Nutrition, infection and stunting: The roles of deficiencies of individual nutrients and foods, and of inflammation, as determinants of reduced linear growth of children

Nutrition Research Reviews

Volumn 30, Issue 1, 2017, Pages 50-72

  Millward, D Joe ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Endochondral ossification; Environmental enteric dysfunction; Iodine; Micronutrients; Milk; Protein; Zinc

Indexed keywords

C REACTIVE PROTEIN; FIBROBLAST GROWTH FACTOR 21; INTERLEUKIN 6; PROTEOGLYCAN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; IGF1 PROTEIN, HUMAN; IODINE; TRACE ELEMENT; ZINC;

AFLATOXICOSIS; ANIMAL SOURCE FOOD; CELL CYCLE PROGRESSION; COHORT ANALYSIS; DIETARY INTAKE; ENCHONDRAL OSSIFICATION; ENERGY DEFICIENCY; EPIPHYSIS PLATE; FOOD; GROWTH REGULATION; HUMAN; IODINE DEFICIENCY; IODINE INTAKE; KWASHIORKOR; NONHUMAN; NUTRITIONAL DEFICIENCY; OBESITY; PARACRINE SIGNALING; PREGNANCY; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN INTAKE; PROTEIN SYNTHESIS; REVIEW; STUNTING; ZINC DEFICIENCY; ZINC INTAKE; ADMINISTRATION AND DOSAGE; ANIMAL; BONE DEVELOPMENT; CALORIC INTAKE; CHILD; CHILD DEVELOPMENT; CHILD NUTRITION; DEFICIENCY; ENDOCRINE SYSTEM; FEMALE; GROWTH DISORDER; INFECTION; INFLAMMATION; NUTRITIONAL STATUS; PATHOPHYSIOLOGY; PHYSIOLOGY; PRENATAL EXPOSURE;

ANIMALS; CHILD; CHILD DEVELOPMENT; CHILD NUTRITIONAL PHYSIOLOGICAL PHENOMENA; DIETARY PROTEINS; ENDOCRINE SYSTEM; ENERGY INTAKE; FEMALE; GROWTH DISORDERS; HUMANS; INFECTION; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR I; IODINE; MICRONUTRIENTS; NUTRITIONAL STATUS; OSTEOGENESIS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEIN DEFICIENCY; ZINC;

EID: 85010915233     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S0954422416000238     Document Type: Review

References (261)

1. Tanner JM (1992) Growth as a measure of the nutritional and hygienic status of a population. Horm Res 38, Suppl. 1, 106-115.
2. Great Britain Inter-Departmental Committee on Physical Deterioration (1904) Report of the Inter-Departmental Committee on Physical Deterioration. London: HM Stationery Office.
3. NCD Risk Factor Collaboration (NCD-RisC) (2016) A century of trends in adult human height. Elife 26, 5 pii: e13410.
4. World Health Organization Multicentre Growth Reference Study Group (2006) WHO Child Growth Standards: length/height-for-age, weight-for-age, weight-for-length, weight-forheight and body mass index-for-age: methods and development. Geneva: WHO. http://www.who.int/childgrowth/standards/Technical-report.pdf (accessed October 2016).
5. Leroy JL, Ruel M, Habicht JP, et al. (2014) Linear growth deficit continues to accumulate beyond the first 1000 days in low-and middle-income countries: global evidence from 51 national surveys. J Nutr 144, 1460-1466.
6. de Onis M & Branca F (2016) Childhood stunting: a global perspective. Mat Child Nutr 12, Suppl. 1, 12-26.
7. United Nations Children's Fund, World Health Organization & World Bank (2012) Joint UNICEF-WHO-The World Bank Child Malnutrition Database: Estimates for 2012 and Launch of Interactive Data Dashboards. http://www.who. int/nutgrowthdb/jme-2012-summary-note-v2.pdf (accessed October 2016).
8. de Onis M, Blossner M & Borgh E (2012) Prevalence and trends of stunting among pre-school children, 1990-2020. Public Health Nutr 15, 142-148.
9. Prentice AM, Ward KA, Goldberg GR, et al. (2013) Critical windows for nutritional interventions against stunting. Am J Clin Nutr 97, 911-918.
10. Prendergast AJ & Humphrey JH (2014) The stunting syndrome in developing countries. Paediatr Int Child Health 34, 250-265.
11. United Nations System Standing Committee on Nutrition (2011) 6th Report on the World Nutrition Situation: Progress in Nutrition. United Nations Standing Committee on Nutrition, Geneva, Switzerland. http://www.fao.org/3/a-as211e. pdf (accessed October 2016).
12. Christian P, Lee SE, Angel MD, et al. (2013) Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low-and middle-income countries. Int J Epidemiol 42, 1340-1355.
13. Martorell R & Zongrone A (2012) Intergenerational influences on child growth and undernutrition. Paediatr Perinat Epidemiol 26, 302-314.
14. United Nations Children's Fund (2011) Infant and Young Child Feeding: Programming Guide. New York: UNICEF.
15. Scrimshaw NS, Taylor CE & Gordon JE (1968) Interactions of nutrition and infection. Monograph Series No. 57. http://apps. who.int/iris/bitstream/10665/41782/1/WHO-MONO-57-(part1).pdf (accessed October 2016).
16. Tanner JM (1979) A concise history of growth studies from Buffon to Boas. In Human Growth: a Comprehensive Treatise, vol. 3, Neurobiology and Nutrition, pp. 515-593 [F Faulkner and JM Tanner, editors]. New York: Plenum Press.
17. Millward DJ & Rivers J (1988) The nutritional role of indispensible amino acids and the metabolic basis for their requirements. Eur J Clin Nutr 42, 367-393.
18. Millward DJ & Rivers JPW (1989) The need for indispensable amino acids: the concept of the anabolic drive. Diabet Metab Rev 5, 191-212.
19. Villemure I & Stokes IAF (2009) Growth plate mechanics and mechanobiology. A survey of present understanding. J Biomech 42, 1793-1803.
