Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age

Cochrane Database of Systematic Reviews

Volumn 2011, Issue 9, 2011, Pages

  De Regil, Luz Maria ^a   Suchdev, Parminder S ^b   Vist, Gunn E ^c   Walleser, Silke ^d   Peña Rosas, Juan Pablo ^a  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

^b EMORY UNIVERSITY   (United States)

^c NORWEGIAN KNOWLEDGE CENTRE FOR THE HEALTH SERVICES   (Norway)

^d NONE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; IRON; RETINOL; TRACE ELEMENT; ZINC;

AFRICA; ANEMIA; ASIA; CARIBBEAN; CHILD DEVELOPMENT; CHILD HEALTH; CHILD NUTRITION; CLINICAL EFFECTIVENESS; CLINICAL OUTCOME; DIARRHEA; ENDEMIC DISEASE; FOOD INTAKE; FORTIFIED FOOD; HEMOGLOBIN DETERMINATION; HOME CARE; HOME PARENTERAL NUTRITION; HUMAN; IRON DEFICIENCY; IRON THERAPY; LOW INCOME COUNTRY; MALARIA; MORBIDITY; POWDER; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENT DISEASE; REVIEW; RISK REDUCTION; SAFETY; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TOOTH COLOR; TREATMENT OUTCOME; VOMITING; COOKING; DIET SUPPLEMENTATION; DIET THERAPY; INFANT; IRON DEFICIENCY ANEMIA; META ANALYSIS; METHODOLOGY; NUTRITIONAL DEFICIENCY;

ANEMIA, IRON-DEFICIENCY; COOKING; DEFICIENCY DISEASES; DIETARY SUPPLEMENTS; FOOD, FORTIFIED; HUMANS; INFANT; MICRONUTRIENTS; POWDERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRACE ELEMENTS;

EID: 80055073620     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD008959.pub2     Document Type: Review

References (98)

1. Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG. Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana. American Journal of Clinical Nutrition 2008;87:929-38.
2. Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG. Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: effects on growth and motor development. American Journal of Clinical Nutrition 2007;86:412-20.
3. Christofides A, Asante KP, Schauer C, Sharieff W, Owusu-Agyei S, Zlotkin S. Multi-micronutrient Sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: a randomized clinical trial. Maternal and Child Nutrition 2006;2(3):169-80.
4. Agostoni C, Giovannini M, Sala D, Usuelli M, Livio L, Francescato C, et al.Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient Sprinkles on fatty acid status in Cambodian infants. Journal of Pediatric Gastroenterology and Nutrition 2007;44(1):136-42.
5. Giovannini M, Sala D, Usuelli M, Livio L, Francescato G, Braga M, et al.Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in Cambodian infants. Journal of Pediatrics Gastroenterology and Nutrition 2006;42(3):306-12.
6. Hirve S, Bhave S. Re-analysis of the sprinkles study conducted by us at KEM Hospital Research Center, Pune, India. (personal communication) February 2011.
7. Hirve S, Bhave S, Bavdekar A, Naik S, Pandit A, Schauer C, et al.Low dose 'Sprinkles' - an innovative approach to treat iron deficiency anemia in infants and young children. Indian Pediatrics 2007;44(2):91-100.
8. Lundeen E, Schueth T, Toktobaev N, Zlotkin S, Hyder SM, Houser R. Daily use of Sprinkles micronutrient powder for 2 months reduces anemia among children 6 to 36 months of age in the Kyrgyz Republic: a cluster-randomized trial. Food and Nutrition Bulletin 2010;31(3):446-60.
9. Loechl CU, Menon P, Arimond M, Ruel MT, Pelto G, Habicht JP, et al.Using programme theory to assess the feasibility of delivering micronutrient Sprinkles through a food-assisted maternal and child health and nutrition programme in rural Haiti. Maternal and Child Nutrition 2009;5(1):33-48.
10. Menon P, Ruel MT, Loechl CU, Arimond M, Habicht JP, Pelto G, et al.Micronutrient Sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti. Journal of Nutrition 2007;137(4):1023-30.
11. Sharieff W, Bhutta Z, Schauer C, Tomlinson G, Zlotkin S. Micronutrients (including zinc) reduce diarrhoea in children: the Pakistan Sprinkles Diarrhoea Study. Archives of Disease in Childhood 2006;91(7):573-9.
12. Centers for Disease Control and Prevention. Baseline data from the Nyando Integrated Child Health and Education Project - Kenya, 2007. Morbidity and Mortality Weekly Report (MMWR) 2007;56(42):1109-13.
13. Suchdev PS, Leeds IL, McFarland DA, Flores R. Is it time to change guidelines for iron supplementation in malarial areas?. Journal of Nutrition 2010;140(4):875-6.
14. Suchdev PS, Ruth L, Woodruff BA, Mbakaya C, Mandava U, Flores R, et al.Sprinkles sales reduce anemia and iron deficiency among young children in Western Kenya. (personal communication) February 2011.
15. Bagni UV, Baiao MR, de Souza Santos MMA, Luiz RR, da Veiga GV. Effect of weekly rice fortification with iron on anaemia prevalence and haemoglobin concentration among children attending public daycare centres in Rio de Janeiro, Brazil [Efeito da fortificao semanel do arroz com ferro quelato sobre a frequencia de anemia e concentracao de hemoglobina em criancas de creches municipais de Rio de Janeiro, Brasil]. Cadernos de Saude Publica 2009;25(2):291-302.
16. Chen K, Li TY, Chen L, Qu P, Liu YX. Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on preschool children in a suburb of Chongqing, China. Journal of Nutritional Science and Vitaminology 2008;54(6):440-7.
17. Chen K, Zhang X, Li TY, Chen L, Wei XP, Qu P, Liu YX. Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children. Nutrition 2011;27(4):428-34.
18. Geltman PL, Hironaka LK, Mehta SD, Padilla P, Rodrigues P, Meyers AF, et al.Iron supplementation of low-income infants: a randomized clinical trial of adherence with ferrous fumarate sprinkles versus ferrous sulfate drops. Journal of Pediatrics 2009;154(5):738-43.
