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Volumn 74, Issue 22, 2014, Pages 6441-6451

SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccines

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; IMMUNOLOGICAL ADJUVANT; PHOSPHORYL LIPID A; PROTEIN E7; SURVIVIN; T CELL COSTIMULATORY MOLECULE SA 4 1BBL; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; CD137 LIGAND; GAMMA INTERFERON; LIPID A; STREPTAVIDIN;

EID: 84918592462     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-1768-A     Document Type: Article
Times cited : (35)

References (50)
  • 3
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11:373-84.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 4
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009;9:271-85.
    • (2009) Nat Rev Immunol , vol.9 , pp. 271-285
    • Croft, M.1
  • 5
    • 71649087760 scopus 로고    scopus 로고
    • Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: Analysis of a randomised placebo-controlled trial up to 6.4 years
    • Romanowski B, De Borba PC, Naud PS, Roteli-Martins CM, De Carvalho NS, Teixeira JC, et al. Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 years. Lancet 2009;374:1975-85.
    • (2009) Lancet , vol.374 , pp. 1975-1985
    • Romanowski, B.1    De Borba, P.C.2    Naud, P.S.3    Roteli-Martins, C.M.4    De Carvalho, N.S.5    Teixeira, J.C.6
  • 6
    • 31544451599 scopus 로고    scopus 로고
    • Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells
    • Myers L, Lee SW, Rossi RJ, Lefrancois L, Kwon BS, Mittler RS, et al. Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells. Int Immunol 2006;18:325-33.
    • (2006) Int Immunol , vol.18 , pp. 325-333
    • Myers, L.1    Lee, S.W.2    Rossi, R.J.3    Lefrancois, L.4    Kwon, B.S.5    Mittler, R.S.6
  • 7
    • 0041975924 scopus 로고    scopus 로고
    • 4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1
    • Lee HW, Nam KO, Park SJ, Kwon BS. 4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1. Eur J Immunol 2003;33:2133-41.
    • (2003) Eur J Immunol , vol.33 , pp. 2133-2141
    • Lee, H.W.1    Nam, K.O.2    Park, S.J.3    Kwon, B.S.4
  • 8
    • 0027320440 scopus 로고
    • Vaccination with cytotoxic T lymphocyte epitopecontaining peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
    • Feltkamp MC, Smits HL, Vierboom MP, Minnaar RP, De Jongh BM, Drijfhout JW, et al. Vaccination with cytotoxic T lymphocyte epitopecontaining peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur J Immunol 1993;23:2242-9.
    • (1993) Eur J Immunol , vol.23 , pp. 2242-2249
    • Feltkamp, M.C.1    Smits, H.L.2    Vierboom, M.P.3    Minnaar, R.P.4    De Jongh, B.M.5    Drijfhout, J.W.6
  • 9
    • 0030068375 scopus 로고    scopus 로고
    • Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
    • Lin KY, Guarnieri FG, Staveley-O'Carroll KF, Levitsky HI, August JT, Pardoll DM, et al. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res 1996;56:21-6.
    • (1996) Cancer Res , vol.56 , pp. 21-26
    • Lin, K.Y.1    Guarnieri, F.G.2    Staveley-O'Carroll, K.F.3    Levitsky, H.I.4    August, J.T.5    Pardoll, D.M.6
  • 10
    • 77952845427 scopus 로고    scopus 로고
    • 4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines
    • Sharma RK, Schabowsky R-H, Srivastava A, Elpek KG, Madireddi S, Zhao H, et al. 4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines. Cancer Res 2010;70:3945-54.