20. Karlberg J (1989) A biologically-oriented mathematical model (ICP) for human growth. Acta Paediatr Scand Suppl 350, 70-94.
21. Ashworth A (1974) Ad lib. feeding during recovery from malnutrition. Br J Nutr 31, 109-112.
22. Ashworth A & Millward DJ (1986) Catch-up growth in children. Nutr Rev 44, 157-163.
23. Waterlow JC (2006) Protein Energy Malnutrition. London: Smith-Gordon & Co Ltd.
24. Golden MHN (1994) Is complete catch-up possible for stunted malnourished children? Eur J Clin Nutr 48, S58-S71.
25. Allen HL, Estrada K, Lettre G, et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838.
26. Lui JC & Baron J (2011) Mechanisms limiting body growth in mammals. Endocr Rev 32, 422-440.
27. Millward DJ (1995) A protein-stat mechanism for the regulation of growth and maintenance of the lean-body mass. Nutr Res Rev 8, 93-120.
28. Kronenberg HM (2003) Developmental regulation of the growth plate. Nature 423, 332-336.
29. Long F & Ornitz DM (2013) Development of the endochondral skeleton. Cold Spring Harb Perspect Biol 5, a008334.
30. Xian CJ (2014) Recent research on the growth plate: regulation, bone growth defects, and potential treatments. J Mol Endocrinol 53, E1-E2.
31. Bassett JHD & Williams GR (2016) Role of thyroid hormones in skeletal development and bone maintenance. Endocr Rev 37, 135-187.
32. Lui JC, Nilsson O & Baron J (2014) Recent insights into the regulation of the growth plate. J Mol Endocrinol 53, T1-T9.
33. Millward DJ (2012) Knowledge gained from studies of leucine consumption in animals and humans. J Nutr 142, 2212S-2219S.
34. Nilsson O, Marino R, De Luca F, et al. (2005) Endocrine regulation of the growth plate. Horm Res 64, 157-165.
35. Wit JM & Camacho-H?bner C (2011) Endocrine regulation of longitudinal bone growth. In Cartilage and Bone Development and its Disorders vol. 21, pp. 30-41 [C Camacho-H?bner, O Nilsson and L S?vendahl, editors]. Basel: Karger.
36. Waters MJ & Kaye PL (2002) The role of growth hormone in fetal development. Growth Horm IGF Res 12, 137-146.
37. Harvey S & Baudet M-L (2014) Extrapituitary growth hormone and growth? Gen Comp Endocrinol 205, 55-61.
38. Higgins MF, Russell NE, Crossey PA, et al. (2012) Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy. PLOS ONE 7, e29164.
39. Zeck W, Widberg C, Maylin E, et al. (2008) Regulation of placental growth hormone secretion in a human trophoblast model-the effects of hormones and adipokines. Pediatr Res 63, 353-357.
40. Chellakooty M, Vangsgaard K, Larsen T, et al. (2004) A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth. J Clin Endocrinol Metab 89, 384-391.
41. McIntyre HD, Serek R, Crane DI, et al. (2000) Placental growth hormone (GH), GH-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: correlations with fetal growth. J Clin Endocrinol Metab 85, 1143-1150.
42. Werther GA, Haynes K & Waters MJ (1993) GH receptors are expressed on human fetal mesenchymal tissues-identification of mRNA and GH binding protein. J Clin Endocrinol Metab 76, 1638-1646.
43. Fern?ndez-Cancio M, Audi L, Carrascosa A, et al. (2009) Vitamin D and growth hormone regulate growth hormone/insulin-like growth factor (GH-IGF) axis gene expression in human fetal epiphyseal chondrocytes. Growth Horm IGF Res 19, 232-237.
44. Zhang F, He Q, Tsang WP, et al. (2014) Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes. Bone Res 2, 14012.
45. Siddle K (2011) Signalling by insulin and IGF receptors: supporting acts and new players. J Mol Endocrinol 47, R1-R10.
46. Guntur AR & Rosen CJ (2013) IGF-1 regulation of key signaling pathways in bone. Bonekey Rep 2, 437.
47. Carter-Su C, Schwartz J & Argetsinger LS (2016) Growth hormone signaling pathways. Growth Horm IGF Res 28, 11-15.
48. Brooks AJ, Wooh JW, Tunny KA, et al. (2008) Growth hormone receptor; mechanism of action. Int J Biochem Cell Biol 40, 1984-1989.
49. Parker EA, Hegde A, Buckley M, et al. (2007) Spatial and temporal regulation of GH-IGF-related gene expression in growth plate cartilage. J Endocrinol 194, 31-40.
50. Darvin P, Joung YH & Yang YM (2013) JAK2-STAT5B pathway and osteoblast differentiation. JAKSTAT 2, e24931.
51. Stratikopoulosa E, Szabolcsb M, Dragatsisc I, et al. (2008) The hormonal action of IGF1 in postnatal mouse growth. Proc Natl Acad Sci U S A 105, 19378-19383.
52. Elis S, Courtland H-W, Wu Y, et al. (2010) Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1. J Bone Miner Res 25, 1257-1266.
53. Clemmons DR (1997) Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev 8, 45-62.
54. Jousse C, Bruhat A, Ferrara M, et al. (1998) Physiological concentration of amino acids regulates insulin-like-growthfactor-binding protein 1 expression. Biochem J 334, 147-153.
55. Thissen JP, Davenport ML, Pucilowska JB, et al. (1992) Increased serum clearance and degradation of 125I-labelled IGF-I in protein-restricted rats. Am J Physiol Endocrinol Metab 262, E406-E411.
56. Boisclair YR, Rhoads RP, Ueki I, et al. (2001) The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system. J Endocrinol 170, 63-70.
57. Kiepe D, Ciarmatori S, Hoeflich A, et al. (2005) Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways. Endocrinology 146, 3096-3104.
58. Forbes BE, McCarthy P & Norton RS (2012) Insulin-like growth factor binding proteins: a structural perspective. Front Endocrinol (Lausanne) 3, 38.