19. Ip H, Hyder SM, Haseen F, Rahman M, Zlotkin SH. Improved adherence and anaemia cure rates with flexible administration of micronutrient Sprinkles: a new public health approach to anaemia control. European Journal of Clinical Nutrition 2009;63(2):165-72.
20. Sharieff W, Yin SA, Wu M, Yang Q, Schauer C, Tomlinson G, et al.Short-term daily or weekly administration of micronutrient Sprinkles has high compliance and does not cause iron overload in Chinese schoolchildren: a cluster-randomized trial. Public Health Nutrition 2006;9(3):336-44.
21. Smuts CM, Dhansay MA, Faber M, van Stuijvenberg ME, Swanevelder S, Gross R, et al.Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, and growth in South African infants. Journal of Nutrition 2005;135(3):653S-9S.
22. Troesch B. Optimized micronutrient powder containing low levels of highly bioavailable iron and zinc together with EDTA, phytase and ascorbic acid improves the nutritional status of children. Sight and Life Magazine 2010, issue 3:9-14.
23. Troesch B, Egli I, Zeder C, Hurrell RF, de Pee S, Zimmermann MB. Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods. American Journal of Clinical Nutrition 2009;89(2):539-44.
24. Troesch B, van Stujivenberg ME, Smuts CM, Kruger HS, Biebinger R, Hurrell RF, et al.A micronutrient powder with low doses of highly absorbable iron and zinc reduces iron and zinc deficiency and improves weight-for-age Z-scores in South African children. Journal of Nutrition 2011;141(2):237-42.
25. Wijaya-Erhardt M, Erhardt JG, Untoro J, Karyadi E, Wibowo L, Gross R. Effects of daily or weekly multiple-micronutrient and iron foodlike tablets on body iron stores of Indonesian infants aged 6-12 mo: a double-blind, randomized, placebo-controlled trial. American Journal of Clinical Nutrition 2007;86(6):1680-6.
26. Zlotkin S, Arthur P, Antwi KY, Yeung G. Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. American Journal of Clinical Nutrition 2001;74(6):791-5.
27. Zlotkin S, Antwi KY, Schauer C, Yeung G. Use of microencapsulated iron (II) fumarate sprinkles to prevent recurrence of anaemia in infants and young children at high risk. Bulletin of the World Health Organization 2003;81(2):108-15.
28. Zlotkin S, Arthus P, Schauer C, Antwi KY, Yeung G, Piekarz A. Home-fortification with iron and zinc Sprinkles of iron Sprinkles alone successfully treats anemia in infants and young children. Journal of Nutrition 2003;133(4):1075-80.
29. Bilenko N, Belmaker I, Vardi H, Fraser D. Efficacy of multiple micronutrient supplementations on child health: study design and baseline characteristics. Israel Medical Association Journal 2010;12(6):342-7.
30. Huamán-Espino L, Aparco JP, Nuñez-Robles E, Gonzáles E, Pillaca J, Mayta-Tristán P. Consumption of chispitas® multimicronutrient supplements and anemia in 6-35-month-old children: cross-cut study in the context of a populational health intervention in Apurimac, Peru [Consumo de suplementos con multimicronutrientes Chispitas® y anemia en niños de 6 a 35 meses: estudio transversal en el contexto de una intervención poblacional en Apurímac, Perú]. Revista Peruana de Medicina Experimental y Salud Pública 2012;29(3):314-323.
31. Jack SJ, Ou K, Chea M, Chhin L, Devenish B, Dunbar M, Eang C. Hou K, Ly S, Khin M, Prak S, Taludkder A, Tokmoh L, Leon de la Barra S, Hill PC, Herbison P, Gilson RS. Effect of Micronutrient Sprinkles on Reducing Anemia. A Cluster-Randomized Effectiveness Trial. Archives of Pediatrics and Adolescent Medicine 2012;Published online July 16, 2012.:E1-E9.
32. Aburto NJ, Ramirez-Zea M, Neufeld LM, Flores-Ayala R. The effect of nutritional supplementation on physical activity and exploratory behavior of Mexican infants aged 8-12 months. European Journal of Clinical Nutrition 2010;64(6):644-51.
33. Colchero A, Neufeld LM. Cost estimations of different types of micronutrient supplements for children and pregnant women (poster presentation). FASEB Journal 2008; Vol. 22, issue Abstract 678.21.
34. García-Guerra A, Neufeld LM, Domínguez CP, García-Feregrino R, Hernández-Cabrera A. Effect of three supplements with identical micronutrient content on anemia in Mexican children (poster presentation). FASEB Journal 2008; Vol. 22, issue Abstract 677.5.