    • (2010) Cancer Res , vol.70 , pp. 3945-3954
    • Sharma, R.K.1    Schabowsky, R.-H.2    Srivastava, A.3    Elpek, K.G.4    Madireddi, S.5    Zhao, H.6
  • 11
    • 77956881584 scopus 로고    scopus 로고
    • Tumor cells engineered to codisplay on their surface 4-1BBL and LIGHT costimulatory proteins as a novel vaccine approach for cancer immunotherapy
    • Sharma RK, Yolcu ES, Elpek KG, Shirwan H. Tumor cells engineered to codisplay on their surface 4-1BBL and LIGHT costimulatory proteins as a novel vaccine approach for cancer immunotherapy. Cancer Gene Ther 2010;17:730-41.
    • (2010) Cancer Gene Ther , vol.17 , pp. 730-741
    • Sharma, R.K.1    Yolcu, E.S.2    Elpek, K.G.3    Shirwan, H.4
  • 12
    • 70649103798 scopus 로고    scopus 로고
    • A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab associated severe toxicity
    • Schabowsky RH, Elpek KG, Sharma RK, Yolcu ES, Bandura-Morgan L, Mittler RS, et al. A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab associated severe toxicity. Vaccine 2009;28:512-22.
    • (2009) Vaccine , vol.28 , pp. 512-522
    • Schabowsky, R.H.1    Elpek, K.G.2    Sharma, R.K.3    Yolcu, E.S.4    Bandura-Morgan, L.5    Mittler, R.S.6
  • 13
    • 66249141668 scopus 로고    scopus 로고
    • Costimulation as a platform for the development of vaccines: A peptide-based vaccine containing a novel from of 4-1BBL eradicates established tumors
    • Sharma RK, Elpek KG, Yolcu ES, Schabowsky R-H, Zhao H, Bandura-Morgan L, et al. Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel from of 4-1BBL eradicates established tumors. Cancer Res 2009;69:4319-26.
    • (2009) Cancer Res , vol.69 , pp. 4319-4326
    • Sharma, R.K.1    Elpek, K.G.2    Yolcu, E.S.3    Schabowsky, R.-H.4    Zhao, H.5    Bandura-Morgan, L.6
  • 14
    • 84869020810 scopus 로고    scopus 로고
    • Prime-boost vaccination with SA-4-1BBL costimulatory molecule and survivin eradicates lung carcinoma in CD8+ T and NK cell dependent manner
    • Srivastava AK, Sharma RK, Yolcu ES, Ulker V, MacLeod K, Dinc G, et al. Prime-boost vaccination with SA-4-1BBL costimulatory molecule and survivin eradicates lung carcinoma in CD8+ T and NK cell dependent manner. PLoS ONE 2012;7:e48463.
    • (2012) PLoS ONE , vol.7 , pp. e48463
    • Srivastava, A.K.1    Sharma, R.K.2    Yolcu, E.S.3    Ulker, V.4    MacLeod, K.5    Dinc, G.6
  • 15
    • 84864749497 scopus 로고    scopus 로고
    • SA-4-1BBL costimulation inhibits conversion of conventionalCD4+T cells into CD4+FoxP3+T regulatory cells by production of IFN-gamma
    • Madireddi S, Schabowsky RH, Srivastava AK, Sharma RK, Yolcu ES, Shirwan H. SA-4-1BBL costimulation inhibits conversion of conventionalCD4+T cells into CD4+FoxP3+T regulatory cells by production of IFN-gamma. PLoS ONE 2012;7:e42459.
    • (2012) PLoS ONE , vol.7 , pp. e42459
    • Madireddi, S.1    Schabowsky, R.H.2    Srivastava, A.K.3    Sharma, R.K.4    Yolcu, E.S.5    Shirwan, H.6
  • 16
    • 77249176352 scopus 로고    scopus 로고
    • AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity
    • Didierlaurent AM, Morel S, Lockman L, Giannini SL, Bisteau M, Carlsen H, et al. AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J Immunol 2009;183:6186-97.
    • (2009) J Immunol , vol.183 , pp. 6186-6197
    • Didierlaurent, A.M.1    Morel, S.2    Lockman, L.3    Giannini, S.L.4    Bisteau, M.5    Carlsen, H.6
  • 17
    • 0842320993 scopus 로고    scopus 로고
    • Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses
    • Bukczynski J, Wen T, Ellefsen K, Gauldie J, Watts TH. Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses. Proc Natl Acad SciUS A 2004;101:1291-6.