59. McCusker RH (1998) Controlling insulin-like growth factor activity and the modulation of insulin-like growth factor binding protein and receptor binding. J Dairy Sci 81, 1790-1800.
60. Williams GR, Robson H & Shalet SM (1998) Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth. J Endocrinol 157, 391-403.
61. Wang Y, Zhu J & DeLuca HF (2014) Identification of the vitamin D receptor in osteoblasts and chondrocytes but not osteoclasts in mouse bone. J Bone Min Res 29, 685-692.
62. Bikle DD (2012) Vitamin D and bone. Curr Osteoporos Rep 10, 151-159.
63. Bach FC, Rutten KR, Hendriks K, et al. (2014) The paracrine feedback loop between vitamin D3 (1,25(OH)2D3) and PTHrP in prehypertrophic chondrocytes. J Cell Physiol 229, 1999-2014.
64. Xie Y, Zhou S, Chen H, et al. (2014) Advances in fibroblast growth factor signalling in growth plate development and disorders. J Mol Endocrinol 53, T11-T34.
65. Seifarth C, Csaki C & Shakibaei M (2009) Anabolic actions of IGF-I and TGF-?1 on interleukin-1?-treated human articular chondrocytes: evaluation in two and three dimensional cultures. Histol Histopathol 24, 1245-1262.
66. Jepson MM, Bates PC & Millward DJ (1988) The role of insulin and thyroid hormones in the regulation of muscle growth and protein turnover in response to dietary protein. Br J Nutr 59, 397-415.
67. Yahya ZAH, Bates PC & Millward DJ (1990) Responses to protein deficiency of plasma and tissue insulin-like growth factor-I levels and proteoglycan synthesis rates in rat skeletal muscle and bone. J Endocrinol 127, 497-503.
68. Divino Filho JC, Hazel SJ, Anderstam B, et al. (1999) Effect of protein intake on plasma and erythrocyte free amino acids and serum IGF-I and IGFBP-1 levels in rats. Am J Physiol 277, E693-E701.
69. Yahya ZAH & Millward DJ (1994) Dietary protein and the regulation of long bone and muscle growth in the rat. Clin Sci 87, 213-224.
70. Tirapegui JO, Yayha ZAH, Bates PC, et al. (1994) Dietary energy, glucocorticoids, and the regulation of long bone and muscle growth in the rat. Clin Sci 87, 599-606.
71. Yahya ZAH, Tirapegui JO, Bates PC, et al. (1994) Influence of dietary protein, energy and corticosteroids on protein turnover, proteoglycan sulphation and growth of long bone and skeletal muscle in the rat. Clin Sci 87, 607-618.
72. Lampl M, Veldhuis JD & Johnson ML (1992) Saltation and stasis: a model of human growth. Science 258, 801-803.
73. Gill MS, Tillmann V, Veldhuis JD, et al. (2001) Patterns of GH output and their synchrony with short-term height increments influence stature and growth performance in normal children. J Clin Endocrinol Metab 86, 5860-5863.
74. Lampl M & Johnson ML (2011) Infant growth in length follows prolonged sleep and increased naps. Sleep 34, 641-650.
75. Van Cauter E & Plat L (1996) Physiology of growth hormone secretion during sleep. J Pediatr 128, S32-S37.
76. Ishikawa Y, Chin JE, Schalk EM, et al. (1986) Effect of amino acid levels on matrix vesicle formation by epiphyseal growth plate chondrocytes in primary culture. J Cell Physiol 126, 399-406.
77. Laplante M & Sabatini D (2012) mTOR signaling in growth control and disease. Cell 149, 274-293.
78. Kimball SR & Jefferson LS (2010) Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. J Biol Chem 285, 29027-29032.
79. Chen J & Long F (2015) mTORC1 signaling promotes osteoblast differentiation from preosteoblasts. PLOS ONE 10, e0130627.
80. Semba RD, Shardell M, Ashour FAS, et al. (2016) Child stunting is associated with low circulating essential amino acids. EBioMedicine 6, 246-252.
81. Cousins RJ, Liuzzi JP & Lichten LA (2006) Mammalian zinc transport, trafficking, and signals. J Biol Chem 281, 24085-24089.
82. Andreini C, Banci L, Bertini I, et al. (2006) Counting the zincproteins encoded in the human genome. J Proteome Res 5, 196-201.
83. Prasad AS (1995) Zinc: an overview. Nutrition 11, Suppl. 1, 93-99.
84. Cousins RJ, Aydemir TB & Lichten LA (2010) Transcription factors, regulatory elements and nutrient-gene communication. Proc Nutr Soc 69, 91-94.
85. Kim J-H, Jeon J, Shin M, et al. (2014) Regulation of the catabolic cascade in osteoarthritis by the Zn-ZIP8-MTF1 axis. Cell 156, 730-743.
86. Fukada T, Civic N, Furuichi T, et al. (2008) The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-? signaling pathways. PLoS ONE 3, e3642.
87. Hojyo S, Fukada T, Shimoda S, et al. (2011) The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS ONE 6, e18059.
88. Wong SC, Dobie R, Altowati MA, et al. (2016) Growth and the growth hormone-insulin like growth factor 1 axis in children with chronic inflammation: current evidence, gaps in knowledge and future directions. Endocr Rev 37, 62-110.
89. Hanada T & Yoshimura A (2002) Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 13, 413-421.
90. Turner MD, Nedjai B, Hurst T, et al. (2014) Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta 1843, 2563-2582.
91. Phillips DJ, de Kretser DM & Hedger MP (2009) Activin and related proteins in inflammation: not just interested bystanders. Cytokine Growth Factor Rev 20, 153-164.
92. Sozzani S & Musso T (2011) The yin and yang of activin A. Blood 117, 5013-5015.
93. Sederquist B, Fernandez-Vojvodich P, Zaman F, et al. (2014) Impact of inflammatory cytokines on longitudinal bone growth. J Mol Endocrinol 53, T35-T44.
94. Prendergast AJ, Rukobo S, Chasekwa B, et al. (2014) Stunting is characterized by chronic inflammation in Zimbabwean infants. PLOS ONE 9, e86928.