35. International Clinical Trials Registry Platform, World Health Organization. Early Childhood Development: A cluster-randomized controlled trial to Identify successful interventions and the mechanisms behind them. http://apps.who.int/trialsearch/Trial.aspx?TrialID=ISRCTN18991160 (accessed 23 January 2011).
36. International Clinical Trials Registry Platform, World Health Organization. Combating anaemia and micronutrient deficiencies among young children in rural Cambodia through in-home multiple micronutrient fortification and nutrition education compared with nutrition education alone. http://apps.who.int/trialsearch/Trial.aspx?TrialID=ACTRN12608000069358 (accessed 24 January 2011).
37. International Clinical Trials Registry Platform, World Health Organization. The impact of the use of zinc supplementation and other micronutrients on the occurence of diarrhea diseases and respiratory infections in children of daycare centers. http://apps.who.int/trialsearch/Trial.aspx?TrialID=NCT00967551 (accessed 24 January 2011).
38. Kam van der S. Effectiveness of nutritional supplementation in preventing malnutrition in children with infection. NIH ClinicalTrials.gov Register NCT01154803 2010.
39. International Clinical Trials Registry Platform, World Health Organization. Efficacy of the nutritional supplement sprinkles with zinc and micronutrients on anaemia and acute diarrhoea in Peruvian children. http://apps.who.int/trialsearch/Trial.aspx?TrialID=ISRCTN39244429 (accessed 24 January 2011). [Identifier ISRCTN39244429]
40. International Clinical trials Registry Platform, World Health Organization. The Effect of iron fortification of complementary foods on iron status and infant gut microbiota in Kenya. Available at http://apps.who.int/trialsearch/Trial.aspx?TrialID=NCT01111864 (accessed 24 January 2011).
41. International Clinical Trials Registry Platform, World Health Organization. Seasonal Impact of iron fortification on malaria incidence in Ghanaian children. Available at http://apps.who.int/trialsearch/Trial.aspx?TrialID=NCT01001871 (accessed 24 January 2011).
42. Adetifa I, Okomo U. Iron supplementation for reducing morbidity and mortality in children with HIV. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD006736.pub2]
43. Angermayr L, Clar C. Iodine supplementation for preventing iodine deficiency disorders in children. Cochrane Database of Systematic Reviews 2004, Issue 2. [DOI: 10.1002/14651858.CD003819.pub2]
44. Balshem H, Helfand M, Schünemann HJ, Oxman AD, Kunz R, Brozek J, et al.GRADE guidelines: Rating the quality of evidence. Journal of Clinical Epidemiology 2011;64(4):401-6.
45. Beaton G, Martorell R, Aronson K, Edmonston B, McCabe G, Ross CA, et al.Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. UN, ACC/SCN State-of-the-art Series. Nutrition Policy Discussion Paper 1993, issue 13.
46. Beaton GH, McCabe GP. Efficacy of intermittent iron supplementation in the control of iron deficiency anaemia in developing countries. The Micronutrient Initiative. Ottawa: The Micronutrient Initiative, 1999.
47. Berger J, Aguayo VM, Tellez W, Lujan C, Traissac P, San Miguel JL. Weekly iron supplementation is as effective as 5 day per week iron supplementation in Bolivian school children living at high altitude. European Journal of Clinical Nutrition 1997;51(6):381-6.
48. Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, et al.What works? Interventions for maternal and child undernutrition and survival. Lancet 2008;371(9610):417-40.
49. Black RE, Allen LH, Bhutta ZA, Caulfield LE, De Onis M, Ezzati M, et al.Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 2008;371(9608):243-60.
50. Brown KH, Wuehler SE, Peerson JM. The importance of zinc in human nutrition and estimation of the global prevalence of zinc deficiency. Food and Nutrition Bulletin 2001;22(2):113-25.
51. Brown KH, Baker SK, IZiNCG Steering Committee (International Zinc Nutrition Consultative Group). Galvanizing action: conclusions and next steps for mainstreaming zinc interventions in public health programs. Food and Nutrition Bulletin 2009;30 Suppl(1):179-84.
52. De Pee S, Kraemer K, van den Briel T, Boy E, Grasset C, Moench-Pfanner R, et al.Quality criteria for micronutrient powder products: report of a meeting organized by the World Food Programme and Sprinkles Global Health Initiative. Food and Nutrition Bulletin 2008;29(3):232-41.
