DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

eLife

Volumn 2012, Issue 1, 2012, Pages

  Ferguson, Brian J ^a,b   Mansur, Daniel S ^a,c   Peters, Nicholas E ^a   Ren, Hongwei ^a,b   Smith, Geoffrey L ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; DNA DEPENDENT PROTEIN KINASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NU 7026; PROTEIN; PROTEIN KINASE INHIBITOR; RANTES; STIMULATOR OF INTERFERON GENE PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; DNA BINDING PROTEIN; INTERFERON; IRF3 PROTEIN, MOUSE; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; NUCLEAR PROTEIN; PRKDC PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, MOUSE; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOTINYLATION; CONTROLLED STUDY; DNA BINDING; DNA REPAIR; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPRECIPITATION; INFLAMMATION; INNATE IMMUNITY; INTERFERON STIMULATED GENE 54; MOUSE; NONHUMAN; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; UPREGULATION; VDJ RECOMBINATION; VIRUS INFECTION; ANIMAL; ANIMAL EMBRYO; BAGG ALBINO MOUSE; BIOSYNTHESIS; DEFICIENCY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HERPES SIMPLEX VIRUS 1; IMMUNOLOGY; INFLUENZA VIRUS A; KNOCKOUT MOUSE; METABOLISM; PRIMARY CELL CULTURE; VACCINIA VIRUS; VIROLOGY;

ANIMALS; CYTOKINES; DNA REPAIR; DNA, VIRAL; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION REGULATION; HERPESVIRUS 1, HUMAN; IMMUNITY, INNATE; INFLUENZA A VIRUS; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NUCLEAR PROTEINS; PRIMARY CELL CULTURE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; V(D)J RECOMBINATION; VACCINIA VIRUS;

EID: 84875224757     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.00047     Document Type: Article

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