95. DeBoer MD, Scharf RJ, Leite AM, et al. (2017) Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition. Nutrition 33, 248-253.
96. Jepson MM, Pell J, Bates PC, et al. (1986) The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats. Biochem J 235, 329-336.
97. Hasegawa-Ishii S, Inaba M, Umegaki H, et al. (2016) Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface. Sci Rep 6, 25457.
98. Omwega AM, Bates PC & Millward DJ (1988) Vitamin E deficiency in the rat and the response to malarial infection. Proc Nutr Soc 47, 12A.
99. Odedra BR & Millward DJ (1982) Effect of corticosterone treatment on muscle protein turnover in adrenalectomised rats and diabetic rats maintained on insulin. Biochem J 204, 663-672.
100. Nakajima S, Naruto T, Miyamae T, et al. (2009) Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells. Cytokine 47, 91-97.
101. Wajant H, Pfizenmaier K & Scheurich P (2003) Tumor necrosis factor signalling. Cell Death Diff 10, 45-65.
102. M?rtensson K, Chrysis D & Savendahl L (2004) Interleukin-1? and TNF-a act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones. J Bone Min Res 19, 1805-1812.
103. Kishimoto T (2010) IL-6: from its discovery to clinical applications. Int Immunol 22, 347-352.
104. Fernandez-Vojvodich P, Zaman F & Savendahl L (2013) Interleukin-6 acts locally on the growth plate to impair bone growth. Ann Rheum Dis 72, e24.
105. Eijken M, Swagemakers S, Koedam M, et al. (2007) The activin A-follistatin system: potent regulator of human extracellular matrix mineralization. FASEB J 21, 2949-2960.
106. Bowser M, Herberg S, Arounleut P, et al. (2013) Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Exp Gerontol 48, 290-297.
107. Feingold KR, Grunfeld C, Heuer JG, et al. (2012) FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis. Endocrinology 153, 2689-2700.
108. Kubicky RA, Wu S, Kharitonenkov A, et al. (2012) Role of fibroblast growth factor 21 (FGF21) in undernutritionrelated attenuation of growth in mice. Endocrinology 153, 2287-2295.
109. Fazeli PK, Lun M, Kim SM, et al. (2015) FGF21 and the late adaptive response to starvation in humans. J Clin Invest 125, 4601-4611.
110. Gariani K, Drifte G, Dunn-Siegrist I, et al. (2013) Increased FGF21 plasma levels in humans with sepsis and SIRS. Endocr Connect 2, 146-153.
111. Wu S, Levenson A, Kharitonenkov A, et al. (2012) Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J Biol Chem 287, 26060-26067.
112. Klein DL (2015) The effect of glucocorticoids on bone and muscle. Osteoporos Sarcopenia 1, 39-45.
113. Mushtaq T & Ahmed SF (2002) The impact of corticosteroids on growth and bone health. Arch Dis Child 87, 93-96.
114. Chrysis D, Zaman F, Chagin AS, et al. (2005) Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the AKTphosphatidylinositol 3'-kinase signaling pathway. Endocrinology 146, 1391-1397.
115. Zaman F, Chrysis D & Huntjens K (2014) Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid. Toxicol Lett 224, 196-200.
116. Golden MH (1988) The role of individual nutrient deficiencies in growth retardation of children as exemplified by zinc and protein. In Linear Growth Retardation in Less Developed Countries, pp. 143-163 [JC Waterlow, editor]. New York: Raven Press.
117. Golden MH (1991) The nature of nutritional deficiency in relation to growth failure and poverty. Acta Paed Scand 374, 95-110.
118. Ramakrishnan U, Nguyen P & Martorell R (2009) Effects of micronutrients on growth of children under 5 y of age:metaanalyses of single and multiple nutrient interventions. Am J Clin Nutr 89, 191-203.
119. Chen H, Hayakawa D, Emura S, et al. (2002) Effect of low or high dietary Ca on the morphology of the rat femur. Histol Histopathol 17, 1129-1135.
120. Prentice A & Bates CJ (1994) Adequacy of dietary mineral supply for human bone growth and mineralisation. Eur J Clin Nutr 48, Suppl. 1, S161-S177.
121. Prentice A, Ginty F, Stear SJ, et al. (2005) Calcium supplementation increases stature and bone mineral mass of 16-to 18-year-old boys. J Clin Endocrinol Metab 90, 3153-3161.
122. Stear SJ, Prentice A, Jones SC, et al. (2003) Effect of a calcium and exercise intervention on the bone mineral status of 16-18-y-old adolescent girls. Am J Clin Nutr 77, 985-992.
123. Zimmermann MB (2009) Iodine Deficiency. Endocr Rev 30, 376-408.
124. Zimmermann MB & Boelaert K (2015) Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol 3, 286-289.
125. Andersson M, Karumbunathan V & Zimmermann MB (2012) Global iodine status in 2011 and trends over the past decade. J Nutr 142, 744-750.
126. Rohner F, Zimmermann M, Jooste P, et al. (2014) Biomarkers of nutrition for development-iodine review. J Nutr 144, 1322S-1342S.
127. Zimmermann MB (2012) The effects of iodine deficiency in pregnancy and infancy. Paediatr Perinat Epidemiol 26, Suppl. 1, 108-117.
128. Zimmermann MB, Jooste PL, Mabapa NS, et al. (2007) Treatment of iodine deficiency in school-age children increases insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations and improves somatic growth. J Clin Endocrinol Metab 92, 437-442.
129. Sarwar G, Peace RW, Botting HG, et al. (1989) Relationship between amino acid scores and protein quality indices based on rat growth. Plant Foods Hum Nutr 39, 33-44.
130. Millward DJ (2012) Amino acid scoring patterns for protein quality assessment. Br J Nutr 108, S31-S43.
131. Millward DJ (2012) Identifying recommended dietary allowances for protein and amino acids: a critique of the 2007 WHO/FAO/UNU report. Br J Nutr 108, S3-S21.
