Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice

Endocrinology

Volumn 153, Issue 5, 2012, Pages 2287-2295

  Kubicky, Rita Ann ^a   Wu, Shufang ^a   Kharitonenkov, Alexei ^b   De Luca, Francesco ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; GROWTH HORMONE RECEPTOR; MESSENGER RNA; RECOMBINANT PROTEIN; SOMATOMEDIN C; STAT5 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BONE GROWTH; CHRONIC DISEASE; CONTROLLED STUDY; DIET RESTRICTION; GROWTH DISORDER; GROWTH PLATE; HORMONE BINDING; HORMONE RESISTANCE; KNOCKOUT MOUSE; LIVER; MALNUTRITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WILD TYPE;

ANIMALS; FIBROBLAST GROWTH FACTORS; GROWTH HORMONE; GROWTH PLATE; LIVER; MALNUTRITION; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; RECEPTORS, SOMATOTROPIN; STAT5 TRANSCRIPTION FACTOR; TIBIA;

EID: 84860341324     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1909     Document Type: Article

References (21)

1. Tannenbaum GS, Rorstad O, Brazeau P 1979 Effects of prolonged food deprivation on the ultradian growth hormone rhythm and immunoreactive somatostatin tissue levels in the rats. Endocrinology 104:1733-1738 (Pubitemid 9194124)
2. Maes M, Underwood LE, Ketelslegers JM 1983 Plasma somatomedin-C in fasted and refed rats: close relationship with changes in somatogenic but not lactogenic binding sites. J Endocrinol 97:243-252 (Pubitemid 13079809)
3. Straus DS, Takemoto CD 1990 Effects of fasting on insulin-like growth factor-1 and growth hormone receptor mRNA levels and IGF-1 gene transcription in rat liver. Mol Endocrinol 4:91-100
4. Bornfeldt KE, Arnqvist HJ, Enberg B, Mathews LS, Norstedt G 1989 Regulation of insulin-like growth factor-1 and growth hormone receptor gene expression by diabetes and nutritional states in rat tissues. J Endocrinol 122:651-656 (Pubitemid 19220620)
5. Counts DR, Gwirtsman H, Carlsson LM, Lesem M, Cutler Jr GB 1992 The effect of anorexia nervosa and refeeding on growth hor mone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab 75:762-767
6. Ho KY, Veldhuis JD, Johnson ML, Furlanetto R, Evans WS, Alberti KG, Thorner MO 1988 Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 81:968-975
7. Bang P, Brismar K, Rosenfeld RG, Hall K 1994 Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differ ently in patients with non-insulin-dependent diabetes mellitus vs. healthy nonobese and obese subjects. J Clin Endocrinol Metab 78: 960-967 (Pubitemid 24118096)
8. Nishimura T, Nakatake Y, Konishi M, Itoh N 2000 Identification of a novel FGF, FGF21, preferentially expressed in the liver. Biochim Biophys Acta 1492:203-206 (Pubitemid 30349198)
9. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB 2005 FGF-21 as a novel metabolic regulator. J Clin Invest 115:1627-1635 (Pubitemid 40814671)
10. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA 2007 En docrine regulation of the fasting response by PPARα-mediated in duction of fibroblast growth factor 21. Cell Metab 5:415-425 (Pubitemid 46825496)
11. Gälman C, Lundåsen T, Kharitonenkov A, Bina HA, Eriksson M, Hafström I, Dahlin M, Amark P, Angelin B, Rudling M 2008 The circulating metabolic regulator FGF21 is induced by prolonged fast ing and PPARα activation in man. Cell Metab 8:169-174
12. Reitman ML 2007 FGF21: a missing link in the biology of fasting. Cell Metab 5:405-407 (Pubitemid 46825502)
13. Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA 2008 Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab 8:77-83
14. Wang X, Jiang J, Warram J, Baumann G, Gan Y, Menon RK, Denson LA, Zinn KR, Frank SJ 2008. Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mech anism for GH insensitivity. Mol Endocrinol 22:1427-1437 (Pubitemid 351787002)
15. Schmittgen TD, Livak KJ 2008 Analyzing real-time PCR databy the comparative C(T) method. Nat Protoc 3:1101-1108 (Pubitemid 351818697)
16. Leung KC, Doyle N, Ballesteros M, Waters MJ, Ho KK 2000 Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation. J Clin Endocrinol Metab 85:4712-4720 (Pubitemid 32157657)
17. Touvier T, Conte-Auriol F, Briand O, Cudejko C, Paumelle R, Caron S, Baugé E, Rouillé Y, Salles JP, Staels B, Bailleul B 2009 LEPROT and LEPROTL1 cooperatively decrease hepatic growth hor mone action in mice. J Clin Invest 119:3830-3838
18. Thomas GB, Mercer JE, Karalis T, Rao A, Cummins JT, Clarke IJ 1990 Effects of restricted feeding on the concentrations of growth hormone (GH), gonadotropins, and prolactin (PRL) in plasma, and on the amounts of messanger ribonucleic acid for GH, gonadotropin subunits, and PRL in the pituitary glands of adult ovariectomized ewes. Endocrinology 126:1361-1367 (Pubitemid 20095735)
19. Breier BH, Bass JJ, Butler JH, Gluckman PD 1986 The somatotrophic axis in young steers: influence of nutritional status on pulsatile release of growth hormone and circulating concentrations of insulin-like growth factor-1. J Endocrinol. 11:209-215 (Pubitemid 16010276)
20. Buonomo FC, Baile CA 1991 Influence of nutrition deprivation on insulin-like growth factor-1, somatotropin, and metabolic hor mones in swine. J Anim Sci. 69:755-760
21. Heinrichs C, Colli M, Yanovski JA, Laue L, Gerstl NA, Kramer AD, Uyeda JA, Baron J 1997 Effects of fasting on the growth plate: systemic and local mechanisms. Endocrinology 138:5359-5365 (Pubitemid 27509698)