    • (2004) Proc Natl Acad SciUS A , vol.101 , pp. 1291-1296
    • Bukczynski, J.1    Wen, T.2    Ellefsen, K.3    Gauldie, J.4    Watts, T.H.5
  • 18
    • 0035423265 scopus 로고    scopus 로고
    • 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy
    • Cannons JL, Lau P, Ghumman B, De Benedette MA, Yagita H, Okumura K, et al. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J Immunol 2001;167:1313-24.
    • (2001) J Immunol , vol.167 , pp. 1313-1324
    • Cannons, J.L.1    Lau, P.2    Ghumman, B.3    De Benedette, M.A.4    Yagita, H.5    Okumura, K.6
  • 19
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005;23:23-68.
    • (2005) Annu Rev Immunol , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 20
    • 0036645294 scopus 로고    scopus 로고
    • Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase
    • Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, et al. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 2002;196:135-40.
    • (2002) J Exp Med , vol.196 , pp. 135-140
    • Cohen, P.L.1    Caricchio, R.2    Abraham, V.3    Camenisch, T.D.4    Jennette, J.C.5    Roubey, R.A.6
  • 22
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 23
    • 62449250053 scopus 로고    scopus 로고
    • Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
    • Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, Arfi V, et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 2009;69:2000-9.
    • (2009) Cancer Res , vol.69 , pp. 2000-2009
    • Gobert, M.1    Treilleux, I.2    Bendriss-Vermare, N.3    Bachelot, T.4    Goddard-Leon, S.5    Arfi, V.6
  • 24
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    • Dannull J, Su Z, Rizzieri D, Yang BK, Coleman D, Yancey D, et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 2005;115:3623-33.
    • (2005) J Clin Invest , vol.115 , pp. 3623-3633
    • Dannull, J.1    Su, Z.2    Rizzieri, D.3    Yang, B.K.4    Coleman, D.5    Yancey, D.6
  • 25
    • 40749114476 scopus 로고    scopus 로고
    • Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo
    • Powell DJ Jr, Felipe-Silva A, Merino MJ, Ahmadzadeh M, Allen T, Levy C, et al. Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo. J Immunol 2007;179:4919-28.
    • (2007) J Immunol , vol.179 , pp. 4919-4928
    • Powell, D.J.1    Felipe-Silva, A.2    Merino, M.J.3    Ahmadzadeh, M.4    Allen, T.5    Levy, C.6
  • 26
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 2006;116:1935-45.
    • (2006) J Clin Invest , vol.116 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 27
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A 2003;100:8372-7.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3    Hwu, P.4    Topalian, S.L.5    Schwartzentruber, D.J.6
  • 28
    • 42449157557 scopus 로고    scopus 로고
    • Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
    • Burgdorf S, Scholz C, Kautz A, Tampe R, Kurts C. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 2008;9:558-66.
    • (2008) Nat Immunol , vol.9 , pp. 558-566
    • Burgdorf, S.1    Scholz, C.2    Kautz, A.3    Tampe, R.4    Kurts, C.5
  • 30
    • 70349506614 scopus 로고    scopus 로고
    • A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverse signaling
    • Ju S, Ju S, Ge Y, Qiu H, Lu B, Qiu Y, et al. A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverse signaling. Int Immunol 2009;21:1135-44.
    • (2009) Int Immunol , vol.21 , pp. 1135-1144
    • Ju, S.1    Ju, S.2    Ge, Y.3    Qiu, H.4    Lu, B.5    Qiu, Y.6
  • 31
    • 34249077931 scopus 로고    scopus 로고
    • Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
    • Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, et al. Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. Nat Immunol 2007;8:601-9.