132. Dickerson JWT & McCance RA (1961) Severe undernutrition in growing and adult animals. 8. The dimensions and chemistry of the long bones. Br J Nutr 15, 567-576.
133. Hambidge KM & Krebs NF (2007) Zinc deficiency: a special challenge. J Nutr 137, 1101-1105.
134. Golden MHN & Golden BE (1981) Effect of zinc supplementation on the dietary intake, rate of weight gain and energy cost of tissue deposition in children recovering from severe malnutrition. Am J Clin Nutr 34, 900-905.
135. Giugliano R & Millward DJ (1984) Growth and zinc homeostasis in the severely zinc deficient rat. Br J Nutr 52, 545-560.
136. Rossi L, Migliaccio S, Corsi A, et al. (2001) Reduced growth and skeletal changes in zinc-deficient growing rats are due to impaired growth plate activity and inanition. J Nutr 131, 1142-1146.
137. Williams RB & Mills CF (1970) The experimental production of zinc deficiency in the rat. Br J Nutr 24, 989-1003.
138. Giugliano R & Millward DJ (1987) The effects of severe zinc deficiency on protein turnover in muscle and thymus. Br J Nutr 51, 139-155.
139. Browning JD, MacDonald RS, Thornton WH, et al. (1998) Reduced food intake in zinc deficient rats is normalized by megestrol acetate but not by insulin-like growth factor-I. J Nutr 128, 136-142.
140. MacDonald RS, Wollard-Biddle LC, Browning JD, et al. (1998) Zinc deprivation of murine 3T3 cells by use of diethylenetrinitrilopentaacetate impairs DNA synthesis upon stimulation with insulin-like growth factor-I (IGF-I). J Nutr 128, 1600-1605.
141. MacDonald RS (2000) The role of zinc in growth and cell proliferation. J Nutr 130, 1500S-1508S.
142. Riesco G, Taurog A, Larsen R, et al. (1977) Acute and chronic responses to iodine deficiency in rats. Endocrinology 100, 303-313.
143. Moreno-Reyes R, Egrise D, Boelaert M, et al. (2006) Iodine deficiency mitigates growth retardation and osteopenia in selenium-deficient rats. J Nutr 136, 595-600.
144. Ren FL, Guo X, Zhang RJ, et al. (2007) Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats. Osteoarthritis Cartilage 15, 1171-1177.
145. Spiegel C, Bestetti GE, Rossi GL, et al. (1993) Normal circulating triiodothyronine concentrations are maintained despite severe hypothyroidism in growing pigs fed rapeseed presscake meal. J Nutr 123, 1554-1561.
146. Tata JR & Widnell CC (1966) Ribonucleic acid synthesis during the early action of thyroid hormones. Biochem J 98, 604-620.
147. Brown JG, Bates PC, Holliday MA, et al. (1981) Thyroid hormones and muscle protein turnover: the effect of thyroid-hormone deficiency and replacement in thyroidectomized and hypophysectomized rats. Biochem J 194, 771-782.
148. Brown JG & Millward DJ (1983) Dose response of protein turnover in rat skeletal muscle to triiodothyronine treatment. Biochim Biophys Acta 757, 182-190.
149. O'Connell JM, Dibley MJ, Sierra J, et al. (1989) Growth of vegetarian children: The Farm Study. Pediatrics 84, 475-481.
150. Dwyer JT, Andrew EM & Berkey C (1983) Growth in 'new' vegetarian preschool children using the Jenss-Bayley curve fitting technique. Am J Clin Nutr 37, 815-827.
151. Dagnelie PC, van Dusseldorp M, van Staveren WA, et al. (1994) Effects of macrobiotic diets on linear growth in infants and children until 10 years of age. Eur J Clin Nutr 48, Suppl. 1, S103-S111.
152. Van Dusseldorp M, Arts ICW, Bergsma JS, et al. (1996) Catch-up growth in children fed a macrobiotic diet in early childhood. J Nutr 126, 2977-2983.
153. Allen LH & Gillespie SR (2001) What Works? A Review of the Efficacy and Effectiveness of Nutrition Interventions. Manila: Asian Development Bank; Geneva: ACC/SCN.
154. Martorell R & Klein RE (1980) Food supplement and growth rates in preschool children. Nutr Rep Int 21, 447-454.
155. Lutter CK, Mora JO, Habicht J-P, et al. (1990) Age-specific responsiveness of weight and length to nutritional supplementation. Am J Clin Nutr 51, 359-364.
156. Walker SP, Powell CA, Grantham-McGregor SM, et al. (1991) Nutritional supplementation, psychosocial stimulation, and growth of stunted children: the Jamaican study. Am J Clin Nutr 54, 642-648.
157. Hegsted DM (1972) Deprivation syndrome or protein-calorie malnutrition. Nutr Rev 30, 51-54.
158. Gopalan C, Swaminathan MC, Kumari VK, et al. (1973) Effect of calorie supplementation on growth of undernourished children. Am J Clin Nutr 26, 563-566.
159. Habicht JP, Martorell R & Rivera JA (1995) Nutritional impact of supplementation in the INCAP longitudinal study: analytic strategies and inferences. J Nutr 125, 1042S-1050S.
160. Martorell R, Habicht JP & Rivera JA (1995) History and design of the INCAP longitudinal study (1969-77) and its follow-up (1988-89). J Nutr 125, 1027S-1041S.
161. Allen LH (1995) Malnutrition and human function: a comparison of conclusions from the INCAP and nutrition CRSP studies. J Nutr 125, 1119S-1126S.
162. Krebs NF, Mazariegos M, Chomba E, et al. (2012) Randomized controlled trial of meat compared with multimicronutrient-fortified cereal in infants and toddlers with high stunting rates in diverse settings. Am J Clin Nutr 96, 840-847.
163. Malcolm LA (1970) Growth retardation in a New Guinea boarding school and its response to supplementary feeding. Br J Nutr 24, 297-305.
164. Lampl M, Johnston FE & Malcolm LA (1978) The effects of protein supplementation on the growth and skeletal maturation of New Guinean school children. Ann Hum Biol 5, 219-227.
