A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss

British Journal of Cancer

Volumn 79, Issue 3-4, 1999, Pages 495-500

  McMillan, D C ^a   Wigmore, S J ^b   Fearon, K C H ^b   O'Gorman, P ^a   Wright, C E ^b   McArdle, C S ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Acute phase response; Gastrointestinal cancer; Ibuprofen; Megestrol acetate; Prospective randomized study; Weight loss

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; IBUPROFEN; MEGESTROL ACETATE; PLACEBO;

ACUTE PHASE RESPONSE; ADULT; AGED; ANTHROPOMETRY; ARTICLE; BODY WEIGHT DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIGESTIVE SYSTEM CANCER; DIGESTIVE SYSTEM HEMORRHAGE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERFORMANCE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; VEIN THROMBOSIS; WEIGHT REDUCTION;

AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APPETITE; APPETITE STIMULANTS; C-REACTIVE PROTEIN; COMBINED MODALITY THERAPY; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; IBUPROFEN; MALE; MEGESTROL ACETATE; MIDDLE AGED; NUTRITIONAL STATUS; PALLIATIVE CARE; PROSPECTIVE STUDIES; QUALITY OF LIFE; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 0032936598     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690077     Document Type: Article

References (25)

1. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, DeHaes JCJM, Kaas S, Klee M, Obosa D, Razavi D, Rofe PB, Schraub S, Sneeuw K, Sullivan M and Takeda F (1993) The European organisation for research and treatment of cancer QLQ-C30. A quality of life instrument for the use in international clinical trials in oncology. J Natl Cancer Inst 85: 365-376
2. Falconer JS, Fearon KCH, Plester CE, Ross JA and Carter DC (1994) Cytokines, the acute phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 219: 325-331
3. Fearon KCH, Falconer JS, Slater C, McMillan DC, Ross JA and Preston T (1998) Albumin synthesis rates are not decreased in hypoalbuminaemic cachectic cancer patients with an ongoing acute phase protein response. Ann Surg 227: 249-254
4. Feliu J, Gonzalez Baron BA, Ordonez A and Baron Saura JM (1991) Treatment of cancer anorexia with megestrol acetate: which is the optimal dose? J Natl Cancer Inst 83: 449-450
5. Goransson J, Jonsson S and Lasson A (1996) Pre-operative plasma levels of C-reactive protein, albumin and various plasma protease inhibitors for the pre-operative assessment of operability and recurrence in cancer surgery. Eur J Surg Oncol 22: 607-617
6. Hannan WJ, Cowen SJ, Plester CE, Fearon KCH and deBeau A (1995) Comparison of bio-impedance spectroscopy and multi-frequency bio-impedance analysis for the assessment of extracellular and total body water in surgical patients. Clin Sci 89: 651-658
7. Harries AD, Jones LA, Heatley RHV, Newcombe RG and Rhodes J (1985) Precision of anthropometric measurements: the value of mid-arm circumference. Clin Nutr 4: 77-801
8. Heymsfield SB, Tighe A and Wang ZM (1994) Nutritional assessment by anthropometric and biochemical methods. In Modern Nutrition in Health and Disease, Shils ME, Olson JA and Shike M (eds.), pp. 816-841. Lea and Febiger: Philadelphia
9. Inagaki J, Rodriguez V and Bodey GP (1974) Causes of death in cancer patients. Cancer 33: 568-573
10. Kern KA and Norton JA (1988) Cancer cachexia. Journal of Parenteral and Enteral Nutrition 12: 286-298
11. Loprinzi CL, Ellison NM, Schaid DJ, Krook JE, Athmann LM, Dose AM, Mailliard JA, Johnson PS, Ebbert LP and Geeraerts LH (1990) Controlled trial of megestrol acetate for the treatment of cancer anorexia and cachexia. J Natl Cancer Inst 82: 1127-1132
12. McMillan DC, Simpson JM, Preston T, Watson WS, Fearon KCH, Shenkin A, Burns HJG and McArdle CS (1994a) Effect of megestrol acetate on weight loss, body composition and blood screen of gastrointestinal cancer patients. Clin Nutr 13: 85-89
13. McMillan DC, Preston T, Watson WS, Simpson JM, Fearon KCH, Shenkin A, Burns HJG and McArdle CS (1994b) The relationship between weight loss, reduction of body cell mass and the inflammatory response in cancer patients. Br J Surg 81: 1011-1014
14. McMillan DC, Graham AF, Smith J, Wotherspoon HA, Fearon KCH and McArdle CS (1994c) Interleukin-6, neutrophilia and the acute phase protein response in colorectal cancer patients. Eur J Surg Oncol 20: 151-154
15. McMillan DC, Leen E, Smith J, Sturgeon CM, Preston T, Cooke TG and McArdle CS (1995) Effect of extended ibuprofen administration on cortisol, interleukin-6 and the acute phase protein response in colorectal cancer patients. Eur J Surg Oncol 21: 531-534
16. McMillan DC, O'Gorman P, Fearon KCH and McArdle CS (1997) A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients. Br J Cancer 76: 788-790
17. Mor V, Laliberte L, Morris JN and Wiemann M (1984) The Karnofsky performance status scale: an examination of its reliability and validity in a research setting. Cancer 53: 2002-2007
18. Ovesen L, Hannibal J and Mortensen EL (1993) The interrelationship of weight loss, dietary intake, and quality of life in ambulatory patients with cancer of the lung, breast and ovary. Nutr Cancer 19: 159-167
19. Preston T, Fearon KCH, McMillan DC, Winstanley FP, Slater R, Shenkin A and Carter DC (1995) Effect of ibuprofen on the acute phase response and protein metabolism in patients with cancer and weight loss. Br J Surg 82: 229-234
20. Raben A, Tagliabue A and Astrup A (1995) The reproducibility of subjective appetite scores. Br J Nutr 73: 517-530
21. Schmoll E, Wilke H, Thole R, Preusser P, Wildfang I and Schmoll HJ (1991) Megestrol acetate in cancer cachexia. Semin Oncol 18 (suppl. 2): 32-34
22. Scott HR, McMillan DC, Crilly A, McArdle CS and Milroy R (1996) The relationship between weight loss and interleukin-6 in non-small cell lung cancer. Br J Cancer 73: 1560-1562
23. Tchemedyian NS, Hickman MS J, Greco FA, Keller J, Browder H and Aisner J (1992) Megestrol acetate in cancer anorexia and weight loss. Cancer 69: 1268-1274
24. The EuroQol Group (1990) EuroQo - a new facility for the measurement of health-related quality of life. Health Policy 16: 199-208
25. Wigmore SJ, Falconer JS, Plester CE, Ross JA, Maingay JP, Carter DC and Fearon KCH (1995) ibuprofen reduces energy expenditure and acute phase protein production compared with placebo in pancreatic cancer patients. Br J Cancer 72: 185-188