Anabolic actions of IGF-I and TGF-ß1 on interleukin-1ß-treated human articular chondrocytes: Evaluation in two and three dimensional cultures

Histology and Histopathology

Volumn 24, Issue 10, 2009, Pages 1245-1262

  Seifarth, Claudia ^a   Csaki, Constanze ^a   Shakibaei, Mehdi ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

ACI; Chondrocyte; Chondrogenesis; Human cartilage; IGF I; Il 1 ; Osteoarthritis; Tgf 1

Indexed keywords

COLLAGENASE 3; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; SOMATOMEDIN C; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL CULTURE; CELL DIFFERENTIATION; CULTURE MEDIUM; CYTOLOGY; DOWN REGULATION; DRUG COMBINATION; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; ORGAN CULTURE TECHNIQUE;

CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; CULTURE MEDIA, SERUM-FREE; CYCLOOXYGENASE 2; DOWN-REGULATION; DRUG COMBINATIONS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 13; ORGAN CULTURE TECHNIQUES; SOX9 TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77954493072     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Aigner T., Gebhard P.M., Schmid E., Bau B., Harley V. and Poschl E. (2003). SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes. Matrix Biol. 22, 363-372.
2. Barbero A., Ploegert S., Heberer M. and Martin I. (2003). Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes. Arthrit. Rheumat. 48, 1315-1325.
3. Brittberg M., Lindahl A., Nilsson A., Ohlsson C., Isaksson O. and Peterson L. (1994). Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N. Engl. J. Med. 331, 889-895.
4. Darling E.M. and Athanasiou K.A. (2005). Growth factor impact on articular cartilage subpopulations. Cell Tissue Res. 322, 463-473.
5. de Crombrugghe B., Lefebvre V., Behringer R.R., Bi W., Murakami S. and Huang W. (2000). Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol. 19, 389-394.
6. Denker A.E., Nicoll S.B. and Tuan R.S. (1995). Formation of cartilagelike spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with transforming growth factor-beta 1. Differentiation 59, 25-34.
7. Enomoto-Iwamoto M., Iwamoto M., Mukudai Y., Kawakami Y., Nohno T., Higuchi Y., Takemoto S., Ohuchi H., Noji S. and Kurisu K. (1998). Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J. Cell Biol. 140, 409-418.
8. Feldmann M., Brennan F.M. and Maini R.N. (1996). Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440.
9. Fernandes J.C., Martel-Pelletier J. and Pelletier J.P. (2002). The role of cytokines in osteoarthritis pathophysiology. Biorheology 39, 237-246.
10. Fukumoto T., Sperling J.W., Sanyal A., Fitzsimmons J.S., Reinholz G.G., Conover C.A. and O'Driscoll S.W. (2003). Combined effects of insulin-like growth factor-1 and transforming growth factor-beta1 on periosteal mesenchymal cells during chondrogenesis in vitro. Osteoarthrit. Cartilage 11, 55-64.
11. Goldring M.B. (2000). Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep. 2, 459-465.
12. Gowen M., Wood D.D., Ihrie E.J., Meats J.E. and Russell R.G. (1984). Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. Biochim. Biophys. Acta 797, 186-193.
13. Im H.J., Pacione C., Chubinskaya S., Van Wijnen A.J., Sun Y. and Loeser R.F. (2003). Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J. Biol. Chem. 278, 25386-25394.
14. Jakob M., Demarteau O., Schafer D., Hintermann B., Dick W., Heberer M. and Martin I. (2001). Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J. Cell Biochem. 81, 368-377.
15. Kulyk W.M., Franklin J.L. and Hoffman L.M. (2000). Sox9 expression during chondrogenesis in micromass cultures of embryonic limb mesenchyme. Exp. Cell Res. 255, 327-332.
16. Largo R., Alvarez-Soria M.A., Diez-Ortego I., Calvo E., Sanchez-Pernaute O., Egido J. and Herrero-Beaumont G. (2003). Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthrit. Cartilage 11, 290-298.
17. Liacini A., Sylvester J., Li W.Q., Huang W., Dehnade F., Ahmad M. and Zafarullah M. (2003). Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp. Cell Res. 288, 208-217.
18. Loeser R.F., Pacione C.A. and Chubinskaya S. (2003). The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. Arthrit. Rheumat. 48, 2188-2196.
19. Longobardi L., O'Rear L., Aakula S., Johnstone B., Shimer K., Chytil A., Horton W.A., Moses H.L. and Spagnoli A. (2006). Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling. J. Bone Miner. Res. 21, 626-636.
20. Mandl E.W., Jahr H., Koevoet J.L., van Leeuwen J.P., Weinans H., Verhaar J.A. and van Osch G.J. (2004). Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture. Matrix Biol. 23, 231-241.
21. Mandl E.W., van der Veen S.W., Verhaar J.A. and van Osch G.J. (2002). Serum-free medium supplemented with high-concentration FGF2 for cell expansion culture of human ear chondrocytes promotes redifferentiation capacity. Tissue Eng. 8, 573-580.
22. Martin I., Vunjak-Novakovic G., Yang J., Langer R. and Freed L.E. (1999). Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue. Exp. Cell Res. 253, 681-688.
23. Mi Z., Ghivizzani S.C., Lechman E.R., Jaffurs D., Glorioso J.C., Evans C.H. and Robbins P.D. (2000). Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthrit. Rheumat. 43, 2563-2570.
