Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: Role of pro-apoptotic Bid

Toxicology Letters

Volumn 224, Issue 2, 2014, Pages 196-200

  Zaman, Farasat ^a   Chrysis, Dionisios ^b   Huntjens, Kirsten ^a   Chagin, Andrei ^a   Takigawa, Masaharu ^c   Fadeel, Bengt ^d   Sävendahl, Lars ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF PATRAS   (Greece)

^c OKAYAMA UNIVERSITY   (Japan)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Bcl 2 family proteins; Bid; Chondrocytes; Dexamethasone; Human growth plate

Indexed keywords

DEXAMETHASONE; PROTEIN BAD; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BID; SMALL INTERFERING RNA;

ADOLESCENT; APOPTOSIS; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; GENE SILENCING; GROWTH PLATE; GROWTH RETARDATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

APOPTOSIS; BCL-2 FAMILY PROTEINS; BID; CHONDROCYTES; CONT; CONTROL; DEXA; DEXAMETHASONE; GCS; GLUCOCORTICOIDS; HUMAN GROWTH PLATE;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; DEXAMETHASONE; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84888179402     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.10.020     Document Type: Article

References (23)

1. Amsterdam A., Sasson R. The anti-inflammatory action of glucocorticoids is mediated by cell type specific regulation of apoptosis. Mol. Cell. Endocrinol. 2002, 189:1-9.
2. Blanco-Colio L.M., Justo P., Daehn I., Lorz C., Ortiz A., Egido J. Bcl-xL overexpression protects from apoptosis induced by HMG-CoA reductase inhibitors in murine tubular cells. Kidney Int. 2003, 64:181-191.
3. Chrysis D., Zaman F., Chagin A.S., Takigawa M., Savendahl L. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway. Endocrinology 2005, 146:1391-1397.
4. Distelhorst C.W. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ. 2002, 9:6-19.
5. Dragovich T., Rudin C.M., Thompson C.B. Signal transduction pathways that regulate cell survival and cell death. Oncogene 1998, 17:3207-3213.
6. Fadeel B., Hassan Z., Hellstrom-Lindberg E., Henter J.I., Orrenius S., Zhivotovsky B. Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia 1999, 13:719-728.
7. Fridman J.S., Parsels J., Rehemtulla A., Maybaum J. Cytochrome c depletion upon expression of Bcl-XS. J. Biol. Chem. 2001, 276:4205-4210.
8. Jeong S.J., Dasgupta A., Jung K.J., Um J.H., Burke A., Park H.U., Brady J.N. PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology 2008, 370:264-272.
9. Jha R.K., Ma Q., Sha H., Palikhe M. Protective effect of resveratrol in severe acute pancreatitis-induced brain injury. Pancreas 2009, 38:947-953.
10. Letai A., Bassik M.C., Walensky L.D., Sorcinelli M.D., Weiler S., Korsmeyer S.J. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2002, 2:183-192.
11. Lima L., Arce V., Diaz M.J., Tresguerres J.A., Devesa J. Glucocorticoids may inhibit growth hormone release by enhancing beta-adrenergic responsiveness in hypothalamic somatostatin neurons. J. Clin. Endocrinol. Metab. 1993, 76:439-444.
12. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998, 94:481-490.
13. Moreau C., Cartron P.F., Hunt A., Meflah K., Green D.R., Evan G., Vallette F.M., Juin P. Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins. J. Biol. Chem. 2003, 278:19426-19435.
14. Mushtaq T., Ahmed S.F. The impact of corticosteroids on growth and bone health. Arch. Dis. Child. 2002, 87:93-96.
15. Mushtaq T., Bijman P., Ahmed S.F., Farquharson C. Insulin-like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid-mediated growth retardation in fetal mice metatarsal cultures. Endocrinology 2004, 145:2478-2486.
16. Nishi Y., Takeno S., Ishino T., Hirakawa K. Glucocorticoids suppress NF-kappaB activation induced by LPS and PGN in paranasal sinus epithelial cells. Rhinology 2009, 47:413-418.
17. Rooman R.P., Kuijpers G., Gresnigt R., Bloemen R., Koster J.G., van Buul-Offers S.C. Dexamethasone differentially inhibits thyroxine- or growth hormone-induced body and organ growth of Snell dwarf mice. Endocrinology 2003, 144:2553-2558.
18. Smink J.J., Gresnigt M.G., Hamers N., Koedam J.A., Berger R., Van Buul-Offers S.C. Short-term glucocorticoid treatment of prepubertal mice decreases growth and IGF-I expression in the growth plate. J. Endocrinol. 2003, 177:381-388.
19. Takigawa M., Tajima K., Pan H.O., Enomoto M., Kinoshita A., Suzuki F., Takano Y., Mori Y. Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes. Cancer Res. 1989, 49:3996-4002.
20. Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., Korsmeyer S.J. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001, 292:727-730.
21. Yeh T.F., Lin Y.J., Lin H.C., Huang C.C., Hsieh W.S., Lin C.H., Tsai C.H. Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. N. Engl. J. Med. 2004, 350:1304-1313.
22. Zaman F., Chrysis D., Huntjens K., Fadeel B., Savendahl L. Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. PLoS ONE 2012, 7:e33168.
23. Zaman F., Menendez-Benito V., Eriksson E., Chagin A.S., Takigawa M., Fadeel B., Dantuma N.P., Chrysis D., Savendahl L. Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice. Cancer Res. 2007, 67:10078-10086.