53. De-Regil LM, Jefferds MED, Pena-Rosas JP. Home fortification with multiple micronutrient powders for preschool and school age children. Cochrane Database of Systematic Reviews To be published.
54. Dewey KG, Brown KH. Update on technical issues concerning complementary feeding of young children in developing countries and implications for intervention programs. Food and Nutrition Bulletin 2003;24(1):5-28.
55. Dewey KG. Increasing iron intake of children through complementary foods. Food and Nutrition Bulletin 2007;28(4):S595-S609.
56. Dewey KG, Adu-Afarwuah S. Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries. Maternal and Child Nutrition 2008;4(Suppl 1):24-85.
57. Fawzi WW, Chalmers TC, Herrera MG, Mosteller F. Vitamin A supplementation and child mortality. A meta-analysis. JAMA 1993;269(7):898-903.
58. Glasziou PP, Mackerras DE. Vitamin A supplementation in infectious diseases: a meta-analysis. BMJ 1993;306(6874):366-70.
59. Brozek J, Oxman A, Schünemann H. GRADEpro Version 3.2 for Windows. Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group, 2008.
60. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
61. Horton S, Alderman H, Rivera JA. Copenhagen Consensus 2008 Challenge Paper: Hunger and Malnutrition. http://www.copenhagenconsensus.com/Admin/Public/Download.aspx?file=Files%2fFiler%2fCC08%2fPapers%2fOfficial+papers%2fCopenhagen_Consensus_2008_-_hunger_and_malnutrition.pdf 2008:1-40.
62. Hyder SMZ, Haseen F, Rahman M, Tondeur M, Zlotkin SH. Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh. Food Nutrition Bulletin 2007;28(2):156-64.
63. Imdad A, Herzer K, Mayo-Wilson E, Yakoob MY, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database of Systematic Reviews 2010, Issue 12. [DOI: 10.1002/14651858.CD008524.pub2]
64. International Nutritional Anemia Consultative Group (INACG). Guidelines for iron supplementation to prevent iron deficiency anemia. In: Stoltzfus RJ, Dreyfuss ML editor(s). Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia. Washington DC: ILSI Press, 1998.
65. Irlam JH, Visser ME, Rollins N, Siegfried N. Micronutrient supplementation in children and adults with HIV infection. Cochrane Database of Systematic Reviews 2010, Issue 12. [DOI: 10.1002/14651858.CD003650.pub3]
66. Jefferds ME, Ogange L, Owuor M, Cruz K, Person B, Obure A, et al.Formative research exploring acceptability, utilization, and promotion in order to develop a micronutrient powder (Sprinkles) intervention among Luo families in western Kenya. Food and Nutrition Bulletin 2010;31 Suppl(2):179-85.
67. Liyanage C, Zlotkin S. Bioavailability of iron from micro-encapsulated iron sprinkle supplement. Food and Nutrition Bulletin 2002;23 Suppl(3):133-7.
68. Loechl CU, Menon P, Arimond M, Ruel MT, Pelto G, Habicht JP, et al.Using programme theory to assess the feasibility of delivering micronutrient Sprinkles through a food-assisted maternal and child health and nutrition programme in rural Haiti. Maternal and Child Nutrition 2009;5(1):33-48.
69. Lozoff B. Iron deficiency and child development. Food and Nutrition Bulletin 2007;28 Suppl(4):560-71.
70. Martins S, Logan S, Gilbert RE. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database of Systematic Reviews 2001, Issue 2. [DOI: 10.1002/14651858.CD001444]
71. Menon P, Ruel MT, Loechl CU, Arimond M, Habicht JP, Pelto G, et al.Micronutrient Sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti. Journal of Nutrition 2007;137(4):1023-30.
72. National Insititutes of Health, Iron and Malaria Technical Working Group. Chapter 3: Interventions. In: Raiten D, Namaste S, Brabin B editor(s). Considerations for the Safe and Effective Use of Iron Interventions. Bethesda: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), 2011 (in press):16-51.
73. Ojukwu JU, Okebe JU, Yahav D, Paul M. Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD006589.pub2]
74. Oppenheimer SJ. Iron and its relation to immunity and infectious disease. Journal of Nutrition 2001;131 Suppl 2:616-33.
75. PAHO/WHO . Guiding Principles for Complementary Feeding of the Breastfed Child. Washington DC: Pan American Health Organization, 2001.
76. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