    • (2007) Nat Immunol , vol.8 , pp. 601-609
    • Kang, Y.J.1    Kim, S.O.2    Shimada, S.3    Otsuka, M.4    Seit-Nebi, A.5    Kwon, B.S.6
  • 32
    • 84885820620 scopus 로고    scopus 로고
    • The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation
    • Ma J, Bang BR, Lu J, Eun SY, Otsuka M, Croft M, et al. The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal 2013;6: ra87.
    • (2013) Sci Signal , vol.6 , pp. ra87
    • Ma, J.1    Bang, B.R.2    Lu, J.3    Eun, S.Y.4    Otsuka, M.5    Croft, M.6
  • 34
    • 33644823583 scopus 로고    scopus 로고
    • Anti-CD137 monoclonal antibody promotes the direct anti-tumor effect mediated by peripheral blood-derived human dendritic cells in vitro
    • Zhang L, Wang Q, Wang X, Ding P, Song J, Ma C, et al. Anti-CD137 monoclonal antibody promotes the direct anti-tumor effect mediated by peripheral blood-derived human dendritic cells in vitro. Cell Mol Immunol 2004;1:71-6.
    • (2004) Cell Mol Immunol , vol.1 , pp. 71-76
    • Zhang, L.1    Wang, Q.2    Wang, X.3    Ding, P.4    Song, J.5    Ma, C.6
  • 36
    • 67449092763 scopus 로고    scopus 로고
    • Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigenspecific CD8+ T cells with tumor regression
    • Imai N, Ikeda H, Tawara I, Wang L, Wang L, Nishikawa H, et al. Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigenspecific CD8+ T cells with tumor regression. Cancer Sci 2009;100:1317-25.
    • (2009) Cancer Sci , vol.100 , pp. 1317-1325
    • Imai, N.1    Ikeda, H.2    Tawara, I.3    Wang, L.4    Wang, L.5    Nishikawa, H.6
  • 37
    • 8644290853 scopus 로고    scopus 로고
    • CD4+ CD25+ T cells regulate vaccinegenerated primary and memory CD8+T-cell responses against herpes simplex virus type 1
    • Toka FN, Suvas S, Rouse BT. CD4+ CD25+ T cells regulate vaccinegenerated primary and memory CD8+T-cell responses against herpes simplex virus type 1. J Virol 2004;78:13082-9.
    • (2004) J Virol , vol.78 , pp. 13082-13089
    • Toka, F.N.1    Suvas, S.2    Rouse, B.T.3
  • 38
    • 33947253487 scopus 로고    scopus 로고
    • CD4 (+) CD25 (+) FoxP3 (+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease
    • Chen X, Zhou B, Li M, Deng Q, Wu X, Le X, et al. CD4 (+) CD25 (+) FoxP3 (+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clin Immunol 2007;123:50-9.
    • (2007) Clin Immunol , vol.123 , pp. 50-59
    • Chen, X.1    Zhou, B.2    Li, M.3    Deng, Q.4    Wu, X.5    Le, X.6
  • 39
    • 15444377017 scopus 로고    scopus 로고
    • Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • Yu P, Lee Y, Liu W, Krausz T, Chong A, Schreiber H, et al. Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med 2005;201:779-91.
    • (2005) J Exp Med , vol.201 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3    Krausz, T.4    Chong, A.5    Schreiber, H.6
  • 40
    • 34249785092 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early, but not late phases of tumor development in a B cell lymphoma model
    • Elpek KG, Lacelle C, Singh NP, Yolcu ES, Shirwan H. CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early, but not late phases of tumor development in a B cell lymphoma model. J Immunol 2007;178:6840-8.
    • (2007) J Immunol , vol.178 , pp. 6840-6848
    • Elpek, K.G.1    Lacelle, C.2    Singh, N.P.3    Yolcu, E.S.4    Shirwan, H.5
  • 41
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma
    • Klages K, Mayer CT, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, et al. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res 2010;70:7788-99.