24. Mort J.S. and Billington C.J. (2001). Articular cartilage and changes in arthritis: matrix degradation. Arthrit. Res. 3, 337-341.
25. Murakami S., Lefebvre V. and de Crombrugghe B. (2000). Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J. Biol. Chem. 275, 3687-3692.
26. Peterson L., Brittberg M., Kiviranta I., Akerlund E.L. and Lindahl A. (2002). Autologous chondrocyte transplantation. Biomechanics and long-term durability. Am. J. Sports Med. 30, 2-12.
27. Quarto R., Dozin B., Tacchetti C., Campanile G., Malfatto C. and Cancedda R. (1990). In vitro development of hypertrophic chondrocytes starting from selected clones of dedifferentiated cells. J. Cell Biol. 110, 1379-1386.
28. Robbins J.R., Thomas B., Tan L., Choy B., Arbiser J.L., Berenbaum F. and Goldring M.B. (2000). Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta. Arthrit. Rheumat. 43, 2189-2201.
29. Ryu J., Treadwell B.V. and Mankin H.J. (1984). Biochemical and metabolic abnormalities in normal and osteoarthritic human articular cartilage. Arthrit. Rheumat. 27, 49-57.
30. Sakai T., Kambe F., Mitsuyama H., Ishiguro N., Kurokouchi K., Takigawa M., Iwata H. and Seo H. (2001). Tumor necrosis factor alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2/8 cells through activation of NF-kappaB: abrogation of the tumor necrosis factor alpha effect by proteasome inhibitors. J. Bone Miner. Res. 16, 1272-1280.
31. Schulze-Tanzil G., de Souza P., Villegas Castrejon H., John T., Merker H.J., Scheid A. and Shakibaei M. (2002). Redifferentiation of dedifferentiated human chondrocytes in high-density cultures. Cell Tissue Res. 308, 371-379.
32. Schulze-Tanzil G., Mobasheri A., de Souza P., John T. and Shakibaei M. (2004). Loss of chondrogenic potential in dedifferentiated chondrocytes correlates with deficient Shc-Erk interaction and apoptosis. Osteoarthrit. Cartilage 12, 448-458.
33. Schulze M., Kuettner K.E. and Cole A.A. (2000). Adult human chondrocytes in alginate culture. Preservation of the phenotype for further use in transplantation models. Der Orthopäde. 29, 100-106 (in German).
34. Shakibaei M. (1995). Integrin expression on epiphyseal mouse chondrocytes in monolayer culture. Histol. Histopathol. 10, 339-349.
35. Shakibaei M. (1998). Inhibition of chondrogenesis by integrin antibody in vitro. Exp. Cell Res. 240, 95-106.
36. Shakibaei M. and De Souza P. (1997). Differentiation of mesenchymal limb bud cells to chondrocytes in alginate beads. Cell Biol. Int. 21, 75-86.
37. Shakibaei M. and Mohamed-Ali H. (1994). Influence of mouse peritoneal macrophages on cartilage matrix and integrins in vitro. A morphological study. Pathobiology 62, 252-261.
38. Shakibaei M., Abou-Rebyeh H. and Merker H.J. (1993). Integrins in ageing cartilage tissue in vitro. Histol. Histopathol. 8, 715-723.
39. Shakibaei M., Zimmermann B. and Merker H.J. (1995). Changes in integrin expression during chondrogenesis in vitro: an immunomorphological study. J. Histochem. Cytochem. 43, 1061-1069.
40. Shakibaei M., De Souza P. and Merker H.J. (1997). Integrin expression and collagen type II implicated in maintenance of chondrocyte shapein monolayer culture: an immunomorphological study. Cell Biol. Int. 21, 115-125.
41. Shakibaei M., John T., De Souza P., Rahmanzadeh R. and Merker H.J. (1999). Signal transduction by beta1 integrin receptors in human chondrocytes in vitro: collaboration with the insulin-like growth factor-I receptor. Biochem. J. 342 Pt 3, 615-623.
42. Shakibaei M., Schulze-Tanzil G., de Souza P., John T., Rahmanzadeh M., Rahmanzadeh R. and Merker H.J. (2001). Inhibition of mitogenactivated protein kinase kinase induces apoptosis of human chondrocytes. J. Biol. Chem. 276, 13289-13294.
43. Shakibaei M., Seifarth C., John T., Rahmanzadeh M. and Mobasheri A. (2006). Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem. Pharmacol. 72, 1382-1395.
44. Shakibaei M., Csaki C., Rahmanzadeh M. and Putz R. (2008). Interaction between human chondrocytes and extracellular matrix in vitro: A contribution to autologous chondrocyte transplantation. Der Orthopäde 37, 440-447. (in German).
45. Studer R., Jaffurs D., Stefanovic-Racic M., Robbins P.D. and Evans C.H. (1999). Nitric oxide in osteoarthritis. Osteoarthrit. Cartilage 7, 377-379.
46. Tsukazaki T., Usa T., Matsumoto T., Enomoto H., Ohtsuru A., Namba H., Iwasaki K. and Yamashita S. (1994). Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes. Exp. Cell Res. 215, 9-16.
47. von der Mark K., Gauss V., von der Mark H. and Muller P. (1977). Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture. Nature 267, 531-532.
48. Yaeger P.C., Masi T.L., de Ortiz J.L., Binette F., Tubo R. and McPherson J.M. (1997). Synergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes. Exp. Cell Res. 237, 318-325.
49. Yang C., Li S.W., Helminen H.J., Khillan J.S., Bao Y. and Prockop D.J. (1997). Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp. Cell Res. 235, 370-373.
50. Zehentner B.K., Dony C. and Burtscher H. (1999). The transcription factor Sox9 is involved in BMP-2 signaling. J. Bone Miner. Res. 14, 1734-1741.