77. Sanghvi T, Ross J, Heymann H. Why is reducing vitamin and mineral deficiencies critical for development? The links between VMD and survival, health, education and productivity. Food and Nutrition Bulletin 2007;28 Suppl 1:167-73.
78. Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, Dutta A, et al.Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomized, placebo-controlled trial. Lancet 2006;367(9505):133-43.
79. Sprinkles Global Health Initiative. Product Information. Standard Formulations. http://www.sghi.org/ (accessed 20 May 2010).
80. Stephensen CB. Vitamin A, infection, and immune function. Annual Review of Nutrition 2001;21:167-92.
81. Stoltzfus RJ. Iron interventions for women and children in low-income countries. Journal of Nutrition 2011;141:S756-S762.
82. Suchdev PS, Leeds I, McFarland D, Flores R. Is it time to change guidelines for iron supplementation in malarial areas?. Journal of Nutrition 2010;140(4):875-6.
83. Micronutrient Initiative, Flour Fortification Initiative, USAID, GAIN, WHO, The World Bank, UNICEF . Investing in the Future: A United Call to Action on Vitamin and Mineral Deficiencies: Global Report 2009. Ottawa, Canada: The Micronutrient Initiative, 2009. [ISBN: 978-1-894217-31-6]
84. UNICEF . Workshop Report on Scaling up the use of Multiple Micronutrient Powders to improve the quality of complementary foods for young children in Asia. Summary, outcomes, conclusions and next steps; 2009 28 Apr-1 May, Bangkok, Thailand. Bangkok: UNICEF, 2009.
85. UNICEF 2011. The state of the world's children 2011: Adolescence An Age of Opportunity. New York: United Nations Children's Fund, 2011.
86. Viteri FE. Iron supplementation for the control of iron deficiency in populations at risk. Nutrition Reviews 1997;55(6):195-209.
87. World Health Organization, UNICEF, UNU . Iron Deficiency Anaemia Assessment, Prevention and Control: a Guide for Programme Managers. Geneva: World Health Organization, 2001.
88. World Health Organization. Guiding Principles for Feeding Non-Breastfed Children 6-24 Months of Age. Geneva: World Health Organization, 2005.
89. World Health Organization. Workshop to review the results of studies evaluating the impact of zinc supplementation on childhood mortality and severe morbidity: conclusions and next steps; 2006 15-16 Sept, Geneva, Switzerland. Geneva: World Health Organization, 2007, issue http://www.who.int/child_adolescent_health/documents/pdfs/zinc_mortality_workshop_2007.pdf.
90. World Health Organization. Global Health Risks: Mortality and Burden of Disease Attributable to Selected Major Risks. Geneva: World Health Organization, 2009.
91. World Health Organization, Centers for Disease Control and Prevention. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. World Health Organization, 2008. Available from http://whqlibdoc.who.int/publications/2008/9789241596657_eng.pdf.
92. World Health Organization/UNICEF. Clinical management of acute diarrhoea. Geneva: World Health Organization, 2004.
93. World Health Organization, World Food Programme, UNICEF . Preventing and controlling micronutrient deficiencies in populations affected by an emergency. Geneva: World Health Organization, 2007.
94. World Bank, UNICEF, WHO, WFP . Scaling Up Nutrition: A Framework For Action. Policy Brief. Food and Nutrition Bulletin 2010;31(1):178-86.
95. World Vision Mongolia. Effectiveness of home-based fortification of complementary foods with Sprinkles in an integrated nutrition program to address rickets and anemia. Ulannbaatar 2005.
96. Zeng X, Wu T. Iron supplementation for iron deficiency anemia in children. Cochrane Database of Systematic Reviews 2007, Issue 2. [DOI: 10.1002/14651858.CD006465]
97. Zlotkin SH, Tondeur M. Specific strategies to address micronutrient deficiencies in the young child: supplementation and home fortification. In: Pettifor J, Zlotkin S editor(s). Micronutrient Deficiencies During the Weaning Period and the First Years of Life. Nestlé Nutrition Workshops Series Pediatric Program. Vol. 54, Basel: Nestec Ltd, 2004:233-48.
98. Zlotkin SH, Schauer C, Christofides A, Sharieff W, Tondeur MC, Hyder SM. Micronutrient sprinkles to control childhood anaemia. PLoS Medicine 2005;2(1):e1.