165. Malcolm LA (1970) Growth and Development in New Guinea: A Study of the Bundi People of the Madang District, Monograph Series No. 1. Madang: Institute of Human Biology of Papua and New Guinea.
166. Garn SM (1972) Growth and development in New Guinea-A study of the Bundi people of the Madang district. By L. A. Malcolm. 105 pp., figures, tables, appendices, bibliography. Monograph Series No. 1, Institute of Human Biology of Papua and New Guinea, Madang. 1970 [Book review]. Am J Phys Anthropol 37, 157-159.
167. World Health Organization (2007) Protein and Amino Acid Requirements in Human Nutrition. Report of a Joint WHO/FAO/UNU Expert Consultation. WHO Technical Report Series no. 935. Geneva: WHO.
168. Millward DJ & Jackson AA (2003) Protein/energy ratios of current diets in developed and developing countries compared with a safe protein/energy ratio: implications for recommended protein and amino acid intakes. Public Health Nutr 7, 387-405.
169. Heinig MJ, Nommsen LA, Peerson JM, et al. (1993) Energy and protein intakes of breast-fed and formula-fed infants during the first year of life and their association with growth velocity: the DARLING Study. Am J Clin Nutr 58, 152-161.
170. R?iha NC, Fazzolari-Nesci A, Cajozzo C, et al. (2002) Whey predominant, whey modified infant formula with protein/energy ratio of 1.8 g/100 kcal: adequate and safe for term infants from birth to four months. J Pediatr Gastroenterol Nutr 35, 275-281.
171. EFSA Panel on Dietetic Products, Nutrition and Allergies (2014) Scientific opinion on the essential composition of infant and follow-on formulae. EFSA J 12, 3760.
172. Mac? K, Steenhout P, Klassen P, et al. (2006) Protein quality and quantity in cow's milk-based formula for healthy term infants: past, present and future. Nestl? Nutr Workshop Ser Pediatr Program 58, 189-205.
173. Hoppe C, Molgaard C, Thomsen BL, et al. (2004) Protein intake at 9 mo of age is associated with body size but not with body fat in 10-y-old Danish children. Am J Clin Nutr 79, 494-501.
174. H?rnell A, Lagstr?m H, Lande B, et al. (2013) Protein intake from 0 to 18 years of age and its relation to health: a systematic literature review for the 5th Nordic Nutrition Recommendations. Food Nutr Res 2013, 57.
175. Hoppe C, Udam TR, Lauritzen L, et al. (2004) Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children. Am J Clin Nutr 80, 447-452.
176. Swaminathan S, Vaz M & Kurpad AV (2012) Protein intakes in India. Br J Nutr 108, S50-S58.
177. Ghosh S, Suri D & Uauy R (2012) Assessment of protein adequacy in developing countries: quality matters. Br J Nutr 108, S77-S87.
178. Mack PB, Vose GP, Kinard CL, et al. (1962) Effects of lysine-supplemented diets on growth and skeletal density of preadolescent children. Am J Clin Nutr 11, 255-262.
179. Civitelli R, Villareal DT, Agnusdei D, et al. (1992) Dietary l-lysine and calcium metabolism in humans. Nutrition 8, 400-405.
180. Graham GG, Lembcke J & Morales E (1990) Quality-protein maize as the sole source of dietary protein and fat for rapidly growing young children. Pediatrics 85, 85-91.
181. Nilupa S, Gunaratna H, De Groote P, et al. (2010) A metaanalysis of community-based studies on quality protein maize. Food Policy 35, 202-210.
182. Beaton GH, Calloway D & Murphy SP (1992) Estimated protein intakes of toddlers: predicted prevalence of inadequate intakes in village populations in Egypt, Kenya, and Mexico. Am J Clin Nutr 55, 902-911.
183. de Benoist B, Darnton-Hill I, Davidsson L, et al. (2007) Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status Indicators. Food Nutr Bull 28, S480-S484.
184. Wessells KR & Brown KH (2012) Estimating the global prevalence of zinc deficiency: results based on zinc availability in national food supplies and the prevalence of stunting. PLOS ONE 7, e50568.
185. Bhutta ZA, Das JK, Rizvi A, et al. (2013) Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? Lancet 382, 452-477.
186. Yakoob MY, Theodoratou E, Jabeen A, et al. (2011) Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health 11, Suppl. 3, S23.
187. Brown KH, Peerson JM & Allen LH (1997) Effect of zinc supplementation on children's growth: a meta-analysis of intervention trials. Bibl Nutr Dieta 54, 76-83.
188. Imdad A & Bhutta ZA (2011) Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool. BMC Public Health 11, Suppl. 3, S22.
189. Mayo-Wilson E, Junior JA, Imdad A, et al. (2014) Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database of Systematic Reviews, Issue 5. Art. No. CD009384. doi: 10.1002/14651858.CD009384.pub2
190. Phuka JC, Maleta K, Thakwalakwa C, et al. (2008) Complementary feeding with fortified spread and the incidence of severe stunting among 6-to-18-month-old rural Malawians. Arch Pediatr Adolesc Med 162, 619-626.
191. Mangani C, Maleta K, Phuka J, et al. (2015) Effect of complementary feeding with lipid based nutrient supplements and corn-soy blend on the incidence of stunting and linear growth among 6-to 18-month-old infants and children in rural Malawi. Matern Child Nutr 11, Suppl. 4, 132-143.
192. Ashorn P, Alho L, Ashorn U, et al. (2015) Supplementation of maternal diets during pregnancy and for 6 months postpartum and infant diets thereafter with small-quantity lipid-based nutrient supplements does not promote child growth by 18 months of age in rural Malawi: a randomized controlled trial. J Nutr 145, 1345-1353.
193. Adu-Afarwuah S, Lartey A, Brown KH, et al. (2007) Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: effects on growth and motor development. Am J Clin Nutr 86, 412-420.
