict response to paclitaxel in metastatic nonsmall cell lung carcinoma
    • King TC, Akerley W, Fan AC, Moore T, Mangray S, Hsiu Chen M, Safran H (2000) p53 mutations do not predict response to paclitaxel in metastatic nonsmall cell lung carcinoma. Cancer 89: 769-773.
    • (2000) Cancer , vol.89 , pp. 769-773
    • King, T.C.1    Akerley, W.2    Fan, A.C.3    Moore, T.4    Mangray, S.5    Hsiu Chen, M.6    Safran, H.7
  • 94
    • 73349110095 scopus 로고    scopus 로고
    • Radiobiology of vestibular schwannomas: Mechanisms of radioresistance and potential targets for therapeutic sensitization
    • Yeung AH, Sughrue ME, Kane AJ, Tihan T, Cheung SW, Parsa AT (2009) Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitization. Neurosurg Focus 27: E2.
    • (2009) Neurosurg Focus , vol.27
    • Yeung, A.H.1    Sughrue, M.E.2    Kane, A.J.3    Tihan, T.4    Cheung, S.W.5    Parsa, A.T.6
  • 95
    • 73349103157 scopus 로고    scopus 로고
    • Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: A prospective translational study of the German Glioma Network
    • Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, Westphal M, Schackert G, Simon M et al (2009) Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network. J Clin Oncol 27: 5743-5750.
    • (2009) J Clin Oncol , vol.27 , pp. 5743-5750
    • Weller, M.1    Felsberg, J.2    Hartmann, C.3    Berger, H.4    Steinbach, J.P.5    Schramm, J.6    Westphal, M.7    Schackert, G.8    Simon, M.9
  • 97
    • 0035105560 scopus 로고    scopus 로고
    • The results of colorectal cancer treatment by p53 status: Treatment-specific overview
    • discussion 333-334
    • Petersen S, Thames HD, Nieder C, Petersen C, Baumann M (2001) The results of colorectal cancer treatment by p53 status: treatment-specific overview. Dis Colon Rectum 44: 322-333. discussion 333-334.
    • (2001) Dis Colon Rectum , vol.44 , pp. 322-333
    • Petersen, S.1    Thames, H.D.2    Nieder, C.3    Petersen, C.4    Baumann, M.5
  • 98
    • 84866636175 scopus 로고    scopus 로고
    • P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: A meta-analysis in rectal cancer
    • Chen MB, Wu XY, Yu R, Li C, Wang LQ, Shen W, Lu PH (2012) P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer. PLoS One 7: e45388.
    • (2012) PLoS One , vol.7
    • Chen, M.B.1    Wu, X.Y.2    Yu, R.3    Li, C.4    Wang, L.Q.5    Shen, W.6    Lu, P.H.7
  • 99
    • 0036208768 scopus 로고    scopus 로고
    • TP53 genotype but not p53 immunohistochemical result predicts response to preoperative short-term radiotherapy in rectal cancer
    • Kandioler D, Zwrtek R, Ludwig C, Janschek E, Ploner M, Hofbauer F, Kuhrer I, Kappel S, Wrba F et al (2002) TP53 genotype but not p53 immunohistochemical result predicts response to preoperative short-term radiotherapy in rectal cancer. Ann Surg 235: 493-498.
    • (2002) Ann Surg , vol.235 , pp. 493-498
    • Kandioler, D.1    Zwrtek, R.2    Ludwig, C.3    Janschek, E.4    Ploner, M.5    Hofbauer, F.6    Kuhrer, I.7    Kappel, S.8    Wrba, F.9
  • 101
    • 24944525406 scopus 로고    scopus 로고
    • Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients
    • Westra JL, Schaapveld M, Hollema H, de Boer JP, Kraak MM, de Jong D, ter Elst A, Mulder NH, Buys CH et al (2005) Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol 23: 5635-5643.
    • (2005) J Clin Oncol , vol.23 , pp. 5635-5643
    • Westra, J.L.1    Schaapveld, M.2    Hollema, H.3    de Boer, J.P.4    Kraak, M.M.5    de Jong, D.6    ter Elst, A.7    Mulder, N.H.8    Buys, C.H.9
  • 102
    • 0030035584 scopus 로고    scopus 로고
    • p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas
    • Benhattar J, Cerottini JP, Saraga E, Metthez G, Givel JC (1996) p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas. Int J Cancer 69: 190-192.
    • (1996) Int J Cancer , vol.69 , pp. 190-192
    • Benhattar, J.1    Cerottini, J.P.2    Saraga, E.3    Metthez, G.4    Givel, J.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.