    • (2010) Cancer Res , vol.70 , pp. 7788-7799
    • Klages, K.1    Mayer, C.T.2    Lahl, K.3    Loddenkemper, C.4    Teng, M.W.5    Ngiow, S.F.6
  • 42
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng MW, Ngiow SF, Von SB, McLaughlin N, Sparwasser T, Smyth MJ. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res 2010;70:7800-9.
    • (2010) Cancer Res , vol.70 , pp. 7800-7809
    • Ngiow, T.M.W.S.F.1    Von, S.B.2    McLaughlin, N.3    Sparwasser, T.4    Smyth, M.J.5
  • 43
    • 70449723156 scopus 로고    scopus 로고
    • Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia
    • Zhou Q, Bucher C, Munger ME, Highfill SL, Tolar J, Munn DH, et al. Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. Blood 2009;114:3793-802.
    • (2009) Blood , vol.114 , pp. 3793-3802
    • Zhou, Q.1    Bucher, C.2    Munger, M.E.3    Highfill, S.L.4    Tolar, J.5    Munn, D.H.6
  • 44
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003;197:403-11.
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 45
    • 75649147911 scopus 로고    scopus 로고
    • TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
    • Gonzalez-Navajas JM, Fine S, Law J, Datta SK, Nguyen KP, Yu M, et al. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest 2010;120:570-81.
    • (2010) J Clin Invest , vol.120 , pp. 570-581
    • Gonzalez-Navajas, J.M.1    Fine, S.2    Law, J.3    Datta, S.K.4    Nguyen, K.P.5    Yu, M.6
  • 46
    • 48549099849 scopus 로고    scopus 로고
    • OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor
    • Gough MJ, Ruby CE, Redmond WL, Dhungel B, Brown A, Weinberg AD. OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor. Cancer Res 2008;68:5206-15.
    • (2008) Cancer Res , vol.68 , pp. 5206-5215
    • Gough, M.J.1    Ruby, C.E.2    Redmond, W.L.3    Dhungel, B.4    Brown, A.5    Weinberg, A.D.6
  • 48
    • 84884192283 scopus 로고    scopus 로고
    • CD4 (+) T cells play a critical role in the generation of primary and memory antitumor immune responses elicited by SA-4-1BBL and TAA-based vaccines in mouse tumor models
    • Sharma RK, Yolcu ES, Srivastava AK, Shirwan H. CD4 (+) T cells play a critical role in the generation of primary and memory antitumor immune responses elicited by SA-4-1BBL and TAA-based vaccines in mouse tumor models. PLoS ONE 2013;8:e73145.
    • (2013) PLoS ONE , vol.8 , pp. e73145
    • Sharma, R.K.1    Yolcu, E.S.2    Srivastava, A.K.3    Shirwan, H.4
  • 49
    • 79151475547 scopus 로고    scopus 로고
    • Selective impairment of CD4+CD25+Foxp3 +regulatory T cells by paclitaxel is explained by Bcl-2/Bax mediated apoptosis
    • Liu N, Zheng Y, Zhu Y, Xiong S, Chu Y. Selective impairment of CD4+CD25+Foxp3 +regulatory T cells by paclitaxel is explained by Bcl-2/Bax mediated apoptosis. Int Immunopharmacol 2011;11:212-9.
    • (2011) Int Immunopharmacol , vol.11 , pp. 212-219
    • Liu, N.1    Zheng, Y.2    Zhu, Y.3    Xiong, S.4    Chu, Y.5
  • 50
    • 34250871751 scopus 로고    scopus 로고
    • Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses
    • Tuve S, Chen BM, Liu Y, Cheng TL, Toure P, Sow PS, et al. Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses. Cancer Res 2007;67:5929-39.
    • (2007) Cancer Res , vol.67 , pp. 5929-5939
    • Tuve, S.1    Chen, B.M.2    Liu, Y.3    Cheng, T.L.4    Toure, P.5    Sow, P.S.6


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