194. Miell JP, Zini M, Quin JD, et al. (1994) Reversible effects of cessation and recommencement of thyroxine treatment on insulin-like growth factors (IGFs) and IGF-binding proteins in patients with total thyroidectomy. J Clin Endocrinol Metab 79, 1507-1512.
195. Iglesias P, Bayon C, Mendez J, et al. (2001) Serum insulin-like growth factor type 1, insulin-like growth factor-binding protein-1, and insulin-like growth factor-binding protein-3 concentrations in patients with thyroid dysfunction. Thyroid 11, 1043-1048.
196. Zhou SJ, Anderson AJ, Gibson RA, et al. (2013) Effect of iodine supplementation in pregnancy on child development and other clinical outcomes: a systematic review of randomized controlled trials. Am J Clin Nutr 98, 1241-1254.
197. Hernandez-Cassis C, Cure-Cure C & Lopez-Jaramillo P (1995) Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction. Eur J Clin Invest 25, 454-456.
198. Centers for Disease Control and Prevention (2016) International Micronutrient Malnutrition Prevention and Control (IMMPaCt). http://www.cdc.gov/immpact/about/index.html (accessed August 2016).
199. United Nations Children's Fund, World Health Organization & United Nations University (1999) Composition of a multimicronutrient supplement to be used in pilot programmes among pregnant women in developing countries: report of a United Nations Children's Fund (UNICEF), World Health Organization (WHO) and United Nations University workshop UNICEF. http://www.who.int/iris/handle/10665-/75358 (accessed August 2016).
200. Haider BA & Bhutta ZA (2015) Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database of Systematic Reviews, Issue 11. Art. No. CD004905. doi: 10.1002/14651858.CD004905.pub4.
201. Rivera JA, Gonzalez-Cossio T, Flores M, et al. (2001) Multiple micronutrient supplementation increases the growth of Mexican infants. Am J Clin Nutr 74, 657-663.
202. De-Regil LM, Suchdev PS, Vist GE, et al. (2011) Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database of Systematic Reviews, Issue 9. Art. No. CD008959. doi: 10.1002/14651858.CD008959.pub2.
203. Salam RA, MacPhail C, Das JK, et al. (2013) Effectiveness of micronutrient powders (MNP) in women and children. BMC Public Health 13, Suppl. 3, S22.
204. Arimond M, Zeilani M, Jungjohann S, et al. (2015) Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project. Matern Child Nutr 11, 31-61.
205. International Lipid-Based Nutrient Supplements Project (2016) iLiNS project. http://www.ilins.org/(accessed October 2016).
206. Arnold BF, Null C, Luby SP, et al. (2013) Cluster-randomised controlled trials of individual and combined water, sanitation, hygiene and nutritional interventions in rural Bangladesh and Kenya: the WASH Benefits study design and rationale. BMJ Open 3, e003476.
207. The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team (2015) The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial: rationale, design, and methods. Clin Infect Dis 61, Suppl. 7, S685-S702.
208. Neumann CG, Harris DM & Rogers LM (2002) Contribution of animal source foods in improving diet quality and function in children in the developing world. Nutr Res 22, 193-220.
209. Allen LH & Dror DK (2011) Effects of animal source foods, with emphasis on milk, in the diet of children in low-income countries. In Milk and Milk Products in Human Nutrition, pp. 113-130 [RA Clemens, O Hernell and KF Michaelsen, editors]. Basel: Nestec Ltd.
210. Neumann CG, Bwibo NO, Murphy SP, et al. (2003) Animal source foods improve dietary quality, micronutrient status, growth and cognitive function in Kenyan school children: background, study design and baseline findings. J Nutr 133, 3941S-3949S.
211. Neumann CG, Murphy SP, Gewa C, et al. (2007) Meat supplementation improves growth, cognitive, and behavioral outcomes in Kenyan children. J Nutr 137, 1119-1123.
212. Pollock JI (2006) Two controlled trials of supplementary feeding of British school children in the 1920s. J R Soc Med 99, 323-327.
213. Atkins PJ (2005) The Milk in Schools Scheme, 1934-45: 'nationalization' and resistance. Hist Educ 34, 1-21.
214. Hoppe C, M?lgaard C & Michaelsen KF (2006) Cow's milk and linear growth in industrialized and developing countries. Annu Rev Nutr 26, 131-173.
215. Takahashi E (1971) Geographic distribution of human stature and environmental factors-an ecologic study. J Anthropol Soc Nippon 76, 259-285.
216. Takahashi E (1984) Secular trend in milk consumption and growth in Japan. Hum Biol 56, 427-437.
217. Bogin B (1988) Patterns of Human Growth. New York: Cambridge University Press.
218. Bogin B (1998) Milk and human development: an essay on the "milk hypothesis". Antropol Portuguesa 15, 23-36.
219. Wiley AS (2005) Does milk make children grow? Relationships between milk consumption and height in NHANES 1999-2002. Am J Hum Biol 17, 425-441.
220. Black RE, Williams SM, Jones IE, et al. (2002) Children who avoid drinking cow milk have low dietary Ca intakes and poor bone health. Am J Clin Nutr 76, 675-680.
221. Romero IG, Mallick CB, Liebert A, et al. (2012) Herders of Indian and European cattle share their predominant allele for lactase persistence. Mol Biol Evol 29, 249-260.
222. Melnik BC, John SM & Schmitz G (2013) Milk is not just food but most likely a genetic transfection system activating mTORC1 signalling for postnatal growth. Nutr J 12, 103.
223. Hoppe C, M?lgaard C, Juul A, et al. (2004) High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. Eur J Clin Nutr 58, 1211-1216.
224. Hoppe C, M?lgaard C, Vaag A, et al. (2005) High intakes of milk, but not meat, increases s-insulin and insulin resistance in 8-year-old boys. Eur J Clin Nutr 59, 393-398.
225. Hegsted DM (2001) Fractures, calcium, and the modern diet. Am J Clin Nutr 74, 571-573.
226. Ruel MT (2003) Milk intake is associated with better growth in Latin America: evidence from the Demographic and Health Surveys. J FASEB 17, A1199.
227. Rutishauser IHE & Whitehead RG (1969) Nutritional status assessed by biological tests. Br J Nutr 23, 1-13.
228. Martorell R, Schroeder DG, Rivera JA, et al. (1995) Patterns of linear growth in rural Guatemalan adolescents and children. J Nutr 125, Suppl. 4, 1060S-1067S.
229. World Health Organization, United Nations Children's Fund (UNICEF) & International Council for the Control of Iodine Deficiency Disorders (ICCIDD) (2007) Assessment of Iodine Deficiency Disorders and Monitoring their Elimination, 3rd ed. Geneva: WHO.
230. Pharoah PO & Connolly KJ (1987) A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. Int J Epidemiol 16, 68-73.
231. Stephensen CB (1999) Burden of infection on growth failure. J Nutr 129, 534S-538S.
232. Guerrant RL, Ori? RB, Moore SR, et al. (2008) Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr Rev 66, 487-505.
233. Kalantar-Zadeh K, Block G, McAllister CJ, et al. (2004) Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 80, 299-307.
234. McMillan DC, Wigmore SJ, Fearon KCH, et al. (1999) A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. Br J Cancer 79, 495-500.
235. Benjamin DK Jr, Miller WC, Benjamin DK, et al. (2003) A comparison of height and weight velocity as part of the composite endpoint in pediatric HIV. AIDS 17, 2331-2336.
236. Arpadi SM (2005) Growth failure in HIV-infected children infected children. WHO Consultation on Nutrition and HIV/AIDS in Africa: Evidence, lessons and recommendations for action. http://www.who.int/nutrition/topics/PN4-Growth failure-Durban.pdf?ua=1 (accessed October 2016).
237. Henderson RA, Saavedra JM, Perman JA, et al. (1994) Effects of enteral tube feeding on growth of children with symptomatic human immunodeficiency virus infection. J Pediatr Gastroenterol Nutr 18, 429-434.
238. Clarick RH, Hanekom WA, Yogev R, et al. (1997) Megestrol acetate treatment of growth failure in children with human immunodeficiency virus. Pediatrics 99, 354-357.
239. Aeberli I, Molinari L, Spinas G, et al. (2006) Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children. Am J Clin Nutr 84, 748-755.
240. Kruger HS, Pretorius R & Schutte AE (2010) Stunting, adiposity, and low-grade inflammation in African adolescents from a township high school. Nutrition 26, 90-99.
241. Checkley W, Buckley G, Gilman RH, et al. (2008) Multi-country analysis of the effects of diarrhoea on childhood stunting. Int J Epidemiol 37, 816-830.
242. Bhutta ZA, Ahmed T, Black RE, et al. (2008) Maternal and child undernutrition 3: what works? Interventions for maternal and child undernutrition and survival. Lancet 371, 417-440.
243. Solomons NW, Mazariegos M, Brown KH, et al. (1993) The underprivileged, developing country child: environmental contamination and growth failure revisited. Nutr Rev 51, 327-332.
244. Richard SA, Black RE, Gilman RH, et al. (2013) Diarrhea in early childhood: short-term association with weight and long-term association with length. Am J Epidemiol 178, 1129-1138.
245. Lunn PG, Northrop-Clewes CA & Downes RM (1991) Intestinal permeability, mucosal injury, and growth faltering in Gambian infants. Lancet 338, 907-910.
246. Campbell DI, Elia M & Lunn PG (2003) Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J Nutr 133, 1332-1338.
247. Campbell DI, Murch SH, Elia M, et al. (2003) Chronic T cellmediated enteropathy in rural West African children: relationship with nutritional status and small bowel function. Pediatr Res 54, 306-311.
248. Kotloff KL, Nataro JP, Blackwelder WC, et al. (2013) Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 382, 209-222.
249. Humphrey JH (2009) Child undernutrition, tropical enteropathy, toilets, and handwashing. Lancet 374, 1032-1035.
250. Korpe PS & Petri WA Jr (2012) Environmental enteropathy: critical implications of a poorly understood condition. Trends Mol Med 18, 328-336.
251. Keusch GT, Rosenberg IH, Denno DM, et al. (2013) Implications of acquired environmental enteric dysfunction for growth and stunting in infants and children living in low-and middle-income countries. Food Nutr Bull 34, 357-364.
252. Crane RJ, Jones KDJ & Berkley JA (2015) Environmental enteric dysfunction: an overview. Food Nutr Bull 36, S76-S87.
253. Gough EK, Stephens DA, Moodie EE, et al. (2015) Linear growth faltering in infants is associated with Acidaminococcus sp. and community-level changes in the gut microbiota. Microbiome 3, 24.
254. Smith LE, Prendergast AJ, Turner PC, et al. (2015) Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team. The potential role of mycotoxins as a contributor to stunting in the SHINE Trial. Clin Infect Dis 61, Suppl. 7, S733-S737.
255. Bennett JW & Klich M (2003) Mycotoxins. Clin Microbiol Rev 16, 497-516.
256. Hendrickse RG, Coulter JB & Lamplugh SM (1982) Aflatoxins and kwashiorkor: a study in Sudanese children. Br Med J (Clin Res Ed) 285, 843-846.
257. Golden MHN (1998) Oedematous malnutrition. Br Med Bull 54, 433-444.
258. Lin A, Arnold BF, Afreen S, et al. (2013) Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh. Am J Trop Med Hyg 89, 130-137.
259. Dewey KG & Adu-Afarwuah S (2008) Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries. Matern Child Nutr 4, Suppl. 1, 24-85.
260. Mbuya MNN, Tavengwa NV, Stoltzfus RJ, et al. (2015) Design of an intervention to minimize ingestion of fecal microbes by young children in rural Zimbabwe. Clin Infect Dis 61, Suppl. 7, S703-S709.
261. Desai A, Smith LE, Mbuya MNN, et al. (2015) The SHINE Trial infant feeding intervention: pilot study of effects on maternal learning and infant diet quality in rural Zimbabwe. Clin Infect Dis 61, Suppl. 7, S710-S715.